当前位置： SCI文献检索 > RESTORATIVE NEUROLOGY AND NEUROSCIENCE期刊下所有文献 > Visualization of outgrowing axons of grafted neurons by anterograde labelling with Phaseolus vulgaris leucoagglutinin in the motor cortex of the rat.

Visualization of outgrowing axons of grafted neurons by anterograde labelling with Phaseolus vulgaris leucoagglutinin in the motor cortex of the rat.

Abstract：

:Fetal cerebral cortical tissue was transplanted into an aspirated lesion cavity made in the sensorimotor cortex of adult rats. Ten weeks after grafting, outgrowing fibers from the graft were visualized by an anterograde tracing technique using Phaseolus vulgaris leucoagglutinin (PHA-L). It was demonstrated that the efferent fibers grew into the neighboring host cortical tissue, the corpus callosum and in some cases approached caudate/putamen. Characteristic axon arborization with abundant boutons were found in the host cortical tissue, but only in close vicinity to the grafts. It is concluded that the PHA-L anterograde tracing technique can be a useful tool to assess the degree of anatomical integration of the transplants into the host tissue.

journal_name

Restor Neurol Neurosci

journal_title

Restorative neurology and neuroscience

authors

Senatorov VV,Nyakas C,Fulop Z

doi

10.3233/RNN-1993-55604

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

337-45

issue

5

eissn

0922-6028

issn

1878-3627

pii

GG0G7730X4022204

journal_volume

5

pub_type

杂志文章

相关文献

RESTORATIVE NEUROLOGY AND NEUROSCIENCE文献大全
  • Vascular insufficiency, not inflammation, contributes to chronic gliosis in a rat CNS transplantation model.

    abstract：PURPOSE:There is considerable variability in the extent and nature of the glial response to injury and neurodegeneration. Transplantation of fetal cortical tissue onto the brain of neonatal host rats or mice results in region-specific changes dependent on where the fetal tissue is placed. These changes include chronic ...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-150591

    authors： Bates KA,Drummond ES,Cozens GS,Harvey AR

    更新日期：2016-01-01 00:00:00

  • Isometric contraction interferes with transcranial direct current stimulation (tDCS) induced plasticity: evidence of state-dependent neuromodulation in human motor cortex.

    abstract：BACKGROUND AND PURPOSE:Neuroplastic alterations of cortical excitability and activity represent the likely neurophysiological foundation of learning and memory formation. Beyond their induction, alterations of these processes by subsequent modification of cortical activity, termed metaplasticity, came into the focus of...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-2011-0601

    authors： Thirugnanasambandam N,Sparing R,Dafotakis M,Meister IG,Paulus W,Nitsche MA,Fink GR

    更新日期：2011-01-01 00:00:00

  • Factors affecting septal graft amelioration of differential reinforcement of low rates (DRL) and activity deficits after fimbria-fornix lesions.

    abstract：:Wound-derived trophic factors released by the injured brain are thought to reach a peak 1-2 weeks after injury. It has been proposed that such factors can promote the survival, growth and functional capacity of embryonic tissue grafts. To test the generality of this hypothesis, control rats and rats with aspirative fi...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-1989-1109

    authors： Dunnett SB,Martel FL,Rogers DC,Finger S

    更新日期：1989-01-01 00:00:00

  • Brain stimulation procedures for treatment of contralesional spatial neglect.

    abstract：:The application of brain stimulation techniques for modulation of cortical excitability changes underlying spatial neglect following right-brain-damage has been the first application of brain stimulation in the rehabilitation setting. Several factors concur in making neglect a prototype of cognitive disorders that can...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章,评审

    doi：10.3233/RNN-2011-0613

    authors： Oliveri M

    更新日期：2011-01-01 00:00:00

  • Fos-like immunoreactivity in the rat spinal cord induced by formalin injection in the forelimb to gauge possible plasticity of primary afferent fibers following partial deafferentation.

    abstract：:The aim of this study was to gauge the possible sprouting of primary afferent fibers following dorsal rhizotomies using Fos-like immunoreactivity (Fos-LI) in order to label neurons activated by formalin injection into the rat forepaw. To assess the functional consequences of possible sprouting of fine diameter primary...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-1994-6304

    authors： Abbadie C,Lombard MC,Morain F,Besson JM

    更新日期：1994-01-01 00:00:00

  • The effects of mechanical focal vibration on walking impairment in multiple sclerosis patients: A randomized, double-blinded vs placebo study.

    abstract：BACKGROUND:Multiple Sclerosis is a heterogeneous disorders involving in early stage gait and balance. Together with immunomodulating therapies, rehabilitation had a crucial role in improving motor tasks and quality of life. Between the emerging techniques, Focal Vibrations (FV) could play a role, but they have been use...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章,随机对照试验

    doi：10.3233/RNN-160665

    authors： Spina E,Carotenuto A,Aceto MG,Cerillo I,Silvestre F,Arace F,Paone P,Orefice G,Iodice R

    更新日期：2016-09-21 00:00:00

  • Bi-hemispheric effects on corticospinal excitability induced by repeated sessions of imagery versus observation of actions.

    abstract：PURPOSE:To investigate whether repeated sessions of motor imagery and action observation modulate corticospinal excitability (CE) over time, whether these processes are susceptible of any training effect and if such effect might be different for the dominant and non dominant hemisphere. METHODS:11 subjects underwent t...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-2012-120241

    authors： Bianco G,Feurra M,Fadiga L,Rossi A,Rossi S

    更新日期：2012-01-01 00:00:00

  • Reorganization in the visual cortex after retinal and cortical damage.

    abstract：:Retinal and cortical lesions are completely different events that trigger visual cortical plasticity. We therefore compared the cortical effects of homonymous lesions of the central retina with effects of cortical lesions. All in vivo experiments were performed in anaesthetized, adult cats. Retinal lesions were made w...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：

    authors： Eysel UT,Schweigart G,Mittmann T,Eyding D,Qu Y,Vandesande F,Orban G,Arckens L

    更新日期：1999-01-01 00:00:00

  • Quality of life in patients with traumatic brain injury-basic issues, assessment and recommendations.

    abstract：INTRODUCTION:Traumatic brain injuries (TBI) are one of the most common consequences of traffic accidents. Patients with mild, moderate or severe brain injuries suffer from physical, cognitive, behavioral, emotional and social problems. Most of these problems have been a long standing focus amongst practitioners and res...

    journal_title：Restorative neurology and neuroscience

    pub_type： 共识发展会议,杂志文章,评审

    doi：

    authors： Bullinger M,Azouvi P,Brooks N,Basso A,Christensen AL,Gobiet W,Greenwood R,Hütter B,Jennett B,Maas A,Truelle JL,von Wild KR,TBI Consensus Group.

    更新日期：2002-01-01 00:00:00

  • Therapeutic effects of oral dimethyl fumarate on stroke induced by middle cerebral artery occlusion: An animal experimental study.

    abstract：BACKGROUND:Dimethyl fumarate (DMF) has immune-modulatory and neuro-protective characteristics that can be used for treatment of acute ischemic stroke. OBJECTIVE:To investigate the therapeutic effects of DMF on histological and functional recovery of rats after transient middle cerebral artery (MCA) occlusion. METHODS...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-160670

    authors： Safari A,Fazeli M,Namavar MR,Tanideh N,Jafari P,Borhani-Haghighi A

    更新日期：2017-01-01 00:00:00

  • Pharmacological enhancement of glutamate transport reduces excitotoxicity in vitro.

    abstract：PURPOSE:Glutamate transporters are responsible for removing glutamate from the extracellular space and have the potential to protect neurons from excitotoxicity. In the present study, the effects of ceftriaxone and (2R, 4R)-APDC (APDC) on the protein expression of GLAST and GLT-1, the rate of glutamate uptake, and neur...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-2011-603

    authors： Beller JA,Gurkoff GG,Berman RF,Lyeth BG

    更新日期：2011-01-01 00:00:00

  • Age at stroke determines post-stroke language lateralization.

    abstract：PURPOSE:To determine how age at the time of left middle cerebral artery stroke affects language lateralization in a combined sample of subjects with perinatal, childhood, and adult stroke. METHODS:19 participants who had perinatal stroke (<1 month of age), 32 with later stroke, and 51 sex-/age-matched healthy controls...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-140402

    authors： Szaflarski JP,Allendorfer JB,Byars AW,Vannest J,Dietz A,Hernando KA,Holland SK

    更新日期：2014-01-01 00:00:00

  • The response to repetitive stimulation of human motor cortex is influenced by the history of synaptic activity.

    abstract：:Non-invasive brain stimulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), can modify cortical excitability in a lasting fashion. The modification can be bi-directional in nature and holds considerable therapeutic promise for a number of neurological conditions. However, the effectiveness ...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章,评审

    doi：10.3233/RNN-2010-0565

    authors： Todd G,Ridding MC

    更新日期：2010-01-01 00:00:00

  • Assessment of auditory temporal-order thresholds - a comparison of different measurement procedures and the influences of age and gender.

    abstract：PURPOSE:The relationship between auditory temporal-order perception and phoneme discrimination has been discussed for several years, based on findings, showing that patients with cerebral damage in the left hemisphere and aphasia, as well as children with specific language impairments, show deficits in temporal-process...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：

    authors： Fink M,Churan J,Wittmann M

    更新日期：2005-01-01 00:00:00

  • Morphology of embryonic hippocampus transplants and generation of long-distance extrinsic graft fiber connections to the lateral septum and the entorhinal cortex in the mature rat brain.

    abstract：:Pyramidal neurons inside transplants of embryonic nervous tissue are capable of generating axonal extrinsic hippocampal fiber connections over considerable distances to appropriate target areas in the mature brain. The establishment of long-distance graft efferents to the lateral septum and to the entorhinal cortex wa...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-1991-3103

    authors： Sprick U

    更新日期：1991-01-01 00:00:00

  • Effects of psychotropic drugs on brain plasticity in humans.

    abstract：:Although neurotransmitter-based hypotheses still prevail current thinking about the mechanism of action of psychotropic drugs, recent insight into the pathophysiology of psychiatric disorders has unveiled a range of new therapeutic actions of the drugs used to treat those disorders. Especially antidepressants seem to ...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章,评审

    doi：10.3233/RNN-139004

    authors： Paulzen M,Veselinovic T,Gründer G

    更新日期：2014-01-01 00:00:00

  • Stimulation of Schwann cell proliferation and axonal regeneration by FK 506.

    abstract：:PURPOSE: Nerve allografts are highly antigenic and, thus, require the continuous use of immunosuppressive drugs. FK 506 was found to pre-vent rejection successfully. However, clinically neurotoxic complications have been noted in the central and peripheral nervous system although an increased rate of axonal regenerati...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：

    authors： Fansa H,Keilhoff G,Horn T,Altmann S,Wolf G,Schneider W

    更新日期：2000-01-01 00:00:00

  • rTMS with motor training modulates cortico-basal ganglia-thalamocortical circuits in stroke patients.

    abstract：BACKGROUND AND PURPOSE:Repetitive transcranial magnetic stimulation (rTMS) may enhance plastic changes in the human cortex and modulation of behavior. However, the underlying neural mechanisms have not been sufficiently investigated. We examined the clinical effects and neural correlates of high-frequency rTMS coupled ...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章,随机对照试验

    doi：10.3233/RNN-2012-110162

    authors： Chang WH,Kim YH,Yoo WK,Goo KH,Park CH,Kim ST,Pascual-Leone A

    更新日期：2012-01-01 00:00:00

  • Vision- and health-related quality of life before and after vision restoration training in cerebrally damaged patients.

    abstract：PURPOSE:The aim of the study was to examine if improvements of stimulus detection performance in visual field tests after intensive visual training of the visual field border zone in patients with visual field defects are associated with changes in self-reported vision- and health-related quality of life (QoL). METHOD...

    journal_title：Restorative neurology and neuroscience

    pub_type： 临床试验,杂志文章

    doi：

    authors： Gall C,Mueller I,Gudlin J,Lindig A,Schlueter D,Jobke S,Franke GH,Sabel BA

    更新日期：2008-01-01 00:00:00

  • Right hemisphere dominance for auditory attention and its modulation by eye position: an event related fMRI study.

    abstract：PURPOSE:Previous neuroimaging studies of oddball tasks and other paradigms measuring attention processes support right hemisphere dominance for attentional processes. Using an auditory selective attention task, we studied the functional asymmetry of the human brain in response to attended or unattended deviant tones. S...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：

    authors： Petit L,Simon G,Joliot M,Andersson F,Bertin T,Zago L,Mellet E,Tzourio-Mazoyer N

    更新日期：2007-01-01 00:00:00

  • Aerobic rehabilitation program for improving muscle function in Parkinson's disease.

    abstract：BACKGROUND:Parkinson's Disease (PD) is characterized by progressive and disabling symptoms. An impaired oxidative metabolism efficiency was supposed to be involved in the systemic impairment. Rehabilitative treatment represents a valid tool in promoting skeletal muscle's adaptations, even if no solid studies on muscle ...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-170738

    authors： Di Martino S,Tramonti C,Unti E,Del Gamba C,Bonuccelli U,Rossi B,Ceravolo R,Chisari C

    更新日期：2018-01-01 00:00:00

  • Fate of afferents to the dentate gyrus following destruction of granule cells with colchicine.

    abstract：:Granule cells of the dentate gyrus can be selectively destroyed by intrahippocampal injections of colchicine. The present study evaluates the consequences of this selective neuronal destruction on the afferent axon terminals which have been deprived of their normal targets. The area of the neuropil in the dentate gyru...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-1992-3605

    authors： Goldschmidt RB,Steward O

    更新日期：1992-01-01 00:00:00

  • The effect of EMG triggered electrical stimulation plus task practice on arm function in chronic stroke patients with moderate-severe arm deficits.

    abstract：PURPOSE:We examined the feasibility and outcome of electromyographically triggered electrical muscle stimulation (EMG-ES) plus unilateral or bilateral task specific practice on arm function in chronic stroke survivors with moderate-severe hemiplegia. Transcranial magnetic stimulation was used to examine inter-hemispher...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章,随机对照试验

    doi：10.3233/RNN-130319

    authors： Singer BJ,Vallence AM,Cleary S,Cooper I,Loftus AM

    更新日期：2013-01-01 00:00:00

  • Administration of monoclonal antibodies neutralizing the inflammatory mediators tumor necrosis factor alpha and interleukin -6 does not attenuate acute behavioral deficits following experimental traumatic brain injury in the rat.

    abstract：PURPOSE:Although many previous studies have indicated that the acute inflammatory response following traumatic brain injury (TBI) is detrimental, inflammation may also positively influence outcome in the more chronic post-injury recovery period. We evaluated the effects of monoclonal antibodies (mAB), neutralizing eith...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：

    authors： Marklund N,Keck C,Hoover R,Soltesz K,Millard M,LeBold D,Spangler Z,Banning A,Benson J,McIntosh TK

    更新日期：2005-01-01 00:00:00

  • Role of apoptosis in acute neurodegenerative disorders.

    abstract：:Many toxic factors are generated during stroke that contribute directly to the death of neurons. Several recent studies suggest that a suicide-like phenomena similar to apoptosis or programmed cell death also contributes to the loss of neurons in stroke. The evidence implicating apoptosis in stroke can be divided into...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-1996-9404

    authors： Linnik MD

    更新日期：1996-01-01 00:00:00

  • Changes in BDNF and neurotrophin receptor expression in degenerating and regenerating rat retinal ganglion cells.

    abstract：PURPOSE:Exogenously applied BDNF has been shown to rescue rat retinal ganglion cells (RGCs) from axotomy-induced apoptotic death, presumably via activation of its high affinity receptor TrkB. Since both TrkB and BDNF are endogenously expressed in RGCs, auto- or para-crine neurotrophic loops in the retina may be involve...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：

    authors： Hirsch S,Labes M,Bähr M

    更新日期：2000-01-01 00:00:00

  • Prolonged T1 values of the crushed nerve are not exclusively attributable to Wallerian degeneration or endoneurial edema.

    abstract：:Axonotmesis of the left sciatic nerve was performed on adult male Wistar rats. T1 values of the crushed nerve samples were determined with proton magnetic resonance spectroscopy. Denervation changes of the dependent hind plantar flexor muscles were assessed with proton magnetic resonance imaging of their cross-section...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-1992-4601

    authors： Ribarič S,Jarh O,Sepe A,Demsar F

    更新日期：1992-01-01 00:00:00

  • Immediate improvement of speech-in-noise perception through multisensory stimulation via an auditory to tactile sensory substitution.

    abstract：BACKGROUND:Hearing loss is becoming a real social and health problem. Its prevalence in the elderly is an epidemic. The risk of developing hearing loss is also growing among younger people. If left untreated, hearing loss can perpetuate development of neurodegenerative diseases, including dementia. Despite recent advan...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-190898

    authors： Cieśla K,Wolak T,Lorens A,Heimler B,Skarżyński H,Amedi A

    更新日期：2019-01-01 00:00:00

  • Two-photon microscopy as a tool to investigate the therapeutic time window of methylprednisolone in a mouse spinal cord injury model.

    abstract：PURPOSE:The aim of the present study was to explore the use of two-photon microscopy for investigating the therapeutic time window of methylprednisolone (MP) treatment after spinal cord injury (SCI). METHODS:Twenty-four YFP H-line mice were subjected to hemisection SCI and then divided into four groups. Group 1 receiv...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-140463

    authors： Zhang Y,Zhang L,Ji X,Pang M,Ju F,Zhang J,Li W,Zhang S,He Z,Gan WB,Tang P

    更新日期：2015-01-01 00:00:00

  • A low-cost system for coil tracking during transcranial magnetic stimulation.

    abstract：PURPOSE:Accurate coil placement over a target area is critical during transcranial magnetic stimulation (TMS), as small deviations can alter testing outcomes. Accordingly, frameless stereotaxic systems (FSS) are recommended for reliable coil placement during TMS applications. However, FSS is not practical due to the co...

    journal_title：Restorative neurology and neuroscience

    pub_type： 杂志文章

    doi：10.3233/RNN-150609

    authors： Washabaugh EP,Krishnan C

    更新日期：2016-01-01 00:00:00