当前位置： SCI文献检索 > RESTORATIVE NEUROLOGY AND NEUROSCIENCE期刊下所有文献 > Allogenic umbilical cord blood therapy combined with erythropoietin for patients with severe traumatic brain injury: three case reports.

Allogenic umbilical cord blood therapy combined with erythropoietin for patients with severe traumatic brain injury: three case reports.

Abstract：

OBJECTIVE:To report the safety and efficacy of a novel therapeutic trial with umbilical cord blood (UCB) and concomitant recombinant human erythropoietin (rhEPO), which was tried for three cases of severe traumatic brain injury (TBI) in rehabilitation. DESIGN:Case series. SETTING:University hospital setting. PARTICIPANTS:Three patients with TBI over 6-months post-injury. INTERVENTIONS:Intravascular administration of allogenic UCB and injection of rhEPO, and rehabilitation therapy. OUTCOMES:For safety, adverse events, symptom, vital signs, blood chemistry, and hematologic study; for efficacy, modified Barthel index, motor assessment scale, Fugl-Meyer assessment of upper extremity, motor-free visual perception test, mini-mental screening examination, and brain images. RESULTS:There were no serious adverse events and the participants showed improvements during the follow-up periods in various aspects. Patient 1 demonstrated improvements in motor and cognitive function. Diffusion tensor images showed increased nerve fibers. Patient 2 displayed improvements in activities of daily living. In Patient 3, neurogenic fever vanished and Brain PET revealed increased glucose metabolism at basal ganglia, thalami, and cerebellum. CONCLUSIONS:The allogenic UCB therapy combined with rhEPO in the present study was safe and suggested potential therapeutic efficacy for patients with TBI. Controlled clinical trials are now needed to document efficiacy and safety in a larger patient sample.

journal_name

Restor Neurol Neurosci

journal_title

Restorative neurology and neuroscience

authors

Min K,Song J,Lee JH,Kang MS,Jang SJ,Kim SH,Kim M

doi

10.3233/RNN-120289

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

397-410

issue

4

eissn

0922-6028

issn

1878-3627

pii

VL8U027563343833

journal_volume

31

pub_type

杂志文章

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