Changes in global gene expression in rat myometrium in transition from late pregnancy to parturition.


:The process of parturition involves the complex interplay of factors that change the excitability and contractile activity of the uterus. We have compared the relative gene expression profile of myometrium from rats before parturition (21 days pregnant) and during delivery, using high-density DNA microarray. Of 8,740 sequences available in the array, a total of 3,782 were detected as present. From the sequences that were significantly altered, 59 genes were upregulated and 82 genes were downregulated. We were able to detect changes in genes described to have altered expression level at term, including connexin 43 and 26, cyclooxygenase 2, and oxytocin receptor, as well as novel genes that have been not previously associated with parturition. Quantitative real-time PCR on selected genes further confirmed the microarray data. Here we report for the first time that aquaporin5 (AQP5), a member of the aquaporin water channel family, was dramatically downregulated during parturition (approximately 100-fold by microarray and approximately 50-fold by real-time PCR). The emerging profile highlights biochemical cascades occurring in a period of approximately 36 h that trigger parturition and the initiation of myometrium reverse remodeling postpartum. The microarray analysis uncovered genes that were previously suspected to play a role in parturition. This regulation involves genes from immune/inflammatory response, steroid/lipid metabolism, calcium homeostasis, cell volume regulation, cell signaling, cell division, and tissue remodeling, suggesting the presence of multiple and redundant mechanisms altered in the process of birth.


Physiol Genomics


Physiological genomics


Helguera G,Eghbali M,Sforza D,Minosyan TY,Toro L,Stefani E




Has Abstract


2009-01-08 00:00:00














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    abstract::Metazoan akirin genes regulate innate immunity, myogenesis, and carcinogenesis. Invertebrates typically have one family member, while most tetrapod and teleost vertebrates have one to three. We demonstrate an expanded repertoire of eight family members in genomes of four salmonid fishes, owing to paralog preservation ...

    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Macqueen DJ,Kristjánsson BK,Johnston IA

    更新日期:2010-06-01 00:00:00

  • Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.

    abstract::Alzheimer's Disease (AD) is the most widespread form of dementia during the later stages of life. If improved therapeutics are not developed, the prevalence of AD will drastically increase in the coming years as the world's population ages. By identifying differences in neuronal gene expression profiles between health...

    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Liang WS,Dunckley T,Beach TG,Grover A,Mastroeni D,Ramsey K,Caselli RJ,Kukull WA,McKeel D,Morris JC,Hulette CM,Schmechel D,Reiman EM,Rogers J,Stephan DA

    更新日期:2008-04-22 00:00:00

  • Leptin gene in rabbit: cloning and expression in mammary epithelial cells during pregnancy and lactation.

    abstract::Leptin is known as a cytokine mostly produced by fat cells and implicated in regulation of energy metabolism and food intake but has also been shown to be involved in many physiological mechanisms such as tissue metabolism and cell differentiation and proliferation. In particular, leptin influences the development of ...

    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Koch E,Hue-Beauvais C,Galio L,Solomon G,Gertler A,Révillon F,Lhotellier V,Aujean E,Devinoy E,Charlier M

    更新日期:2013-08-01 00:00:00

  • Transgenic rescue demonstrates involvement of the Ian5 gene in T cell development in the rat.

    abstract::A single point mutation in a novel immune-associated nucleotide gene 5 (Ian5) coincides with severe T cell lymphopenia in BB rats. We used a transgenic rescue approach in lymphopenic BB-derived congenic F344.lyp/lyp rats to determine whether this mutation is responsible for lymphopenia and to establish the functional ...

    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Michalkiewicz M,Michalkiewicz T,Ettinger RA,Rutledge EA,Fuller JM,Moralejo DH,Van Yserloo B,MacMurray AJ,Kwitek AE,Jacob HJ,Lander ES,Lernmark A

    更新日期:2004-10-04 00:00:00

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    journal_title:Physiological genomics

    pub_type: 杂志文章


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    更新日期:2011-02-11 00:00:00

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    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Riehle MM,Bennett AF,Lenski RE,Long AD

    更新日期:2003-06-24 00:00:00

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    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Filesi I,Gullotta F,Lattanzi G,D'Apice MR,Capanni C,Nardone AM,Columbaro M,Scarano G,Mattioli E,Sabatelli P,Maraldi NM,Biocca S,Novelli G

    更新日期:2005-10-17 00:00:00

  • Ultrafine mapping of Dyscalc1 to an 80-kb chromosomal segment on chromosome 7 in mice susceptible for dystrophic calcification.

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    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Aherrahrou Z,Doehring LC,Kaczmarek PM,Liptau H,Ehlers EM,Pomarino A,Wrobel S,Götz A,Mayer B,Erdmann J,Schunkert H

    更新日期:2007-01-17 00:00:00

  • Evaluation of hypothalamic gene expression in mice divergently selected for heat loss.

    abstract::Mouse lines divergently selected for heat loss were evaluated for correlated responses in the hypothalamic transcriptome. High (MH) heat loss mice have approximately 50% greater heat loss, approximately 35% less body fat, approximately 20% greater feed intake, approximately 100% greater locomotor activity levels, and ...

    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Wesolowski SR,Allan MF,Nielsen MK,Pomp D

    更新日期:2003-04-16 00:00:00

  • Therapeutic potential of microRNAs for the treatment of renal fibrosis and CKD.

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    journal_title:Physiological genomics

    pub_type: 杂志文章,评审


    authors: Lv W,Fan F,Wang Y,Gonzalez-Fernandez E,Wang C,Yang L,Booz GW,Roman RJ

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    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Lee JI,Dominy JE Jr,Sikalidis AK,Hirschberger LL,Wang W,Stipanuk MH

    更新日期:2008-04-22 00:00:00

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    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Lambrecht NW,Yakubov I,Zer C,Sachs G

    更新日期:2006-03-13 00:00:00

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    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Suchyta SP,Sipkovsky S,Kruska R,Jeffers A,McNulty A,Coussens MJ,Tempelman RJ,Halgren RG,Saama PM,Bauman DE,Boisclair YR,Burton JL,Collier RJ,DePeters EJ,Ferris TA,Lucy MC,McGuire MA,Medrano JF,Overton TR,Smith TP,

    更新日期:2003-10-17 00:00:00

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    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Tian J,Fratz S,Hou Y,Lu Q,Görlach A,Hess J,Schreiber C,Datar SA,Oishi P,Nechtman J,Podolsky R,She JX,Fineman JR,Black SM

    更新日期:2011-01-01 00:00:00

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    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Ren YY,Koch LG,Britton SL,Qi NR,Treutelaar MK,Burant CF,Li JZ

    更新日期:2016-11-01 00:00:00

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    abstract::The mammary gland undergoes extensive remodeling between the beginning of pregnancy and lactation; this involves cellular processes including cell proliferation, differentiation, and apoptosis, all of which are under the control of numerous regulators. To unravel the role played by miRNA, we describe here 47 new ovine...

    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Galio L,Droineau S,Yeboah P,Boudiaf H,Bouet S,Truchet S,Devinoy E

    更新日期:2013-02-15 00:00:00

  • Cell dormancy plasticity: quiescence deepens into senescence through a dimmer switch.

    abstract::Both being dormant cellular states, quiescence and senescence are traditionally considered distinct. Quiescence is reversible to proliferation upon growth signals, whereas senescence is irreversible in physiological conditions. Recent findings, however, suggest that quiescence deepening with a decreased proliferative ...

    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Fujimaki K,Yao G

    更新日期:2020-11-01 00:00:00

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    abstract::In functional genomics, the high-throughput methods such as microarrays 1) allow analysis of the relationships between genes considering them as elements of a network and 2) lead to biological interpretations thanks to Gene Ontology. But up to now it has not been possible to find relationships between the functions an...

    journal_title:Physiological genomics

    pub_type: 杂志文章,meta分析


    authors: Gustin MP,Paultre CZ,Randon J,Bricca G,Cerutti C

    更新日期:2008-06-12 00:00:00

  • Gene homology resources on the World Wide Web.

    abstract::As the amount of information available to biologists increases exponentially, data analysis becomes progressively more challenging. Sequence homology has been a traditional tool in the researchers' armamentarium; it is a very versatile instrument and can be employed to assist in numerous tasks, from establishing the f...

    journal_title:Physiological genomics

    pub_type: 杂志文章,评审


    authors: Turchin A,Kohane IS

    更新日期:2002-12-03 00:00:00

  • Detection of SNP epistasis effects of quantitative traits using an extended Kempthorne model.

    abstract::Epistasis effects (gene interactions) have been increasingly recognized as important genetic factors underlying complex traits. The existence of a large number of single nucleotide polymorphisms (SNPs) provides opportunities and challenges to screen DNA variations affecting complex traits using a candidate gene analys...

    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Mao Y,London NR,Ma L,Dvorkin D,Da Y

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    abstract::Adenosine deaminase acting on RNA (ADAR) in Drosophila and mammals has recently become the target of numerous investigations. It is now clear that this protein has a number of functions in the nervous system. Indeed, the mutation of ADAR in Drosophila (dADAR) results in many pathological and physiological changes, suc...

    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Xia S,Yang J,Su Y,Qian J,Ma E,Haddad GG

    更新日期:2005-01-20 00:00:00

  • Angiopoietin-1 and vascular endothelial growth factor induce expression of inflammatory cytokines before angiogenesis.

    abstract::The purpose of this study was to identify novel transcriptional events occurring in the aortic wall before angiogenesis. We used a defined tissue culture system that takes advantage of the capacity of rat aortic rings to generate neovessels ex vivo in response to angiogenic factor stimulation. Total RNA isolated from ...

    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Aplin AC,Gelati M,Fogel E,Carnevale E,Nicosia RF

    更新日期:2006-10-03 00:00:00

  • PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training.

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    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Blond MB,Schnurr TM,Rosenkilde M,Quist JS,Gram AS,Reichkendler MH,Auerbach PL,Nordby P,Skovgaard LT,Ribel-Madsen R,Justesen JM,Kilpeläinen TO,Ploug T,Stallknecht BM,Hansen T

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    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Del Monte F,Butler K,Boecker W,Gwathmey JK,Hajjar RJ

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  • Novel slc22 transporter homologs in fly, worm, and human clarify the phylogeny of organic anion and cation transporters.

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    journal_title:Physiological genomics

    pub_type: 杂志文章,评审


    authors: Eraly SA,Monte JC,Nigam SK

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    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Keogh K,Kenny DA,Kelly AK,Waters SM

    更新日期:2015-08-01 00:00:00

  • High cardiorespiratory fitness can reduce glycated hemoglobin levels regardless of polygenic risk for Type 2 diabetes mellitus in nondiabetic Japanese men.

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    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Tanisawa K,Ito T,Sun X,Ise R,Oshima S,Cao ZB,Sakamoto S,Tanaka M,Higuchi M

    更新日期:2014-07-15 00:00:00

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    abstract::Megakaryocyte (MK) development is critically informed by plasma membrane-localized receptors that integrate a multiplicity of environmental cues. Given that the current understanding about receptors and ligands involved in megakaryocytopoiesis is based on single targets, we performed a genome-wide search to identify a...

    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Sun S,Wang W,Latchman Y,Gao D,Aronow B,Reems JA

    更新日期:2013-03-18 00:00:00

  • Muscles of mice deficient in alpha-sarcoglycan maintain large masses and near control force values throughout the life span.

    abstract::alpha-Sarcoglycan-deficient (Sgca-null) mice provide potential for elucidating the pathogenesis of limb girdle muscular dystrophy type 2D (LGMD 2D) as well as for studying the effectiveness of therapeutic strategies. Skeletal muscles of Sgca-null mice demonstrate an early onset of extensive fiber necrosis, degeneratio...

    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Consolino CM,Duclos F,Lee J,Williamson RA,Campbell KP,Brooks SV

    更新日期:2005-07-14 00:00:00

  • Serum response factor induces endothelial-mesenchymal transition in glomerular endothelial cells to aggravate proteinuria in diabetic nephropathy.

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    journal_title:Physiological genomics

    pub_type: 杂志文章


    authors: Zhao L,Zhao J,Wang X,Chen Z,Peng K,Lu X,Meng L,Liu G,Guan G,Wang F

    更新日期:2016-10-01 00:00:00