Abstract:
PURPOSE:This study investigated whether enrichment improves hindlimb movement following complete spinal cord transection and transplantation of olfactory ensheathing glia (OEG), with or without a Schwann cell (SC) bridge. METHODS:Motor activity was encouraged through provision of motor enrichment housing (MEH); a multi-level cage containing ramps, textured surfaces and rewards. Hindlimb joint movement was assessed weekly for 22 weeks starting one week post-surgery, comparing rats housed in MEH to those in basic housing (BH). Transganglionic tracer was injected into the crushed right sciatic nerve three days prior to sacrifice, allowing sensory axons in the dorsal columns to be visualized by immunolabeling. Serotonergic axons and glial cells expressing low affinity nerve growth factor receptor were identified by immunolabeling. RESULTS:All rats, having received transplants, recovered some hindlimb movement. Rats housed in BH progressively lost recovered hindlimb function whereas recovered hindlimb movements were sustained in most rats in MEH. In rats transplanted with SCs and OEG, effects of MEH were first significant 14 weeks after injury. In rats transplanted with OEG, a trend was seen from 14 weeks after injury, but this did not reach significance. In all rats, traced sensory axons died back from sites of transplantation and did not regenerate rostrally. Further, in no rat were serotonergic axons observed regenerating into, around or beyond transplants. CONCLUSIONS:Transection and transplantation of SC/OEG or OEG induced recovery of hindlimb function. This recovered hindlimb movement was sustained in rats housed in MEH but was progressively lost in rats housed in BH. Because benefits of MEH were not observed until 14 weeks after injury, long-term assessment of behavior is recommended. BH conditions are not conducive to maintenance of recovered hindlimb function, and MEH should be used in studies of recovery of function following spinal cord injury.
journal_name
Restor Neurol Neuroscijournal_title
Restorative neurology and neuroscienceauthors
Moon LD,Leasure JL,Gage FH,Bunge MBsubject
Has Abstractpub_date
2006-01-01 00:00:00pages
147-61issue
3eissn
0922-6028issn
1878-3627journal_volume
24pub_type
杂志文章abstract:PURPOSE:Many studies have investigated the roles of neurotrophic factors in nerve regeneration by examining either anatomical recovery (regenerated axon count) or functional recovery as measured by sensory and motor behavior. This longitudinal study examined the effects of NGF and NT3 on functional and anatomical recov...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:To analyze the effects of CGP 3466, a compound structurally related to deprenyl, on survival and function of fetal ventral mesencephalic dopaminergic neurons. METHODS:Free-floating roller tube (FFRT) cultures of rat (E14) ventral mesencephalon were treated with CGP 3466 [10-8 M] for 7 days. Tyrosine hydroxylas...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract:BACKGROUND:Patients suffering from chronic disorders of consciousness (DOC), including minimally conscious state (MCS) and unresponsive wakefulness syndrome (UWS), typically show an awareness impairment paralleled by a significant reflex hyper-excitability, which depend on the cortical deafferentation following brain-d...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-160655
更新日期:2017-01-01 00:00:00
abstract:PURPOSE:To assess whether insights from postural control without additional visual feedback (VFB) could be gained to explain the possible VFB effects (or non-effects) on upright stance performance. METHODS:The center-of-pressure (CP) displacements of 39 patients with a recent hemispheric stroke (93 days ± 56; mean ± s...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-2010-0544
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:Immunomodulatory agents are often combined in organ transplantation to minimize toxicity and enhance therapeutic effect. We hypothesized that combining low-dose FK506 with anti-CD40 Ligand (anti-CD40L mAb) would enhance regeneration through peripheral nerve allografts while preserving immune unresponsiveness. ...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::The authors used different kinds of peripheral nerve grafts to reconstruct a terminal branch of the brachial plexus (the median nerve) gap of adult Sprague-Dawley rats, including fresh or frozen autografts and allografts from Norway rats. They also performed acellular allograft repopulation by autogenous Schwann cells...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:Glutamate transporters are responsible for removing glutamate from the extracellular space and have the potential to protect neurons from excitotoxicity. In the present study, the effects of ceftriaxone and (2R, 4R)-APDC (APDC) on the protein expression of GLAST and GLT-1, the rate of glutamate uptake, and neur...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-2011-603
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:The effectiveness of embryonic stem cell (eSC) therapy has been explored in many models of neurological disease and several research groups have shown that eSC treatment leads to improved outcomes in pre-clinical models of traumatic brain injury (TBI). Though functional recovery occurs, few surviving eSCs appea...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-120299
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:Traumatic brain injury (TBI) -induced brain edema can be reduced by acute progesterone (PROG) treatment in young adult males and females, and in aged males. To extend these findings we tested these hypotheses: 1. Acute PROG treatment post-TBI will reduce cortical edema in aged females as much as in young adults...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-2009-0475
更新日期:2009-01-01 00:00:00
abstract:PURPOSE:Current models of intracerebral hematoma are difficult to use for neurotransplantation studies because of high mortality and important variations of morphology, size and location of blood deposits. We propose a modification of the autologous blood infusion technique in rats to reduce these limitations. METHODS...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:Aging is believed to affect epigenetic marking of brain DNA with 5-methylcytosine (5mC) and possibly via the 5mC to 5-hydroxymethylcytosine (5hmC) conversion by TET (ten-eleven translocation) enzymes. We investigated the impact of aging on hippocampal DNA 5-hydroxymethylation including in the sequence of aging-...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-2012-110223
更新日期:2012-01-01 00:00:00
abstract::IVth International Symposium on Neural TransplantationEdited by William J. Freed and Jeffrey M. RosensteinThe George Washington University, Washington, DC, USAJuly 12-16, 1992. ...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-1992-4301
更新日期:1992-01-01 00:00:00
abstract::Non-invasive brain stimulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), can modify cortical excitability in a lasting fashion. The modification can be bi-directional in nature and holds considerable therapeutic promise for a number of neurological conditions. However, the effectiveness ...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,评审
doi:10.3233/RNN-2010-0565
更新日期:2010-01-01 00:00:00
abstract:BACKGROUND:A cerebral ischemic stroke involves mitochondrial dysfunction, motor deficits, and paralysis; and Danhong injection (DHI) might possess mitochondrial protection and functional recovery in a stroke subject through promoting expression of parkin, a ubiquitin ligase playing a key role in the regulation of prote...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-180828
更新日期:2019-01-01 00:00:00
abstract::In 2009 the German BMBF (German Ministry of Education and Research) established an Integrated Center for Research and Treatment (IFB(LMU)) of Vertigo, Balance and Ocular Motor Disorders in Munich. After the 10-year period of funding by the BMBF, it is envisioned that the (IFB(LMU)) will continue over the long term wit...
journal_title:Restorative neurology and neuroscience
pub_type: 社论
doi:10.3233/RNN-2010-0510
更新日期:2010-01-01 00:00:00
abstract::A long-term goal in motor rehabilitation is that treatment is not selected on the basis of 'schools of thought', but rather, based on knowledge about efficacy and effectiveness of specific interventions for specific situations (e.g. functional syndromes). Motor dysfunction after stroke or TBI can be caused by many dif...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Repetitive transcranial magnetic stimulation (rTMS) may enhance plastic changes in the human cortex and modulation of behavior. However, the underlying neural mechanisms have not been sufficiently investigated. We examined the clinical effects and neural correlates of high-frequency rTMS coupled ...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.3233/RNN-2012-110162
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:The purpose of this study was to delineate the relationship between several types of T1-weighted MRI pathology and motor rehabilitation potential following Constraint Induced Movement therapy (CI therapy) in chronic stroke. METHODS:Stepwise regression was employed (n = 80) to identify predictors of motor recov...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-130366
更新日期:2014-01-01 00:00:00
abstract:PURPOSE:To determine how age at the time of left middle cerebral artery stroke affects language lateralization in a combined sample of subjects with perinatal, childhood, and adult stroke. METHODS:19 participants who had perinatal stroke (<1 month of age), 32 with later stroke, and 51 sex-/age-matched healthy controls...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-140402
更新日期:2014-01-01 00:00:00
abstract::The lamination of dentate gyrus afferents established during development is maintained following lesion-induced reactive growth in the adult. After partial deafferentation sprouts from undamaged afferents restore most synapses, while respecting the laminae relative boundaries. No evidence of trans-laminar sprouting ha...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2001-01-01 00:00:00
abstract::The effects of striatal transplantation of PC12 cells on amphetamine-induced rotational behavior and monoamine levels were examined in rats with unilateral 6-hydroxydopamine (6-OHDA) lesions in the nigrostriatal pathway. A total of 9 × 104 or 9 × 105 cells of PC12 was implanted into 3 sites in the striatum and changes...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-1993-6105
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:A realistic body representation needs to be constantly updated. In case of physiological modifications, body representations integrate information coming from different sensory sources, including the sense of touch. Previous studies described transient modifications of these representations following illusory d...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-120286
更新日期:2013-01-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy of an expanded form of Constraint-Induced Movement Therapy (eCIMT) that renders CIMT, originally designed for treating mild-to-moderate upper-extremity hemiparesis, suitable for treating severe hemiparesis. METHODS:Twenty-one adults ≥1 year after stroke with severe upper-extremity hemi...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.3233/RNN-170792
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Previous neuroimaging studies of oddball tasks and other paradigms measuring attention processes support right hemisphere dominance for attentional processes. Using an auditory selective attention task, we studied the functional asymmetry of the human brain in response to attended or unattended deviant tones. S...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Hearing loss is becoming a real social and health problem. Its prevalence in the elderly is an epidemic. The risk of developing hearing loss is also growing among younger people. If left untreated, hearing loss can perpetuate development of neurodegenerative diseases, including dementia. Despite recent advan...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-190898
更新日期:2019-01-01 00:00:00
abstract::Retinal and cortical lesions are completely different events that trigger visual cortical plasticity. We therefore compared the cortical effects of homonymous lesions of the central retina with effects of cortical lesions. All in vivo experiments were performed in anaesthetized, adult cats. Retinal lesions were made w...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:INTRODUCTION:Traumatic brain injuries (TBI) are one of the most common consequences of traffic accidents. Patients with mild, moderate or severe brain injuries suffer from physical, cognitive, behavioral, emotional and social problems. Most of these problems have been a long standing focus amongst practitioners and res...
journal_title:Restorative neurology and neuroscience
pub_type: 共识发展会议,杂志文章,评审
doi:
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Parkinson's Disease (PD) is characterized by progressive and disabling symptoms. An impaired oxidative metabolism efficiency was supposed to be involved in the systemic impairment. Rehabilitative treatment represents a valid tool in promoting skeletal muscle's adaptations, even if no solid studies on muscle ...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-170738
更新日期:2018-01-01 00:00:00
abstract::In four patients with left visuo-spatial hemineglect and right brain- damage, the therapeutic effects of Transcutaneous Electrical Nervous Stimulation (TENS) of the left neck muscles, associated with a non-specific treatment, and of a specific rehabilitation paradigm were investigated. The two treatments were given fo...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-1996-10402
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Multiple Sclerosis is a heterogeneous disorders involving in early stage gait and balance. Together with immunomodulating therapies, rehabilitation had a crucial role in improving motor tasks and quality of life. Between the emerging techniques, Focal Vibrations (FV) could play a role, but they have been use...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.3233/RNN-160665
更新日期:2016-09-21 00:00:00