CGP 3466 increases survival of cultured fetal dopaminergic neurons.

abstract：:Over the past few decades astrocytes have emerged from being considered simple packing tissue in the brain to become major players in the development, survival and functioning of central nervous system (CNS) neurons. As the influence that astrocytes (and the various molecules they produce) have on the development of C...

journal_title：Restorative neurology and neuroscience

authors： Gates MA,Dunnett SB

更新日期：2001-01-01 00:00:00

abstract：:The mechanisms underlying recovery of function following damage to the CNS, although suspected, are virtually unknown. After damage to the adult cat spinal cord, recovery of motor behavior depends on which systems have been interrupted and which remain intact. For example, following hemisection, overground (voluntary)...

journal_title：Restorative neurology and neuroscience

authors： Goldberger ME

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:To assess whether insights from postural control without additional visual feedback (VFB) could be gained to explain the possible VFB effects (or non-effects) on upright stance performance. METHODS:The center-of-pressure (CP) displacements of 39 patients with a recent hemispheric stroke (93 days ± 56; mean ± s...

journal_title：Restorative neurology and neuroscience

authors： Rougier P,Boudrahem S

更新日期：2010-01-01 00:00:00

abstract：:Purpose: Caspase-3 is known as a crucial effector for apoptotic cell death. Apoptosis has recently been recognized as an important cell death mechanism after spinal cord injury (SCI). This study attempts to define the effect of methylprednisolone (MP) on the activation of caspase-3 in the lesioned area following SCI. ...

journal_title：Restorative neurology and neuroscience

authors： Li X,Oudega M,Dancausse HA,Levi AD

更新日期：2000-01-01 00:00:00

abstract：:Pyramidal neurons inside transplants of embryonic nervous tissue are capable of generating axonal extrinsic hippocampal fiber connections over considerable distances to appropriate target areas in the mature brain. The establishment of long-distance graft efferents to the lateral septum and to the entorhinal cortex wa...

journal_title：Restorative neurology and neuroscience

authors： Sprick U

更新日期：1991-01-01 00:00:00

abstract：:The lamination of dentate gyrus afferents established during development is maintained following lesion-induced reactive growth in the adult. After partial deafferentation sprouts from undamaged afferents restore most synapses, while respecting the laminae relative boundaries. No evidence of trans-laminar sprouting ha...

journal_title：Restorative neurology and neuroscience

authors： Collazos-Castro JE,Nieto-Sampedro M

更新日期：2001-01-01 00:00:00

abstract：:The aim of this study was to gauge the possible sprouting of primary afferent fibers following dorsal rhizotomies using Fos-like immunoreactivity (Fos-LI) in order to label neurons activated by formalin injection into the rat forepaw. To assess the functional consequences of possible sprouting of fine diameter primary...

journal_title：Restorative neurology and neuroscience

authors： Abbadie C,Lombard MC,Morain F,Besson JM

更新日期：1994-01-01 00:00:00

abstract：:In the present study, we have developed an animal model for central nervous system (CNS) damage using the graded crush injury of the adult rat optic nerve. This injury model has the following characteristics: (a) the injuries are reproducible; (b) the injuries can be created with controlled severity; and (c) variation...

journal_title：Restorative neurology and neuroscience

authors： Duvdevani R,Rosner M,Belkin M,Sautter J,Sabel BA,Schwartz M

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Hemispatial neglect, a failure to orient to the contralateral side of the lesion, is a disabling disorder after stroke. Previously arm activation combined with visual training or visual scanning training were found effective in rehabilitation of hemispatial neglect. The aim of this study was to determine whethe...

journal_title：Restorative neurology and neuroscience

authors： Luukkainen-Markkula R,Tarkka IM,Pitkänen K,Sivenius J,Hämäläinen H

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:Freezing of gait (FOG) affects mobility and balance seriously. Few reports have investigated the effects of repetitive transcranial magnetic stimulation (rTMS) on FOG in Parkinson's disease (PD). We investigated the efficacy of high-frequency rTMS for the treatment of FOG in PD. METHODS:Seventeen patients diag...

journal_title：Restorative neurology and neuroscience

authors： Kim MS,Chang WH,Cho JW,Youn J,Kim YK,Kim SW,Kim YH

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:The effectiveness of embryonic stem cell (eSC) therapy has been explored in many models of neurological disease and several research groups have shown that eSC treatment leads to improved outcomes in pre-clinical models of traumatic brain injury (TBI). Though functional recovery occurs, few surviving eSCs appea...

journal_title：Restorative neurology and neuroscience

authors： Peruzzaro ST,Gallagher J,Dunkerson J,Fluharty S,Mudd D,Hoane MR,Smith JS

更新日期：2013-01-01 00:00:00

abstract：:Wound-derived trophic factors released by the injured brain are thought to reach a peak 1-2 weeks after injury. It has been proposed that such factors can promote the survival, growth and functional capacity of embryonic tissue grafts. To test the generality of this hypothesis, control rats and rats with aspirative fi...

journal_title：Restorative neurology and neuroscience

authors： Dunnett SB,Martel FL,Rogers DC,Finger S

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Bacopa monnieri (L.) WETTST. is extensively used in traditional Indian medicine as a nerve tonic. The neuropharmacological properties of bacopaside I, an important component from B. monnieri, have not been studied so far. The present study investigated the effects and possible mechanisms of bacopaside I in a ra...

journal_title：Restorative neurology and neuroscience

authors： Liu X,Yue R,Zhang J,Shan L,Wang R,Zhang W

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:To investigate whether repeated sessions of motor imagery and action observation modulate corticospinal excitability (CE) over time, whether these processes are susceptible of any training effect and if such effect might be different for the dominant and non dominant hemisphere. METHODS:11 subjects underwent t...

journal_title：Restorative neurology and neuroscience

authors： Bianco G,Feurra M,Fadiga L,Rossi A,Rossi S

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:The relationship between auditory temporal-order perception and phoneme discrimination has been discussed for several years, based on findings, showing that patients with cerebral damage in the left hemisphere and aphasia, as well as children with specific language impairments, show deficits in temporal-process...

journal_title：Restorative neurology and neuroscience

authors： Fink M,Churan J,Wittmann M

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:We hypothesized that recovery of upper extremity motor function is associated with reduction of intracortical inhibition and improved reciprocal inhibition. This study examines the relationships of functional recovery in chronic stroke with the intracortical inhibition and spinal reciprocal inhibition. METHODS...

journal_title：Restorative neurology and neuroscience

authors： Fujiwara T,Honaga K,Kawakami M,Nishimoto A,Abe K,Mizuno K,Kodama M,Masakado Y,Tsuji T,Liu M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The dopamine system plays a key role in motor learning and neuroplasticity. Several studies have studied the efficacy of dopaminergic drugs in enhancing motor recovery after stroke, but the effects are controversial. Although genetic variations in plasticity-related genes influence each individual's capacity...

journal_title：Restorative neurology and neuroscience

authors： Kim BR,Kim HY,Chun YI,Yun YM,Kim H,Choi DH,Lee J

更新日期：2016-11-22 00:00:00

abstract：PURPOSE:Repetitive mild traumatic brain injury (TBI) is a major military and sports health concern. The purpose of this study was to determine if a diet rich in omega-3 fatty acids would reduce cognitive deficits and neuronal cell death in a novel fluid percussion rat model of repetitive mild TBIs. METHODS:Thirty-two ...

journal_title：Restorative neurology and neuroscience

authors： Wang T,Van KC,Gavitt BJ,Grayson JK,Lu YC,Lyeth BG,Pichakron KO

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:To investigate the effects of the androgen testosterone propionate (TP), on regeneration of the recurrent laryngeal nerve (RLN) after unilateral crush injury using assessment of vocal fold mobility (VFM) as a measure of behavioral recovery. METHODS:48 adult male rats underwent standardized crush injury of left...

journal_title：Restorative neurology and neuroscience

authors： Brown TJ,Pittman AL,Monaco GN,Benscoter BJ,Mantravadi AV,Akst LM,Jones KJ,Foecking EM

更新日期：2013-01-01 00:00:00

abstract：:The effects of striatal transplantation of PC12 cells on amphetamine-induced rotational behavior and monoamine levels were examined in rats with unilateral 6-hydroxydopamine (6-OHDA) lesions in the nigrostriatal pathway. A total of 9 × 104 or 9 × 105 cells of PC12 was implanted into 3 sites in the striatum and changes...

journal_title：Restorative neurology and neuroscience

authors： Hori Y,Kageyama H,Kihara T,Ikeda M,Nakano A,Kurosawa A

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Several studies have shown that transcranial direct current stimulation (tDCS) is a useful tool to enhance language recovery in aphasia. It has also been suggested that modulation of the neurotrophin brain-derived neurotrophic factor (BDNF) might be part of the mechanisms involved in tDCS effects on synaptic co...

journal_title：Restorative neurology and neuroscience

authors： Marangolo P,Fiori V,Gelfo F,Shofany J,Razzano C,Caltagirone C,Angelucci F

更新日期：2014-01-01 00:00:00

abstract：:In four patients with left visuo-spatial hemineglect and right brain- damage, the therapeutic effects of Transcutaneous Electrical Nervous Stimulation (TENS) of the left neck muscles, associated with a non-specific treatment, and of a specific rehabilitation paradigm were investigated. The two treatments were given fo...

journal_title：Restorative neurology and neuroscience

authors： Pizzamiglio L,Vallar G,Magnotti L

更新日期：1996-01-01 00:00:00

abstract：:Contemporary strategies to promote motor recovery following stroke focus on repetitive voluntary movements. Although successful movement relies on efficient sensorimotor integration, functional outcomes often bias motor therapy toward motor-related impairments such as weakness, spasticity and synergies; sensory therap...

journal_title：Restorative neurology and neuroscience

authors： Bolognini N,Russo C,Edwards DJ

更新日期：2016-04-11 00:00:00

abstract：BACKGROUND:Patients suffering from chronic disorders of consciousness (DOC), including minimally conscious state (MCS) and unresponsive wakefulness syndrome (UWS), typically show an awareness impairment paralleled by a significant reflex hyper-excitability, which depend on the cortical deafferentation following brain-d...

journal_title：Restorative neurology and neuroscience

authors： Naro A,Bruno R,Leo A,Russo M,Salviera C,Bramanti A,Bramanti P,Calabrò RS

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Dimethyl fumarate (DMF) has immune-modulatory and neuro-protective characteristics that can be used for treatment of acute ischemic stroke. OBJECTIVE:To investigate the therapeutic effects of DMF on histological and functional recovery of rats after transient middle cerebral artery (MCA) occlusion. METHODS...

journal_title：Restorative neurology and neuroscience

authors： Safari A,Fazeli M,Namavar MR,Tanideh N,Jafari P,Borhani-Haghighi A

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Ischemic stroke is associated with a variety pathophysiological changes affecting both glial and neuronal brain tissue. These changes are mirrored in the release of specific proteins into peripheral blood. Neurone-specific enolase (NSE), protein S100B and glial fibrillary acidic protein (GFAP) are those protein...

journal_title：Restorative neurology and neuroscience

authors： Herrmann M,Ehrenreich H

更新日期：2003-01-01 00:00:00

abstract：:The outgrowth of neurites in neuronal cell cultures reflects the intrinsic capacity for neurite regeneration and morphological rearrangements after axotomy and in plasticity. The role of fast axonal transport in these neurite outgrowth responses has not been investigated. We have recently shown that sabeluzole (R58735...

journal_title：Restorative neurology and neuroscience

authors： Geerts H,Nuydens R,Nuyens R,Cornelissen F

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The current treatment intervention study determined the effect of coupled bilateral training (i.e., bilateral movements and EMG-triggered neuromuscular stimulation) and resistive load (mass) on upper extremity motor recovery in chronic stroke. METHODS:Thirty chronic stroke subjects were randomly assigned to...

journal_title：Restorative neurology and neuroscience

authors： Cauraugh JH,Coombes SA,Lodha N,Naik SK,Summers JJ

更新日期：2009-01-01 00:00:00

abstract：:The response of astroglial cells in the hippocampus to long-term portacaval anastomosis (PCA), an experimental model of hepatic encephalopathy, was studied in adult male rats and compared with controls. Six months after PCA, the rat hippocampi were processed for glial fibrillary acidic protein (GFAP). GFAP-immunoposit...

journal_title：Restorative neurology and neuroscience

authors： Suarez I,Bodega G,Fernandez B

更新日期：1998-01-01 00:00:00

abstract：PURPOSE:Previous neuroimaging studies of oddball tasks and other paradigms measuring attention processes support right hemisphere dominance for attentional processes. Using an auditory selective attention task, we studied the functional asymmetry of the human brain in response to attended or unattended deviant tones. S...

journal_title：Restorative neurology and neuroscience

authors： Petit L,Simon G,Joliot M,Andersson F,Bertin T,Zago L,Mellet E,Tzourio-Mazoyer N

更新日期：2007-01-01 00:00:00