Abstract:
PURPOSE:The aim of the study was to examine if improvements of stimulus detection performance in visual field tests after intensive visual training of the visual field border zone in patients with visual field defects are associated with changes in self-reported vision- and health-related quality of life (QoL). METHODS:We studied a clinical sample of 85 patients suffering from visual field loss after brain damage that underwent repetitive, daily light stimulation (vision restoration training, VRT) of the visual field border and the blind visual field for up to 75 hrs (N=16) or 150 hrs (N=69). Stimulus detection was quantified in the central visual field with a campimetric method before and after intervention. Health-related QoL was assessed by the Health-Survey SF-36 and vision-related QoL by the 39-item National Eye Institute Visual Function Questionnaire (NEI-VFQ). RESULTS:Both vision- and health-related QoL measures improved after VRT. Significant increases were found in 8 out of 12 NEI-VFQ and 3 out of 8 SF-36 subscales. Of the 85 participants 6% showed a decrease in stimulus detection performance, 42% showed an increase of less than 5% detected stimuli, 24% showed an increase of 5-10% detected stimuli and 28% of more than 10% detected stimuli. Changes in campimetric stimulus detection rates were related to NEI-VFQ subscales point differences general vision (3 points), difficulty with near vision activities (4 points), limitations in social functioning due to vision (4 points) and driving problems (12 points). There was no relation of visual field changes to changes in SF-36 component and subscale scores. CONCLUSIONS:The NEI-VFQ is a valuable measure of self-reported visual impairment in patients with visual field defects. Stimulation of the visual field by training may lead to improvements of vision-related QoL which were correlated with the extent of visual field enlargements.
journal_name
Restor Neurol Neuroscijournal_title
Restorative neurology and neuroscienceauthors
Gall C,Mueller I,Gudlin J,Lindig A,Schlueter D,Jobke S,Franke GH,Sabel BAsubject
Has Abstractpub_date
2008-01-01 00:00:00pages
341-53issue
4-5eissn
0922-6028issn
1878-3627journal_volume
26pub_type
临床试验,杂志文章abstract::Animals with unilateral neurotoxic lesions in the striatum exhibit a stereotypical biased rotational behavior in response to dopamine agonists. We recently argued that the rotational test may be subject to sensitization effects of the drug. Accordingly, we proposed the drug-free elevated body swing test (EBST) as an a...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-1995-9103
更新日期:1995-01-01 00:00:00
abstract::Retinal and cortical lesions are completely different events that trigger visual cortical plasticity. We therefore compared the cortical effects of homonymous lesions of the central retina with effects of cortical lesions. All in vivo experiments were performed in anaesthetized, adult cats. Retinal lesions were made w...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:Previous studies demonstrated that administering extradural cortical stimulation (ECS) to rats during the acute phase of a photothrombotic infarct enhances motor recovery. However, the effect of ECS during the subacute phase was unknown. We aimed to evaluate the effects of ECS on motor recovery in a rat model o...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-140445
更新日期:2015-01-01 00:00:00
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journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-120287
更新日期:2013-01-01 00:00:00
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journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.3233/RNN-150574
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The patients with chronic Disorders of Consciousness (DoC) mostly present with extremely challenging differential diagnosis. The advanced analysis of electroencephalographic (EEG) signals induced by brain stimulation paradigms may provide an appropriate approach to differentiate patients with DoC, besides th...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-170741
更新日期:2017-01-01 00:00:00
abstract::Over the past few decades astrocytes have emerged from being considered simple packing tissue in the brain to become major players in the development, survival and functioning of central nervous system (CNS) neurons. As the influence that astrocytes (and the various molecules they produce) have on the development of C...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:High definition transcranial direct current stimulation (HD-tDCS) has been administered over single brain regions for small numbers of sessions. Safety, feasibility and tolerability of HD-tDCS over multiple brain regions, multiple daily stimulations and long periods are not established. OBJECTIVE:We studied...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-170757
更新日期:2017-01-01 00:00:00
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journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-130312
更新日期:2013-01-01 00:00:00
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journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-2011-603
更新日期:2011-01-01 00:00:00
abstract::The hypothesis that a destabilization of mitochondrial function during neuronal exposure to excitatory amino acids may be involved in the mechanism of neuronal death was examined. The mitochondrial membrane potential (Delta(psi)m) and the cytoplasmic Ca2+ concentration ([Ca2+]c) were monitored simultaneously in single...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract:PURPOSE:Ischemic stroke is associated with a variety pathophysiological changes affecting both glial and neuronal brain tissue. These changes are mirrored in the release of specific proteins into peripheral blood. Neurone-specific enolase (NSE), protein S100B and glial fibrillary acidic protein (GFAP) are those protein...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2003-01-01 00:00:00
abstract::Regenerating nerve fiber sprouts enveloped by olfactory bulb (OB) ensheathing cells (ECs) seem to escape the inhibitory influence of gliotic tissue. Accordingly, these cells may be useful for general repair of injured CNS. Relatively large numbers of ECs could be purified from confluent cultures of adult rat olfactory...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-1996-10104
更新日期:1996-01-01 00:00:00
abstract:PURPOSE:Aging is believed to affect epigenetic marking of brain DNA with 5-methylcytosine (5mC) and possibly via the 5mC to 5-hydroxymethylcytosine (5hmC) conversion by TET (ten-eleven translocation) enzymes. We investigated the impact of aging on hippocampal DNA 5-hydroxymethylation including in the sequence of aging-...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-2012-110223
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Traumatic brain injury can result in lasting cognitive dysfunction due to degeneration of mature hippocampal neurons as well as the loss of immature neurons within the dentate gyrus. While endogenous neurogenesis affords a partial recovery of the immature neuron population, hippocampal neurogenesis may be en...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-180831
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Neuroplastic alterations of cortical excitability and activity represent the likely neurophysiological foundation of learning and memory formation. Beyond their induction, alterations of these processes by subsequent modification of cortical activity, termed metaplasticity, came into the focus of...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-2011-0601
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:The interest in human conscious awareness has increasingly propelled the study of neglect, the most striking occurrence of an acquired lack of conscious experience of space. Neglect syndromes commonly arise after unilateral brain damage that spares primary sensory areas nonetheless leading to a lack of consciou...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-01 00:00:00
abstract:PURPOSE:To determine how age at the time of left middle cerebral artery stroke affects language lateralization in a combined sample of subjects with perinatal, childhood, and adult stroke. METHODS:19 participants who had perinatal stroke (<1 month of age), 32 with later stroke, and 51 sex-/age-matched healthy controls...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-140402
更新日期:2014-01-01 00:00:00
abstract::Traumatic brain and spinal cord injuries are severe burdens for the patients, their relatives, the health care providers and society as a whole. Recent data demonstrate the magnitude of the problem: It is mostly a disease of the young gen-eration (age 20-45 years) with mortality rates for severe traumatic brain injury...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:The relationship between auditory temporal-order perception and phoneme discrimination has been discussed for several years, based on findings, showing that patients with cerebral damage in the left hemisphere and aphasia, as well as children with specific language impairments, show deficits in temporal-process...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Dimethyl fumarate (DMF) has immune-modulatory and neuro-protective characteristics that can be used for treatment of acute ischemic stroke. OBJECTIVE:To investigate the therapeutic effects of DMF on histological and functional recovery of rats after transient middle cerebral artery (MCA) occlusion. METHODS...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-160670
更新日期:2017-01-01 00:00:00
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journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-130361
更新日期:2014-01-01 00:00:00
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journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,评审
doi:10.3233/RNN-150606
更新日期:2016-04-11 00:00:00
abstract:BACKGROUND:Patients suffering from chronic disorders of consciousness (DOC), including minimally conscious state (MCS) and unresponsive wakefulness syndrome (UWS), typically show an awareness impairment paralleled by a significant reflex hyper-excitability, which depend on the cortical deafferentation following brain-d...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-160655
更新日期:2017-01-01 00:00:00
abstract::Various basic qualitative and quantitative methods for the evaluation of sensorimotor functions after Traumatic Brain Injury (TBI) are introduced and discussed. Methodological aspects are illustrated by a single case follow-up study of a child after severe TBI (age 11; 712;1 yrs; 6, 8 and 12 month post TBI) in compar...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::PURPOSE: Nerve allografts are highly antigenic and, thus, require the continuous use of immunosuppressive drugs. FK 506 was found to pre-vent rejection successfully. However, clinically neurotoxic complications have been noted in the central and peripheral nervous system although an increased rate of axonal regenerati...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract:PURPOSE:The aim of the present study was to explore the use of two-photon microscopy for investigating the therapeutic time window of methylprednisolone (MP) treatment after spinal cord injury (SCI). METHODS:Twenty-four YFP H-line mice were subjected to hemisection SCI and then divided into four groups. Group 1 receiv...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-140463
更新日期:2015-01-01 00:00:00
abstract::Non-invasive brain stimulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), can modify cortical excitability in a lasting fashion. The modification can be bi-directional in nature and holds considerable therapeutic promise for a number of neurological conditions. However, the effectiveness ...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,评审
doi:10.3233/RNN-2010-0565
更新日期:2010-01-01 00:00:00
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journal_title:Restorative neurology and neuroscience
pub_type: 社论
doi:10.3233/RNN-2010-0510
更新日期:2010-01-01 00:00:00
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journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-1990-2205
更新日期:1990-01-01 00:00:00