Deciphering the luteal transcriptome: potential mechanisms mediating stage-specific luteolytic response of the corpus luteum to prostaglandin F₂α.

Abstract:

:The objective of this study was to identify prostaglandin F(2α) (PG)-induced changes in the transcriptome of bovine corpora lutea (CL) that are specific to mature, PG-responsive (day 11) CL vs. developing (day 4) CL, which do not undergo luteolysis in response to PG administration. CL were collected at 0, 4, and 24 h after PG injection on days 4 and 11 of the estrous cycle (n = 5 per day and time point), and microarray analysis was performed with GeneChip Bovine Genome Arrays. Data normalization was performed with affy package and significance testing with maanova from Bioconductor. Significance (relative to 0 h time point) was declared at fold change >2.0 or <0.5 and false discovery rate of <5%. At 4 and 24 h after PG, 221 (day 4) and 661 (day 11) and 248 (day 4) and 1,421 (day 11) regulated genes, respectively, were identified. The accentuated gene expression response in day 11 CL was accompanied by specific enrichment of PG-regulated genes in distinctive gene ontology categories (immune related and other), particularly at 24 h after injection. Specificity in putative transcription factor binding sites was observed among PG-regulated genes on day 11 vs. day 4, including a potential association of ETS transcription factors with acute PG-induced gene expression specific to day 11 CL. Temporal and PG-induced regulation of abundance of mRNA for ETS transcription factor family members linked to the stage-specific response to PG was not observed. Increased abundance of protein and/or mRNA for six PG-regulated putative ETS-responsive genes was noted in day 11 but not day 4 CL. Results reveal insight into stage-specific gene expression in bovine CL in response to PG and potential transcriptional mediators of luteolysis.

journal_name

Physiol Genomics

journal_title

Physiological genomics

authors

Mondal M,Schilling B,Folger J,Steibel JP,Buchnick H,Zalman Y,Ireland JJ,Meidan R,Smith GW

doi

10.1152/physiolgenomics.00155.2010

subject

Has Abstract

pub_date

2011-04-27 00:00:00

pages

447-56

issue

8

eissn

1094-8341

issn

1531-2267

pii

physiolgenomics.00155.2010

journal_volume

43

pub_type

杂志文章
  • Loss of bone marrow adrenergic beta 1 and 2 receptors modifies transcriptional networks, reduces circulating inflammatory factors, and regulates blood pressure.

    abstract::Hypertension (HTN) is a prevalent condition with complex etiology and pathophysiology. Evidence exists of significant communication between the nervous system and the immune system (IS), and there appears to be a direct role for inflammatory bone marrow (BM) cells in the pathophysiology of hypertension. However, the m...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00039.2016

    authors: Ahmari N,Schmidt JT,Krane GA,Malphurs W,Cunningham BE,Owen JL,Martyniuk CJ,Zubcevic J

    更新日期:2016-07-01 00:00:00

  • Iron-related transcriptomic variations in CaCo-2 cells, an in vitro model of intestinal absorptive cells.

    abstract::Regulation of iron absorption by duodenal enterocytes is essential for the maintenance of homeostasis by preventing iron deficiency or overload. Despite the identification of a number of genes implicated in iron absorption and its regulation, it is likely that further factors remain to be identified. For that purpose,...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00297.2005

    authors: Chicault C,Toutain B,Monnier A,Aubry M,Fergelot P,Le Treut A,Galibert MD,Mosser J

    更新日期:2006-06-16 00:00:00

  • Novel technique of aortic banding followed by gene transfer during hypertrophy and heart failure.

    abstract::Aortic banding in the rat has become a popular method to induce left ventricular (LV) hypertrophy and heart failure. However, because of often extensive intrathoracic adhesions and inflammatory cell infiltrates resulting from the traditional surgical approach, an uncomplicated second thoracic incision for genetic mani...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00035.2001

    authors: Del Monte F,Butler K,Boecker W,Gwathmey JK,Hajjar RJ

    更新日期:2002-01-01 00:00:00

  • Implementation of convolutional neural network approach for COVID-19 disease detection.

    abstract::In this paper, two novel, powerful, and robust convolutional neural network (CNN) architectures are designed and proposed for two different classification tasks using publicly available data sets. The first architecture is able to decide whether a given chest X-ray image of a patient contains COVID-19 or not with 98.9...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00084.2020

    authors: Irmak E

    更新日期:2020-12-01 00:00:00

  • Epigenetic differences between male and female bovine blastocysts produced in vitro.

    abstract::Epigenetic differences between male and female bovine blastocysts provide a plausible link between physiological and gene transcription differences observed between male and female embryos. The aim of this study was to examine sex-related epigenetic differences in bovine blastocysts produced in vitro. Oocytes were mat...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00234.2007

    authors: Bermejo-Alvarez P,Rizos D,Rath D,Lonergan P,Gutierrez-Adan A

    更新日期:2008-01-17 00:00:00

  • Suppression subtractive hybridization analysis of low-protein diet- and vitamin D-induced gene expression from rat kidney inner medullary base.

    abstract::Protein restriction and hypercalcemia result in a urinary concentrating defect in rats and humans. Previous tubular perfusion studies show that there is an increased active urea transport activity in the initial inner medullary (IM) collecting duct in low-protein diet (LPD) and vitamin D (Vit D) animal models. To inve...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00129.2009

    authors: Chen G,Yang Y,Fröhlich O,Klein JD,Sands JM

    更新日期:2010-05-01 00:00:00

  • Genetic influence on exercise-induced changes in physical function among mobility-limited older adults.

    abstract::To date, physical exercise is the only intervention consistently demonstrated to attenuate age-related declines in physical function. However, variability exists in seniors' responsiveness to training. One potential source of variability is the insertion (I allele) or deletion (D allele) of a 287 bp fragment in intron...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00169.2013

    authors: Buford TW,Hsu FC,Brinkley TE,Carter CS,Church TS,Dodson JA,Goodpaster BH,McDermott MM,Nicklas BJ,Yank V,Johnson JA,Pahor M,LIFE Research Group.

    更新日期:2014-03-01 00:00:00

  • Genomic dissection of the cytokine-controlled STAT5 signaling network in liver.

    abstract::Growth hormone (GH) controls the physiology and pathophysiology of the liver, and its signals are conducted by two members of the family of signal transducers and activators of transcription, STAT5A and STAT5B. Mice in which the Stat5a/b locus has been inactivated specifically in hepatocytes display GH resistance, the...

    journal_title:Physiological genomics

    pub_type: 杂志文章,评审

    doi:10.1152/physiolgenomics.00048.2008

    authors: Hosui A,Hennighausen L

    更新日期:2008-07-15 00:00:00

  • Rapid changes in gene expression direct rapid shifts in intestinal form and function in the Burmese python after feeding.

    abstract::Snakes provide a unique and valuable model system for studying the extremes of physiological remodeling because of the ability of some species to rapidly upregulate organ form and function upon feeding. The predominant model species used to study such extreme responses has been the Burmese python because of the extrem...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00131.2014

    authors: Andrew AL,Card DC,Ruggiero RP,Schield DR,Adams RH,Pollock DD,Secor SM,Castoe TA

    更新日期:2015-05-01 00:00:00

  • Transcriptional reprogramming and ultrastructure during atrophy and recovery of mouse soleus muscle.

    abstract::This study investigated the use of the hindlimb suspension (HS) and reloading model of mice for the mapping of ultrastructural and gene expressional alterations underlying load-dependent muscular adaptations. Mice were hindlimb suspended for 7 days or kept as controls (n = 12). Soleus muscles were harvested after HS (...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00100.2004

    authors: Däpp C,Schmutz S,Hoppeler H,Flück M

    更新日期:2004-12-15 00:00:00

  • A novel genetic locus modulates infarct volume independently of the extent of collateral circulation.

    abstract::In the mouse model of permanent, middle cerebral artery occlusion, infarct volume varies widely across inbred strains but generally is inversely correlated with collateral vessel number. However, we also observed certain mouse strains that share similar collateral vessel anatomy but exhibit significantly different inf...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00063.2013

    authors: Chu PL,Keum S,Marchuk DA

    更新日期:2013-09-03 00:00:00

  • Integrative pathway knowledge bases as a tool for systems molecular medicine.

    abstract::There exists a sense of urgency to begin to generate a cohesive assembly of biomedical knowledge as the pace of knowledge accumulation accelerates. The urgency is in part driven by the emergence of systems molecular medicine that emphasizes the combination of systems analysis and molecular dissection in the future of ...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00002.2007

    authors: Liang M

    更新日期:2007-08-20 00:00:00

  • Roles of estrogen receptor-alpha in mediating life span: the hypothalamic deregulation hypothesis.

    abstract::In several species caloric restriction (CR) extends life span. In this paper we integrate data from studies on CR and other sources to articulate the hypothalamic deregulation hypothesis by which estrogen receptor-alpha (ER-α) signaling in the hypothalamus and limbic system affects life span under the stress of CR in ...

    journal_title:Physiological genomics

    pub_type: 杂志文章,评审

    doi:10.1152/physiolgenomics.00073.2016

    authors: Gouw AM,Efe G,Barakat R,Preecha A,Mehdizadeh M,Garan SA,Brooks GA

    更新日期:2017-02-01 00:00:00

  • Dynamic macrophage polarization-specific miRNA patterns reveal increased soluble VEGF receptor 1 by miR-125a-5p inhibition.

    abstract::Dynamic, epigenetic mechanisms can regulate macrophage phenotypes following exposure to different stimulating conditions and environments. However, temporal patterns of microRNAs (miRNAs or miRs) across multiple macrophage polarization phenotypes have not been defined. We determined miRNA expression in bone marrow-der...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00098.2015

    authors: Melton DW,Lei X,Gelfond JA,Shireman PK

    更新日期:2016-05-01 00:00:00

  • Transcriptomes of purified gastric ECL and parietal cells: identification of a novel pathway regulating acid secretion.

    abstract::The gastric entero-chromaffin-like (ECL) cell plays a key regulatory role in peripheral regulation of acid secretion due to the release of histamine that stimulates acid secretion by the parietal cell. Studies in intact animals, gastric glands, and isolated cells after short-term culture have shown expression of stimu...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00271.2005

    authors: Lambrecht NW,Yakubov I,Zer C,Sachs G

    更新日期:2006-03-13 00:00:00

  • Chicken genomics resource: sequencing and annotation of 35,407 ESTs from single and multiple tissue cDNA libraries and CAP3 assembly of a chicken gene index.

    abstract::Its accessibility, unique evolutionary position, and recently assembled genome sequence have advanced the chicken to the forefront of comparative genomics and developmental biology research as a model organism. Several chicken expressed sequence tag (EST) projects have placed the chicken in 10th place for accrued ESTs...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00207.2005

    authors: Carre W,Wang X,Porter TE,Nys Y,Tang J,Bernberg E,Morgan R,Burnside J,Aggrey SE,Simon J,Cogburn LA

    更新日期:2006-05-16 00:00:00

  • High cardiorespiratory fitness can reduce glycated hemoglobin levels regardless of polygenic risk for Type 2 diabetes mellitus in nondiabetic Japanese men.

    abstract::High cardiorespiratory fitness (CRF) is associated with a reduced risk of Type 2 diabetes mellitus (T2DM) and improved β-cell function; genetic factors also determine these risks. This cross-sectional study investigated whether CRF modifies the association of polygenic risk of T2DM with glucose metabolism in nondiabet...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00027.2014

    authors: Tanisawa K,Ito T,Sun X,Ise R,Oshima S,Cao ZB,Sakamoto S,Tanaka M,Higuchi M

    更新日期:2014-07-15 00:00:00

  • A mini review: Proteomics approaches to understand disused vs. exercised human skeletal muscle.

    abstract::Immobilization, bed rest, or denervation leads to muscle disuse and subsequent skeletal muscle atrophy. Muscle atrophy can also occur as a component of various chronic diseases such as cancer, AIDS, sepsis, diabetes, and chronic heart failure or as a direct result of genetic muscle disorders. In addition to this atrop...

    journal_title:Physiological genomics

    pub_type: 杂志文章,评审

    doi:10.1152/physiolgenomics.00043.2018

    authors: Cho Y,Ross RS

    更新日期:2018-09-01 00:00:00

  • Comprehensive transthoracic cardiac imaging in mice using ultrasound biomicroscopy with anatomical confirmation by magnetic resonance imaging.

    abstract::High-frequency ultrasound biomicroscopy (UBM) has recently emerged as a high-resolution means of phenotyping genetically altered mice and has great potential to evaluate the cardiac morphology and hemodynamics of mouse mutants. However, there is no standard procedure of in vivo transthoracic cardiac imaging using UBM ...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00026.2004

    authors: Zhou YQ,Foster FS,Nieman BJ,Davidson L,Chen XJ,Henkelman RM

    更新日期:2004-07-08 00:00:00

  • Noninjurious mechanical ventilation activates a proinflammatory transcriptional program in the lung.

    abstract::Mechanical ventilation is a life-saving intervention in patients with respiratory failure. However, human and animal studies have demonstrated that mechanical ventilation using large tidal volumes (>or=12 ml/kg) induces a potent inflammatory response and can cause acute lung injury. We hypothesized that mechanical ven...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00027.2009

    authors: Gharib SA,Liles WC,Klaff LS,Altemeier WA

    更新日期:2009-05-13 00:00:00

  • Improved method for the analysis of membrane proteins by mass spectrometry.

    abstract::Membrane-bound and membrane-associated proteins are difficult to analyze by mass spectrometry, since the association with lipids impedes the isolation and solubilization of the proteins in buffers suitable for mass spectrometry and the efficient generation of positively charged peptide ions by electrospray ionization....

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00279.2006

    authors: Mirza SP,Halligan BD,Greene AS,Olivier M

    更新日期:2007-06-19 00:00:00

  • Functional properties of skeletal muscle from transgenic animals with upregulated heat shock protein 70.

    abstract::The influence of inducible heat stress proteins on protecting contracting skeletal muscle against fatigue-induced injury was investigated. A line of transgenic mice overexpressing the inducible form of the 72-kDa heat shock protein (HSP72) in skeletal muscles was used. We examined the relationship between muscle contr...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.2000.4.1.25

    authors: Nosek TM,Brotto MA,Essig DA,Mestril R,Conover RC,Dillmann WH,Kolbeck RC

    更新日期:2000-11-09 00:00:00

  • Gene expression of the liver in response to chronic hypoxia.

    abstract::Hypoxia is an important ecological, evolutionary, and biomedical stressor. While physiological acclimatization of mammals to hypoxia is well studied, the variation in gene expression that underlies acclimatization is not well studied. We acclimatized inbred mice for 32 days to hypoxic conditions that simulated altitud...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00075.2009

    authors: Baze MM,Schlauch K,Hayes JP

    更新日期:2010-05-01 00:00:00

  • Microarray analyses identify molecular biomarkers of Atlantic salmon macrophage and hematopoietic kidney response to Piscirickettsia salmonis infection.

    abstract::Piscirickettsia salmonis is the intracellular bacterium that causes salmonid rickettsial septicemia, an infectious disease that kills millions of farmed fish each year. The mechanisms used by P. salmonis to survive and replicate within host cells are not known. Piscirickettsiosis causes severe necrosis of hematopoieti...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00036.2004

    authors: Rise ML,Jones SR,Brown GD,von Schalburg KR,Davidson WS,Koop BF

    更新日期:2004-12-15 00:00:00

  • LncRNA IUR downregulates ZEB1 by upregulating miR-200 to inhibit prostate carcinoma.

    abstract::We in this study investigated the role of imatinib-upregulated lncRNA (IUR) in prostate carcinoma (PC). We observed that IUR was downregulated in PC, and its expression levels decreased with the increase of clinical stages. In PC tissues, microRNA (miR)-200 was positively, while ZEB1 was inversely correlated with IUR....

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00062.2019

    authors: Sun L,Chen T,Li T,Yu J

    更新日期:2019-11-01 00:00:00

  • Exercise-induced changes in insulin action are associated with ACE gene polymorphisms in older adults.

    abstract::We evaluated the association between insulin resistance and the angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) gene polymorphism in a group of older hypertensive subjects (63 +/- 1 yr, n = 35) before and after a 6-mo aerobic exercise program (AEX). Insulin sensitivity index (S(I)), assessed by the freq...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00048.2002

    authors: Dengel DR,Brown MD,Ferrell RE,Reynolds TH 4th,Supiano MA

    更新日期:2002-10-29 00:00:00

  • Quantitative trait loci for impaired glucose tolerance in nondiabetic SM/J and A/J mice.

    abstract::The SMXA-5 recombinant inbred strain, which was established from nondiabetic parental SM/J and A/J mice, develops diabetic phenotypes such as impaired glucose tolerance. The combination of diabetogenic genes in the SM/J and A/J genomes impairs glucose tolerance in SMXA-5 mice. Using (SM/J x SMXA-5)F2 mice fed a high-f...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00027.2008

    authors: Hada N,Kobayashi M,Fujiyoshi M,Ishikawa A,Kuga M,Nishimura M,Ebihara S,Ohno T,Horio F

    更新日期:2008-09-17 00:00:00

  • Influence of the microenvironment on cell fate determination and migration.

    abstract::Several critical cell functions are influenced not only by internal cellular machinery but also by external mechanical and biochemical cues from the surrounding microenvironment. Slight changes to the microenvironment can result in dramatic changes to the cell's phenotype; for example, a change in the nutrients or pH ...

    journal_title:Physiological genomics

    pub_type: 杂志文章,评审

    doi:10.1152/physiolgenomics.00170.2013

    authors: Bloom AB,Zaman MH

    更新日期:2014-05-01 00:00:00

  • Quantitative PCR-based approach for rapid phage display analysis: a foundation for high throughput vascular proteomic profiling.

    abstract::Functional proteomic strategies offer unique advantages over current molecular array approaches, as the epitopes identified can directly provide bioactive peptides for investigational and/or translational applications. The vascular endothelium is well suited to proteomic assessment by in vivo phage display, but extens...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00025.2006

    authors: Ballard VL,Holm JM,Edelberg JM

    更新日期:2006-08-16 00:00:00

  • Changes in behavior and gene expression induced by caloric restriction in C57BL/6 mice.

    abstract::Caloric restriction (CR) is an effective method for prevention of age-associated diseases as well as overweight and obesity; however, there is controversy regarding the effects of dieting regimens on behavior. In this study, we investigated two different dieting regimens: repeated fasting and refeeding (RFR) and daily...

    journal_title:Physiological genomics

    pub_type: 杂志文章

    doi:10.1152/physiolgenomics.00082.2009

    authors: Yamamoto Y,Tanahashi T,Kawai T,Chikahisa S,Katsuura S,Nishida K,Teshima-Kondo S,Sei H,Rokutan K

    更新日期:2009-11-06 00:00:00