Changes in global gene expression in rat myometrium in transition from late pregnancy to parturition.

abstract：:We previously reported that markers on rat chromosome 1 are genetically linked to blood pressure in an F(2) population derived from Dahl salt hypertension-sensitive (S) and Lewis (LEW) rats. Because there was evidence for more than one blood pressure quantitative trait locus (QTL) on chromosome 1, an initial congenic ...

journal_title：Physiological genomics

authors： Saad Y,Garrett MR,Lee SJ,Dene H,Rapp JP

更新日期：1999-11-11 00:00:00

abstract：:The purpose of this study was to determine the influence of age, sex, and strength training (ST) on large-scale gene expression patterns in vastus lateralis muscle biopsies using high-density cDNA microarrays and quantitative PCR. Muscle samples from sedentary young (20-30 yr) and older (65-75 yr) men and women (5 per...

journal_title：Physiological genomics

authors： Roth SM,Ferrell RE,Peters DG,Metter EJ,Hurley BF,Rogers MA

更新日期：2002-09-03 00:00:00

abstract：:Vasopressin is a peptide hormone that regulates renal water excretion in part through its actions on the collecting duct. The regulation occurs in part via control of transcription of genes coding for the water channels aquaporin-2 (Aqp2) and aquaporin-3 (Aqp3). To identify transcription factors expressed in collectin...

journal_title：Physiological genomics

authors： Tchapyjnikov D,Li Y,Pisitkun T,Hoffert JD,Yu MJ,Knepper MA

更新日期：2010-02-04 00:00:00

abstract：:Exercise as well as hypoxia cause an increase in angiogenesis, changes in mitochondrial density and alterations in metabolism, but it is still under debate whether the hypoxia inducible factor (HIF) is active during both situations. In this study gene expression analysis of zebrafish larvae that were raised under norm...

journal_title：Physiological genomics

authors： Kopp R,Köblitz L,Egg M,Pelster B

更新日期：2011-05-13 00:00:00

abstract：:Usher syndrome (USH) is a neurosensory disorder affecting both hearing and vision in humans. Linkage studies of families of USH patients, studies in animals, and characterization of purified proteins have provided insight into the molecular mechanisms of hearing. To date, 11 USH proteins have been identified, and evid...

journal_title：Physiological genomics

authors： Ahmed ZM,Frolenkov GI,Riazuddin S

更新日期：2013-11-01 00:00:00

abstract：:The p21 activated kinase 1(PAK1) gene encodes a serine/threonine kinase that is overexpressed in a subset of human breast carcinomas with poor prognosis. The laboratory rat (Rattus norvegicus)orthologous gene is located at Mammary carcinoma susceptibility 3 (Mcs3) QTL on rat chromosome 1. We used quantitative PCR to d...

journal_title：Physiological genomics

authors： Duderstadt EL,McQuaide SA,Sanders MA,Samuelson DJ

更新日期：2020-12-21 00:00:00

abstract：:Essential hypertension is highly prevalent in the elderly population, exceeding 70% in people older than 60 yr of age, and remains a leading risk factor for heart disease, stroke, and chronic renal disease. Elucidation of genetic determinants is critical but remains a challenge due to its complex, multifactorial patho...

journal_title：Physiological genomics

authors： Glorioso N,Herrera VL,Didishvili T,Argiolas G,Troffa C,Bulla P,Bulla E,Ruiz-Opazo N

更新日期：2011-11-07 00:00:00

abstract：:Myocardial infarction (MI) induced by acute coronary arterial occlusion is usually secondary to atherosclerotic plaque rupture. Dysregulated response of vascular smooth muscle cells (VSMCs) in atherosclerotic plaques may promote plaque rupture. Cadherins (CDHs) form adherens junctions and are known stabilizers of athe...

journal_title：Physiological genomics

authors： Derda AA,Woo CC,Wongsurawat T,Richards M,Lee CN,Kofidis T,Kuznetsov VA,Sorokin VA

更新日期：2018-08-01 00:00:00

abstract：:The renin-angiotensin system (RAS), known for its roles in cardiovascular, metabolic, and developmental regulation, is present in both the circulation and in many individual tissues throughout the body. Substantial evidence supports the existence of a brain RAS, though quantification and localization of brain renin ha...

journal_title：Physiological genomics

authors： Xu D,Borges GR,Davis DR,Agassandian K,Sequeira Lopez ML,Gomez RA,Cassell MD,Grobe JL,Sigmund CD

更新日期：2011-03-29 00:00:00

abstract：:Besides neuronal plasticity, the neurotrophin brain-derived neurotrophic factor (BDNF) is also important in vascular function. The BDNF has been associated with angiogenesis through its specific receptor tropomyosin-related kinase B (TrkB). Additionally, Val66Met polymorphism decreases activity-induced BDNF. Since BDN...

journal_title：Physiological genomics

authors： Lemos JR Jr,Alves CR,de Souza SB,Marsiglia JD,Silva MS,Pereira AC,Teixeira AL,Vieira EL,Krieger JE,Negrão CE,Alves GB,de Oliveira EM,Bolani W,Dias RG,Trombetta IC

更新日期：2016-02-01 00:00:00

abstract：:Epistasis effects (gene interactions) have been increasingly recognized as important genetic factors underlying complex traits. The existence of a large number of single nucleotide polymorphisms (SNPs) provides opportunities and challenges to screen DNA variations affecting complex traits using a candidate gene analys...

journal_title：Physiological genomics

authors： Mao Y,London NR,Ma L,Dvorkin D,Da Y

更新日期：2006-12-13 00:00:00

abstract：:Regulation of iron absorption by duodenal enterocytes is essential for the maintenance of homeostasis by preventing iron deficiency or overload. Despite the identification of a number of genes implicated in iron absorption and its regulation, it is likely that further factors remain to be identified. For that purpose,...

journal_title：Physiological genomics

authors： Chicault C,Toutain B,Monnier A,Aubry M,Fergelot P,Le Treut A,Galibert MD,Mosser J

更新日期：2006-06-16 00:00:00

abstract：:To facilitate the development of assays for the discovery of pharmaceuticals capable of mimicking the effects of caloric restriction (CR) on life- and healthspan (CR mimetics), we evaluated the effectiveness of glucoregulatory and putative cancer chemopreventatives in reproducing the hepatic gene expression profile pr...

journal_title：Physiological genomics

authors： Dhahbi JM,Mote PL,Fahy GM,Spindler SR

更新日期：2005-11-17 00:00:00

abstract：:MicroRNAs (miRs) are small, noncoding RNAs that are emerging as crucial regulators of cardiac remodeling in left ventricular hypertrophy (LVH) and failure (LVF). However, there are no data on their role in right ventricular hypertrophy (RVH) and failure (RVF). This is a critical question given that the RV is uniquely ...

journal_title：Physiological genomics

authors： Reddy S,Zhao M,Hu DQ,Fajardo G,Hu S,Ghosh Z,Rajagopalan V,Wu JC,Bernstein D

更新日期：2012-05-01 00:00:00

abstract：:We previously constructed a congenic mouse, B6.S-D2Mit194-D2Mit311 (B6.S-2) with 27 Mb of SPRET/Ei donor DNA on distal chromosome 2 in a C57BL/6J background that captured an obesity quantitative trait locus (QTL). Mice homozygous for SPRET/Ei alleles at the donor region had decreased body weight and obesity-related ph...

journal_title：Physiological genomics

authors： Chiu S,Kim K,Haus KA,Espinal GM,Millon LV,Warden CH

更新日期：2007-09-19 00:00:00

abstract：:Morbidity and mortality associated with acute lung injury (ALI) and acute respiratory distress syndrome remain substantial. Although many candidate genes have been tested, a clear understanding of the pathogenesis is lacking, as is our ability to predict individual outcome. Because ALI is a complex disease, single gen...

journal_title：Physiological genomics

authors： Prows DR,Winterberg AV,Gibbons WJ Jr,Burzynski BB,Liu C,Nick TG

更新日期：2009-07-09 00:00:00

abstract：:We in this study investigated the role of imatinib-upregulated lncRNA (IUR) in prostate carcinoma (PC). We observed that IUR was downregulated in PC, and its expression levels decreased with the increase of clinical stages. In PC tissues, microRNA (miR)-200 was positively, while ZEB1 was inversely correlated with IUR....

journal_title：Physiological genomics

authors： Sun L,Chen T,Li T,Yu J

更新日期：2019-11-01 00:00:00

abstract：:To better understand the genetic basis of essential hypertension, we conducted a quantitative trait locus (QTL) analysis of a population of 207 (BALB/cJ x CBA/CaJ) F(2) male mice to identify genomic regions that regulate blood pressure, heart rate, and heart weight. We identified two loci, Bpq6 (blood pressure quantit...

journal_title：Physiological genomics

authors： Sugiyama F,Churchill GA,Li R,Libby LJ,Carver T,Yagami K,John SW,Paigen B

更新日期：2002-07-12 00:00:00

abstract：:Recombinant human erythropoietin (rHuEPO) is frequently abused by athletes as a performance-enhancing drug, despite being prohibited by the World Anti-Doping Agency. Although the methods to detect blood doping, including rHuEPO injections, have improved in recent years, they remain imperfect. In a proof-of-principle s...

journal_title：Physiological genomics

authors： Durussel J,Haile DW,Mooses K,Daskalaki E,Beattie W,Mooses M,Mekonen W,Ongaro N,Anjila E,Patel RK,Padmanabhan N,McBride MW,McClure JD,Pitsiladis YP

更新日期：2016-03-01 00:00:00

abstract：:Previous studies have indicated that hemorrhage may predispose the lung to respiratory distress syndrome. Gene expression profiling with oligonucleotide microarrays was used to evaluate the genetic responses of the lung to hemorrhage. Conscious rats, chronically instrumented with a catheter and telemetry device to rec...

journal_title：Physiological genomics

authors： Bowman PD,Sondeen JL,Zhao B,Coppes VG,Nelson JJ,Dubick MA,Vaughan GM

更新日期：2005-11-17 00:00:00

abstract：:Hypertension (HTN) is a prevalent condition with complex etiology and pathophysiology. Evidence exists of significant communication between the nervous system and the immune system (IS), and there appears to be a direct role for inflammatory bone marrow (BM) cells in the pathophysiology of hypertension. However, the m...

journal_title：Physiological genomics

authors： Ahmari N,Schmidt JT,Krane GA,Malphurs W,Cunningham BE,Owen JL,Martyniuk CJ,Zubcevic J

更新日期：2016-07-01 00:00:00

abstract：:Although Escherichia coli LPS is known to elicit various proinflammatory responses in macrophages, its effect on the translational states of transcripts has not yet been explored on a genome-wide scale. To address this, we investigated the mRNA profiles in polysomal and free messenger ribonucleoprotein particle (mRNP)...

journal_title：Physiological genomics

authors： Kitamura H,Ito M,Yuasa T,Kikuguchi C,Hijikata A,Takayama M,Kimura Y,Yokoyama R,Kaji T,Ohara O

更新日期：2008-03-14 00:00:00

abstract：:The airway epithelium represents an important barrier between the host and the environment. It is a first site of contact with pathogens, particulates, and other stimuli, and has evolved the means to dynamically respond to these challenges. In an effort to define the transcript profile of airway epithelia, we created ...

journal_title：Physiological genomics

authors： Scheetz TE,Zabner J,Welsh MJ,Coco J,Eyestone Mde F,Bonaldo M,Kucaba T,Casavant TL,Soares MB,McCray PB Jr

更新日期：2004-03-12 00:00:00

abstract：:The aim of the study was to explore the genetic architecture influencing weight of fast- and slow-twitch skeletal muscles. The weights of the slow-twitch soleus, the mixed gastrocnemius, the fast-twitch tibialis anterior (TA), and extensor digitorum longus (EDL) muscles were 11-34% greater (P < 0.001) in 200-day-old C...

journal_title：Physiological genomics

authors： Lionikas A,Blizard DA,Vandenbergh DJ,Glover MG,Stout JT,Vogler GP,McClearn GE,Larsson L

更新日期：2003-12-16 00:00:00

abstract：:High cardiorespiratory fitness (CRF) is associated with a reduced risk of Type 2 diabetes mellitus (T2DM) and improved β-cell function; genetic factors also determine these risks. This cross-sectional study investigated whether CRF modifies the association of polygenic risk of T2DM with glucose metabolism in nondiabet...

journal_title：Physiological genomics

authors： Tanisawa K,Ito T,Sun X,Ise R,Oshima S,Cao ZB,Sakamoto S,Tanaka M,Higuchi M

更新日期：2014-07-15 00:00:00

abstract：:The limited availability of genomic tools and data for nonmodel species impedes computational and systems biology approaches in nonmodel organisms. Here we describe the development, functional annotation, and utilization of genomic tools for the avian wildlife species Northern bobwhite (Colinus virginianus) to determi...

journal_title：Physiological genomics

authors： Rawat A,Gust KA,Deng Y,Garcia-Reyero N,Quinn MJ Jr,Johnson MS,Indest KJ,Elasri MO,Perkins EJ

更新日期：2010-07-07 00:00:00

abstract：:To further define genes that are differentially expressed during cysteine deprivation and to evaluate the roles of amino acid deprivation vs. oxidative stress in the response to cysteine deprivation, we assessed gene expression in human hepatoma cells cultured in complete or cysteine-deficient medium. Overall, C3A cel...

journal_title：Physiological genomics

authors： Lee JI,Dominy JE Jr,Sikalidis AK,Hirschberger LL,Wang W,Stipanuk MH

更新日期：2008-04-22 00:00:00

abstract：:Electrotaxis, directional cell movement in response to an electric potential, has been demonstrated in a wide range of cell types including lymphocytes. Exoelectrogens, microorganisms capable of generating electrical currents, have been identified in microbial fuel cells. However, no studies have investigated exoelect...

journal_title：Physiological genomics

authors： Ericsson AC,Davis DJ,Franklin CL,Hagan CE

更新日期：2015-07-01 00:00:00

abstract：:Genetic analysis of polygenic traits in rats and mice has been very useful for finding the approximate chromosomal locations of the genes causing quantitative phenotypic variation, so-called quantitative trait loci (QTL). Further localization of the causative genes and their ultimate identification has, however, prove...

journal_title：Physiological genomics

authors： Rapp JP,Joe B

更新日期：2012-02-01 00:00:00

abstract：:Aortic banding in the rat has become a popular method to induce left ventricular (LV) hypertrophy and heart failure. However, because of often extensive intrathoracic adhesions and inflammatory cell infiltrates resulting from the traditional surgical approach, an uncomplicated second thoracic incision for genetic mani...

journal_title：Physiological genomics

authors： Del Monte F,Butler K,Boecker W,Gwathmey JK,Hajjar RJ

更新日期：2002-01-01 00:00:00