Promoting central nervous system regeneration: lessons from cranial nerve I.

abstract：:Non-invasive brain stimulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), can modify cortical excitability in a lasting fashion. The modification can be bi-directional in nature and holds considerable therapeutic promise for a number of neurological conditions. However, the effectiveness ...

journal_title：Restorative neurology and neuroscience

authors： Todd G,Ridding MC

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:We wished to evaluate the efficacy of vision restoration therapy (VRT) in patients with post-chiasmatic brain damage using different functional perimetric tests. These were compared with measures of subjective vision and reaction time. METHODS:An open trial was conducted with hemianopia/scotoma (n=16) patients...

journal_title：Restorative neurology and neuroscience

authors： Sabel BA,Kenkel S,Kasten E

更新日期：2004-01-01 00:00:00

abstract：:The brain can undergo self-repair and has the ability to compensate for functions lost after a stroke. The plasticity of the ischemic brain is influenced by several factors including aging and pharmacotherapy. Fluoxetine is an antidepressant which enhances serotonergic neurotransmission through selective inhibition of...

journal_title：Restorative neurology and neuroscience

authors： Sun Y,Sun X,Qu H,Zhao S,Xiao T,Zhao C

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Traumatic brain injury can result in lasting cognitive dysfunction due to degeneration of mature hippocampal neurons as well as the loss of immature neurons within the dentate gyrus. While endogenous neurogenesis affords a partial recovery of the immature neuron population, hippocampal neurogenesis may be en...

journal_title：Restorative neurology and neuroscience

authors： Sama DM,Carlson SW,Joseph B,Saenger S,Metzger F,Saatman KE

更新日期：2018-01-01 00:00:00

abstract：:It is widely accepted that the suprachiasmatic nuclei (SCN) of the hypothalamus serve as biological pacemakers, organizing daily activities. However some circadian rhythms are controlled by extra-SCN structures. Transplantation of fetal donor SCN in SCN-lesioned rodents induces recovery of rhythmic locomotor and drink...

journal_title：Restorative neurology and neuroscience

authors： Le Sauter J,Silver R

更新日期：1994-01-01 00:00:00

abstract：:Vestibular habituation was studied in normal subjects and in patients with cerebellar disease using a stimulation paradigm proposed in this paper. Six caloric stimuli were repeated daily in the same ear during six days and electronystagmographic responses at the beginning and the end of that period were compared. The ...

journal_title：Restorative neurology and neuroscience

authors： Suarez H,Caffa C,Macadar O

更新日期：1992-01-01 00:00:00

abstract：:Axonotmesis of the left sciatic nerve was performed on adult male Wistar rats. T1 values of the crushed nerve samples were determined with proton magnetic resonance spectroscopy. Denervation changes of the dependent hind plantar flexor muscles were assessed with proton magnetic resonance imaging of their cross-section...

journal_title：Restorative neurology and neuroscience

authors： Ribarič S,Jarh O,Sepe A,Demsar F

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:The current treatment intervention study determined the effect of coupled bilateral training (i.e., bilateral movements and EMG-triggered neuromuscular stimulation) and resistive load (mass) on upper extremity motor recovery in chronic stroke. METHODS:Thirty chronic stroke subjects were randomly assigned to...

journal_title：Restorative neurology and neuroscience

authors： Cauraugh JH,Coombes SA,Lodha N,Naik SK,Summers JJ

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Focal dystonia in musicians (MD) is a task-specific movement disorder with a loss of voluntary motor control during instrumental playing. Defective inhibition on different levels of the central nervous system is involved in the pathophysiology. Sensorimotor retraining is a therapeutic approach to MD and aims...

journal_title：Restorative neurology and neuroscience

authors： Buttkus F,Baur V,Jabusch HC,de la Cruz Gomez-Pellin M,Paulus W,Nitsche MA,Altenmüller E

更新日期：2011-01-01 00:00:00

abstract：:A long-term goal in motor rehabilitation is that treatment is not selected on the basis of 'schools of thought', but rather, based on knowledge about efficacy and effectiveness of specific interventions for specific situations (e.g. functional syndromes). Motor dysfunction after stroke or TBI can be caused by many dif...

journal_title：Restorative neurology and neuroscience

authors： Platz T,Hesse S,Mauritz KH

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Neuroplastic alterations of cortical excitability and activity represent the likely neurophysiological foundation of learning and memory formation. Beyond their induction, alterations of these processes by subsequent modification of cortical activity, termed metaplasticity, came into the focus of...

journal_title：Restorative neurology and neuroscience

authors： Thirugnanasambandam N,Sparing R,Dafotakis M,Meister IG,Paulus W,Nitsche MA,Fink GR

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:There is considerable variability in the extent and nature of the glial response to injury and neurodegeneration. Transplantation of fetal cortical tissue onto the brain of neonatal host rats or mice results in region-specific changes dependent on where the fetal tissue is placed. These changes include chronic ...

journal_title：Restorative neurology and neuroscience

authors： Bates KA,Drummond ES,Cozens GS,Harvey AR

更新日期：2016-01-01 00:00:00

abstract：:Pyramidal neurons inside transplants of embryonic nervous tissue are capable of generating axonal extrinsic hippocampal fiber connections over considerable distances to appropriate target areas in the mature brain. The establishment of long-distance graft efferents to the lateral septum and to the entorhinal cortex wa...

journal_title：Restorative neurology and neuroscience

authors： Sprick U

更新日期：1991-01-01 00:00:00

abstract：:We have tested the capacity of several compounds with in vitro and/or in vivo antioxidant or antilipolytic activity to ameliorate locomotor function in cats subjected to static loading (i.e. compression) injury of the spinal cord. These include the synthetic glucocorticoid, methylprednisolone sodium succinate (MP), an...

journal_title：Restorative neurology and neuroscience

authors： Anderson DK

更新日期：1991-01-01 00:00:00

abstract：:The effects of striatal transplantation of PC12 cells on amphetamine-induced rotational behavior and monoamine levels were examined in rats with unilateral 6-hydroxydopamine (6-OHDA) lesions in the nigrostriatal pathway. A total of 9 × 104 or 9 × 105 cells of PC12 was implanted into 3 sites in the striatum and changes...

journal_title：Restorative neurology and neuroscience

authors： Hori Y,Kageyama H,Kihara T,Ikeda M,Nakano A,Kurosawa A

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:In brain-computer interfaces (BCIs), electrical brain signals during motor imagery are utilized as commands connecting the brain to a computer. To use BCI in patients with stroke, unique brain signal changes should be characterized during motor imagery process. This study aimed to examine the trial-dependent mo...

journal_title：Restorative neurology and neuroscience

authors： Lee M,Park CH,Im CH,Kim JH,Kwon GH,Kim L,Chang WH,Kim YH

更新日期：2015-08-26 00:00:00

abstract：BACKGROUND:After stroke, the learned non-use of a paretic arm is a major obstacle to the improvement of hand function. OBJECTIVE:We examined whether patients with a central paresis could profit from applying the self-regulation strategy of making if-then plans that specify situational triggers to using the paretic arm...

journal_title：Restorative neurology and neuroscience

authors： Marquardt MK,Cohen AL,Gollwitzer PM,Gilbert SJ,Dettmers C

更新日期：2017-01-01 00:00:00

abstract：:The outgrowth of neurites in neuronal cell cultures reflects the intrinsic capacity for neurite regeneration and morphological rearrangements after axotomy and in plasticity. The role of fast axonal transport in these neurite outgrowth responses has not been investigated. We have recently shown that sabeluzole (R58735...

journal_title：Restorative neurology and neuroscience

authors： Geerts H,Nuydens R,Nuyens R,Cornelissen F

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:The present study was aimed to investigate whether combination treatment with progesterone and rehabilitation training would be more effective than monotherapy after cerebral ischemia. METHODS:C57BL/6 mice were subjected to focal ischemia by photothrombosis and were treated with progesterone (2 mg/kg), rehabil...

journal_title：Restorative neurology and neuroscience

authors： Wang J,Feng X,Du Y,Wang L,Zhang S

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Glutamate transporters are responsible for removing glutamate from the extracellular space and have the potential to protect neurons from excitotoxicity. In the present study, the effects of ceftriaxone and (2R, 4R)-APDC (APDC) on the protein expression of GLAST and GLT-1, the rate of glutamate uptake, and neur...

journal_title：Restorative neurology and neuroscience

authors： Beller JA,Gurkoff GG,Berman RF,Lyeth BG

更新日期：2011-01-01 00:00:00

abstract：:The hypothesis that a destabilization of mitochondrial function during neuronal exposure to excitatory amino acids may be involved in the mechanism of neuronal death was examined. The mitochondrial membrane potential (Delta(psi)m) and the cytoplasmic Ca2+ concentration ([Ca2+]c) were monitored simultaneously in single...

journal_title：Restorative neurology and neuroscience

authors： Kiedrowski L

更新日期：1998-06-01 00:00:00

abstract：PURPOSE:Understanding the neural mechanisms of stroke recovery is of paramount importance for neurorehabilitation. METHODS:For this purpose, we analyzed several TMS and EEG variables and their association with motor recovery. Thirty-five subjects with chronic stroke were recruited. The neurophysiological examination i...

journal_title：Restorative neurology and neuroscience

authors： Simis M,Doruk D,Imamura M,Anghinah R,Morales-Quezada L,Fregni F,Battistella LR

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Dimethyl fumarate (DMF) has immune-modulatory and neuro-protective characteristics that can be used for treatment of acute ischemic stroke. OBJECTIVE:To investigate the therapeutic effects of DMF on histological and functional recovery of rats after transient middle cerebral artery (MCA) occlusion. METHODS...

journal_title：Restorative neurology and neuroscience

authors： Safari A,Fazeli M,Namavar MR,Tanideh N,Jafari P,Borhani-Haghighi A

更新日期：2017-01-01 00:00:00

abstract：:Bridging large defects in mixed nerves is still an unsolved problem in reconstructive microsurgery. Two main aspects may be distinguished: one is to obtain an appropriate substitute for the lost neural tissue, the second to direct fibers toward their previous end-organs with the highest possible specificity. In the pr...

journal_title：Restorative neurology and neuroscience

authors： Papaloïzos MY,Holmquist B,Lundborg G

更新日期：1997-01-01 00:00:00

abstract：INTRODUCTION:Traumatic brain injuries (TBI) are one of the most common consequences of traffic accidents. Patients with mild, moderate or severe brain injuries suffer from physical, cognitive, behavioral, emotional and social problems. Most of these problems have been a long standing focus amongst practitioners and res...

journal_title：Restorative neurology and neuroscience

authors： Bullinger M,Azouvi P,Brooks N,Basso A,Christensen AL,Gobiet W,Greenwood R,Hütter B,Jennett B,Maas A,Truelle JL,von Wild KR,TBI Consensus Group.

更新日期：2002-01-01 00:00:00

abstract：:Traumatic brain and spinal cord injuries are severe burdens for the patients, their relatives, the health care providers and society as a whole. Recent data demonstrate the magnitude of the problem: It is mostly a disease of the young gen-eration (age 20-45 years) with mortality rates for severe traumatic brain injury...

journal_title：Restorative neurology and neuroscience

authors： Neugebauer E,Lefering R,Noth J

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Oxidative stress is an important factor in the pathophysiologic changes after traumatic brain injury (TBI). Connexin43 (Cx43) was reported to contribute to cerebral damage. However, the impacts of Cx40 have not been investigated in detail. OBJECTIVE:In the present study, we hypothesized that Cx40 was involv...

journal_title：Restorative neurology and neuroscience

authors： Chen W,Guo Y,Yang W,Zheng P,Zeng J,Tong W

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Parkinson's Disease (PD) is characterized by progressive and disabling symptoms. An impaired oxidative metabolism efficiency was supposed to be involved in the systemic impairment. Rehabilitative treatment represents a valid tool in promoting skeletal muscle's adaptations, even if no solid studies on muscle ...

journal_title：Restorative neurology and neuroscience

authors： Di Martino S,Tramonti C,Unti E,Del Gamba C,Bonuccelli U,Rossi B,Ceravolo R,Chisari C

更新日期：2018-01-01 00:00:00

abstract：:Fetal neocortical block transplants were implanted into the excitotoxically ablated sensorimotor cortex of adult rats in order to examine the density of innervation and distribution of presumptive host derived afferent fibers within these transplants. Cholinergic fiber innervation was examined at 3 months post graftin...

journal_title：Restorative neurology and neuroscience

authors： Schulz MK,McNulty JA,Hogan TP,Zimmer J,Castro AJ

更新日期：1995-01-01 00:00:00

abstract：:Purpose: Damage of primary visual cortex in adult humans, monkeys and cats severely disrupts vision by disconnecting much of the cogni-tive processing machinery of extrastriate cortex from its source of visual signals in the retina. Equivalent lesions sustained early in life result in partial sparing of visual process...

journal_title：Restorative neurology and neuroscience

authors： Payne BR,Lomber SG

更新日期：2000-01-01 00:00:00