Alterations in mitochondrial membrane potential in peripheral blood mononuclear cells in Parkinson's Disease: Potential for a novel biomarker.

abstract：:In rat sciatic nerves, IGF-I or bFGF was applied distal to a crush to evaluate their effects upon the restoration of the neuromuscular function. In comparison with the recovery following a simple crush, treatment with growth factors resulted in (i) enhanced elongation of regenerating axons ( + 24%) up to day 3 post le...

journal_title：Restorative neurology and neuroscience

authors： Vergara J,Medina L,Maulén J,Inestrosa NC,Alvarez J

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Ischemic stroke is associated with a variety pathophysiological changes affecting both glial and neuronal brain tissue. These changes are mirrored in the release of specific proteins into peripheral blood. Neurone-specific enolase (NSE), protein S100B and glial fibrillary acidic protein (GFAP) are those protein...

journal_title：Restorative neurology and neuroscience

authors： Herrmann M,Ehrenreich H

更新日期：2003-01-01 00:00:00

abstract：:The aim of this study was to gauge the possible sprouting of primary afferent fibers following dorsal rhizotomies using Fos-like immunoreactivity (Fos-LI) in order to label neurons activated by formalin injection into the rat forepaw. To assess the functional consequences of possible sprouting of fine diameter primary...

journal_title：Restorative neurology and neuroscience

authors： Abbadie C,Lombard MC,Morain F,Besson JM

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:To investigate whether repeated sessions of motor imagery and action observation modulate corticospinal excitability (CE) over time, whether these processes are susceptible of any training effect and if such effect might be different for the dominant and non dominant hemisphere. METHODS:11 subjects underwent t...

journal_title：Restorative neurology and neuroscience

authors： Bianco G,Feurra M,Fadiga L,Rossi A,Rossi S

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Dimethyl fumarate (DMF) has immune-modulatory and neuro-protective characteristics that can be used for treatment of acute ischemic stroke. OBJECTIVE:To investigate the therapeutic effects of DMF on histological and functional recovery of rats after transient middle cerebral artery (MCA) occlusion. METHODS...

journal_title：Restorative neurology and neuroscience

authors： Safari A,Fazeli M,Namavar MR,Tanideh N,Jafari P,Borhani-Haghighi A

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:The relationship between auditory temporal-order perception and phoneme discrimination has been discussed for several years, based on findings, showing that patients with cerebral damage in the left hemisphere and aphasia, as well as children with specific language impairments, show deficits in temporal-process...

journal_title：Restorative neurology and neuroscience

authors： Fink M,Churan J,Wittmann M

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:This article reviews the literature on far transfer effects in training of older adults. METHODS:Adapting a taxonomy of transfer developed by Barnett and Ceci (2002), to rehabilitation or enhancement of existing cognitive skills; results of studies assessing transfer effects from training of memory, reasoning,...

journal_title：Restorative neurology and neuroscience

authors： Zelinski EM

更新日期：2009-01-01 00:00:00

abstract：:The effects of striatal transplantation of PC12 cells on amphetamine-induced rotational behavior and monoamine levels were examined in rats with unilateral 6-hydroxydopamine (6-OHDA) lesions in the nigrostriatal pathway. A total of 9 × 104 or 9 × 105 cells of PC12 was implanted into 3 sites in the striatum and changes...

journal_title：Restorative neurology and neuroscience

authors： Hori Y,Kageyama H,Kihara T,Ikeda M,Nakano A,Kurosawa A

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Glutamate transporters are responsible for removing glutamate from the extracellular space and have the potential to protect neurons from excitotoxicity. In the present study, the effects of ceftriaxone and (2R, 4R)-APDC (APDC) on the protein expression of GLAST and GLT-1, the rate of glutamate uptake, and neur...

journal_title：Restorative neurology and neuroscience

authors： Beller JA,Gurkoff GG,Berman RF,Lyeth BG

更新日期：2011-01-01 00:00:00

abstract：:Non-invasive brain stimulation techniques, such as repetitive transcranial magnetic stimulation (rTMS), can modify cortical excitability in a lasting fashion. The modification can be bi-directional in nature and holds considerable therapeutic promise for a number of neurological conditions. However, the effectiveness ...

journal_title：Restorative neurology and neuroscience

authors： Todd G,Ridding MC

更新日期：2010-01-01 00:00:00

abstract：PURPOSE:To evaluate whether repetitive optokinetic stimulation with active pursuit eye movements leads to substantial and greater recovery from visual neglect as compared to conventional visual scanning training. METHODS:Two groups of five patients with leftsided hemineglect were consecutively collected and matched fo...

journal_title：Restorative neurology and neuroscience

authors： Kerkhoff G,Keller I,Ritter V,Marquardt C

更新日期：2006-01-01 00:00:00

abstract：PURPOSE:The illusory ownership of a fake hand as part the body follows synchronous tactile stimulation over a visible rubber hand and a covered hand. Whether brain plasticity mechanisms after sensory and motor disconnection modulates this illusion remain unexplored. METHODS:We tested a tetraplegic man after synchronou...

journal_title：Restorative neurology and neuroscience

authors： Tidoni E,Grisoni L,Liuzza MT,Aglioti SM

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Hearing loss is becoming a real social and health problem. Its prevalence in the elderly is an epidemic. The risk of developing hearing loss is also growing among younger people. If left untreated, hearing loss can perpetuate development of neurodegenerative diseases, including dementia. Despite recent advan...

journal_title：Restorative neurology and neuroscience

authors： Cieśla K,Wolak T,Lorens A,Heimler B,Skarżyński H,Amedi A

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:Repairing the spinal cord with peripheral nerve grafts (PNG) and adjuvant acidic fibroblast growth factor (FGF1) has previously resulted in partial functional recovery. To aid microsurgical placement of PNGs, a graft holder device was previously developed by our group. In hope for a translational development we...

journal_title：Restorative neurology and neuroscience

authors： Nordblom J,Persson JK,Aberg J,Blom H,Engqvist H,Brismar H,Sjödahl J,Josephson A,Frostell A,Thams S,Brundin L,Svensson M,Mattsson P

更新日期：2012-01-01 00:00:00

abstract：:Contemporary strategies to promote motor recovery following stroke focus on repetitive voluntary movements. Although successful movement relies on efficient sensorimotor integration, functional outcomes often bias motor therapy toward motor-related impairments such as weakness, spasticity and synergies; sensory therap...

journal_title：Restorative neurology and neuroscience

authors： Bolognini N,Russo C,Edwards DJ

更新日期：2016-04-11 00:00:00

abstract：BACKGROUND AND PURPOSE:Neuroplastic alterations of cortical excitability and activity represent the likely neurophysiological foundation of learning and memory formation. Beyond their induction, alterations of these processes by subsequent modification of cortical activity, termed metaplasticity, came into the focus of...

journal_title：Restorative neurology and neuroscience

authors： Thirugnanasambandam N,Sparing R,Dafotakis M,Meister IG,Paulus W,Nitsche MA,Fink GR

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:Although many previous studies have indicated that the acute inflammatory response following traumatic brain injury (TBI) is detrimental, inflammation may also positively influence outcome in the more chronic post-injury recovery period. We evaluated the effects of monoclonal antibodies (mAB), neutralizing eith...

journal_title：Restorative neurology and neuroscience

authors： Marklund N,Keck C,Hoover R,Soltesz K,Millard M,LeBold D,Spangler Z,Banning A,Benson J,McIntosh TK

更新日期：2005-01-01 00:00:00

abstract：:Animals with unilateral neurotoxic lesions in the striatum exhibit a stereotypical biased rotational behavior in response to dopamine agonists. We recently argued that the rotational test may be subject to sensitization effects of the drug. Accordingly, we proposed the drug-free elevated body swing test (EBST) as an a...

journal_title：Restorative neurology and neuroscience

authors： Borlongan CV,Cahill DW,Sanberg PR

更新日期：1995-01-01 00:00:00

abstract：:Melatonin (MLT) is a methoxyindole secreted principally by the pineal gland. It is synthesized at night under normal environmental conditions. The endogenous rhythm of secretion is generated by the suprachiasmatic nuclei and entrained by the light/dark cycle. Light is able to both suppress or synchronize melatonin pro...

journal_title：Restorative neurology and neuroscience

authors： Claustrat B,Brun J,Geoffriau M,Chazot G

更新日期：1998-06-01 00:00:00

abstract：:Basic science studies demonstrated mechanisms of plasticity and metaplasticity. More recent human studies identified some of these mechanisms as operating in multiple areas of human cognition, such as learning and memory, and in functional recovery from lesions in the CNS, as in stroke. One of the goals of neurorehabi...

journal_title：Restorative neurology and neuroscience

authors： Celnik PA,Cohen LG

更新日期：2004-01-01 00:00:00

abstract：:Following brain injury there is an excessive release of glutamate, a reduction in levels of cellular Mg+ +, and the generation of oxygen free radicals. These processes may contribute to the severity of the behavioral impairments seen following brain injury by leading to secondary neuronal degeneration. The present exp...

journal_title：Restorative neurology and neuroscience

authors： Hoane MR,Raad C,Barth TM

更新日期：1997-01-01 00:00:00

abstract：:Fetal cerebral cortical tissue was transplanted into an aspirated lesion cavity made in the sensorimotor cortex of adult rats. Ten weeks after grafting, outgrowing fibers from the graft were visualized by an anterograde tracing technique using Phaseolus vulgaris leucoagglutinin (PHA-L). It was demonstrated that the ef...

journal_title：Restorative neurology and neuroscience

authors： Senatorov VV,Nyakas C,Fulop Z

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:To analyze the effects of CGP 3466, a compound structurally related to deprenyl, on survival and function of fetal ventral mesencephalic dopaminergic neurons. METHODS:Free-floating roller tube (FFRT) cultures of rat (E14) ventral mesencephalon were treated with CGP 3466 [10-8 M] for 7 days. Tyrosine hydroxylas...

journal_title：Restorative neurology and neuroscience

authors： Matarredona ER,Meyer M,Seiler RW,Widmer HR

更新日期：2003-01-01 00:00:00

abstract：:Retinal and cortical lesions are completely different events that trigger visual cortical plasticity. We therefore compared the cortical effects of homonymous lesions of the central retina with effects of cortical lesions. All in vivo experiments were performed in anaesthetized, adult cats. Retinal lesions were made w...

journal_title：Restorative neurology and neuroscience

authors： Eysel UT,Schweigart G,Mittmann T,Eyding D,Qu Y,Vandesande F,Orban G,Arckens L

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:To report the safety and efficacy of a novel therapeutic trial with umbilical cord blood (UCB) and concomitant recombinant human erythropoietin (rhEPO), which was tried for three cases of severe traumatic brain injury (TBI) in rehabilitation. DESIGN:Case series. SETTING:University hospital setting. PARTICI...

journal_title：Restorative neurology and neuroscience

authors： Min K,Song J,Lee JH,Kang MS,Jang SJ,Kim SH,Kim M

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Previous studies demonstrated that administering extradural cortical stimulation (ECS) to rats during the acute phase of a photothrombotic infarct enhances motor recovery. However, the effect of ECS during the subacute phase was unknown. We aimed to evaluate the effects of ECS on motor recovery in a rat model o...

journal_title：Restorative neurology and neuroscience

authors： Chang WH,Kim H,Sun W,Kim JY,Shin YI,Kim YH

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:We hypothesized that recovery of upper extremity motor function is associated with reduction of intracortical inhibition and improved reciprocal inhibition. This study examines the relationships of functional recovery in chronic stroke with the intracortical inhibition and spinal reciprocal inhibition. METHODS...

journal_title：Restorative neurology and neuroscience

authors： Fujiwara T,Honaga K,Kawakami M,Nishimoto A,Abe K,Mizuno K,Kodama M,Masakado Y,Tsuji T,Liu M

更新日期：2015-01-01 00:00:00

abstract：PURPOSE:Exogenously applied BDNF has been shown to rescue rat retinal ganglion cells (RGCs) from axotomy-induced apoptotic death, presumably via activation of its high affinity receptor TrkB. Since both TrkB and BDNF are endogenously expressed in RGCs, auto- or para-crine neurotrophic loops in the retina may be involve...

journal_title：Restorative neurology and neuroscience

authors： Hirsch S,Labes M,Bähr M

更新日期：2000-01-01 00:00:00

abstract：PURPOSE:A realistic body representation needs to be constantly updated. In case of physiological modifications, body representations integrate information coming from different sensory sources, including the sense of touch. Previous studies described transient modifications of these representations following illusory d...

journal_title：Restorative neurology and neuroscience

authors： Cimmino RL,Spitoni G,Serino A,Antonucci G,Catagni M,Camagni M,Haggard P,Pizzamiglio L

更新日期：2013-01-01 00:00:00

abstract：:Bridging large defects in mixed nerves is still an unsolved problem in reconstructive microsurgery. Two main aspects may be distinguished: one is to obtain an appropriate substitute for the lost neural tissue, the second to direct fibers toward their previous end-organs with the highest possible specificity. In the pr...

journal_title：Restorative neurology and neuroscience

authors： Papaloïzos MY,Holmquist B,Lundborg G

更新日期：1997-01-01 00:00:00