Abstract:
:A long-term goal in motor rehabilitation is that treatment is not selected on the basis of 'schools of thought', but rather, based on knowledge about efficacy and effectiveness of specific interventions for specific situations (e.g. functional syndromes). Motor dysfunction after stroke or TBI can be caused by many different functional syndromes such as paresis, ataxia, deafferentaion, visuo-perceptual deficits, or apraxia. Examples are provided showing that theory-based analysis of motor behavior makes it possible to describe 'syndrome-specific motor deficits'. Its potential implications for motor rehabilitation are that our understanding of altered motor behavior as well as specific therapeutic approaches might be promoted. A methodological prerequisite for clinical trials in rehabilitation is knowledge about test properties of assessment tools in follow-up situations such as test-retest reliability and responsiveness to change. Test-retest reliability assesses whether a test can produce stable measures with test repetition, while sensitivity to change reflects whether a test detects changes that occur over time. Exemplifying these considerations, a reliability and validity study of a kinematic arm movement analysis is summarized. In terms of new therapeutic developments, two examples of clinical therapeutic studies are provided assessing the efficacy of specific inter-ventions for specific situations in arm and gait rehabilitation: the Arm Ability Training for high functioning hemiparetic stroke and TBI patients, and the treadmill training for non-ambulatory hemiparetic patients. In addition, a new technical development, a machine-controlled gait trainer ist introduced.
journal_name
Restor Neurol Neuroscijournal_title
Restorative neurology and neuroscienceauthors
Platz T,Hesse S,Mauritz KHsubject
Has Abstractpub_date
1999-01-01 00:00:00pages
161-166issue
2-3eissn
0922-6028issn
1878-3627journal_volume
14pub_type
杂志文章abstract::The olfactory nerve differs from cranial nerves III-XII in that it contains a specialised type of glial cell, called 'olfactory ensheathing cell' (OEC), rather than Schwann cells. In addition, functional neurogenesis persists postnatally in the olfactory system, i.e. the primary olfactory pathway continuously rebuilds...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2008-01-01 00:00:00
abstract::Retinal and cortical lesions are completely different events that trigger visual cortical plasticity. We therefore compared the cortical effects of homonymous lesions of the central retina with effects of cortical lesions. All in vivo experiments were performed in anaesthetized, adult cats. Retinal lesions were made w...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::In the present study, we have developed an animal model for central nervous system (CNS) damage using the graded crush injury of the adult rat optic nerve. This injury model has the following characteristics: (a) the injuries are reproducible; (b) the injuries can be created with controlled severity; and (c) variation...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-1990-2104
更新日期:1990-01-01 00:00:00
abstract::Many toxic factors are generated during stroke that contribute directly to the death of neurons. Several recent studies suggest that a suicide-like phenomena similar to apoptosis or programmed cell death also contributes to the loss of neurons in stroke. The evidence implicating apoptosis in stroke can be divided into...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-1996-9404
更新日期:1996-01-01 00:00:00
abstract::Following brain injury there is an excessive release of glutamate, a reduction in levels of cellular Mg+ +, and the generation of oxygen free radicals. These processes may contribute to the severity of the behavioral impairments seen following brain injury by leading to secondary neuronal degeneration. The present exp...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-1997-111208
更新日期:1997-01-01 00:00:00
abstract:BACKGROUND:High definition transcranial direct current stimulation (HD-tDCS) has been administered over single brain regions for small numbers of sessions. Safety, feasibility and tolerability of HD-tDCS over multiple brain regions, multiple daily stimulations and long periods are not established. OBJECTIVE:We studied...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-170757
更新日期:2017-01-01 00:00:00
abstract::Injury of the nervous system initiates a cascade of signal transduction including a rise in extracellular glutamate which leads to subsequent secondary neuronal loss. Excitotoxicity is known to play a crucial role in cell death spinal cord trauma. Gangliosides, particularly monosialogangliosides (GM1), are protective ...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract:PURPOSE:The present study was aimed to investigate whether combination treatment with progesterone and rehabilitation training would be more effective than monotherapy after cerebral ischemia. METHODS:C57BL/6 mice were subjected to focal ischemia by photothrombosis and were treated with progesterone (2 mg/kg), rehabil...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-130312
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Neuroplastic alterations of cortical excitability and activity represent the likely neurophysiological foundation of learning and memory formation. Beyond their induction, alterations of these processes by subsequent modification of cortical activity, termed metaplasticity, came into the focus of...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-2011-0601
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:We examined the feasibility and outcome of electromyographically triggered electrical muscle stimulation (EMG-ES) plus unilateral or bilateral task specific practice on arm function in chronic stroke survivors with moderate-severe hemiplegia. Transcranial magnetic stimulation was used to examine inter-hemispher...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.3233/RNN-130319
更新日期:2013-01-01 00:00:00
abstract::To examine the regeneration capacity of dorsal septohippocampal neurons in the presence of an artificial growth-promoting substrate, biocompatible polymeric hydrogels were implanted between the septum and the hippocampus in a fimbria-fornix lesion cavity. Unmodified (control) or aminosugar-containing (glucosamines or ...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract::Melatonin (MLT) is a methoxyindole secreted principally by the pineal gland. It is synthesized at night under normal environmental conditions. The endogenous rhythm of secretion is generated by the suprachiasmatic nuclei and entrained by the light/dark cycle. Light is able to both suppress or synchronize melatonin pro...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::Many ocular diseases (such as glaucoma, diabetic retinopathy, age-related macular degeneration, and traumatic eye injuries) can result in the degeneration of retinal cells and the subsequent loss of vision. Some kinds of treatments, such as drugs, stem cell transplantation and surgery are reported to be effective in c...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,评审
doi:10.3233/RNN-190945
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Dimethyl fumarate (DMF) has immune-modulatory and neuro-protective characteristics that can be used for treatment of acute ischemic stroke. OBJECTIVE:To investigate the therapeutic effects of DMF on histological and functional recovery of rats after transient middle cerebral artery (MCA) occlusion. METHODS...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-160670
更新日期:2017-01-01 00:00:00
abstract::While the regenerating capacity of peripheral nerves has been the subject of intensive study, little is known about the regenerative capacity of the autonomic nervous system. Using an animal model, where the pupil diameter of the eye in the rat serves as a parameter of autonomic function, we studied whether systemic t...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-1994-7106
更新日期:1994-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Repetitive transcranial magnetic stimulation (rTMS) may enhance plastic changes in the human cortex and modulation of behavior. However, the underlying neural mechanisms have not been sufficiently investigated. We examined the clinical effects and neural correlates of high-frequency rTMS coupled ...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.3233/RNN-2012-110162
更新日期:2012-01-01 00:00:00
abstract::Fetal cerebral cortical tissue was transplanted into an aspirated lesion cavity made in the sensorimotor cortex of adult rats. Ten weeks after grafting, outgrowing fibers from the graft were visualized by an anterograde tracing technique using Phaseolus vulgaris leucoagglutinin (PHA-L). It was demonstrated that the ef...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-1993-55604
更新日期:1993-01-01 00:00:00
abstract:PURPOSE:Current models of intracerebral hematoma are difficult to use for neurotransplantation studies because of high mortality and important variations of morphology, size and location of blood deposits. We propose a modification of the autologous blood infusion technique in rats to reduce these limitations. METHODS...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:To demonstrate, in a proof-of-concept study, whether potentiating ipsilesional higher motor areas (premotor cortex and supplementary motor area) augments and accelerates recovery associated with constraint induced movement. METHODS:In a randomized, double-blinded pilot clinical study, 12 patients with chronic ...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.3233/RNN-150574
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:The interest in human conscious awareness has increasingly propelled the study of neglect, the most striking occurrence of an acquired lack of conscious experience of space. Neglect syndromes commonly arise after unilateral brain damage that spares primary sensory areas nonetheless leading to a lack of consciou...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-01 00:00:00
abstract:BACKGROUND:Patients suffering from chronic disorders of consciousness (DOC), including minimally conscious state (MCS) and unresponsive wakefulness syndrome (UWS), typically show an awareness impairment paralleled by a significant reflex hyper-excitability, which depend on the cortical deafferentation following brain-d...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-160655
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND:The dopamine system plays a key role in motor learning and neuroplasticity. Several studies have studied the efficacy of dopaminergic drugs in enhancing motor recovery after stroke, but the effects are controversial. Although genetic variations in plasticity-related genes influence each individual's capacity...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-160667
更新日期:2016-11-22 00:00:00
abstract:PURPOSE:To investigate the effect and underlying mechanism of Aceglutamide on motor dysfunction in rats after cerebral ischemia-reperfusion. METHODS:Adult male Sprague-Dawley rats were subjected to 2 h transient middle cerebral artery occlusion (MCAO). Aceglutamide or vehicle was intraperitoneally given to rats at 24 ...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-150509
更新日期:2015-01-01 00:00:00
abstract::Vestibular habituation was studied in normal subjects and in patients with cerebellar disease using a stimulation paradigm proposed in this paper. Six caloric stimuli were repeated daily in the same ear during six days and electronystagmographic responses at the beginning and the end of that period were compared. The ...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-1992-4403
更新日期:1992-01-01 00:00:00
abstract::Administration of gangliosides accelerates recovery of function after entorhinal cortex lesions on open field activity and learned spatial alternation tasks. In the present study, we examined whether GM1 ganglioside might enhance recovery from bilateral entorhinal cortex lesions on a differential reinforcement of low-...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:
更新日期:1998-01-01 00:00:00
abstract:PURPOSE:Previous studies demonstrated that administering extradural cortical stimulation (ECS) to rats during the acute phase of a photothrombotic infarct enhances motor recovery. However, the effect of ECS during the subacute phase was unknown. We aimed to evaluate the effects of ECS on motor recovery in a rat model o...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-140445
更新日期:2015-01-01 00:00:00
abstract:PURPOSE:The quality of presurgical evaluation in focal extratemporal epilepsy surgery is highly dependent on precise structural and functional identification of the epileptic focus. Navigated transcranial magnetic stimulation (nTMS) is a tool that combines the spatial information of high-resolution magnetic resonance i...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-2010-0540
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:Despite advances towards potential clinically viable therapies there has been only limited success in improving functional recovery following traumatic brain injury (TBI). In rats, exposure to an enriched environment (EE) improves learning and fosters motor skill development. Induced pluripotent stem cells (iPS...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-140408
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Parkinson's Disease (PD) is characterized by progressive and disabling symptoms. An impaired oxidative metabolism efficiency was supposed to be involved in the systemic impairment. Rehabilitative treatment represents a valid tool in promoting skeletal muscle's adaptations, even if no solid studies on muscle ...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章
doi:10.3233/RNN-170738
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Focal dystonia in musicians (MD) is a task-specific movement disorder with a loss of voluntary motor control during instrumental playing. Defective inhibition on different levels of the central nervous system is involved in the pathophysiology. Sensorimotor retraining is a therapeutic approach to MD and aims...
journal_title:Restorative neurology and neuroscience
pub_type: 杂志文章,随机对照试验
doi:10.3233/RNN-2011-0582
更新日期:2011-01-01 00:00:00