Abstract：
BACKGROUND:The current treatment intervention study determined the effect of coupled bilateral training (i.e., bilateral movements and EMG-triggered neuromuscular stimulation) and resistive load (mass) on upper extremity motor recovery in chronic stroke. METHODS:Thirty chronic stroke subjects were randomly assigned to one of three behavioral treatment groups and completed 6 hours of rehabilitation in 4 days: (1) coupled bilateral training with a load on the unimpaired hand, (2) coupled bilateral training with no load on the unimpaired hand, and (3) control (no stimulation assistance or load). RESULTS:Separate mixed design ANOVAs revealed improved motor capabilities by the coupled bilateral groups. From the pretest to the posttest, both the coupled bilateral no load and load groups moved a higher number of blocks and demonstrated more regularity in the sustained contraction task. Faster motor reaction times across test sessions for the coupled bilateral load group provided additional evidence for improved motor capabilities. CONCLUSIONS:Together these behavioral findings lend support to the contribution of coupled bilateral training with a load on the unimpaired arm to improved motor capabilities on the impaired arm. This evidence supports a neural explanation in that simultaneously moving both limbs during stroke rehabilitation training appears to activate balanced interhemispheric interactions while an extra load on the unimpaired limb provides stability to the system.
journal_name
Restor Neurol Neuroscijournal_title
Restorative neurology and neuroscienceauthors
Cauraugh JH,Coombes SA,Lodha N,Naik SK,Summers JJdoi
10.3233/RNN-2009-0455subject
Has Abstractpub_date
2009-01-01 00:00:00pages
17-25issue
1eissn
0922-6028issn
1878-3627pii
040779168H163785journal_volume
27pub_type
杂志文章,随机对照试验abstract：:The aim of this study was to gauge the possible sprouting of primary afferent fibers following dorsal rhizotomies using Fos-like immunoreactivity (Fos-LI) in order to label neurons activated by formalin injection into the rat forepaw. To assess the functional consequences of possible sprouting of fine diameter primary...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1994-6304
更新日期：1994-01-01 00:00:00
abstract：PURPOSE:The aim of the study was to examine if improvements of stimulus detection performance in visual field tests after intensive visual training of the visual field border zone in patients with visual field defects are associated with changes in self-reported vision- and health-related quality of life (QoL). METHOD...
journal_title：Restorative neurology and neuroscience
pub_type： 临床试验,杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:The patients with chronic Disorders of Consciousness (DoC) mostly present with extremely challenging differential diagnosis. The advanced analysis of electroencephalographic (EEG) signals induced by brain stimulation paradigms may provide an appropriate approach to differentiate patients with DoC, besides th...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-170741
更新日期：2017-01-01 00:00:00
abstract：:Retinal and cortical lesions are completely different events that trigger visual cortical plasticity. We therefore compared the cortical effects of homonymous lesions of the central retina with effects of cortical lesions. All in vivo experiments were performed in anaesthetized, adult cats. Retinal lesions were made w...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Administration of gangliosides accelerates recovery of function after entorhinal cortex lesions on open field activity and learned spatial alternation tasks. In the present study, we examined whether GM1 ganglioside might enhance recovery from bilateral entorhinal cortex lesions on a differential reinforcement of low-...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Many of the present limitations of peripheral nerve repair might be overcome by performing nerve repairs at the axon level. One approach to nerve repair at this level would be to implant a neuroprosthesis in the form of a microelectronic switchboard which could route the connections of regenerated axons to their corre...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1990-2205
更新日期：1990-01-01 00:00:00
abstract：PURPOSE:The purpose of this study was to delineate the relationship between several types of T1-weighted MRI pathology and motor rehabilitation potential following Constraint Induced Movement therapy (CI therapy) in chronic stroke. METHODS:Stepwise regression was employed (n = 80) to identify predictors of motor recov...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-130366
更新日期：2014-01-01 00:00:00
abstract：:Following brain injury there is an excessive release of glutamate, a reduction in levels of cellular Mg+ +, and the generation of oxygen free radicals. These processes may contribute to the severity of the behavioral impairments seen following brain injury by leading to secondary neuronal degeneration. The present exp...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1997-111208
更新日期：1997-01-01 00:00:00
abstract：BACKGROUND:High definition transcranial direct current stimulation (HD-tDCS) has been administered over single brain regions for small numbers of sessions. Safety, feasibility and tolerability of HD-tDCS over multiple brain regions, multiple daily stimulations and long periods are not established. OBJECTIVE:We studied...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-170757
更新日期：2017-01-01 00:00:00
abstract：:PURPOSE: Until recently, there has been a limited amount of research comparing functional and anatomical recovery following nerve injury. Previous studies emphasizing anatomical recovery (such as axonal number) have shown that testosterone promotes regeneration in crushed and transected nerves. The purpose of this stu...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Injuries to peripheral nerves represent a challenging clinical problem. In spite of the use of microsurgical techniques, repair of severed nerves seldom results in complete recovery of motor and sensory functions. Misdirection of axons at the suture line as well as a slow axonal outgrowth contribute to the bad results...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1990-13418
更新日期：1990-01-01 00:00:00
abstract：PURPOSE:To demonstrate, in a proof-of-concept study, whether potentiating ipsilesional higher motor areas (premotor cortex and supplementary motor area) augments and accelerates recovery associated with constraint induced movement. METHODS:In a randomized, double-blinded pilot clinical study, 12 patients with chronic ...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.3233/RNN-150574
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:A cerebral ischemic stroke involves mitochondrial dysfunction, motor deficits, and paralysis; and Danhong injection (DHI) might possess mitochondrial protection and functional recovery in a stroke subject through promoting expression of parkin, a ubiquitin ligase playing a key role in the regulation of prote...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-180828
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Specific investigation of dual task-interference (DTI) may help researchers to develop the optimal training exercise for enhancing the performance of daily activities. OBJECTIVES:To reveal the DTI by comparing the performances between personalized single tasks (cognitive or motor task) and dual task with se...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.3233/RNN-180825
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:In low vision patients, the assessment of contrast sensitivity is an essential tool to determine the stage of visual impairment. However, traditional contrast sensitivity tests rely on verbal feedback, and the expertise of the examiner. OBJECTIVE:In the current study, a fast, OKN-based virtual diagnosis too...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-190937
更新日期：2020-01-01 00:00:00
abstract：:We are interested in the role cyclic AMP may play as a mediator of growth factor-induced gene expression in regenerating peripheral nerves. As a first step, we investigated mRNA levels and protein synthesis in intact frog dorsal root ganglia (DRG) treated with the adenylate cyclase activator, forskolin in vitro. Forsk...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1990-13408
更新日期：1990-01-01 00:00:00
abstract：PURPOSE:Freezing of gait (FOG) affects mobility and balance seriously. Few reports have investigated the effects of repetitive transcranial magnetic stimulation (rTMS) on FOG in Parkinson's disease (PD). We investigated the efficacy of high-frequency rTMS for the treatment of FOG in PD. METHODS:Seventeen patients diag...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.3233/RNN-140489
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:Contralateral primary sensori-motor cortex (SM1) activation by passive movement was investigated by functional MRI (fMRI) at the early stage of stroke, to determine whether SM1 activation can be used to predict the degree of motor recovery of the hemiplegic hand. METHODS:We studied 17 stroke patients who showe...
journal_title：Restorative neurology and neuroscience
pub_type： 临床试验,杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：BACKGROUND:The dopamine system plays a key role in motor learning and neuroplasticity. Several studies have studied the efficacy of dopaminergic drugs in enhancing motor recovery after stroke, but the effects are controversial. Although genetic variations in plasticity-related genes influence each individual's capacity...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-160667
更新日期：2016-11-22 00:00:00
abstract：:Contemporary strategies to promote motor recovery following stroke focus on repetitive voluntary movements. Although successful movement relies on efficient sensorimotor integration, functional outcomes often bias motor therapy toward motor-related impairments such as weakness, spasticity and synergies; sensory therap...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,评审
doi：10.3233/RNN-150606
更新日期：2016-04-11 00:00:00
abstract：PURPOSE:Ischemic stroke is associated with a variety pathophysiological changes affecting both glial and neuronal brain tissue. These changes are mirrored in the release of specific proteins into peripheral blood. Neurone-specific enolase (NSE), protein S100B and glial fibrillary acidic protein (GFAP) are those protein...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2003-01-01 00:00:00
abstract：:Pyramidal neurons inside transplants of embryonic nervous tissue are capable of generating axonal extrinsic hippocampal fiber connections over considerable distances to appropriate target areas in the mature brain. The establishment of long-distance graft efferents to the lateral septum and to the entorhinal cortex wa...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1991-3103
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Low-frequency rTMS can induce upregulation of excitability in the contralateral hemisphere by interhemispheric interaction. OBJECTIVE:The aim of this study was to compare the effects of interhemispheric modulation on hemodynamic changes after applying low-frequency rTMS over the anatomical hand knob (HK) an...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-201032
更新日期：2020-01-01 00:00:00
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journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1994-6405
更新日期：1994-01-01 00:00:00
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journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-130385
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy of an expanded form of Constraint-Induced Movement Therapy (eCIMT) that renders CIMT, originally designed for treating mild-to-moderate upper-extremity hemiparesis, suitable for treating severe hemiparesis. METHODS:Twenty-one adults ≥1 year after stroke with severe upper-extremity hemi...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.3233/RNN-170792
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:The present study was designed to investigate the neural correlates of German Sign Language (Deutsche Gebärdensprache; DGS) processing. In particular, was expected the impact of the visuo-spatial mode in sign language on underlying neural networks compared to the impact of the interpretation of linguistic infor...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:Traumatic brain and spinal cord injuries are severe burdens for the patients, their relatives, the health care providers and society as a whole. Recent data demonstrate the magnitude of the problem: It is mostly a disease of the young gen-eration (age 20-45 years) with mortality rates for severe traumatic brain injury...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：PURPOSE:Previous neuroimaging studies of oddball tasks and other paradigms measuring attention processes support right hemisphere dominance for attentional processes. Using an auditory selective attention task, we studied the functional asymmetry of the human brain in response to attended or unattended deviant tones. S...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:The olfactory nerve differs from cranial nerves III-XII in that it contains a specialised type of glial cell, called 'olfactory ensheathing cell' (OEC), rather than Schwann cells. In addition, functional neurogenesis persists postnatally in the olfactory system, i.e. the primary olfactory pathway continuously rebuilds...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
