Abstract：
PURPOSE:Repetitive mild traumatic brain injury (TBI) is a major military and sports health concern. The purpose of this study was to determine if a diet rich in omega-3 fatty acids would reduce cognitive deficits and neuronal cell death in a novel fluid percussion rat model of repetitive mild TBIs. METHODS:Thirty-two Sprague-Dawley rats were assigned to either an experimental rat chow enhanced with 6% fish oil (source of omega-3 fatty acids) or a control rat chow. Both rat chows contained equivalent quantities of calories, oil, and nutrients. After four weeks, both groups received mild repetitive bilateral fluid percussion TBIs on two sequential days. Pre-injury diets were resumed, and the animals were monitored for two weeks. On post-injury days 10-14, Morris Water Maze testing was performed to assess spatial learning and cognitive function. Animals were euthanized at 14 days post-injury to obtain specimens for neurohistopathology. RESULTS:There was no difference in pre-injury weight gain between groups. Post-injury, animals on the fish oil diet lost less weight and recovered their weight significantly faster. By 14 days, the fish oil diet group performed significantly better in the Morris Water Maze. Neurohistopathology identified a non-significant trend toward a higher density of hippocampal neurons in the fish oil diet group. CONCLUSIONS:Pre-injury dietary supplementation with fish oil improves recovery of body weight and provides a small improvement in cognitive performance in a rat model of multiple mild TBIs.
journal_name
Restor Neurol Neuroscijournal_title
Restorative neurology and neuroscienceauthors
Wang T,Van KC,Gavitt BJ,Grayson JK,Lu YC,Lyeth BG,Pichakron KOdoi
10.3233/RNN-130316subject
Has Abstractpub_date
2013-01-01 00:00:00pages
647-59issue
5eissn
0922-6028issn
1878-3627pii
FK18624X0J637863journal_volume
31pub_type
杂志文章abstract：PURPOSE:Hemispatial neglect, a failure to orient to the contralateral side of the lesion, is a disabling disorder after stroke. Previously arm activation combined with visual training or visual scanning training were found effective in rehabilitation of hemispatial neglect. The aim of this study was to determine whethe...
journal_title：Restorative neurology and neuroscience
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.3233/RNN-2009-0520
更新日期：2009-01-01 00:00:00
abstract：BACKGROUND:Multiple Sclerosis is a heterogeneous disorders involving in early stage gait and balance. Together with immunomodulating therapies, rehabilitation had a crucial role in improving motor tasks and quality of life. Between the emerging techniques, Focal Vibrations (FV) could play a role, but they have been use...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.3233/RNN-160665
更新日期：2016-09-21 00:00:00
abstract：PURPOSE:The illusory ownership of a fake hand as part the body follows synchronous tactile stimulation over a visible rubber hand and a covered hand. Whether brain plasticity mechanisms after sensory and motor disconnection modulates this illusion remain unexplored. METHODS:We tested a tetraplegic man after synchronou...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-130385
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:The aim of the study was to examine if improvements of stimulus detection performance in visual field tests after intensive visual training of the visual field border zone in patients with visual field defects are associated with changes in self-reported vision- and health-related quality of life (QoL). METHOD...
journal_title：Restorative neurology and neuroscience
pub_type： 临床试验,杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：BACKGROUND:Progressive apoptosis in the dopaminergic neurons of substantia nigra lead to Parkinson's disease. Since neurons require substantially higher supply of energy, their mitochondria have a pivotal status in neuronal survival. These organelles have a key role to play in apoptosis and any impairment thereof may l...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-180852
更新日期：2018-01-01 00:00:00
abstract：:Injury of the nervous system initiates a cascade of signal transduction including a rise in extracellular glutamate which leads to subsequent secondary neuronal loss. Excitotoxicity is known to play a crucial role in cell death spinal cord trauma. Gangliosides, particularly monosialogangliosides (GM1), are protective ...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：PURPOSE:To investigate the effects of the androgen testosterone propionate (TP), on regeneration of the recurrent laryngeal nerve (RLN) after unilateral crush injury using assessment of vocal fold mobility (VFM) as a measure of behavioral recovery. METHODS:48 adult male rats underwent standardized crush injury of left...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-120287
更新日期：2013-01-01 00:00:00
abstract：:While the regenerating capacity of peripheral nerves has been the subject of intensive study, little is known about the regenerative capacity of the autonomic nervous system. Using an animal model, where the pupil diameter of the eye in the rat serves as a parameter of autonomic function, we studied whether systemic t...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1994-7106
更新日期：1994-01-01 00:00:00
abstract：:Many of the present limitations of peripheral nerve repair might be overcome by performing nerve repairs at the axon level. One approach to nerve repair at this level would be to implant a neuroprosthesis in the form of a microelectronic switchboard which could route the connections of regenerated axons to their corre...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1990-2205
更新日期：1990-01-01 00:00:00
abstract：:The application of brain stimulation techniques for modulation of cortical excitability changes underlying spatial neglect following right-brain-damage has been the first application of brain stimulation in the rehabilitation setting. Several factors concur in making neglect a prototype of cognitive disorders that can...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,评审
doi：10.3233/RNN-2011-0613
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:The purpose of this study was to delineate the relationship between several types of T1-weighted MRI pathology and motor rehabilitation potential following Constraint Induced Movement therapy (CI therapy) in chronic stroke. METHODS:Stepwise regression was employed (n = 80) to identify predictors of motor recov...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-130366
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:We wished to evaluate the efficacy of vision restoration therapy (VRT) in patients with post-chiasmatic brain damage using different functional perimetric tests. These were compared with measures of subjective vision and reaction time. METHODS:An open trial was conducted with hemianopia/scotoma (n=16) patients...
journal_title：Restorative neurology and neuroscience
pub_type： 临床试验,杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Animals with unilateral neurotoxic lesions in the striatum exhibit a stereotypical biased rotational behavior in response to dopamine agonists. We recently argued that the rotational test may be subject to sensitization effects of the drug. Accordingly, we proposed the drug-free elevated body swing test (EBST) as an a...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1995-9103
更新日期：1995-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:Repetitive transcranial magnetic stimulation (rTMS) may enhance plastic changes in the human cortex and modulation of behavior. However, the underlying neural mechanisms have not been sufficiently investigated. We examined the clinical effects and neural correlates of high-frequency rTMS coupled ...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.3233/RNN-2012-110162
更新日期：2012-01-01 00:00:00
abstract：PURPOSE:The effectiveness of embryonic stem cell (eSC) therapy has been explored in many models of neurological disease and several research groups have shown that eSC treatment leads to improved outcomes in pre-clinical models of traumatic brain injury (TBI). Though functional recovery occurs, few surviving eSCs appea...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-120299
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Parkinson's Disease (PD) is characterized by progressive and disabling symptoms. An impaired oxidative metabolism efficiency was supposed to be involved in the systemic impairment. Rehabilitative treatment represents a valid tool in promoting skeletal muscle's adaptations, even if no solid studies on muscle ...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-170738
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:To demonstrate, in a proof-of-concept study, whether potentiating ipsilesional higher motor areas (premotor cortex and supplementary motor area) augments and accelerates recovery associated with constraint induced movement. METHODS:In a randomized, double-blinded pilot clinical study, 12 patients with chronic ...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,随机对照试验
doi：10.3233/RNN-150574
更新日期：2015-01-01 00:00:00
abstract：PURPOSE:Several studies have shown that transcranial direct current stimulation (tDCS) is a useful tool to enhance language recovery in aphasia. It has also been suggested that modulation of the neurotrophin brain-derived neurotrophic factor (BDNF) might be part of the mechanisms involved in tDCS effects on synaptic co...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-130323
更新日期：2014-01-01 00:00:00
abstract：PURPOSE:Study the effect of peripheral nerve extracts and BDNF on retinal ganglion cell (RGC) regeneration in adult rats. METHODS:Postmicrosomal fractions were obtained from 7-day, predegenerated, as well as non-predegenerated peripheral adult rats nerves. Autologous connective tissue chambers filled with fibrin were ...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Bridging large defects in mixed nerves is still an unsolved problem in reconstructive microsurgery. Two main aspects may be distinguished: one is to obtain an appropriate substitute for the lost neural tissue, the second to direct fibers toward their previous end-organs with the highest possible specificity. In the pr...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1997-11306
更新日期：1997-01-01 00:00:00
abstract：:The olfactory nerve differs from cranial nerves III-XII in that it contains a specialised type of glial cell, called 'olfactory ensheathing cell' (OEC), rather than Schwann cells. In addition, functional neurogenesis persists postnatally in the olfactory system, i.e. the primary olfactory pathway continuously rebuilds...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,评审
doi：
更新日期：2008-01-01 00:00:00
abstract：:Non-invasive brain stimulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), can modify cortical excitability in a lasting fashion. The modification can be bi-directional in nature and holds considerable therapeutic promise for a number of neurological conditions. However, the effectiveness ...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章,评审
doi：10.3233/RNN-2010-0565
更新日期：2010-01-01 00:00:00
abstract：PURPOSE:Contralateral primary sensori-motor cortex (SM1) activation by passive movement was investigated by functional MRI (fMRI) at the early stage of stroke, to determine whether SM1 activation can be used to predict the degree of motor recovery of the hemiplegic hand. METHODS:We studied 17 stroke patients who showe...
journal_title：Restorative neurology and neuroscience
pub_type： 临床试验,杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Melatonin (MLT) is a methoxyindole secreted principally by the pineal gland. It is synthesized at night under normal environmental conditions. The endogenous rhythm of secretion is generated by the suprachiasmatic nuclei and entrained by the light/dark cycle. Light is able to both suppress or synchronize melatonin pro...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:We have tested the capacity of several compounds with in vitro and/or in vivo antioxidant or antilipolytic activity to ameliorate locomotor function in cats subjected to static loading (i.e. compression) injury of the spinal cord. These include the synthetic glucocorticoid, methylprednisolone sodium succinate (MP), an...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1991-245603
更新日期：1991-01-01 00:00:00
abstract：:Vestibular habituation was studied in normal subjects and in patients with cerebellar disease using a stimulation paradigm proposed in this paper. Six caloric stimuli were repeated daily in the same ear during six days and electronystagmographic responses at the beginning and the end of that period were compared. The ...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1992-4403
更新日期：1992-01-01 00:00:00
abstract：:Regenerating nerve fiber sprouts enveloped by olfactory bulb (OB) ensheathing cells (ECs) seem to escape the inhibitory influence of gliotic tissue. Accordingly, these cells may be useful for general repair of injured CNS. Relatively large numbers of ECs could be purified from confluent cultures of adult rat olfactory...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-1996-10104
更新日期：1996-01-01 00:00:00
abstract：PURPOSE:To investigate the effect and underlying mechanism of Aceglutamide on motor dysfunction in rats after cerebral ischemia-reperfusion. METHODS:Adult male Sprague-Dawley rats were subjected to 2 h transient middle cerebral artery occlusion (MCAO). Aceglutamide or vehicle was intraperitoneally given to rats at 24 ...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-150509
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Oxidative stress is an important factor in the pathophysiologic changes after traumatic brain injury (TBI). Connexin43 (Cx43) was reported to contribute to cerebral damage. However, the impacts of Cx40 have not been investigated in detail. OBJECTIVE:In the present study, we hypothesized that Cx40 was involv...
journal_title：Restorative neurology and neuroscience
pub_type： 杂志文章
doi：10.3233/RNN-160705
更新日期：2017-01-01 00:00:00
abstract：INTRODUCTION:Traumatic brain injuries (TBI) are one of the most common consequences of traffic accidents. Patients with mild, moderate or severe brain injuries suffer from physical, cognitive, behavioral, emotional and social problems. Most of these problems have been a long standing focus amongst practitioners and res...
journal_title：Restorative neurology and neuroscience
pub_type： 共识发展会议,杂志文章,评审
doi：
更新日期：2002-01-01 00:00:00
