Functional genomic characterization of delipidation elicited by trans-10, cis-12-conjugated linoleic acid (t10c12-CLA) in a polygenic obese line of mice.

abstract：:Preeclampsia (PE) is a devastating adverse outcome of pregnancy. Characterized by maternal hypertension, PE, when left untreated, can result in death of both mother and baby. The cause of PE remains unknown, and there is no way to predict which women will develop PE during pregnancy. The only known treatment is delive...

journal_title：Physiological genomics

authors： Olson KN,Redman LM,Sones JL

更新日期：2019-03-01 00:00:00

abstract：:We previously reported that markers on rat chromosome 1 are genetically linked to blood pressure in an F(2) population derived from Dahl salt hypertension-sensitive (S) and Lewis (LEW) rats. Because there was evidence for more than one blood pressure quantitative trait locus (QTL) on chromosome 1, an initial congenic ...

journal_title：Physiological genomics

authors： Saad Y,Garrett MR,Lee SJ,Dene H,Rapp JP

更新日期：1999-11-11 00:00:00

abstract：:Previous studies have indicated that hemorrhage may predispose the lung to respiratory distress syndrome. Gene expression profiling with oligonucleotide microarrays was used to evaluate the genetic responses of the lung to hemorrhage. Conscious rats, chronically instrumented with a catheter and telemetry device to rec...

journal_title：Physiological genomics

authors： Bowman PD,Sondeen JL,Zhao B,Coppes VG,Nelson JJ,Dubick MA,Vaughan GM

更新日期：2005-11-17 00:00:00

abstract：:Electrotaxis, directional cell movement in response to an electric potential, has been demonstrated in a wide range of cell types including lymphocytes. Exoelectrogens, microorganisms capable of generating electrical currents, have been identified in microbial fuel cells. However, no studies have investigated exoelect...

journal_title：Physiological genomics

authors： Ericsson AC,Davis DJ,Franklin CL,Hagan CE

更新日期：2015-07-01 00:00:00

abstract：:Chronic kidney disease (CKD), defined as reduced glomerular filtration rate, is increasingly becoming a major public health issue. At the histological level, renal fibrosis is the final common pathway leading to end-stage renal disease, irrespective of the initial injury. According to this view, antifibrotic agents sh...

journal_title：Physiological genomics

authors： Lv W,Fan F,Wang Y,Gonzalez-Fernandez E,Wang C,Yang L,Booz GW,Roman RJ

更新日期：2018-01-01 00:00:00

abstract：:The recent development of genetic mouse models presenting life-long alterations in expression of the genes for atrial natriuretic peptide (ANP) or its receptors (NPR-A, NPR-C) has uncovered a physiological role of this hormone in chronic blood pressure homeostasis. Transgenic mice overexpressing a transthyretin-ANP fu...

journal_title：Physiological genomics

authors： Melo LG,Steinhelper ME,Pang SC,Tse Y,Ackermann U

更新日期：2000-06-29 00:00:00

abstract：:Cystic fibrosis (CF) lung disease severity is influenced by unknown genetic factors apart from the disease causative gene, cystic fibrosis transmembrane conductance regulator (CFTR). Previous studies have shown the C57BL/6J congenic Cftr(-/-) (B6 CF) mouse to develop a fibrotic lung disease compared with both CF mice ...

journal_title：Physiological genomics

authors： Haston CK,Cory S,Lafontaine L,Dorion G,Hallett MT

更新日期：2006-04-13 00:00:00

abstract：:There exists a sense of urgency to begin to generate a cohesive assembly of biomedical knowledge as the pace of knowledge accumulation accelerates. The urgency is in part driven by the emergence of systems molecular medicine that emphasizes the combination of systems analysis and molecular dissection in the future of ...

journal_title：Physiological genomics

authors： Liang M

更新日期：2007-08-20 00:00:00

abstract：:The purpose of this study was to identify novel transcriptional events occurring in the aortic wall before angiogenesis. We used a defined tissue culture system that takes advantage of the capacity of rat aortic rings to generate neovessels ex vivo in response to angiogenic factor stimulation. Total RNA isolated from ...

journal_title：Physiological genomics

authors： Aplin AC,Gelati M,Fogel E,Carnevale E,Nicosia RF

更新日期：2006-10-03 00:00:00

abstract：:Consumption of a protein-containing meal by a fasted animal promotes protein accretion in skeletal muscle, in part through leucine stimulation of protein synthesis and indirectly through repression of protein degradation mediated by its metabolite, α-ketoisocaproate. Mice lacking the mitochondrial branched-chain amino...

journal_title：Physiological genomics

authors： Lynch CJ,Kimball SR,Xu Y,Salzberg AC,Kawasawa YI

更新日期：2015-11-01 00:00:00

abstract：:Megakaryocyte (MK) development is critically informed by plasma membrane-localized receptors that integrate a multiplicity of environmental cues. Given that the current understanding about receptors and ligands involved in megakaryocytopoiesis is based on single targets, we performed a genome-wide search to identify a...

journal_title：Physiological genomics

authors： Sun S,Wang W,Latchman Y,Gao D,Aronow B,Reems JA

更新日期：2013-03-18 00:00:00

abstract：:11beta-Hydroxysteroid dehydrogenase type 2 (11betaHSD2) is a short-chain dehydrogenase/reductase (SDR) responsible for inactivating cortisol and preventing its binding to the mineralocorticoid receptor (MR). Nonfunctional mutations in HSD11B2, the gene encoding 11betaHSD2, cause the hypertensive syndrome of apparent m...

journal_title：Physiological genomics

authors： Manning JR,Bailey MA,Soares DC,Dunbar DR,Mullins JJ

更新日期：2010-08-01 00:00:00

abstract：:Cardiac microvascular endothelial cells (CMVECs) are the most numerous cells in the myocardium and orchestrate cardiogenesis during development, regulate adult cardiac function, and modulate pathophysiology of heart failure. It has been shown that the transcriptome of CMVECs differs from other endothelial cell types, ...

journal_title：Physiological genomics

authors： Vermeulen Z,Mateiu L,Dugaucquier L,De Keulenaer GW,Segers VFM

更新日期：2019-06-01 00:00:00

abstract：:Sulfate plays an essential role during growth, development and cellular metabolism. In this study, we characterized the function and structure of the zebrafish (Danio rerio) Na+-sulfate cotransporter 1 (NaS1) cDNA and gene (slc13a1). Zebrafish NaS1 encodes a protein of 583 amino acids with 13 putative transmembrane do...

journal_title：Physiological genomics

authors： Markovich D,Romano A,Storelli C,Verri T

更新日期：2008-08-15 00:00:00

abstract：:Mast cell numbers are significantly increased in bladder disorders including malignancy and interstitial cystitis, but their precise role has been difficult to determine. We characterized the role of mast cells on gene regulation associated with antigen-induced bladder inflammation in mice. For this purpose, we examin...

journal_title：Physiological genomics

authors： Saban R,Saban MR,Nguyen NB,Hammond TG,Wershil BK

更新日期：2001-10-10 00:00:00

abstract：:Dahl salt-sensitive SS and consomic, salt-resistant SS-13(BN)/Mcw rats possess a highly similar genetic background but exhibit substantial differences in blood pressure salt sensitivity. We used cDNA microarrays to examine sequential changes of mRNA expression of approximately 2,000 currently known rat genes in the re...

journal_title：Physiological genomics

authors： Liang M,Yuan B,Rute E,Greene AS,Olivier M,Cowley AW Jr

更新日期：2003-02-06 00:00:00

abstract：:We analyzed the global transcriptional response of Saccharomyces cerevisiae cells exposed to different concentrations of CsCl in the growth medium and at different times after addition. Early responsive genes were mainly involved in cell wall structure and biosynthesis. About half of the induced genes were previously ...

journal_title：Physiological genomics

authors： Del Vescovo V,Casagrande V,Bianchi MM,Piccinni E,Frontali L,Militti C,Fardeau V,Devaux F,Di Sanza C,Presutti C,Negri R

更新日期：2008-03-14 00:00:00

abstract：:The relative importance of regulatory versus structural evolution for the evolution of different biological systems is a subject of controversy. The primacy of regulatory evolution in the diversification of morphological traits has been promoted by many evolutionary developmental biologists. For physiological traits, ...

journal_title：Physiological genomics

authors： Rosati B,Dong M,Cheng L,Liou SR,Yan Q,Park JY,Shiang E,Sanguinetti M,Wang HS,McKinnon D

更新日期：2008-11-12 00:00:00

abstract：:Genetic analysis of polygenic traits in rats and mice has been very useful for finding the approximate chromosomal locations of the genes causing quantitative phenotypic variation, so-called quantitative trait loci (QTL). Further localization of the causative genes and their ultimate identification has, however, prove...

journal_title：Physiological genomics

authors： Rapp JP,Joe B

更新日期：2012-02-01 00:00:00

abstract：:Although Escherichia coli LPS is known to elicit various proinflammatory responses in macrophages, its effect on the translational states of transcripts has not yet been explored on a genome-wide scale. To address this, we investigated the mRNA profiles in polysomal and free messenger ribonucleoprotein particle (mRNP)...

journal_title：Physiological genomics

authors： Kitamura H,Ito M,Yuasa T,Kikuguchi C,Hijikata A,Takayama M,Kimura Y,Yokoyama R,Kaji T,Ohara O

更新日期：2008-03-14 00:00:00

abstract：:This study was the first to explore the potential role of the myostatin (GDF8) pathway in relation to muscle strength and estimated muscle cross-sectional area in humans using linkage analysis with a candidate gene approach. In young male sibs (n = 329) 11 polymorphic markers in or near 10 candidate genes from the myo...

journal_title：Physiological genomics

authors： Huygens W,Thomis MA,Peeters MW,Aerssens J,Janssen R,Vlietinck RF,Beunen G

更新日期：2004-05-19 00:00:00

abstract：:Experimental rat models of arthritis are extensively studied with a view to understand the genetic underpinnings of rheumatoid arthritis (RA). Genome scans using these models have led to the detection of arthritis regulatory quantitative trait loci (QTLs) on all but three chromosomes of the rat. Whereas some of the QT...

journal_title：Physiological genomics

authors： Joe B

更新日期：2006-10-03 00:00:00

abstract：:We previously reported that mice deficient in stearoyl-CoA desaturase-1 (Scd1) and maintained on a very low-fat (VLF) diet for 10 days developed severe loss of body weight, hypoglycemia, hypercholesterolemia, and many cholestasis-like phenotypes. To better understand the metabolic changes associated with these phenoty...

journal_title：Physiological genomics

authors： Flowers MT,Keller MP,Choi Y,Lan H,Kendziorski C,Ntambi JM,Attie AD

更新日期：2008-05-13 00:00:00

abstract：:The objective of this study was to identify prostaglandin F(2α) (PG)-induced changes in the transcriptome of bovine corpora lutea (CL) that are specific to mature, PG-responsive (day 11) CL vs. developing (day 4) CL, which do not undergo luteolysis in response to PG administration. CL were collected at 0, 4, and 24 h ...

journal_title：Physiological genomics

authors： Mondal M,Schilling B,Folger J,Steibel JP,Buchnick H,Zalman Y,Ireland JJ,Meidan R,Smith GW

更新日期：2011-04-27 00:00:00

abstract：:To date, physical exercise is the only intervention consistently demonstrated to attenuate age-related declines in physical function. However, variability exists in seniors' responsiveness to training. One potential source of variability is the insertion (I allele) or deletion (D allele) of a 287 bp fragment in intron...

journal_title：Physiological genomics

authors： Buford TW,Hsu FC,Brinkley TE,Carter CS,Church TS,Dodson JA,Goodpaster BH,McDermott MM,Nicklas BJ,Yank V,Johnson JA,Pahor M,LIFE Research Group.

更新日期：2014-03-01 00:00:00

abstract：:We used next-generation RNA sequencing (RNA-Seq) technology on the whole transcriptome to identify genes whose expression is consistently affected by obesity across multiple arteries. Specifically, we examined transcriptional profiles of the iliac artery as well as the feed artery, first, second, and third branch orde...

journal_title：Physiological genomics

authors： Padilla J,Jenkins NT,Thorne PK,Martin JS,Rector RS,Davis JW,Laughlin MH

更新日期：2014-11-15 00:00:00

abstract：:Peripheral blood cells are an accessible environment in which to visualize exercise-induced alterations in global gene expression patterns. We aimed to identify a peripheral blood mononuclear cell (PBMC) signature represented by alterations in gene expression, in response to a standardized endurance exercise training ...

journal_title：Physiological genomics

authors： Dias RG,Silva MS,Duarte NE,Bolani W,Alves CR,Junior JR,da Silva JL,de Oliveira PA,Alves GB,de Oliveira EM,Rocha CS,Marsiglia JD,Negrao CE,Krieger EM,Krieger JE,Pereira AC

更新日期：2015-02-01 00:00:00

abstract：:A high-resolution time series of transcript abundance was generated to describe global expression dynamics in response to nutrition in Drosophila. Nonparametric change-point statistics revealed that within 7 h of feeding upon yeast, transcript levels changed significantly for approximately 3,500 genes or 20% of the Dr...

journal_title：Physiological genomics

authors： Gershman B,Puig O,Hang L,Peitzsch RM,Tatar M,Garofalo RS

更新日期：2007-03-14 00:00:00

abstract：:Following vascular injury medial smooth muscle cells dedifferentiate and migrate through the internal elastic lamina where they form a neointima. The goal of the current study was to identify changes in gene expression that occur before the development of neointima and are associated with the early response to injury....

journal_title：Physiological genomics

authors： Herring BP,Hoggatt AM,Griffith SL,McClintick JN,Gallagher PJ

更新日期：2017-03-01 00:00:00

abstract：:Regulation of iron absorption by duodenal enterocytes is essential for the maintenance of homeostasis by preventing iron deficiency or overload. Despite the identification of a number of genes implicated in iron absorption and its regulation, it is likely that further factors remain to be identified. For that purpose,...

journal_title：Physiological genomics

authors： Chicault C,Toutain B,Monnier A,Aubry M,Fergelot P,Le Treut A,Galibert MD,Mosser J

更新日期：2006-06-16 00:00:00