Abstract：
:Injuries to peripheral nerves represent a challenging clinical problem. In spite of the use of microsurgical techniques, repair of severed nerves seldom results in complete recovery of motor and sensory functions. Misdirection of axons at the suture line as well as a slow axonal outgrowth contribute to the bad results. Recent experimental data indicate that growth factors, synthesized by the damaged nerve tissue as well as protein-associated neurite-promoting factors in the local micro-environment play an important role for the regulation of axonal growth and directionality. Future studies should aim at an application of this knowledge to the clinical treatment of nerve injuries.
journal_name
Restor Neurol Neuroscijournal_title
Restorative neurology and neuroscienceauthors
Lundborg Gdoi
10.3233/RNN-1990-13418subject
Has Abstractpub_date
1990-01-01 00:00:00pages
297-302issue
3eissn
0922-6028issn
1878-3627pii
L155867UU2028250journal_volume
1pub_type
杂志文章abstract：BACKGROUND:Low-frequency rTMS can induce upregulation of excitability in the contralateral hemisphere by interhemispheric interaction. OBJECTIVE:The aim of this study was to compare the effects of interhemispheric modulation on hemodynamic changes after applying low-frequency rTMS over the anatomical hand knob (HK) an...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-201032
更新日期：2020-01-01 00:00:00
abstract：:Portions of 1 cm length of the sensory radial nerve from the cat forelimb were used to replace an excised portion of the dorsal columns in the upper lumbar spinal cord. Observations were made on the clinical recovery of the animals, and cine recordings were made of their ability to traverse a horizontal ladder 5 month...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1991-245613
更新日期：1991-01-01 00:00:00
abstract：:Many toxic factors are generated during stroke that contribute directly to the death of neurons. Several recent studies suggest that a suicide-like phenomena similar to apoptosis or programmed cell death also contributes to the loss of neurons in stroke. The evidence implicating apoptosis in stroke can be divided into...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1996-9404
更新日期：1996-01-01 00:00:00
abstract：:The antagonizing effect of the β-adrenoceptor antagonist propranolol (PRP) on the desipramine (DMI)-induced regeneration of brain noradrenergic fibers was examined. The symmetrical sites of the rat frontal cortex were pretreated with 6-hydroxydopamine (6-OHDA). Then, the same cortical site of one hemisphere was infuse...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1994-6405
更新日期：1994-01-01 00:00:00
abstract：BACKGROUND:The current treatment intervention study determined the effect of coupled bilateral training (i.e., bilateral movements and EMG-triggered neuromuscular stimulation) and resistive load (mass) on upper extremity motor recovery in chronic stroke. METHODS:Thirty chronic stroke subjects were randomly assigned to...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.3233/RNN-2009-0455
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:High definition transcranial direct current stimulation (HD-tDCS) has been administered over single brain regions for small numbers of sessions. Safety, feasibility and tolerability of HD-tDCS over multiple brain regions, multiple daily stimulations and long periods are not established. OBJECTIVE:We studied...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-170757
更新日期：2017-01-01 00:00:00
abstract：PURPOSE:To analyze the effects of CGP 3466, a compound structurally related to deprenyl, on survival and function of fetal ventral mesencephalic dopaminergic neurons. METHODS:Free-floating roller tube (FFRT) cultures of rat (E14) ventral mesencephalon were treated with CGP 3466 [10-8 M] for 7 days. Tyrosine hydroxylas...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：PURPOSE:The present work compared the behavioral outcomes of ACCS therapy delivered either intravenously (i.v.) or intracerebroventricularly (i.c.v.) after penetrating ballistic-like brain injury (PBBI). Histological markers for neuroinflammation and neurodegeneration were employed to investigate the potential therapeu...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-140455
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:This study investigated whether enrichment improves hindlimb movement following complete spinal cord transection and transplantation of olfactory ensheathing glia (OEG), with or without a Schwann cell (SC) bridge. METHODS:Motor activity was encouraged through provision of motor enrichment housing (MEH); a mult...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：:It is widely accepted that the suprachiasmatic nuclei (SCN) of the hypothalamus serve as biological pacemakers, organizing daily activities. However some circadian rhythms are controlled by extra-SCN structures. Transplantation of fetal donor SCN in SCN-lesioned rodents induces recovery of rhythmic locomotor and drink...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1994-6207
更新日期：1994-01-01 00:00:00
abstract：:Contemporary strategies to promote motor recovery following stroke focus on repetitive voluntary movements. Although successful movement relies on efficient sensorimotor integration, functional outcomes often bias motor therapy toward motor-related impairments such as weakness, spasticity and synergies; sensory therap...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,评审
doi：10.3233/RNN-150606
更新日期：2016-04-11 00:00:00
abstract：PURPOSE:The quality of presurgical evaluation in focal extratemporal epilepsy surgery is highly dependent on precise structural and functional identification of the epileptic focus. Navigated transcranial magnetic stimulation (nTMS) is a tool that combines the spatial information of high-resolution magnetic resonance i...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-2010-0540
更新日期：2010-01-01 00:00:00
abstract：PURPOSE:Repetitive mild traumatic brain injury (TBI) is a major military and sports health concern. The purpose of this study was to determine if a diet rich in omega-3 fatty acids would reduce cognitive deficits and neuronal cell death in a novel fluid percussion rat model of repetitive mild TBIs. METHODS:Thirty-two ...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-130316
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:We wished to evaluate the efficacy of vision restoration therapy (VRT) in patients with post-chiasmatic brain damage using different functional perimetric tests. These were compared with measures of subjective vision and reaction time. METHODS:An open trial was conducted with hemianopia/scotoma (n=16) patients...
journal_title：Restorative neurology and neuroscience
pub_type： 临床试验,杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：PURPOSE:We examined the feasibility and outcome of electromyographically triggered electrical muscle stimulation (EMG-ES) plus unilateral or bilateral task specific practice on arm function in chronic stroke survivors with moderate-severe hemiplegia. Transcranial magnetic stimulation was used to examine inter-hemispher...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.3233/RNN-130319
更新日期：2013-01-01 00:00:00
abstract：:We are interested in the role cyclic AMP may play as a mediator of growth factor-induced gene expression in regenerating peripheral nerves. As a first step, we investigated mRNA levels and protein synthesis in intact frog dorsal root ganglia (DRG) treated with the adenylate cyclase activator, forskolin in vitro. Forsk...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1990-13408
更新日期：1990-01-01 00:00:00
abstract：BACKGROUND:Dimethyl fumarate (DMF) has immune-modulatory and neuro-protective characteristics that can be used for treatment of acute ischemic stroke. OBJECTIVE:To investigate the therapeutic effects of DMF on histological and functional recovery of rats after transient middle cerebral artery (MCA) occlusion. METHODS...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-160670
更新日期：2017-01-01 00:00:00
abstract：PURPOSE:Transgenic manipulation of mouse physiology facilitates the preclinical study of genetic risk factors, neural plasticity, and reactive processes accompanying Alzheimer's disease. Alternatively, entorhinal cortex lesions (ECLs) model pathophysiological denervation and axonal sprouting in rat. Given reports of an...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-130311
更新日期：2013-01-01 00:00:00
abstract：:Wound-derived trophic factors released by the injured brain are thought to reach a peak 1-2 weeks after injury. It has been proposed that such factors can promote the survival, growth and functional capacity of embryonic tissue grafts. To test the generality of this hypothesis, control rats and rats with aspirative fi...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1989-1109
更新日期：1989-01-01 00:00:00
abstract：PURPOSE:Previous neuroimaging studies of oddball tasks and other paradigms measuring attention processes support right hemisphere dominance for attentional processes. Using an auditory selective attention task, we studied the functional asymmetry of the human brain in response to attended or unattended deviant tones. S...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：PURPOSE:The purpose of this study was to delineate the relationship between several types of T1-weighted MRI pathology and motor rehabilitation potential following Constraint Induced Movement therapy (CI therapy) in chronic stroke. METHODS:Stepwise regression was employed (n = 80) to identify predictors of motor recov...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-130366
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:Contralateral primary sensori-motor cortex (SM1) activation by passive movement was investigated by functional MRI (fMRI) at the early stage of stroke, to determine whether SM1 activation can be used to predict the degree of motor recovery of the hemiplegic hand. METHODS:We studied 17 stroke patients who showe...
journal_title：Restorative neurology and neuroscience
pub_type： 临床试验,杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:To report the safety and efficacy of a novel therapeutic trial with umbilical cord blood (UCB) and concomitant recombinant human erythropoietin (rhEPO), which was tried for three cases of severe traumatic brain injury (TBI) in rehabilitation. DESIGN:Case series. SETTING:University hospital setting. PARTICI...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-120289
更新日期：2013-01-01 00:00:00
abstract：PURPOSE:Hemispatial neglect, a failure to orient to the contralateral side of the lesion, is a disabling disorder after stroke. Previously arm activation combined with visual training or visual scanning training were found effective in rehabilitation of hemispatial neglect. The aim of this study was to determine whethe...
journal_title：Restorative neurology and neuroscience
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3233/RNN-2009-0520
更新日期：2009-01-01 00:00:00
abstract：PURPOSE:Study the effect of peripheral nerve extracts and BDNF on retinal ganglion cell (RGC) regeneration in adult rats. METHODS:Postmicrosomal fractions were obtained from 7-day, predegenerated, as well as non-predegenerated peripheral adult rats nerves. Autologous connective tissue chambers filled with fibrin were ...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:In low vision patients, the assessment of contrast sensitivity is an essential tool to determine the stage of visual impairment. However, traditional contrast sensitivity tests rely on verbal feedback, and the expertise of the examiner. OBJECTIVE:In the current study, a fast, OKN-based virtual diagnosis too...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-190937
更新日期：2020-01-01 00:00:00
abstract：BACKGROUND:Virtual reality (VR) has the potential to provide intensive, repetitive, and task-oriented training, and game-based therapy can enhance patients' motivation and enjoyment. OBJECTIVE:The objective of the present study was to develop a mobile game-based upper extremity VR program for patients who have experie...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.3233/RNN-150626
更新日期：2016-05-02 00:00:00
abstract：PURPOSE:The aim of the study was to examine if improvements of stimulus detection performance in visual field tests after intensive visual training of the visual field border zone in patients with visual field defects are associated with changes in self-reported vision- and health-related quality of life (QoL). METHOD...
journal_title：Restorative neurology and neuroscience
pub_type： 临床试验,杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:There is considerable variability in the extent and nature of the glial response to injury and neurodegeneration. Transplantation of fetal cortical tissue onto the brain of neonatal host rats or mice results in region-specific changes dependent on where the fetal tissue is placed. These changes include chronic ...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-150591
更新日期：2016-01-01 00:00:00
abstract：:Many of the present limitations of peripheral nerve repair might be overcome by performing nerve repairs at the axon level. One approach to nerve repair at this level would be to implant a neuroprosthesis in the form of a microelectronic switchboard which could route the connections of regenerated axons to their corre...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1990-2205
更新日期：1990-01-01 00:00:00
