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The effect of propranolol on the desipramine-induced regeneration of brain noradrenergic axons in the rat.

Abstract：

:The antagonizing effect of the β-adrenoceptor antagonist propranolol (PRP) on the desipramine (DMI)-induced regeneration of brain noradrenergic fibers was examined. The symmetrical sites of the rat frontal cortex were pretreated with 6-hydroxydopamine (6-OHDA). Then, the same cortical site of one hemisphere was infused with DMI, while the corresponding site of the other hemisphere was infused with DMI (1 mM) plus PRP (1 mM). The DMI-induced axonal regeneration was attenuated by PRP. This finding suggests that activation of β-adrenoceptors is involved at least in part in the regeneration of brain noradrenergic axons.

journal_name

Restor Neurol Neurosci

journal_title

Restorative neurology and neuroscience

authors

Nakamura S

doi

10.3233/RNN-1994-6405

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

297-300

issue

4

eissn

0922-6028

issn

1878-3627

pii

L61UT14420362058

journal_volume

6

pub_type

杂志文章

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