Association between genetic variation in the dopamine system and motor recovery after stroke.

abstract：:The mechanisms underlying recovery of function following damage to the CNS, although suspected, are virtually unknown. After damage to the adult cat spinal cord, recovery of motor behavior depends on which systems have been interrupted and which remain intact. For example, following hemisection, overground (voluntary)...

journal_title：Restorative neurology and neuroscience

authors： Goldberger ME

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Virtual reality (VR) has the potential to provide intensive, repetitive, and task-oriented training, and game-based therapy can enhance patients' motivation and enjoyment. OBJECTIVE:The objective of the present study was to develop a mobile game-based upper extremity VR program for patients who have experie...

journal_title：Restorative neurology and neuroscience

authors： Choi YH,Ku J,Lim H,Kim YH,Paik NJ

更新日期：2016-05-02 00:00:00

abstract：BACKGROUND:High definition transcranial direct current stimulation (HD-tDCS) has been administered over single brain regions for small numbers of sessions. Safety, feasibility and tolerability of HD-tDCS over multiple brain regions, multiple daily stimulations and long periods are not established. OBJECTIVE:We studied...

journal_title：Restorative neurology and neuroscience

authors： Turski CA,Kessler-Jones A,Chow C,Hermann B,Hsu D,Jones J,Seeger SK,Chappell R,Boly M,Ikonomidou C

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:We examined the feasibility and outcome of electromyographically triggered electrical muscle stimulation (EMG-ES) plus unilateral or bilateral task specific practice on arm function in chronic stroke survivors with moderate-severe hemiplegia. Transcranial magnetic stimulation was used to examine inter-hemispher...

journal_title：Restorative neurology and neuroscience

authors： Singer BJ,Vallence AM,Cleary S,Cooper I,Loftus AM

更新日期：2013-01-01 00:00:00

abstract：:Various basic qualitative and quantitative methods for the evaluation of sensorimotor functions after Traumatic Brain Injury (TBI) are introduced and discussed. Methodological aspects are illustrated by a single case follow-up study of a child after severe TBI (age 11; 7–12;1 yrs; 6, 8 and 12 month post TBI) in compar...

journal_title：Restorative neurology and neuroscience

authors： Jöhnk K,Kuhtz-Buschbeck JP,Stolze H,Serocki G,Kalwa S,Ritz A,Benz B,Illert M

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:To determine how age at the time of left middle cerebral artery stroke affects language lateralization in a combined sample of subjects with perinatal, childhood, and adult stroke. METHODS:19 participants who had perinatal stroke (<1 month of age), 32 with later stroke, and 51 sex-/age-matched healthy controls...

journal_title：Restorative neurology and neuroscience

authors： Szaflarski JP,Allendorfer JB,Byars AW,Vannest J,Dietz A,Hernando KA,Holland SK

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:To evaluate whether repetitive optokinetic stimulation with active pursuit eye movements leads to substantial and greater recovery from visual neglect as compared to conventional visual scanning training. METHODS:Two groups of five patients with leftsided hemineglect were consecutively collected and matched fo...

journal_title：Restorative neurology and neuroscience

authors： Kerkhoff G,Keller I,Ritter V,Marquardt C

更新日期：2006-01-01 00:00:00

abstract：:The objective of this study was to develop an optimal dissection procedure for fetal porcine ventral mesencephalon (VM) grafts and to characterize the cellular composition of such an explant, in particular with respect to the dopaminergic and GABAergic components. We have used a monolayer cell culture system to study ...

journal_title：Restorative neurology and neuroscience

authors： van Roon WM,Copray JC,Hogenesch RI,Kema I,Meyer EM,Molenaar G,Lugard C,Staal MJ,Go KG

更新日期：1995-01-01 00:00:00

abstract：:In the present study, we have developed an animal model for central nervous system (CNS) damage using the graded crush injury of the adult rat optic nerve. This injury model has the following characteristics: (a) the injuries are reproducible; (b) the injuries can be created with controlled severity; and (c) variation...

journal_title：Restorative neurology and neuroscience

authors： Duvdevani R,Rosner M,Belkin M,Sautter J,Sabel BA,Schwartz M

更新日期：1990-01-01 00:00:00

abstract：:Purpose: Caspase-3 is known as a crucial effector for apoptotic cell death. Apoptosis has recently been recognized as an important cell death mechanism after spinal cord injury (SCI). This study attempts to define the effect of methylprednisolone (MP) on the activation of caspase-3 in the lesioned area following SCI. ...

journal_title：Restorative neurology and neuroscience

authors： Li X,Oudega M,Dancausse HA,Levi AD

更新日期：2000-01-01 00:00:00

abstract：:Traumatic brain and spinal cord injuries are severe burdens for the patients, their relatives, the health care providers and society as a whole. Recent data demonstrate the magnitude of the problem: It is mostly a disease of the young gen-eration (age 20-45 years) with mortality rates for severe traumatic brain injury...

journal_title：Restorative neurology and neuroscience

authors： Neugebauer E,Lefering R,Noth J

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Repetitive transcranial magnetic stimulation (rTMS) may enhance plastic changes in the human cortex and modulation of behavior. However, the underlying neural mechanisms have not been sufficiently investigated. We examined the clinical effects and neural correlates of high-frequency rTMS coupled ...

journal_title：Restorative neurology and neuroscience

authors： Chang WH,Kim YH,Yoo WK,Goo KH,Park CH,Kim ST,Pascual-Leone A

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:Several studies on auditory temporal-order processing showed gender differences. Women needed longer inter-stimulus intervals than men when indicating the temporal order of two clicks presented to the left and right ear. In this study, we examined whether we could reproduce these results in order to further inv...

journal_title：Restorative neurology and neuroscience

authors： van Kesteren MT,Wiersinga-Post JE

更新日期：2007-01-01 00:00:00

abstract：PURPOSE:The relationship between auditory temporal-order perception and phoneme discrimination has been discussed for several years, based on findings, showing that patients with cerebral damage in the left hemisphere and aphasia, as well as children with specific language impairments, show deficits in temporal-process...

journal_title：Restorative neurology and neuroscience

authors： Fink M,Churan J,Wittmann M

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Although many previous studies have indicated that the acute inflammatory response following traumatic brain injury (TBI) is detrimental, inflammation may also positively influence outcome in the more chronic post-injury recovery period. We evaluated the effects of monoclonal antibodies (mAB), neutralizing eith...

journal_title：Restorative neurology and neuroscience

authors： Marklund N,Keck C,Hoover R,Soltesz K,Millard M,LeBold D,Spangler Z,Banning A,Benson J,McIntosh TK

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Parkinson's Disease (PD) is characterized by progressive and disabling symptoms. An impaired oxidative metabolism efficiency was supposed to be involved in the systemic impairment. Rehabilitative treatment represents a valid tool in promoting skeletal muscle's adaptations, even if no solid studies on muscle ...

journal_title：Restorative neurology and neuroscience

authors： Di Martino S,Tramonti C,Unti E,Del Gamba C,Bonuccelli U,Rossi B,Ceravolo R,Chisari C

更新日期：2018-01-01 00:00:00

abstract：:Many of the present limitations of peripheral nerve repair might be overcome by performing nerve repairs at the axon level. One approach to nerve repair at this level would be to implant a neuroprosthesis in the form of a microelectronic switchboard which could route the connections of regenerated axons to their corre...

journal_title：Restorative neurology and neuroscience

authors： Rosen JM,Grosser M,Hentz VR

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Accurate coil placement over a target area is critical during transcranial magnetic stimulation (TMS), as small deviations can alter testing outcomes. Accordingly, frameless stereotaxic systems (FSS) are recommended for reliable coil placement during TMS applications. However, FSS is not practical due to the co...

journal_title：Restorative neurology and neuroscience

authors： Washabaugh EP,Krishnan C

更新日期：2016-01-01 00:00:00

abstract：:Fetal neocortical block transplants were implanted into the excitotoxically ablated sensorimotor cortex of adult rats in order to examine the density of innervation and distribution of presumptive host derived afferent fibers within these transplants. Cholinergic fiber innervation was examined at 3 months post graftin...

journal_title：Restorative neurology and neuroscience

authors： Schulz MK,McNulty JA,Hogan TP,Zimmer J,Castro AJ

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To report the safety and efficacy of a novel therapeutic trial with umbilical cord blood (UCB) and concomitant recombinant human erythropoietin (rhEPO), which was tried for three cases of severe traumatic brain injury (TBI) in rehabilitation. DESIGN:Case series. SETTING:University hospital setting. PARTICI...

journal_title：Restorative neurology and neuroscience

authors： Min K,Song J,Lee JH,Kang MS,Jang SJ,Kim SH,Kim M

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:To demonstrate, in a proof-of-concept study, whether potentiating ipsilesional higher motor areas (premotor cortex and supplementary motor area) augments and accelerates recovery associated with constraint induced movement. METHODS:In a randomized, double-blinded pilot clinical study, 12 patients with chronic ...

journal_title：Restorative neurology and neuroscience

authors： Cunningham DA,Varnerin N,Machado A,Bonnett C,Janini D,Roelle S,Potter-Baker K,Sankarasubramanian V,Wang X,Yue G,Plow EB

更新日期：2015-01-01 00:00:00

abstract：:We are interested in the role cyclic AMP may play as a mediator of growth factor-induced gene expression in regenerating peripheral nerves. As a first step, we investigated mRNA levels and protein synthesis in intact frog dorsal root ganglia (DRG) treated with the adenylate cyclase activator, forskolin in vitro. Forsk...

journal_title：Restorative neurology and neuroscience

authors： Carlsen RC,De Leon M,Tetzlaff W,Parhad IM,Bisby MA

更新日期：1990-01-01 00:00:00

abstract：:In four patients with left visuo-spatial hemineglect and right brain- damage, the therapeutic effects of Transcutaneous Electrical Nervous Stimulation (TENS) of the left neck muscles, associated with a non-specific treatment, and of a specific rehabilitation paradigm were investigated. The two treatments were given fo...

journal_title：Restorative neurology and neuroscience

authors： Pizzamiglio L,Vallar G,Magnotti L

更新日期：1996-01-01 00:00:00

abstract：:Injury of the nervous system initiates a cascade of signal transduction including a rise in extracellular glutamate which leads to subsequent secondary neuronal loss. Excitotoxicity is known to play a crucial role in cell death spinal cord trauma. Gangliosides, particularly monosialogangliosides (GM1), are protective ...

journal_title：Restorative neurology and neuroscience

authors： Vorwerk CK,Bonheur J,Kreutz MR,Dreyer EB,Laev H

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:The aim of the present study was to explore the use of two-photon microscopy for investigating the therapeutic time window of methylprednisolone (MP) treatment after spinal cord injury (SCI). METHODS:Twenty-four YFP H-line mice were subjected to hemisection SCI and then divided into four groups. Group 1 receiv...

journal_title：Restorative neurology and neuroscience

authors： Zhang Y,Zhang L,Ji X,Pang M,Ju F,Zhang J,Li W,Zhang S,He Z,Gan WB,Tang P

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Several studies have shown that transcranial direct current stimulation (tDCS) is a useful tool to enhance language recovery in aphasia. It has also been suggested that modulation of the neurotrophin brain-derived neurotrophic factor (BDNF) might be part of the mechanisms involved in tDCS effects on synaptic co...

journal_title：Restorative neurology and neuroscience

authors： Marangolo P,Fiori V,Gelfo F,Shofany J,Razzano C,Caltagirone C,Angelucci F

更新日期：2014-01-01 00:00:00

abstract：:Axonotmesis of the left sciatic nerve was performed on adult male Wistar rats. T1 values of the crushed nerve samples were determined with proton magnetic resonance spectroscopy. Denervation changes of the dependent hind plantar flexor muscles were assessed with proton magnetic resonance imaging of their cross-section...

journal_title：Restorative neurology and neuroscience

authors： Ribarič S,Jarh O,Sepe A,Demsar F

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Multiple Sclerosis is a heterogeneous disorders involving in early stage gait and balance. Together with immunomodulating therapies, rehabilitation had a crucial role in improving motor tasks and quality of life. Between the emerging techniques, Focal Vibrations (FV) could play a role, but they have been use...

journal_title：Restorative neurology and neuroscience

authors： Spina E,Carotenuto A,Aceto MG,Cerillo I,Silvestre F,Arace F,Paone P,Orefice G,Iodice R

更新日期：2016-09-21 00:00:00

abstract：PURPOSE:The primary somatosensory cortex (S1) is somatotopically reorganized after limb amputation. The duration of the amputation, the intensity of phantom limb pain but also a multifactoral model of altered cerebral input have been discussed to be associated with cortical changes. Patients with finger amputation rare...

journal_title：Restorative neurology and neuroscience

authors： Oelschläger M,Pfannmöller J,Langner I,Lotze M

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Robotic rehabilitation is a highly promising approach to recover lost functions after stroke or other neurological disorders. Unfortunately, robotic rehabilitation currently suffers from "motor slacking", a phenomenon in which the human motor system reduces muscle activation levels and movement excursions, o...

journal_title：Restorative neurology and neuroscience

authors： Washabaugh EP,Treadway E,Gillespie RB,Remy CD,Krishnan C

更新日期：2018-01-01 00:00:00