Genome-wide identification and characterization of transcripts translationally regulated by bacterial lipopolysaccharide in macrophage-like J774.1 cells.

abstract：:The process of parturition involves the complex interplay of factors that change the excitability and contractile activity of the uterus. We have compared the relative gene expression profile of myometrium from rats before parturition (21 days pregnant) and during delivery, using high-density DNA microarray. Of 8,740 ...

journal_title：Physiological genomics

authors： Helguera G,Eghbali M,Sforza D,Minosyan TY,Toro L,Stefani E

更新日期：2009-01-08 00:00:00

abstract：:Valproic acid (VPA) and lithium are widely used in the treatment of bipolar disorder. However, the underlying mechanism of action of these drugs is not clearly understood. We used RNA-Seq analysis to examine the global profile of gene expression in a rat serotonergic cell line (RN46A) after exposure to these two mood ...

journal_title：Physiological genomics

authors： Balasubramanian D,Pearson JF,Kennedy MA

更新日期：2019-02-01 00:00:00

abstract：:A high-fat (HF) diet is associated with progression of liver diseases. To illustrate genome-wide landscape of DNA methylation in liver of rats fed either a control or HF diet, two enrichment-based methods, namely methyl-DNA immunoprecipitation assay with high-throughput sequencing (MeDIP-seq) and methylation-sensitive...

journal_title：Physiological genomics

authors： Zhang Y,Wang H,Zhou D,Moody L,Lezmi S,Chen H,Pan YX

更新日期：2015-10-01 00:00:00

abstract：:The bacterium Piscirickettsia salmonis is the etiological agent of salmonid rickettsial septicemia (SRS), a severe disease that causes major economic losses to the Atlantic salmon aquaculture industry every year. Little is known about the infective strategy of P. salmonis, which is able to infect, survive within, and ...

journal_title：Physiological genomics

authors： Tacchi L,Bron JE,Taggart JB,Secombes CJ,Bickerdike R,Adler MA,Takle H,Martin SA

更新日期：2011-11-07 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChR) are assembled from a pool of nine alpha-subunits and three beta-subunits into functional pentamers in peripheral autonomic neurons. The contribution of different subunits to native, physiologically important nAChR for synaptic transmission in autonomic ganglia is unclear. Here...

journal_title：Physiological genomics

authors： Deck J,Bibevski S,Gnecchi-Ruscone T,Bellina V,Montano N,Dunlap ME

更新日期：2005-06-16 00:00:00

abstract：:Loss of innervation in skeletal muscles leads to degeneration, atrophy, and loss of force. These dramatic changes are reflected in modifications of the mRNA expression of a large number of genes. Our goal was to clarify the broad spectrum of molecular events associated with long-term denervation of skeletal muscles. A...

journal_title：Physiological genomics

authors： Kostrominova TY,Dow DE,Dennis RG,Miller RA,Faulkner JA

更新日期：2005-07-14 00:00:00

abstract：:Expression patterns of monocarboxylate transporter 2 (MCT2) display mRNA diversity in a tissue-specific fashion. We cloned and characterized multiple mct2 5'-cDNA ends from the mouse and determined the structural organization of the mct2 gene. We found that transcription of this gene was initiated from five independen...

journal_title：Physiological genomics

authors： Zhang SX,Searcy TR,Wu Y,Gozal D,Wang Y

更新日期：2007-12-19 00:00:00

abstract：:An increased phospholamban (PLB)-to-sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) ratio has been suggested to contribute to the slowing of relaxation in failing human ventricle. We have used an adenoviral vector carrying the sequence for PLB to increase this ratio in isolated adult rat ventricular myocytes, and w...

journal_title：Physiological genomics

authors： Davia K,Hajjar RJ,Terracciano CM,Kent NS,Ranu HK,O'Gara P,Rosenzweig A,Harding SE

更新日期：1999-08-31 00:00:00

abstract：:Dynamic, epigenetic mechanisms can regulate macrophage phenotypes following exposure to different stimulating conditions and environments. However, temporal patterns of microRNAs (miRNAs or miRs) across multiple macrophage polarization phenotypes have not been defined. We determined miRNA expression in bone marrow-der...

journal_title：Physiological genomics

authors： Melton DW,Lei X,Gelfond JA,Shireman PK

更新日期：2016-05-01 00:00:00

abstract：:Insulin resistance is a heterogeneous disorder caused by a range of genetic and environmental factors, and we hypothesize that its etiology varies considerably between individuals. This heterogeneity provides significant challenges to the development of effective therapeutic regimes for long-term management of type 2 ...

journal_title：Physiological genomics

authors： Konstantopoulos N,Foletta VC,Segal DH,Shields KA,Sanigorski A,Windmill K,Swinton C,Connor T,Wanyonyi S,Dyer TD,Fahey RP,Watt RA,Curran JE,Molero JC,Krippner G,Collier GR,James DE,Blangero J,Jowett JB,Walder KR

更新日期：2011-02-11 00:00:00

abstract：:Heart disease is the major cause of death in diabetes, a disorder characterized by chronic hyperglycemia and cardiovascular complications. Diabetic cardiomyopathy (DCM) is increasingly recognized as a major contributor to diastolic dysfunction and heart failure in diabetes, but its molecular basis has remained obscure...

journal_title：Physiological genomics

authors： Glyn-Jones S,Song S,Black MA,Phillips AR,Choong SY,Cooper GJ

更新日期：2007-02-12 00:00:00

abstract：:Little is known regarding the graft response to transplantation injury. This study investigates the posttransplantation response of genes that are constitutively expressed in the heart. Constitutive heart and lymph node tissue-restricted gene expression was first analyzed with DNA microarrays. To demonstrate changes f...

journal_title：Physiological genomics

authors： Christopher K,Mueller TF,DeFina R,Liang Y,Zhang J,Gentleman R,Perkins DL

更新日期：2003-09-29 00:00:00

abstract：:Uncoupling protein 1 (UCP1) is the first UCP described. It belongs to the family of mitochondrial carrier proteins and is expressed mainly in brown adipose tissue. Recently, the family of the UCPs has rapidly been growing due to the successive cloning of UCP2, UCP3, UCP4, and UCP5, also called brain mitochondrial carr...

journal_title：Physiological genomics

authors： Keller PA,Lehr L,Giacobino JP,Charnay Y,Assimacopoulos-Jeannet F,Giovannini N

更新日期：2005-08-11 00:00:00

abstract：:alpha-Sarcoglycan-deficient (Sgca-null) mice provide potential for elucidating the pathogenesis of limb girdle muscular dystrophy type 2D (LGMD 2D) as well as for studying the effectiveness of therapeutic strategies. Skeletal muscles of Sgca-null mice demonstrate an early onset of extensive fiber necrosis, degeneratio...

journal_title：Physiological genomics

authors： Consolino CM,Duclos F,Lee J,Williamson RA,Campbell KP,Brooks SV

更新日期：2005-07-14 00:00:00

abstract：:High-frequency ultrasound biomicroscopy (UBM) has recently emerged as a high-resolution means of phenotyping genetically altered mice and has great potential to evaluate the cardiac morphology and hemodynamics of mouse mutants. However, there is no standard procedure of in vivo transthoracic cardiac imaging using UBM ...

journal_title：Physiological genomics

authors： Zhou YQ,Foster FS,Nieman BJ,Davidson L,Chen XJ,Henkelman RM

更新日期：2004-07-08 00:00:00

abstract：:Metazoan akirin genes regulate innate immunity, myogenesis, and carcinogenesis. Invertebrates typically have one family member, while most tetrapod and teleost vertebrates have one to three. We demonstrate an expanded repertoire of eight family members in genomes of four salmonid fishes, owing to paralog preservation ...

journal_title：Physiological genomics

authors： Macqueen DJ,Kristjánsson BK,Johnston IA

更新日期：2010-06-01 00:00:00

abstract：:Adenosine deaminase acting on RNA (ADAR) in Drosophila and mammals has recently become the target of numerous investigations. It is now clear that this protein has a number of functions in the nervous system. Indeed, the mutation of ADAR in Drosophila (dADAR) results in many pathological and physiological changes, suc...

journal_title：Physiological genomics

authors： Xia S,Yang J,Su Y,Qian J,Ma E,Haddad GG

更新日期：2005-01-20 00:00:00

abstract：:The aims of this study were to 1) identify the earliest transcriptional response of the bovine endometrium to the presence of the conceptus (using RNAseq), 2) investigate if these genes are regulated by interferon tau (IFNT) in vivo, and 3) determine if they are predictive of the pregnancy status of postpartum dairy c...

journal_title：Physiological genomics

authors： Forde N,Duffy GB,McGettigan PA,Browne JA,Mehta JP,Kelly AK,Mansouri-Attia N,Sandra O,Loftus BJ,Crowe MA,Fair T,Roche JF,Lonergan P,Evans AC

更新日期：2012-08-17 00:00:00

abstract：:We previously reported that mice deficient in stearoyl-CoA desaturase-1 (Scd1) and maintained on a very low-fat (VLF) diet for 10 days developed severe loss of body weight, hypoglycemia, hypercholesterolemia, and many cholestasis-like phenotypes. To better understand the metabolic changes associated with these phenoty...

journal_title：Physiological genomics

authors： Flowers MT,Keller MP,Choi Y,Lan H,Kendziorski C,Ntambi JM,Attie AD

更新日期：2008-05-13 00:00:00

abstract：:The zebrafish has become a popular model system for the study of vertebrate developmental biology because of its numerous strengths as a molecular genetic and embryological system. To determine the requirement for specific genes during embryogenesis, it is necessary to generate organisms carrying loss-of-function muta...

journal_title：Physiological genomics

authors： Lekven AC,Helde KA,Thorpe CJ,Rooke R,Moon RT

更新日期：2000-03-13 00:00:00

abstract：:The structural organization of the brain is important for normal brain function and is critical to understand in order to evaluate changes that occur during disease processes. Three-dimensional (3D) imaging of the mouse brain is necessary to appreciate the spatial context of structures within the brain. In addition, t...

journal_title：Physiological genomics

authors： Gleave JA,Wong MD,Dazai J,Altaf M,Henkelman RM,Lerch JP,Nieman BJ

更新日期：2012-08-01 00:00:00

abstract：:A microarray study of the effect of senescence in mice on gene expression in muscle has been published recently. The present analysis was done to evaluate the extent to which the age-related differences in gene expression in murine muscle are also evident in human muscle. RNA extracted from muscle of young (21-24 yr) ...

journal_title：Physiological genomics

authors： Welle S,Brooks A,Thornton CA

更新日期：2001-03-08 00:00:00

abstract：:Hypoxia is a widely occurring condition experienced by diverse organisms under numerous physiological and disease conditions. To probe the molecular mechanisms underlying hypoxia responses and tolerance, we performed a genome-wide screen to identify mutants with enhanced hypoxia tolerance in the model eukaryote, the y...

journal_title：Physiological genomics

authors： Shah AN,Cadinu D,Henke RM,Xin X,Dastidar RG,Zhang L

更新日期：2011-07-27 00:00:00

abstract：:Hypoxia is an important ecological, evolutionary, and biomedical stressor. While physiological acclimatization of mammals to hypoxia is well studied, the variation in gene expression that underlies acclimatization is not well studied. We acclimatized inbred mice for 32 days to hypoxic conditions that simulated altitud...

journal_title：Physiological genomics

authors： Baze MM,Schlauch K,Hayes JP

更新日期：2010-05-01 00:00:00

abstract：:The gastric entero-chromaffin-like (ECL) cell plays a key regulatory role in peripheral regulation of acid secretion due to the release of histamine that stimulates acid secretion by the parietal cell. Studies in intact animals, gastric glands, and isolated cells after short-term culture have shown expression of stimu...

journal_title：Physiological genomics

authors： Lambrecht NW,Yakubov I,Zer C,Sachs G

更新日期：2006-03-13 00:00:00

abstract：:Activation of NF-kappaB is essential for protease-activated receptor-1 (PAR-1)-mediated ICAM-1 expression in endothelial cells. Here we show that PAR-1 activation induces binding of both p65/RelA and NFATc1 to the NF-kappaB binding site localized in intron-1 of the ICAM-1 gene to initiate transcription in endothelial ...

journal_title：Physiological genomics

authors： Xue J,Thippegowda PB,Hu G,Bachmaier K,Christman JW,Malik AB,Tiruppathi C

更新日期：2009-06-10 00:00:00

abstract：:Although increased vascular stiffness is more prominent in aging males than females, and males are more prone to vascular disease with aging, no study has investigated the genes potentially responsible for sex differences in vascular aging. We tested the hypothesis that the transcriptional adaptation to aging differs ...

journal_title：Physiological genomics

authors： Qiu H,Tian B,Resuello RG,Natividad FF,Peppas A,Shen YT,Vatner DE,Vatner SF,Depre C

更新日期：2007-04-24 00:00:00

abstract：:To further define genes that are differentially expressed during cysteine deprivation and to evaluate the roles of amino acid deprivation vs. oxidative stress in the response to cysteine deprivation, we assessed gene expression in human hepatoma cells cultured in complete or cysteine-deficient medium. Overall, C3A cel...

journal_title：Physiological genomics

authors： Lee JI,Dominy JE Jr,Sikalidis AK,Hirschberger LL,Wang W,Stipanuk MH

更新日期：2008-04-22 00:00:00

abstract：:Our objective was to resequence insulin receptor substrate 2 (IRS2) to identify variants associated with obesity- and diabetes-related traits in Hispanic children. Exonic and intronic segments, 5' and 3' flanking regions of IRS2 (∼14.5 kb), were bidirectionally sequenced for single nucleotide polymorphism (SNP) discov...

journal_title：Physiological genomics

authors： Butte NF,Voruganti VS,Cole SA,Haack K,Comuzzie AG,Muzny DM,Wheeler DA,Chang K,Hawes A,Gibbs RA

更新日期：2011-09-22 00:00:00

abstract：:Usher syndrome (USH) is a neurosensory disorder affecting both hearing and vision in humans. Linkage studies of families of USH patients, studies in animals, and characterization of purified proteins have provided insight into the molecular mechanisms of hearing. To date, 11 USH proteins have been identified, and evid...

journal_title：Physiological genomics

authors： Ahmed ZM,Frolenkov GI,Riazuddin S

更新日期：2013-11-01 00:00:00