Institutional profile: integrated center for research and treatment of vertigo, balance and ocular motor disorders.

Abstract:

:In 2009 the German BMBF (German Ministry of Education and Research) established an Integrated Center for Research and Treatment (IFB(LMU)) of Vertigo, Balance and Ocular Motor Disorders in Munich. After the 10-year period of funding by the BMBF, it is envisioned that the (IFB(LMU)) will continue over the long term with the joint support of the University Hospital, the Medical Faculty, and the Bavarian State. Vertigo is one of the most common complaints in medicine. Despite its high prevalence, patients with vertigo generally receive either inappropriate or inadequate treatment. This deplorable situation is internationally well known and its causes are multiple: insufficient interdisciplinary cooperation, no standardized diagnostics and therapy, the failure to translate findings of basic science into clinical applications, and the scarcity of clinical multicenter studies. The (IFB(LMU)) will constitute a suitable tool with which these structural, clinical, and scientific deficits can be overcome. It will also make possible the establishment of an international interdisciplinary referral center. Munich has become the site of a unique concentration of leading experts on vertigo, balance and ocular motor disorders, both in the clinical and basic sciences. Academic structures have paved the way for the creation of an interdisciplinary horizontal network that also allows structured, vertical academic career paths via the Bachelor's and Master's degree programs in Neuroscience, a Graduate School of Systemic Neurosciences, and the Munich Center for Neurosciences - Brain and Mind. The (IFB(LMU)) has the following objectives as regards structure and content: to create an independent patient-oriented clinical research center under the auspices of the Medical Faculty but with autonomous administration and budget; to overcome existing clinical and academic barriers separating the traditional specializations; to establish a standardized interdisciplinary longitudinal and transversal network at one site for the management of patients. This should professionalize both the management and the international recruitment of patients (integrated care, telemedicine); to organize the study infrastructure for prospective multicenter clinical studies as well as to free clinical scientists from administrative tasks; to promote translational research with a focus on the innovative topics of molecular, functional and structural imaging, experimental and clinical pharmacotherapy, clinical research of vertigo and balance disorders, mathematical modelling, interaction between biological and technical systems (robotics), and research on functionality and the quality of life; to offer new attractive educational paths and career images for medical doctors, students of the natural sciences, and engineers in clinical research in order to overcome traditional hierarchical structures. This should promote the principles of efficiency and self-reliance; to supplement the existing excellence with up to eight groups of young scientists and up to eight professorships (tenure track). This should also be seen as an incentive that will attract the best young scientists; to incorporate (IFB(LMU)) competence into the existing medical and biological graduate schools. The (IFB(LMU)) is a unique center - worldwide.

journal_name

Restor Neurol Neurosci

authors

Brandt T,Zwergal A,Jahn K,Strupp M

doi

10.3233/RNN-2010-0510

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

135-43

issue

1

eissn

0922-6028

issn

1878-3627

pii

V77814130V6083U3

journal_volume

28

pub_type

社论
  • Brain derived proteins as markers of acute stroke: their relation to pathophysiology, outcome prediction and neuroprotective drug monitoring.

    abstract:PURPOSE:Ischemic stroke is associated with a variety pathophysiological changes affecting both glial and neuronal brain tissue. These changes are mirrored in the release of specific proteins into peripheral blood. Neurone-specific enolase (NSE), protein S100B and glial fibrillary acidic protein (GFAP) are those protein...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章,评审

    doi:

    authors: Herrmann M,Ehrenreich H

    更新日期:2003-01-01 00:00:00

  • GM1 ganglioside administration protects spinal neurons after glutamate excitotoxicity.

    abstract::Injury of the nervous system initiates a cascade of signal transduction including a rise in extracellular glutamate which leads to subsequent secondary neuronal loss. Excitotoxicity is known to play a crucial role in cell death spinal cord trauma. Gangliosides, particularly monosialogangliosides (GM1), are protective ...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:

    authors: Vorwerk CK,Bonheur J,Kreutz MR,Dreyer EB,Laev H

    更新日期:1999-01-01 00:00:00

  • Plasticity of body representations after surgical arm elongation in an achondroplasic patient.

    abstract:PURPOSE:A realistic body representation needs to be constantly updated. In case of physiological modifications, body representations integrate information coming from different sensory sources, including the sense of touch. Previous studies described transient modifications of these representations following illusory d...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-120286

    authors: Cimmino RL,Spitoni G,Serino A,Antonucci G,Catagni M,Camagni M,Haggard P,Pizzamiglio L

    更新日期:2013-01-01 00:00:00

  • Anatomical and physiological assessments of peripheral nerve grafts in the dorsal columns of the spinal cord.

    abstract::Portions of 1 cm length of the sensory radial nerve from the cat forelimb were used to replace an excised portion of the dorsal columns in the upper lumbar spinal cord. Observations were made on the clinical recovery of the animals, and cine recordings were made of their ability to traverse a horizontal ladder 5 month...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-1991-245613

    authors: Wilson DH

    更新日期:1991-01-01 00:00:00

  • Correlation between vestibular habituation and postural recovery in cerebellar patients.

    abstract::Vestibular habituation was studied in normal subjects and in patients with cerebellar disease using a stimulation paradigm proposed in this paper. Six caloric stimuli were repeated daily in the same ear during six days and electronystagmographic responses at the beginning and the end of that period were compared. The ...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-1992-4403

    authors: Suarez H,Caffa C,Macadar O

    更新日期:1992-01-01 00:00:00

  • Neuroprotective effects of Aceglutamide on motor function in a rat model of cerebral ischemia and reperfusion.

    abstract:PURPOSE:To investigate the effect and underlying mechanism of Aceglutamide on motor dysfunction in rats after cerebral ischemia-reperfusion. METHODS:Adult male Sprague-Dawley rats were subjected to 2 h transient middle cerebral artery occlusion (MCAO). Aceglutamide or vehicle was intraperitoneally given to rats at 24 ...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-150509

    authors: Zhang R,Yang N,Ji C,Zheng J,Liang Z,Hou CY,Liu YY,Zuo PP

    更新日期:2015-01-01 00:00:00

  • Assessment of systemic administration of PEGylated IGF-1 in a mouse model of traumatic brain injury.

    abstract:BACKGROUND:Traumatic brain injury can result in lasting cognitive dysfunction due to degeneration of mature hippocampal neurons as well as the loss of immature neurons within the dentate gyrus. While endogenous neurogenesis affords a partial recovery of the immature neuron population, hippocampal neurogenesis may be en...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-180831

    authors: Sama DM,Carlson SW,Joseph B,Saenger S,Metzger F,Saatman KE

    更新日期:2018-01-01 00:00:00

  • CGP 3466 increases survival of cultured fetal dopaminergic neurons.

    abstract:PURPOSE:To analyze the effects of CGP 3466, a compound structurally related to deprenyl, on survival and function of fetal ventral mesencephalic dopaminergic neurons. METHODS:Free-floating roller tube (FFRT) cultures of rat (E14) ventral mesencephalon were treated with CGP 3466 [10-8 M] for 7 days. Tyrosine hydroxylas...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:

    authors: Matarredona ER,Meyer M,Seiler RW,Widmer HR

    更新日期:2003-01-01 00:00:00

  • Assessment of sensorimotor functions after traumatic brain injury (TBI) in childhood - Methodological aspects.

    abstract::Various basic qualitative and quantitative methods for the evaluation of sensorimotor functions after Traumatic Brain Injury (TBI) are introduced and discussed. Methodological aspects are illustrated by a single case follow-up study of a child after severe TBI (age 11; 7–12;1 yrs; 6, 8 and 12 month post TBI) in compar...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:

    authors: Jöhnk K,Kuhtz-Buschbeck JP,Stolze H,Serocki G,Kalwa S,Ritz A,Benz B,Illert M

    更新日期:1999-01-01 00:00:00

  • Nerve regeneration problems in a clinical perspective.

    abstract::Injuries to peripheral nerves represent a challenging clinical problem. In spite of the use of microsurgical techniques, repair of severed nerves seldom results in complete recovery of motor and sensory functions. Misdirection of axons at the suture line as well as a slow axonal outgrowth contribute to the bad results...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-1990-13418

    authors: Lundborg G

    更新日期:1990-01-01 00:00:00

  • Motor enrichment sustains hindlimb movement recovered after spinal cord injury and glial transplantation.

    abstract:PURPOSE:This study investigated whether enrichment improves hindlimb movement following complete spinal cord transection and transplantation of olfactory ensheathing glia (OEG), with or without a Schwann cell (SC) bridge. METHODS:Motor activity was encouraged through provision of motor enrichment housing (MEH); a mult...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:

    authors: Moon LD,Leasure JL,Gage FH,Bunge MB

    更新日期:2006-01-01 00:00:00

  • Rehabilitation of hemispatial neglect: A randomized study using either arm activation or visual scanning training.

    abstract:PURPOSE:Hemispatial neglect, a failure to orient to the contralateral side of the lesion, is a disabling disorder after stroke. Previously arm activation combined with visual training or visual scanning training were found effective in rehabilitation of hemispatial neglect. The aim of this study was to determine whethe...

    journal_title:Restorative neurology and neuroscience

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3233/RNN-2009-0520

    authors: Luukkainen-Markkula R,Tarkka IM,Pitkänen K,Sivenius J,Hämäläinen H

    更新日期:2009-01-01 00:00:00

  • Isometric contraction interferes with transcranial direct current stimulation (tDCS) induced plasticity: evidence of state-dependent neuromodulation in human motor cortex.

    abstract:BACKGROUND AND PURPOSE:Neuroplastic alterations of cortical excitability and activity represent the likely neurophysiological foundation of learning and memory formation. Beyond their induction, alterations of these processes by subsequent modification of cortical activity, termed metaplasticity, came into the focus of...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-2011-0601

    authors: Thirugnanasambandam N,Sparing R,Dafotakis M,Meister IG,Paulus W,Nitsche MA,Fink GR

    更新日期:2011-01-01 00:00:00

  • Efficacy of cumulative high-frequency rTMS on freezing of gait in Parkinson's disease.

    abstract:PURPOSE:Freezing of gait (FOG) affects mobility and balance seriously. Few reports have investigated the effects of repetitive transcranial magnetic stimulation (rTMS) on FOG in Parkinson's disease (PD). We investigated the efficacy of high-frequency rTMS for the treatment of FOG in PD. METHODS:Seventeen patients diag...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/RNN-140489

    authors: Kim MS,Chang WH,Cho JW,Youn J,Kim YK,Kim SW,Kim YH

    更新日期:2015-01-01 00:00:00

  • Bi-hemispheric effects on corticospinal excitability induced by repeated sessions of imagery versus observation of actions.

    abstract:PURPOSE:To investigate whether repeated sessions of motor imagery and action observation modulate corticospinal excitability (CE) over time, whether these processes are susceptible of any training effect and if such effect might be different for the dominant and non dominant hemisphere. METHODS:11 subjects underwent t...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-2012-120241

    authors: Bianco G,Feurra M,Fadiga L,Rossi A,Rossi S

    更新日期:2012-01-01 00:00:00

  • Transcutaneous electrical stimulation of the neck muscles and hemineglect rehabilitation.

    abstract::In four patients with left visuo-spatial hemineglect and right brain- damage, the therapeutic effects of Transcutaneous Electrical Nervous Stimulation (TENS) of the left neck muscles, associated with a non-specific treatment, and of a specific rehabilitation paradigm were investigated. The two treatments were given fo...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-1996-10402

    authors: Pizzamiglio L,Vallar G,Magnotti L

    更新日期:1996-01-01 00:00:00

  • Association between genetic variation in the dopamine system and motor recovery after stroke.

    abstract:BACKGROUND:The dopamine system plays a key role in motor learning and neuroplasticity. Several studies have studied the efficacy of dopaminergic drugs in enhancing motor recovery after stroke, but the effects are controversial. Although genetic variations in plasticity-related genes influence each individual's capacity...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-160667

    authors: Kim BR,Kim HY,Chun YI,Yun YM,Kim H,Choi DH,Lee J

    更新日期:2016-11-22 00:00:00

  • Repetitive optokinetic stimulation induces lasting recovery from visual neglect.

    abstract:PURPOSE:To evaluate whether repetitive optokinetic stimulation with active pursuit eye movements leads to substantial and greater recovery from visual neglect as compared to conventional visual scanning training. METHODS:Two groups of five patients with leftsided hemineglect were consecutively collected and matched fo...

    journal_title:Restorative neurology and neuroscience

    pub_type: 临床试验,杂志文章

    doi:

    authors: Kerkhoff G,Keller I,Ritter V,Marquardt C

    更新日期:2006-01-01 00:00:00

  • The effects of mechanical focal vibration on walking impairment in multiple sclerosis patients: A randomized, double-blinded vs placebo study.

    abstract:BACKGROUND:Multiple Sclerosis is a heterogeneous disorders involving in early stage gait and balance. Together with immunomodulating therapies, rehabilitation had a crucial role in improving motor tasks and quality of life. Between the emerging techniques, Focal Vibrations (FV) could play a role, but they have been use...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/RNN-160665

    authors: Spina E,Carotenuto A,Aceto MG,Cerillo I,Silvestre F,Arace F,Paone P,Orefice G,Iodice R

    更新日期:2016-09-21 00:00:00

  • Stimulation targeting higher motor areas in stroke rehabilitation: A proof-of-concept, randomized, double-blinded placebo-controlled study of effectiveness and underlying mechanisms.

    abstract:PURPOSE:To demonstrate, in a proof-of-concept study, whether potentiating ipsilesional higher motor areas (premotor cortex and supplementary motor area) augments and accelerates recovery associated with constraint induced movement. METHODS:In a randomized, double-blinded pilot clinical study, 12 patients with chronic ...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/RNN-150574

    authors: Cunningham DA,Varnerin N,Machado A,Bonnett C,Janini D,Roelle S,Potter-Baker K,Sankarasubramanian V,Wang X,Yue G,Plow EB

    更新日期:2015-01-01 00:00:00

  • Vision restoration therapy (VRT) efficacy as assessed by comparative perimetric analysis and subjective questionnaires.

    abstract:PURPOSE:We wished to evaluate the efficacy of vision restoration therapy (VRT) in patients with post-chiasmatic brain damage using different functional perimetric tests. These were compared with measures of subjective vision and reaction time. METHODS:An open trial was conducted with hemianopia/scotoma (n=16) patients...

    journal_title:Restorative neurology and neuroscience

    pub_type: 临床试验,杂志文章

    doi:

    authors: Sabel BA,Kenkel S,Kasten E

    更新日期:2004-01-01 00:00:00

  • Long term evaluation of experimental median nerve repair by frozen and fresh nerve autografts, allografts and allografts repopulated by autologous Schwann cells.

    abstract::The authors used different kinds of peripheral nerve grafts to reconstruct a terminal branch of the brachial plexus (the median nerve) gap of adult Sprague-Dawley rats, including fresh or frozen autografts and allografts from Norway rats. They also performed acellular allograft repopulation by autogenous Schwann cells...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:

    authors: Accioli-De-Vaconcellos ZA,Kassar-Duchossoy L,Mira JC

    更新日期:1999-01-01 00:00:00

  • Assessment of auditory temporal-order thresholds - a comparison of different measurement procedures and the influences of age and gender.

    abstract:PURPOSE:The relationship between auditory temporal-order perception and phoneme discrimination has been discussed for several years, based on findings, showing that patients with cerebral damage in the left hemisphere and aphasia, as well as children with specific language impairments, show deficits in temporal-process...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:

    authors: Fink M,Churan J,Wittmann M

    更新日期:2005-01-01 00:00:00

  • Prolonged T1 values of the crushed nerve are not exclusively attributable to Wallerian degeneration or endoneurial edema.

    abstract::Axonotmesis of the left sciatic nerve was performed on adult male Wistar rats. T1 values of the crushed nerve samples were determined with proton magnetic resonance spectroscopy. Denervation changes of the dependent hind plantar flexor muscles were assessed with proton magnetic resonance imaging of their cross-section...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-1992-4601

    authors: Ribarič S,Jarh O,Sepe A,Demsar F

    更新日期:1992-01-01 00:00:00

  • Mobile game-based virtual reality rehabilitation program for upper limb dysfunction after ischemic stroke.

    abstract:BACKGROUND:Virtual reality (VR) has the potential to provide intensive, repetitive, and task-oriented training, and game-based therapy can enhance patients' motivation and enjoyment. OBJECTIVE:The objective of the present study was to develop a mobile game-based upper extremity VR program for patients who have experie...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/RNN-150626

    authors: Choi YH,Ku J,Lim H,Kim YH,Paik NJ

    更新日期:2016-05-02 00:00:00

  • FGF1 containing biodegradable device with peripheral nerve grafts induces corticospinal tract regeneration and motor evoked potentials after spinal cord resection.

    abstract:PURPOSE:Repairing the spinal cord with peripheral nerve grafts (PNG) and adjuvant acidic fibroblast growth factor (FGF1) has previously resulted in partial functional recovery. To aid microsurgical placement of PNGs, a graft holder device was previously developed by our group. In hope for a translational development we...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-2011-0623

    authors: Nordblom J,Persson JK,Aberg J,Blom H,Engqvist H,Brismar H,Sjödahl J,Josephson A,Frostell A,Thams S,Brundin L,Svensson M,Mattsson P

    更新日期:2012-01-01 00:00:00

  • Increase in protein and tubulin mRNA synthesis in frog sensory neurons treated with the adenylate cyclase activator, forskolin.

    abstract::We are interested in the role cyclic AMP may play as a mediator of growth factor-induced gene expression in regenerating peripheral nerves. As a first step, we investigated mRNA levels and protein synthesis in intact frog dorsal root ganglia (DRG) treated with the adenylate cyclase activator, forskolin in vitro. Forsk...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-1990-13408

    authors: Carlsen RC,De Leon M,Tetzlaff W,Parhad IM,Bisby MA

    更新日期:1990-01-01 00:00:00

  • Visualization of outgrowing axons of grafted neurons by anterograde labelling with Phaseolus vulgaris leucoagglutinin in the motor cortex of the rat.

    abstract::Fetal cerebral cortical tissue was transplanted into an aspirated lesion cavity made in the sensorimotor cortex of adult rats. Ten weeks after grafting, outgrowing fibers from the graft were visualized by an anterograde tracing technique using Phaseolus vulgaris leucoagglutinin (PHA-L). It was demonstrated that the ef...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-1993-55604

    authors: Senatorov VV,Nyakas C,Fulop Z

    更新日期:1993-01-01 00:00:00

  • rTMS with motor training modulates cortico-basal ganglia-thalamocortical circuits in stroke patients.

    abstract:BACKGROUND AND PURPOSE:Repetitive transcranial magnetic stimulation (rTMS) may enhance plastic changes in the human cortex and modulation of behavior. However, the underlying neural mechanisms have not been sufficiently investigated. We examined the clinical effects and neural correlates of high-frequency rTMS coupled ...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章,随机对照试验

    doi:10.3233/RNN-2012-110162

    authors: Chang WH,Kim YH,Yoo WK,Goo KH,Park CH,Kim ST,Pascual-Leone A

    更新日期:2012-01-01 00:00:00

  • Twist and turn into chronic disorders of consciousness: Potential role of the auditory stapedial reflex.

    abstract:BACKGROUND:Patients suffering from chronic disorders of consciousness (DOC), including minimally conscious state (MCS) and unresponsive wakefulness syndrome (UWS), typically show an awareness impairment paralleled by a significant reflex hyper-excitability, which depend on the cortical deafferentation following brain-d...

    journal_title:Restorative neurology and neuroscience

    pub_type: 杂志文章

    doi:10.3233/RNN-160655

    authors: Naro A,Bruno R,Leo A,Russo M,Salviera C,Bramanti A,Bramanti P,Calabrò RS

    更新日期:2017-01-01 00:00:00