Abstract：
:Traumatic brain and spinal cord injuries are severe burdens for the patients, their relatives, the health care providers and society as a whole. Recent data demonstrate the magnitude of the problem: It is mostly a disease of the young gen-eration (age 20-45 years) with mortality rates for severe traumatic brain injury (TBI) between 40-50%. In approximately 60% of cases, multiple trauma is accompanied by head injury. The outcome of TBI is determined not only by the extent and severity of the primary insult, but also by the degree of secondary brain damage. In the subgroup of severe TBI (GCS
journal_name
Restor Neurol Neuroscijournal_title
Restorative neurology and neuroscienceauthors
Neugebauer E,Lefering R,Noth Jsubject
Has Abstractpub_date
1999-01-01 00:00:00pages
83-84issue
2-3eissn
0922-6028issn
1878-3627journal_volume
14pub_type
杂志文章abstract：BACKGROUND:In low vision patients, the assessment of contrast sensitivity is an essential tool to determine the stage of visual impairment. However, traditional contrast sensitivity tests rely on verbal feedback, and the expertise of the examiner. OBJECTIVE:In the current study, a fast, OKN-based virtual diagnosis too...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-190937
更新日期：2020-01-01 00:00:00
abstract：:Fetal cerebral cortical tissue was transplanted into an aspirated lesion cavity made in the sensorimotor cortex of adult rats. Ten weeks after grafting, outgrowing fibers from the graft were visualized by an anterograde tracing technique using Phaseolus vulgaris leucoagglutinin (PHA-L). It was demonstrated that the ef...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1993-55604
更新日期：1993-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Neuroplastic alterations of cortical excitability and activity represent the likely neurophysiological foundation of learning and memory formation. Beyond their induction, alterations of these processes by subsequent modification of cortical activity, termed metaplasticity, came into the focus of...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-2011-0601
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:Exogenously applied BDNF has been shown to rescue rat retinal ganglion cells (RGCs) from axotomy-induced apoptotic death, presumably via activation of its high affinity receptor TrkB. Since both TrkB and BDNF are endogenously expressed in RGCs, auto- or para-crine neurotrophic loops in the retina may be involve...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND:Robotic rehabilitation is a highly promising approach to recover lost functions after stroke or other neurological disorders. Unfortunately, robotic rehabilitation currently suffers from "motor slacking", a phenomenon in which the human motor system reduces muscle activation levels and movement excursions, o...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-180830
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Virtual reality (VR) has the potential to provide intensive, repetitive, and task-oriented training, and game-based therapy can enhance patients' motivation and enjoyment. OBJECTIVE:The objective of the present study was to develop a mobile game-based upper extremity VR program for patients who have experie...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.3233/RNN-150626
更新日期：2016-05-02 00:00:00
abstract：:Fetal neocortical block transplants were implanted into the excitotoxically ablated sensorimotor cortex of adult rats in order to examine the density of innervation and distribution of presumptive host derived afferent fibers within these transplants. Cholinergic fiber innervation was examined at 3 months post graftin...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1994-7301
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND:Traumatic brain injury can result in lasting cognitive dysfunction due to degeneration of mature hippocampal neurons as well as the loss of immature neurons within the dentate gyrus. While endogenous neurogenesis affords a partial recovery of the immature neuron population, hippocampal neurogenesis may be en...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-180831
更新日期：2018-01-01 00:00:00
abstract：:Various basic qualitative and quantitative methods for the evaluation of sensorimotor functions after Traumatic Brain Injury (TBI) are introduced and discussed. Methodological aspects are illustrated by a single case follow-up study of a child after severe TBI (age 11; 712;1 yrs; 6, 8 and 12 month post TBI) in compar...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：PURPOSE:Freezing of gait (FOG) affects mobility and balance seriously. Few reports have investigated the effects of repetitive transcranial magnetic stimulation (rTMS) on FOG in Parkinson's disease (PD). We investigated the efficacy of high-frequency rTMS for the treatment of FOG in PD. METHODS:Seventeen patients diag...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.3233/RNN-140489
更新日期：2015-01-01 00:00:00
abstract：:Following brain injury there is an excessive release of glutamate, a reduction in levels of cellular Mg+ +, and the generation of oxygen free radicals. These processes may contribute to the severity of the behavioral impairments seen following brain injury by leading to secondary neuronal degeneration. The present exp...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1997-111208
更新日期：1997-01-01 00:00:00
abstract：:Wound-derived trophic factors released by the injured brain are thought to reach a peak 1-2 weeks after injury. It has been proposed that such factors can promote the survival, growth and functional capacity of embryonic tissue grafts. To test the generality of this hypothesis, control rats and rats with aspirative fi...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1989-1109
更新日期：1989-01-01 00:00:00
abstract：PURPOSE:Repairing the spinal cord with peripheral nerve grafts (PNG) and adjuvant acidic fibroblast growth factor (FGF1) has previously resulted in partial functional recovery. To aid microsurgical placement of PNGs, a graft holder device was previously developed by our group. In hope for a translational development we...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-2011-0623
更新日期：2012-01-01 00:00:00
abstract：PURPOSE:The illusory ownership of a fake hand as part the body follows synchronous tactile stimulation over a visible rubber hand and a covered hand. Whether brain plasticity mechanisms after sensory and motor disconnection modulates this illusion remain unexplored. METHODS:We tested a tetraplegic man after synchronou...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-130385
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:A cerebral ischemic stroke involves mitochondrial dysfunction, motor deficits, and paralysis; and Danhong injection (DHI) might possess mitochondrial protection and functional recovery in a stroke subject through promoting expression of parkin, a ubiquitin ligase playing a key role in the regulation of prote...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-180828
更新日期：2019-01-01 00:00:00
abstract：:Many of the present limitations of peripheral nerve repair might be overcome by performing nerve repairs at the axon level. One approach to nerve repair at this level would be to implant a neuroprosthesis in the form of a microelectronic switchboard which could route the connections of regenerated axons to their corre...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1990-2205
更新日期：1990-01-01 00:00:00
abstract：:The brain can undergo self-repair and has the ability to compensate for functions lost after a stroke. The plasticity of the ischemic brain is influenced by several factors including aging and pharmacotherapy. Fluoxetine is an antidepressant which enhances serotonergic neurotransmission through selective inhibition of...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,评审
doi：10.3233/RNN-170725
更新日期：2017-01-01 00:00:00
abstract：:A long-term goal in motor rehabilitation is that treatment is not selected on the basis of 'schools of thought', but rather, based on knowledge about efficacy and effectiveness of specific interventions for specific situations (e.g. functional syndromes). Motor dysfunction after stroke or TBI can be caused by many dif...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:The application of brain stimulation techniques for modulation of cortical excitability changes underlying spatial neglect following right-brain-damage has been the first application of brain stimulation in the rehabilitation setting. Several factors concur in making neglect a prototype of cognitive disorders that can...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,评审
doi：10.3233/RNN-2011-0613
更新日期：2011-01-01 00:00:00
abstract：:Melatonin (MLT) is a methoxyindole secreted principally by the pineal gland. It is synthesized at night under normal environmental conditions. The endogenous rhythm of secretion is generated by the suprachiasmatic nuclei and entrained by the light/dark cycle. Light is able to both suppress or synchronize melatonin pro...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:Injury of the nervous system initiates a cascade of signal transduction including a rise in extracellular glutamate which leads to subsequent secondary neuronal loss. Excitotoxicity is known to play a crucial role in cell death spinal cord trauma. Gangliosides, particularly monosialogangliosides (GM1), are protective ...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:The objective of this study was to develop an optimal dissection procedure for fetal porcine ventral mesencephalon (VM) grafts and to characterize the cellular composition of such an explant, in particular with respect to the dopaminergic and GABAergic components. We have used a monolayer cell culture system to study ...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1994-7402
更新日期：1995-01-01 00:00:00
abstract：PURPOSE:We wished to evaluate the efficacy of vision restoration therapy (VRT) in patients with post-chiasmatic brain damage using different functional perimetric tests. These were compared with measures of subjective vision and reaction time. METHODS:An open trial was conducted with hemianopia/scotoma (n=16) patients...
journal_title：Restorative neurology and neuroscience
pub_type： 临床试验,杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:Low-frequency rTMS can induce upregulation of excitability in the contralateral hemisphere by interhemispheric interaction. OBJECTIVE:The aim of this study was to compare the effects of interhemispheric modulation on hemodynamic changes after applying low-frequency rTMS over the anatomical hand knob (HK) an...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-201032
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:There is considerable variability in the extent and nature of the glial response to injury and neurodegeneration. Transplantation of fetal cortical tissue onto the brain of neonatal host rats or mice results in region-specific changes dependent on where the fetal tissue is placed. These changes include chronic ...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-150591
更新日期：2016-01-01 00:00:00
abstract：:Basic science studies demonstrated mechanisms of plasticity and metaplasticity. More recent human studies identified some of these mechanisms as operating in multiple areas of human cognition, such as learning and memory, and in functional recovery from lesions in the CNS, as in stroke. One of the goals of neurorehabi...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
abstract：PURPOSE:To investigate whether repeated sessions of motor imagery and action observation modulate corticospinal excitability (CE) over time, whether these processes are susceptible of any training effect and if such effect might be different for the dominant and non dominant hemisphere. METHODS:11 subjects underwent t...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-2012-120241
更新日期：2012-01-01 00:00:00
abstract：PURPOSE:We hypothesized that recovery of upper extremity motor function is associated with reduction of intracortical inhibition and improved reciprocal inhibition. This study examines the relationships of functional recovery in chronic stroke with the intracortical inhibition and spinal reciprocal inhibition. METHODS...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-150547
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Oxidative stress is an important factor in the pathophysiologic changes after traumatic brain injury (TBI). Connexin43 (Cx43) was reported to contribute to cerebral damage. However, the impacts of Cx40 have not been investigated in detail. OBJECTIVE:In the present study, we hypothesized that Cx40 was involv...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-160705
更新日期：2017-01-01 00:00:00
abstract：PURPOSE:Several studies have shown that transcranial direct current stimulation (tDCS) is a useful tool to enhance language recovery in aphasia. It has also been suggested that modulation of the neurotrophin brain-derived neurotrophic factor (BDNF) might be part of the mechanisms involved in tDCS effects on synaptic co...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-130323
更新日期：2014-01-01 00:00:00
