Abstract:
:Corticomotor excitability is reduced during rhythmic passive movement compared to rest, but it is not known whether the mechanism is purely segmental or includes a supraspinal pathway. To determine how interruption of sensory projections at a supraspinal level affects corticomotor excitability during passive movement, we measured the amplitude of motor evoked potential (MEP) during 1 Hz cyclic index finger movements in a patient with a brainstem and thalamus lesion that resulted in a pure sensory stroke. Measurements of MEP amplitude and proprioception were made 14 and 64 days post-stroke. In the first study, when subjective position sense was reduced for the index finger, MEP amplitude was significantly increased during passive movement compared to rest (4.6+/-0.2 SEM mV vs. 4.0+/-0.2 mV; p=0.0281). However in the second study, when position sense had returned to normal, MEP amplitude was significantly reduced during movement compared to rest (6.2+/-0.3 mV vs. 6.6+/-0.1 mV; p=0.0224). These observations provide evidence that supraspinal sensory pathways are involved in reducing corticomotor excitability during rhythmic passive movement.
journal_name
Restor Neurol Neuroscijournal_title
Restorative neurology and neuroscienceauthors
Edwards DJ,Mastaglia FL,Byrnes ML,Fregni F,Pascual-Leone A,Thickbroom GWsubject
Has Abstractpub_date
2007-01-01 00:00:00pages
527-33issue
5-6eissn
0922-6028issn
1878-3627journal_volume
25pub_type
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journal_title:Restorative neurology and neuroscience
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journal_title:Restorative neurology and neuroscience
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