Abstract:
:The human miR-29 family of microRNAs has three mature members, miR-29a, miR-29b, and miR-29c. miR-29s are encoded by two gene clusters. Binding sites for several transcriptional factors have been identified in the promoter regions of miR-29 genes. The miR-29 family members share a common seed region sequence and are predicted to target largely overlapping sets of genes. However, the miR-29 family members exhibit differential regulation in several cases and different subcellular distribution, suggesting their functional relevance may not be identical. miR-29s directly target at least 16 extracellular matrix genes, providing a dramatic example of a single microRNA targeting a large group of functionally related genes. Strong antifibrotic effects of miR-29s have been demonstrated in heart, kidney, and other organs. miR-29s have also been shown to be proapoptotic and involved in the regulation of cell differentiation. It remains to be explored how various cellular effects of miR-29s determine functional relevance of miR-29s to specific diseases and how the miR-29 family members may function cooperatively or separately.
journal_name
Physiol Genomicsjournal_title
Physiological genomicsauthors
Kriegel AJ,Liu Y,Fang Y,Ding X,Liang Mdoi
10.1152/physiolgenomics.00141.2011subject
Has Abstractpub_date
2012-02-27 00:00:00pages
237-44issue
4eissn
1094-8341issn
1531-2267pii
physiolgenomics.00141.2011journal_volume
44pub_type
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