Exercise, sex, menstrual cycle phase, and 17beta-estradiol influence metabolism-related genes in human skeletal muscle.

abstract：:Current models in skeletal muscle biology do not fully account for the breadth, causes, and consequences of phenotypic variation among skeletal muscle groups. The muscle allotype concept arose to explain frank differences between limb, masticatory, and extraocular (EOM) muscles, but there is little understanding of th...

journal_title：Physiological genomics

authors： Cheng G,Merriam AP,Gong B,Leahy P,Khanna S,Porter JD

更新日期：2004-07-08 00:00:00

abstract：:Autosomal recessive mandibuloacral dysplasia [mandibuloacral dysplasia type A (MADA); Online Mendelian Inheritance in Man (OMIM) no. 248370] is caused by a mutation in LMNA encoding lamin A/C. Here we show that this mutation causes accumulation of the lamin A precursor protein, a marked alteration of the nuclear archi...

journal_title：Physiological genomics

authors： Filesi I,Gullotta F,Lattanzi G,D'Apice MR,Capanni C,Nardone AM,Columbaro M,Scarano G,Mattioli E,Sabatelli P,Maraldi NM,Biocca S,Novelli G

更新日期：2005-10-17 00:00:00

abstract：:In recent years, it has become evident that the adult mammalian CNS contains a population of neural stem cells (NSCs) described as immature, undifferentiated, multipotent cells, that may be called upon for repair in neurodegenerative and demyelinating diseases. NSCs may give rise to oligodendrocyte progenitor cells (O...

journal_title：Physiological genomics

authors： Imitola J,Snyder EY,Khoury SJ

更新日期：2003-08-15 00:00:00

abstract：:Several vasoregulatory systems including the renin-angiotensin system, sympathetic vasoregulation, and cytokine release have been studied extensively. The aim of the present study was to establish a physiogenomic screening model for differentially expressed genes in the regulation of blood pressure that might give a h...

journal_title：Physiological genomics

authors： Westhoff TH,Scheid S,Tölle M,Kaynak B,Schmidt S,Zidek W,Sperling S,van der Giet M

更新日期：2005-09-21 00:00:00

abstract：:We previously reported that mice deficient in stearoyl-CoA desaturase-1 (Scd1) and maintained on a very low-fat (VLF) diet for 10 days developed severe loss of body weight, hypoglycemia, hypercholesterolemia, and many cholestasis-like phenotypes. To better understand the metabolic changes associated with these phenoty...

journal_title：Physiological genomics

authors： Flowers MT,Keller MP,Choi Y,Lan H,Kendziorski C,Ntambi JM,Attie AD

更新日期：2008-05-13 00:00:00

abstract：:Our objective was to resequence insulin receptor substrate 2 (IRS2) to identify variants associated with obesity- and diabetes-related traits in Hispanic children. Exonic and intronic segments, 5' and 3' flanking regions of IRS2 (∼14.5 kb), were bidirectionally sequenced for single nucleotide polymorphism (SNP) discov...

journal_title：Physiological genomics

authors： Butte NF,Voruganti VS,Cole SA,Haack K,Comuzzie AG,Muzny DM,Wheeler DA,Chang K,Hawes A,Gibbs RA

更新日期：2011-09-22 00:00:00

abstract：:Cardiomyocytes derived from pluripotent embryonic stem cells (ESC) have the advantage of providing a source for standardized cell cultures. However, little is known on the regulation of the genome during differentiation of ESC to cardiomyocytes. Here, we characterize the transcriptome of the mouse ESC line CM7/1 durin...

journal_title：Physiological genomics

authors： Seewald MJ,Ellinghaus P,Kassner A,Stork I,Barg M,Niebrügge S,Golz S,Summer H,Zweigerdt R,Schräder EM,Feicht S,Jaquet K,Reis S,Körfer R,Milting H

更新日期：2009-06-10 00:00:00

abstract：:Essential hypertension is highly prevalent in the elderly population, exceeding 70% in people older than 60 yr of age, and remains a leading risk factor for heart disease, stroke, and chronic renal disease. Elucidation of genetic determinants is critical but remains a challenge due to its complex, multifactorial patho...

journal_title：Physiological genomics

authors： Glorioso N,Herrera VL,Didishvili T,Argiolas G,Troffa C,Bulla P,Bulla E,Ruiz-Opazo N

更新日期：2011-11-07 00:00:00

abstract：:Uncoupling protein 1 (UCP1) is the first UCP described. It belongs to the family of mitochondrial carrier proteins and is expressed mainly in brown adipose tissue. Recently, the family of the UCPs has rapidly been growing due to the successive cloning of UCP2, UCP3, UCP4, and UCP5, also called brain mitochondrial carr...

journal_title：Physiological genomics

authors： Keller PA,Lehr L,Giacobino JP,Charnay Y,Assimacopoulos-Jeannet F,Giovannini N

更新日期：2005-08-11 00:00:00

abstract：:Proteomics, analogous with genomics, is the analysis of the protein complement present in a cell, organ, or organism at any given time. While the genome provides information about the theoretical status of the cellular proteins, the proteome describes the actual content, which ultimately determines the phenotype. The ...

journal_title：Physiological genomics

authors： Matt P,Fu Z,Fu Q,Van Eyk JE

更新日期：2008-03-14 00:00:00

abstract：:Repair and regeneration are key processes for tissue maintenance, and their disruption may lead to disease states. Little is known about the molecular mechanisms that underline the repair and regeneration of the digestive tract. The sea cucumber Holothuria glaberrima represents an excellent model to dissect and charac...

journal_title：Physiological genomics

authors： Rojas-Cartagena C,Ortíz-Pineda P,Ramírez-Gómez F,Suárez-Castillo EC,Matos-Cruz V,Rodríguez C,Ortíz-Zuazaga H,García-Arrarás JE

更新日期：2007-10-22 00:00:00

abstract：:We previously generated a conditional floxed mouse line to study androgen action, in which exon 3 of the androgen receptor (AR) gene is flanked by loxP sites, with the neomycin resistance gene present in intron 3. Deletion of exon 3 in global AR knockout mice causes androgen insensitivity syndrome, characterized by ge...

journal_title：Physiological genomics

authors： MacLean HE,Chiu WS,Ma C,McManus JF,Davey RA,Cameron R,Notini AJ,Zajac JD

更新日期：2008-03-14 00:00:00

abstract：:In type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, the pathogenic destruction of the insulin-producing pancreatic beta-cells is under the control of and influenced by distinct subsets of T lymphocytes. To identify the critical genes expressed by autoimmune T cells, antigen presenting cells, and pan...

journal_title：Physiological genomics

authors： Vukkadapu SS,Belli JM,Ishii K,Jegga AG,Hutton JJ,Aronow BJ,Katz JD

更新日期：2005-04-14 00:00:00

abstract：:Epigenetic differences between male and female bovine blastocysts provide a plausible link between physiological and gene transcription differences observed between male and female embryos. The aim of this study was to examine sex-related epigenetic differences in bovine blastocysts produced in vitro. Oocytes were mat...

journal_title：Physiological genomics

authors： Bermejo-Alvarez P,Rizos D,Rath D,Lonergan P,Gutierrez-Adan A

更新日期：2008-01-17 00:00:00

abstract：:Activation of NF-kappaB is essential for protease-activated receptor-1 (PAR-1)-mediated ICAM-1 expression in endothelial cells. Here we show that PAR-1 activation induces binding of both p65/RelA and NFATc1 to the NF-kappaB binding site localized in intron-1 of the ICAM-1 gene to initiate transcription in endothelial ...

journal_title：Physiological genomics

authors： Xue J,Thippegowda PB,Hu G,Bachmaier K,Christman JW,Malik AB,Tiruppathi C

更新日期：2009-06-10 00:00:00

abstract：:The SMXA-5 recombinant inbred strain, which was established from nondiabetic parental SM/J and A/J mice, develops diabetic phenotypes such as impaired glucose tolerance. The combination of diabetogenic genes in the SM/J and A/J genomes impairs glucose tolerance in SMXA-5 mice. Using (SM/J x SMXA-5)F2 mice fed a high-f...

journal_title：Physiological genomics

authors： Hada N,Kobayashi M,Fujiyoshi M,Ishikawa A,Kuga M,Nishimura M,Ebihara S,Ohno T,Horio F

更新日期：2008-09-17 00:00:00

abstract：:Gene expression was measured during t10c12-CLA-induced body fat reduction in a polygenic obese line of mice. Adult mice (n = 185) were allotted to a 2 x 2 factorial experiment consisting of either nonobese (ICR-control) or obese (M16-selected) mice fed a 7% fat, purified diet containing either 1% linoleic acid (LA) or...

journal_title：Physiological genomics

authors： House RL,Cassady JP,Eisen EJ,Eling TE,Collins JB,Grissom SF,Odle J

更新日期：2005-05-11 00:00:00

abstract：:Caloric restriction (CR) is an effective method for prevention of age-associated diseases as well as overweight and obesity; however, there is controversy regarding the effects of dieting regimens on behavior. In this study, we investigated two different dieting regimens: repeated fasting and refeeding (RFR) and daily...

journal_title：Physiological genomics

authors： Yamamoto Y,Tanahashi T,Kawai T,Chikahisa S,Katsuura S,Nishida K,Teshima-Kondo S,Sei H,Rokutan K

更新日期：2009-11-06 00:00:00

abstract：:Chronic kidney disease (CKD), defined as reduced glomerular filtration rate, is increasingly becoming a major public health issue. At the histological level, renal fibrosis is the final common pathway leading to end-stage renal disease, irrespective of the initial injury. According to this view, antifibrotic agents sh...

journal_title：Physiological genomics

authors： Lv W,Fan F,Wang Y,Gonzalez-Fernandez E,Wang C,Yang L,Booz GW,Roman RJ

更新日期：2018-01-01 00:00:00

abstract：:In several species caloric restriction (CR) extends life span. In this paper we integrate data from studies on CR and other sources to articulate the hypothalamic deregulation hypothesis by which estrogen receptor-alpha (ER-α) signaling in the hypothalamus and limbic system affects life span under the stress of CR in ...

journal_title：Physiological genomics

authors： Gouw AM,Efe G,Barakat R,Preecha A,Mehdizadeh M,Garan SA,Brooks GA

更新日期：2017-02-01 00:00:00

abstract：:To better understand the genetic basis of essential hypertension, we conducted a quantitative trait locus (QTL) analysis of a population of 207 (BALB/cJ x CBA/CaJ) F(2) male mice to identify genomic regions that regulate blood pressure, heart rate, and heart weight. We identified two loci, Bpq6 (blood pressure quantit...

journal_title：Physiological genomics

authors： Sugiyama F,Churchill GA,Li R,Libby LJ,Carver T,Yagami K,John SW,Paigen B

更新日期：2002-07-12 00:00:00

abstract：:Preeclampsia is a progressive hypertensive disorder of pregnancy affecting 2-8% of pregnancies globally. Preexisting chronic hypertension is a major risk factor associated with developing preeclampsia, and growing evidence suggests a role for the gut microbiome in the development of preeclampsia. However, neither alte...

journal_title：Physiological genomics

authors： Ishimwe JA,Akinleye AA,Johnson AC,Garrett MR,Sasser JM

更新日期：2021-01-25 00:00:00

abstract：:This study analyzes the electrophysiological cause and behavioral consequence of dopaminergic cell loss in a knockin mouse strain bearing hypersensitive nicotinic alpha4-receptor subunits ("L9'S mice"). Adult brains of L9'S mice show moderate loss of substantia nigra dopaminergic neurons and of striatal dopaminergic i...

journal_title：Physiological genomics

authors： Orb S,Wieacker J,Labarca C,Fonck C,Lester HA,Schwarz J

更新日期：2004-08-11 00:00:00

abstract：:We previously reported that markers on rat chromosome 1 are genetically linked to blood pressure in an F(2) population derived from Dahl salt hypertension-sensitive (S) and Lewis (LEW) rats. Because there was evidence for more than one blood pressure quantitative trait locus (QTL) on chromosome 1, an initial congenic ...

journal_title：Physiological genomics

authors： Saad Y,Garrett MR,Lee SJ,Dene H,Rapp JP

更新日期：1999-11-11 00:00:00

abstract：:alpha-Sarcoglycan-deficient (Sgca-null) mice provide potential for elucidating the pathogenesis of limb girdle muscular dystrophy type 2D (LGMD 2D) as well as for studying the effectiveness of therapeutic strategies. Skeletal muscles of Sgca-null mice demonstrate an early onset of extensive fiber necrosis, degeneratio...

journal_title：Physiological genomics

authors： Consolino CM,Duclos F,Lee J,Williamson RA,Campbell KP,Brooks SV

更新日期：2005-07-14 00:00:00

abstract：:Psoriasis is a chronic and common human skin disorder currently with no cure. Psoriatic skin displays inflammatory, raised, and scaly lesions with widely aberrant gene expression. Recent studies have revealed critical roles that microRNAs play as a class of posttranscriptional gene regulator in skin development and sk...

journal_title：Physiological genomics

authors： Xia J,Zhang W

更新日期：2014-02-15 00:00:00

abstract：:Exercise as well as hypoxia cause an increase in angiogenesis, changes in mitochondrial density and alterations in metabolism, but it is still under debate whether the hypoxia inducible factor (HIF) is active during both situations. In this study gene expression analysis of zebrafish larvae that were raised under norm...

journal_title：Physiological genomics

authors： Kopp R,Köblitz L,Egg M,Pelster B

更新日期：2011-05-13 00:00:00

abstract：:The bacterium Piscirickettsia salmonis is the etiological agent of salmonid rickettsial septicemia (SRS), a severe disease that causes major economic losses to the Atlantic salmon aquaculture industry every year. Little is known about the infective strategy of P. salmonis, which is able to infect, survive within, and ...

journal_title：Physiological genomics

authors： Tacchi L,Bron JE,Taggart JB,Secombes CJ,Bickerdike R,Adler MA,Takle H,Martin SA

更新日期：2011-11-07 00:00:00

abstract：:To date, physical exercise is the only intervention consistently demonstrated to attenuate age-related declines in physical function. However, variability exists in seniors' responsiveness to training. One potential source of variability is the insertion (I allele) or deletion (D allele) of a 287 bp fragment in intron...

journal_title：Physiological genomics

authors： Buford TW,Hsu FC,Brinkley TE,Carter CS,Church TS,Dodson JA,Goodpaster BH,McDermott MM,Nicklas BJ,Yank V,Johnson JA,Pahor M,LIFE Research Group.

更新日期：2014-03-01 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChR) are assembled from a pool of nine alpha-subunits and three beta-subunits into functional pentamers in peripheral autonomic neurons. The contribution of different subunits to native, physiologically important nAChR for synaptic transmission in autonomic ganglia is unclear. Here...

journal_title：Physiological genomics

authors： Deck J,Bibevski S,Gnecchi-Ruscone T,Bellina V,Montano N,Dunlap ME

更新日期：2005-06-16 00:00:00