Plasticity of body representations after surgical arm elongation in an achondroplasic patient.

Abstract:

PURPOSE:A realistic body representation needs to be constantly updated. In case of physiological modifications, body representations integrate information coming from different sensory sources, including the sense of touch. Previous studies described transient modifications of these representations following illusory distortions. In this single case study, we documented the changes occurred in lower-level, primary somatosensory, and higher-level representations, in a case of upper arms elongation. METHOD:We explored effects of arm lengthening on primary tactile perception (sensitivity and acuity), an implicit perceptual measure of body size (tactile distance judgement), body image (Daurat-Hmelijak test), and peri-personal space representation (audio-tactile interaction task). RESULTS:We show that patient's arm representation was changed after surgery. Specifically, we observed significant changes on tactile distance judgments, body image test and audio-tactile interaction task; also even though no changes were found on primary tactile perception a significant modification emerged in tactile acuity. CONCLUSIONS:These findings are in line with evidence of cortical reorganization after arm elongation. They also support the view that the body representation of achondroplasics are modified after body-size reconstruction, and became similar to that of healthy controls.

journal_name

Restor Neurol Neurosci

authors

Cimmino RL,Spitoni G,Serino A,Antonucci G,Catagni M,Camagni M,Haggard P,Pizzamiglio L

doi

10.3233/RNN-120286

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

287-98

issue

3

eissn

0922-6028

issn

1878-3627

pii

51W701102171R155

journal_volume

31

pub_type

杂志文章
  • Influence of repetitive transcranial magnetic stimulation on special symptoms in depressed patients.

    abstract::Since various studies, including multi-centre studies, investigating the effect of repetitive transcranial magnetic stimulation (rTMS) in depression have shown different results, it is now important to research, which symptoms of depression are most responsive to this kind of non-invasive brain stimulation. Furthermor...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章,评审

    doi:10.3233/RNN-2010-0557

    authors: Höppner J,Berger C,Walter U,Padberg F,Buchmann J,Herwig U,Domes G

    更新日期:2010-01-01 00:00:00

  • Motor recovery from constraint induced movement therapy is not constrained by extent of tissue damage following stroke.

    abstract:PURPOSE:The purpose of this study was to delineate the relationship between several types of T1-weighted MRI pathology and motor rehabilitation potential following Constraint Induced Movement therapy (CI therapy) in chronic stroke. METHODS:Stepwise regression was employed (n = 80) to identify predictors of motor recov...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-130366

    authors: Gauthier LV,Mark VW,Taub E,McCullars A,Barghi A,Rickards T,Hicks J,Uswatte G

    更新日期:2014-01-01 00:00:00

  • Vision restoration therapy (VRT) efficacy as assessed by comparative perimetric analysis and subjective questionnaires.

    abstract:PURPOSE:We wished to evaluate the efficacy of vision restoration therapy (VRT) in patients with post-chiasmatic brain damage using different functional perimetric tests. These were compared with measures of subjective vision and reaction time. METHODS:An open trial was conducted with hemianopia/scotoma (n=16) patients...

    journal_title:Restorative neurology and neuroscience

    pub_type: 临床试验,杂志文章

    doi:

    authors: Sabel BA,Kenkel S,Kasten E

    更新日期:2004-01-01 00:00:00

  • Exercise and retinal health.

    abstract::Many ocular diseases (such as glaucoma, diabetic retinopathy, age-related macular degeneration, and traumatic eye injuries) can result in the degeneration of retinal cells and the subsequent loss of vision. Some kinds of treatments, such as drugs, stem cell transplantation and surgery are reported to be effective in c...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章,评审

    doi:10.3233/RNN-190945

    authors: Li HY,Rong SS,Hong X,Guo R,Yang FZ,Liang YY,Li A,So KF

    更新日期:2019-01-01 00:00:00

  • Immunohistochemical characterization of axonal sprouting in mice.

    abstract:PURPOSE:Transgenic manipulation of mouse physiology facilitates the preclinical study of genetic risk factors, neural plasticity, and reactive processes accompanying Alzheimer's disease. Alternatively, entorhinal cortex lesions (ECLs) model pathophysiological denervation and axonal sprouting in rat. Given reports of an...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-130311

    authors: Feeney EJ,Stephenson D,Kleiman R,Bove S,Cron C,Moody L,Robinson M,Ramirez JJ

    更新日期:2013-01-01 00:00:00

  • Self-powered robots to reduce motor slacking during upper-extremity rehabilitation: a proof of concept study.

    abstract:BACKGROUND:Robotic rehabilitation is a highly promising approach to recover lost functions after stroke or other neurological disorders. Unfortunately, robotic rehabilitation currently suffers from "motor slacking", a phenomenon in which the human motor system reduces muscle activation levels and movement excursions, o...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-180830

    authors: Washabaugh EP,Treadway E,Gillespie RB,Remy CD,Krishnan C

    更新日期:2018-01-01 00:00:00

  • Asymmetrical behavior in rats following striatal lesions and fetal transplants: the elevated body swing test.

    abstract::Animals with unilateral neurotoxic lesions in the striatum exhibit a stereotypical biased rotational behavior in response to dopamine agonists. We recently argued that the rotational test may be subject to sensitization effects of the drug. Accordingly, we proposed the drug-free elevated body swing test (EBST) as an a...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-1995-9103

    authors: Borlongan CV,Cahill DW,Sanberg PR

    更新日期:1995-01-01 00:00:00

  • Experimentally induced autonomic neuropathy: beneficial effect of a systemic ACTH4-9 analogue on oculomotor nerve regeneration.

    abstract::While the regenerating capacity of peripheral nerves has been the subject of intensive study, little is known about the regenerative capacity of the autonomic nervous system. Using an animal model, where the pupil diameter of the eye in the rat serves as a parameter of autonomic function, we studied whether systemic t...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-1994-7106

    authors: Vandertop WP,de Vries WB,Notermans NC,Tulleken CA,Gispen WH

    更新日期:1994-01-01 00:00:00

  • GM1 ganglioside administration protects spinal neurons after glutamate excitotoxicity.

    abstract::Injury of the nervous system initiates a cascade of signal transduction including a rise in extracellular glutamate which leads to subsequent secondary neuronal loss. Excitotoxicity is known to play a crucial role in cell death spinal cord trauma. Gangliosides, particularly monosialogangliosides (GM1), are protective ...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:

    authors: Vorwerk CK,Bonheur J,Kreutz MR,Dreyer EB,Laev H

    更新日期:1999-01-01 00:00:00

  • Neuroplasticity of sign language: implications from structural and functional brain imaging.

    abstract:PURPOSE:The present study was designed to investigate the neural correlates of German Sign Language (Deutsche Gebärdensprache; DGS) processing. In particular, was expected the impact of the visuo-spatial mode in sign language on underlying neural networks compared to the impact of the interpretation of linguistic infor...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:

    authors: Meyer M,Toepel U,Keller J,Nussbaumer D,Zysset S,Friederici AD

    更新日期:2007-01-01 00:00:00

  • Aerobic rehabilitation program for improving muscle function in Parkinson's disease.

    abstract:BACKGROUND:Parkinson's Disease (PD) is characterized by progressive and disabling symptoms. An impaired oxidative metabolism efficiency was supposed to be involved in the systemic impairment. Rehabilitative treatment represents a valid tool in promoting skeletal muscle's adaptations, even if no solid studies on muscle ...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-170738

    authors: Di Martino S,Tramonti C,Unti E,Del Gamba C,Bonuccelli U,Rossi B,Ceravolo R,Chisari C

    更新日期:2018-01-01 00:00:00

  • Stimulation of Schwann cell proliferation and axonal regeneration by FK 506.

    abstract::PURPOSE: Nerve allografts are highly antigenic and, thus, require the continuous use of immunosuppressive drugs. FK 506 was found to pre-vent rejection successfully. However, clinically neurotoxic complications have been noted in the central and peripheral nervous system although an increased rate of axonal regenerati...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:

    authors: Fansa H,Keilhoff G,Horn T,Altmann S,Wolf G,Schneider W

    更新日期:2000-01-01 00:00:00

  • Efficacy of cumulative high-frequency rTMS on freezing of gait in Parkinson's disease.

    abstract:PURPOSE:Freezing of gait (FOG) affects mobility and balance seriously. Few reports have investigated the effects of repetitive transcranial magnetic stimulation (rTMS) on FOG in Parkinson's disease (PD). We investigated the efficacy of high-frequency rTMS for the treatment of FOG in PD. METHODS:Seventeen patients diag...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/RNN-140489

    authors: Kim MS,Chang WH,Cho JW,Youn J,Kim YK,Kim SW,Kim YH

    更新日期:2015-01-01 00:00:00

  • Motor enrichment sustains hindlimb movement recovered after spinal cord injury and glial transplantation.

    abstract:PURPOSE:This study investigated whether enrichment improves hindlimb movement following complete spinal cord transection and transplantation of olfactory ensheathing glia (OEG), with or without a Schwann cell (SC) bridge. METHODS:Motor activity was encouraged through provision of motor enrichment housing (MEH); a mult...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:

    authors: Moon LD,Leasure JL,Gage FH,Bunge MB

    更新日期:2006-01-01 00:00:00

  • A low-cost system for coil tracking during transcranial magnetic stimulation.

    abstract:PURPOSE:Accurate coil placement over a target area is critical during transcranial magnetic stimulation (TMS), as small deviations can alter testing outcomes. Accordingly, frameless stereotaxic systems (FSS) are recommended for reliable coil placement during TMS applications. However, FSS is not practical due to the co...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-150609

    authors: Washabaugh EP,Krishnan C

    更新日期:2016-01-01 00:00:00

  • Treatment with amnion-derived cellular cytokine solution (ACCS) induces persistent motor improvement and ameliorates neuroinflammation in a rat model of penetrating ballistic-like brain injury.

    abstract:PURPOSE:The present work compared the behavioral outcomes of ACCS therapy delivered either intravenously (i.v.) or intracerebroventricularly (i.c.v.) after penetrating ballistic-like brain injury (PBBI). Histological markers for neuroinflammation and neurodegeneration were employed to investigate the potential therapeu...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-140455

    authors: Deng-Bryant Y,Readnower RD,Leung LY,Cunningham TL,Shear DA,Tortella FC

    更新日期:2015-01-01 00:00:00

  • Supraspinal inputs reduce corticomotor excitability during passive movement: evidence from a pure sensory stroke.

    abstract::Corticomotor excitability is reduced during rhythmic passive movement compared to rest, but it is not known whether the mechanism is purely segmental or includes a supraspinal pathway. To determine how interruption of sensory projections at a supraspinal level affects corticomotor excitability during passive movement,...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:

    authors: Edwards DJ,Mastaglia FL,Byrnes ML,Fregni F,Pascual-Leone A,Thickbroom GW

    更新日期:2007-01-01 00:00:00

  • Motor rehabilitation after traumatic brain injury and stroke - Advances in assessment and therapy.

    abstract::A long-term goal in motor rehabilitation is that treatment is not selected on the basis of 'schools of thought', but rather, based on knowledge about efficacy and effectiveness of specific interventions for specific situations (e.g. functional syndromes). Motor dysfunction after stroke or TBI can be caused by many dif...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:

    authors: Platz T,Hesse S,Mauritz KH

    更新日期:1999-01-01 00:00:00

  • Institutional profile: integrated center for research and treatment of vertigo, balance and ocular motor disorders.

    abstract::In 2009 the German BMBF (German Ministry of Education and Research) established an Integrated Center for Research and Treatment (IFB(LMU)) of Vertigo, Balance and Ocular Motor Disorders in Munich. After the 10-year period of funding by the BMBF, it is envisioned that the (IFB(LMU)) will continue over the long term wit...

    journal_title:Restorative neurology and neuroscience

    pub_type: 社论

    doi:10.3233/RNN-2010-0510

    authors: Brandt T,Zwergal A,Jahn K,Strupp M

    更新日期:2010-01-01 00:00:00

  • Anatomical and physiological assessments of peripheral nerve grafts in the dorsal columns of the spinal cord.

    abstract::Portions of 1 cm length of the sensory radial nerve from the cat forelimb were used to replace an excised portion of the dorsal columns in the upper lumbar spinal cord. Observations were made on the clinical recovery of the animals, and cine recordings were made of their ability to traverse a horizontal ladder 5 month...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-1991-245613

    authors: Wilson DH

    更新日期:1991-01-01 00:00:00

  • Sabeluzole accelerates neurite outgrowth in different neuronal cell lines.

    abstract::The outgrowth of neurites in neuronal cell cultures reflects the intrinsic capacity for neurite regeneration and morphological rearrangements after axotomy and in plasticity. The role of fast axonal transport in these neurite outgrowth responses has not been investigated. We have recently shown that sabeluzole (R58735...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-1992-4103

    authors: Geerts H,Nuydens R,Nuyens R,Cornelissen F

    更新日期:1992-01-01 00:00:00

  • Neuroplasticity and behavioral effects of fluoxetine after experimental stroke.

    abstract::The brain can undergo self-repair and has the ability to compensate for functions lost after a stroke. The plasticity of the ischemic brain is influenced by several factors including aging and pharmacotherapy. Fluoxetine is an antidepressant which enhances serotonergic neurotransmission through selective inhibition of...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章,评审

    doi:10.3233/RNN-170725

    authors: Sun Y,Sun X,Qu H,Zhao S,Xiao T,Zhao C

    更新日期:2017-01-01 00:00:00

  • The development of emotion perception in face and voice during infancy.

    abstract:PURPOSE:Interacting with others by reading their emotional expressions is an essential social skill in humans. How this ability develops during infancy and what brain processes underpin infants' perception of emotion in different modalities are the questions dealt with in this paper. METHODS:Literature review. RESULT...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章,评审

    doi:10.3233/RNN-2010-0499

    authors: Grossmann T

    更新日期:2010-01-01 00:00:00

  • Morphology of embryonic hippocampus transplants and generation of long-distance extrinsic graft fiber connections to the lateral septum and the entorhinal cortex in the mature rat brain.

    abstract::Pyramidal neurons inside transplants of embryonic nervous tissue are capable of generating axonal extrinsic hippocampal fiber connections over considerable distances to appropriate target areas in the mature brain. The establishment of long-distance graft efferents to the lateral septum and to the entorhinal cortex wa...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-1991-3103

    authors: Sprick U

    更新日期:1991-01-01 00:00:00

  • Rehabilitation of hemispatial neglect: A randomized study using either arm activation or visual scanning training.

    abstract:PURPOSE:Hemispatial neglect, a failure to orient to the contralateral side of the lesion, is a disabling disorder after stroke. Previously arm activation combined with visual training or visual scanning training were found effective in rehabilitation of hemispatial neglect. The aim of this study was to determine whethe...

    journal_title:Restorative neurology and neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3233/RNN-2009-0520

    authors: Luukkainen-Markkula R,Tarkka IM,Pitkänen K,Sivenius J,Hämäläinen H

    更新日期:2009-01-01 00:00:00

  • Danhong injection facilitates recovery of post-stroke motion deficit via Parkin-enhanced mitochondrial function.

    abstract:BACKGROUND:A cerebral ischemic stroke involves mitochondrial dysfunction, motor deficits, and paralysis; and Danhong injection (DHI) might possess mitochondrial protection and functional recovery in a stroke subject through promoting expression of parkin, a ubiquitin ligase playing a key role in the regulation of prote...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-180828

    authors: Orgah JO,Ren J,Liu X,Orgah EA,Gao XM,Zhu Y

    更新日期:2019-01-01 00:00:00

  • Mobile game-based virtual reality rehabilitation program for upper limb dysfunction after ischemic stroke.

    abstract:BACKGROUND:Virtual reality (VR) has the potential to provide intensive, repetitive, and task-oriented training, and game-based therapy can enhance patients' motivation and enjoyment. OBJECTIVE:The objective of the present study was to develop a mobile game-based upper extremity VR program for patients who have experie...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/RNN-150626

    authors: Choi YH,Ku J,Lim H,Kim YH,Paik NJ

    更新日期:2016-05-02 00:00:00

  • Vascular insufficiency, not inflammation, contributes to chronic gliosis in a rat CNS transplantation model.

    abstract:PURPOSE:There is considerable variability in the extent and nature of the glial response to injury and neurodegeneration. Transplantation of fetal cortical tissue onto the brain of neonatal host rats or mice results in region-specific changes dependent on where the fetal tissue is placed. These changes include chronic ...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-150591

    authors: Bates KA,Drummond ES,Cozens GS,Harvey AR

    更新日期:2016-01-01 00:00:00

  • Role of apoptosis in acute neurodegenerative disorders.

    abstract::Many toxic factors are generated during stroke that contribute directly to the death of neurons. Several recent studies suggest that a suicide-like phenomena similar to apoptosis or programmed cell death also contributes to the loss of neurons in stroke. The evidence implicating apoptosis in stroke can be divided into...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-1996-9404

    authors: Linnik MD

    更新日期:1996-01-01 00:00:00

  • Experimental intracerebral hematoma in the rat.

    abstract:PURPOSE:Current models of intracerebral hematoma are difficult to use for neurotransplantation studies because of high mortality and important variations of morphology, size and location of blood deposits. We propose a modification of the autologous blood infusion technique in rats to reduce these limitations. METHODS...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:

    authors: Barth A,Guzman R,Andres RH,Mordasini P,Barth L,Widmer HR

    更新日期:2007-01-01 00:00:00