GM1-Ganglioside Suppresses Septodentate Sprouting and Enhances Recovery from Entorhinal Cortex Lesions on DRL Perfomance and Locomotor Behavior in Rats.

abstract：PURPOSE:Despite advances towards potential clinically viable therapies there has been only limited success in improving functional recovery following traumatic brain injury (TBI). In rats, exposure to an enriched environment (EE) improves learning and fosters motor skill development. Induced pluripotent stem cells (iPS...

journal_title：Restorative neurology and neuroscience

authors： Dunkerson J,Moritz KE,Young J,Pionk T,Fink K,Rossignol J,Dunbar G,Smith JS

更新日期：2014-01-01 00:00:00

abstract：:Many toxic factors are generated during stroke that contribute directly to the death of neurons. Several recent studies suggest that a suicide-like phenomena similar to apoptosis or programmed cell death also contributes to the loss of neurons in stroke. The evidence implicating apoptosis in stroke can be divided into...

journal_title：Restorative neurology and neuroscience

authors： Linnik MD

更新日期：1996-01-01 00:00:00

abstract：:Pyramidal neurons inside transplants of embryonic nervous tissue are capable of generating axonal extrinsic hippocampal fiber connections over considerable distances to appropriate target areas in the mature brain. The establishment of long-distance graft efferents to the lateral septum and to the entorhinal cortex wa...

journal_title：Restorative neurology and neuroscience

authors： Sprick U

更新日期：1991-01-01 00:00:00

abstract：:Since various studies, including multi-centre studies, investigating the effect of repetitive transcranial magnetic stimulation (rTMS) in depression have shown different results, it is now important to research, which symptoms of depression are most responsive to this kind of non-invasive brain stimulation. Furthermor...

journal_title：Restorative neurology and neuroscience

authors： Höppner J,Berger C,Walter U,Padberg F,Buchmann J,Herwig U,Domes G

更新日期：2010-01-01 00:00:00

abstract：:Many ocular diseases (such as glaucoma, diabetic retinopathy, age-related macular degeneration, and traumatic eye injuries) can result in the degeneration of retinal cells and the subsequent loss of vision. Some kinds of treatments, such as drugs, stem cell transplantation and surgery are reported to be effective in c...

journal_title：Restorative neurology and neuroscience

authors： Li HY,Rong SS,Hong X,Guo R,Yang FZ,Liang YY,Li A,So KF

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Immunomodulatory agents are often combined in organ transplantation to minimize toxicity and enhance therapeutic effect. We hypothesized that combining low-dose FK506 with anti-CD40 Ligand (anti-CD40L mAb) would enhance regeneration through peripheral nerve allografts while preserving immune unresponsiveness. ...

journal_title：Restorative neurology and neuroscience

authors： Brenner MJ,Mackinnon SE,Rickman SR,Jaramillo A,Tung TH,Hunter DA,Mohanakumar T

更新日期：2005-01-01 00:00:00

abstract：:In four patients with left visuo-spatial hemineglect and right brain- damage, the therapeutic effects of Transcutaneous Electrical Nervous Stimulation (TENS) of the left neck muscles, associated with a non-specific treatment, and of a specific rehabilitation paradigm were investigated. The two treatments were given fo...

journal_title：Restorative neurology and neuroscience

authors： Pizzamiglio L,Vallar G,Magnotti L

更新日期：1996-01-01 00:00:00

abstract：:The effects of striatal transplantation of PC12 cells on amphetamine-induced rotational behavior and monoamine levels were examined in rats with unilateral 6-hydroxydopamine (6-OHDA) lesions in the nigrostriatal pathway. A total of 9 × 104 or 9 × 105 cells of PC12 was implanted into 3 sites in the striatum and changes...

journal_title：Restorative neurology and neuroscience

authors： Hori Y,Kageyama H,Kihara T,Ikeda M,Nakano A,Kurosawa A

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Aging is believed to affect epigenetic marking of brain DNA with 5-methylcytosine (5mC) and possibly via the 5mC to 5-hydroxymethylcytosine (5hmC) conversion by TET (ten-eleven translocation) enzymes. We investigated the impact of aging on hippocampal DNA 5-hydroxymethylation including in the sequence of aging-...

journal_title：Restorative neurology and neuroscience

authors： Chen H,Dzitoyeva S,Manev H

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:A realistic body representation needs to be constantly updated. In case of physiological modifications, body representations integrate information coming from different sensory sources, including the sense of touch. Previous studies described transient modifications of these representations following illusory d...

journal_title：Restorative neurology and neuroscience

authors： Cimmino RL,Spitoni G,Serino A,Antonucci G,Catagni M,Camagni M,Haggard P,Pizzamiglio L

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Traumatic brain injury (TBI) -induced brain edema can be reduced by acute progesterone (PROG) treatment in young adult males and females, and in aged males. To extend these findings we tested these hypotheses: 1. Acute PROG treatment post-TBI will reduce cortical edema in aged females as much as in young adults...

journal_title：Restorative neurology and neuroscience

authors： Kasturi BS,Stein DG

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:We hypothesized that recovery of upper extremity motor function is associated with reduction of intracortical inhibition and improved reciprocal inhibition. This study examines the relationships of functional recovery in chronic stroke with the intracortical inhibition and spinal reciprocal inhibition. METHODS...

journal_title：Restorative neurology and neuroscience

authors： Fujiwara T,Honaga K,Kawakami M,Nishimoto A,Abe K,Mizuno K,Kodama M,Masakado Y,Tsuji T,Liu M

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Exogenously applied BDNF has been shown to rescue rat retinal ganglion cells (RGCs) from axotomy-induced apoptotic death, presumably via activation of its high affinity receptor TrkB. Since both TrkB and BDNF are endogenously expressed in RGCs, auto- or para-crine neurotrophic loops in the retina may be involve...

journal_title：Restorative neurology and neuroscience

authors： Hirsch S,Labes M,Bähr M

更新日期：2000-01-01 00:00:00

abstract：:We are interested in the role cyclic AMP may play as a mediator of growth factor-induced gene expression in regenerating peripheral nerves. As a first step, we investigated mRNA levels and protein synthesis in intact frog dorsal root ganglia (DRG) treated with the adenylate cyclase activator, forskolin in vitro. Forsk...

journal_title：Restorative neurology and neuroscience

authors： Carlsen RC,De Leon M,Tetzlaff W,Parhad IM,Bisby MA

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:To report the safety and efficacy of a novel therapeutic trial with umbilical cord blood (UCB) and concomitant recombinant human erythropoietin (rhEPO), which was tried for three cases of severe traumatic brain injury (TBI) in rehabilitation. DESIGN:Case series. SETTING:University hospital setting. PARTICI...

journal_title：Restorative neurology and neuroscience

authors： Min K,Song J,Lee JH,Kang MS,Jang SJ,Kim SH,Kim M

更新日期：2013-01-01 00:00:00

abstract：:Wound-derived trophic factors released by the injured brain are thought to reach a peak 1-2 weeks after injury. It has been proposed that such factors can promote the survival, growth and functional capacity of embryonic tissue grafts. To test the generality of this hypothesis, control rats and rats with aspirative fi...

journal_title：Restorative neurology and neuroscience

authors： Dunnett SB,Martel FL,Rogers DC,Finger S

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Study the effect of peripheral nerve extracts and BDNF on retinal ganglion cell (RGC) regeneration in adult rats. METHODS:Postmicrosomal fractions were obtained from 7-day, predegenerated, as well as non-predegenerated peripheral adult rats nerves. Autologous connective tissue chambers filled with fibrin were ...

journal_title：Restorative neurology and neuroscience

authors： Swiech-Sabuda E,Gołka B,Kotulska K,Larysz-Brysz M,Górka D,Gołka D,Marcol W,Lewin-Kowalik J

更新日期：2004-01-01 00:00:00

abstract：PURPOSE:Several studies on auditory temporal-order processing showed gender differences. Women needed longer inter-stimulus intervals than men when indicating the temporal order of two clicks presented to the left and right ear. In this study, we examined whether we could reproduce these results in order to further inv...

journal_title：Restorative neurology and neuroscience

authors： van Kesteren MT,Wiersinga-Post JE

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Specific investigation of dual task-interference (DTI) may help researchers to develop the optimal training exercise for enhancing the performance of daily activities. OBJECTIVES:To reveal the DTI by comparing the performances between personalized single tasks (cognitive or motor task) and dual task with se...

journal_title：Restorative neurology and neuroscience

authors： Kang EK,Shin D,Yun JY,Park W,Park HW

更新日期：2018-01-01 00:00:00

abstract：PURPOSE:Previous studies demonstrated that administering extradural cortical stimulation (ECS) to rats during the acute phase of a photothrombotic infarct enhances motor recovery. However, the effect of ECS during the subacute phase was unknown. We aimed to evaluate the effects of ECS on motor recovery in a rat model o...

journal_title：Restorative neurology and neuroscience

authors： Chang WH,Kim H,Sun W,Kim JY,Shin YI,Kim YH

更新日期：2015-01-01 00:00:00

abstract：:The objective of this study was to develop an optimal dissection procedure for fetal porcine ventral mesencephalon (VM) grafts and to characterize the cellular composition of such an explant, in particular with respect to the dopaminergic and GABAergic components. We have used a monolayer cell culture system to study ...

journal_title：Restorative neurology and neuroscience

authors： van Roon WM,Copray JC,Hogenesch RI,Kema I,Meyer EM,Molenaar G,Lugard C,Staal MJ,Go KG

更新日期：1995-01-01 00:00:00

abstract：:Injuries to peripheral nerves represent a challenging clinical problem. In spite of the use of microsurgical techniques, repair of severed nerves seldom results in complete recovery of motor and sensory functions. Misdirection of axons at the suture line as well as a slow axonal outgrowth contribute to the bad results...

journal_title：Restorative neurology and neuroscience

authors： Lundborg G

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Repetitive mild traumatic brain injury (TBI) is a major military and sports health concern. The purpose of this study was to determine if a diet rich in omega-3 fatty acids would reduce cognitive deficits and neuronal cell death in a novel fluid percussion rat model of repetitive mild TBIs. METHODS:Thirty-two ...

journal_title：Restorative neurology and neuroscience

authors： Wang T,Van KC,Gavitt BJ,Grayson JK,Lu YC,Lyeth BG,Pichakron KO

更新日期：2013-01-01 00:00:00

abstract：INTRODUCTION:Traumatic brain injuries (TBI) are one of the most common consequences of traffic accidents. Patients with mild, moderate or severe brain injuries suffer from physical, cognitive, behavioral, emotional and social problems. Most of these problems have been a long standing focus amongst practitioners and res...

journal_title：Restorative neurology and neuroscience

authors： Bullinger M,Azouvi P,Brooks N,Basso A,Christensen AL,Gobiet W,Greenwood R,Hütter B,Jennett B,Maas A,Truelle JL,von Wild KR,TBI Consensus Group.

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The current treatment intervention study determined the effect of coupled bilateral training (i.e., bilateral movements and EMG-triggered neuromuscular stimulation) and resistive load (mass) on upper extremity motor recovery in chronic stroke. METHODS:Thirty chronic stroke subjects were randomly assigned to...

journal_title：Restorative neurology and neuroscience

authors： Cauraugh JH,Coombes SA,Lodha N,Naik SK,Summers JJ

更新日期：2009-01-01 00:00:00

abstract：:Embryonic stem (ES) cells have the ability to differentiate into a variety of cell lineages. We are examining ES cell differentiation in vitro by using cDNA microarrays to generate a molecular phenotype for each cell type. El4 ES cells induced by retinoic acid after forming embryoid bodies differentiate almost exclusi...

journal_title：Restorative neurology and neuroscience

authors： Loring JF,Porter JG,Seilhammer J,Kaser MR,Wesselschmidt R

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:The present work compared the behavioral outcomes of ACCS therapy delivered either intravenously (i.v.) or intracerebroventricularly (i.c.v.) after penetrating ballistic-like brain injury (PBBI). Histological markers for neuroinflammation and neurodegeneration were employed to investigate the potential therapeu...

journal_title：Restorative neurology and neuroscience

authors： Deng-Bryant Y,Readnower RD,Leung LY,Cunningham TL,Shear DA,Tortella FC

更新日期：2015-01-01 00:00:00

abstract：:The hypothesis that a destabilization of mitochondrial function during neuronal exposure to excitatory amino acids may be involved in the mechanism of neuronal death was examined. The mitochondrial membrane potential (Delta(psi)m) and the cytoplasmic Ca2+ concentration ([Ca2+]c) were monitored simultaneously in single...

journal_title：Restorative neurology and neuroscience

authors： Kiedrowski L

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Low-frequency rTMS can induce upregulation of excitability in the contralateral hemisphere by interhemispheric interaction. OBJECTIVE:The aim of this study was to compare the effects of interhemispheric modulation on hemodynamic changes after applying low-frequency rTMS over the anatomical hand knob (HK) an...

journal_title：Restorative neurology and neuroscience

authors： Kim J,Kim H,Lee J,Lee HJ,Na Y,Chang WH,Kim YH

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:Interacting with others by reading their emotional expressions is an essential social skill in humans. How this ability develops during infancy and what brain processes underpin infants' perception of emotion in different modalities are the questions dealt with in this paper. METHODS:Literature review. RESULT...

journal_title：Restorative neurology and neuroscience

authors： Grossmann T

更新日期：2010-01-01 00:00:00