Dead or alive: gene expression profiles of advanced atherosclerotic plaques from autopsy and surgery.

abstract：:Abnormalities in dopamine production and receptor function have been described in human essential hypertension and rodent models of genetic hypertension. Under normal conditions, D(1)-like receptors (D(1) and D(5)) inhibit sodium transport in the kidney and intestine. However, in the Dahl salt-sensitive and spontaneou...

journal_title：Physiological genomics

authors： Zeng C,Sanada H,Watanabe H,Eisner GM,Felder RA,Jose PA

更新日期：2004-11-17 00:00:00

abstract：:The cardiovascular restricted transcription factor CHF1/Hey2 has been previously shown to regulate the smooth muscle response to growth factors. To determine how CHF1/Hey2 affects the smooth muscle response to growth factors, we performed a genomic screen for transcripts that are differentially expressed in wild-type ...

journal_title：Physiological genomics

authors： Shirvani SM,Mookanamparambil L,Ramoni MF,Chin MT

更新日期：2007-06-19 00:00:00

abstract：:This study investigated the use of the hindlimb suspension (HS) and reloading model of mice for the mapping of ultrastructural and gene expressional alterations underlying load-dependent muscular adaptations. Mice were hindlimb suspended for 7 days or kept as controls (n = 12). Soleus muscles were harvested after HS (...

journal_title：Physiological genomics

authors： Däpp C,Schmutz S,Hoppeler H,Flück M

更新日期：2004-12-15 00:00:00

abstract：:Several vasoregulatory systems including the renin-angiotensin system, sympathetic vasoregulation, and cytokine release have been studied extensively. The aim of the present study was to establish a physiogenomic screening model for differentially expressed genes in the regulation of blood pressure that might give a h...

journal_title：Physiological genomics

authors： Westhoff TH,Scheid S,Tölle M,Kaynak B,Schmidt S,Zidek W,Sperling S,van der Giet M

更新日期：2005-09-21 00:00:00

abstract：:Resiquimod is a compound belonging to the imidazoquinoline family of compounds known to signal through Toll-like receptor 7. Resiquimod treatment has been demonstrated to inhibit the development of allergen induced asthma in experimental models. The aim of the present study was to elucidate the molecular processes tha...

journal_title：Physiological genomics

authors： Camateros P,Kanagaratham C,Henri J,Sladek R,Hudson TJ,Radzioch D

更新日期：2009-08-07 00:00:00

abstract：:Exercise as well as hypoxia cause an increase in angiogenesis, changes in mitochondrial density and alterations in metabolism, but it is still under debate whether the hypoxia inducible factor (HIF) is active during both situations. In this study gene expression analysis of zebrafish larvae that were raised under norm...

journal_title：Physiological genomics

authors： Kopp R,Köblitz L,Egg M,Pelster B

更新日期：2011-05-13 00:00:00

abstract：:Since the discovery of the microbiome in humans, it has been studied in many mammalian species. Different microbiological communities with variable richness and diversity have been found among these species in distinct areas of the reproductive tract. Human studies have shown that the composition of the microbiome is ...

journal_title：Physiological genomics

authors： Heil BA,Paccamonti DL,Sones JL

更新日期：2019-08-01 00:00:00

abstract：:It is generally accepted that exhausting endurance exercise exhibits strong effects on the immune system. Such effects have been attributed to changes in the cellular composition of peripheral blood as well as to changes in the expression of plausible candidate genes. The list of candidate genes is far from being comp...

journal_title：Physiological genomics

authors： Zieker D,Fehrenbach E,Dietzsch J,Fliegner J,Waidmann M,Nieselt K,Gebicke-Haerter P,Spanagel R,Simon P,Niess AM,Northoff H

更新日期：2005-11-17 00:00:00

abstract：:The objectives of this study were to examine systemic insulin response to a glucose tolerance test (GTT) and transcript abundance of genes of the insulin signaling pathway in skeletal muscle, during both dietary restriction and re-alimentation-induced compensatory growth. Holstein Friesian bulls were blocked to one of...

journal_title：Physiological genomics

authors： Keogh K,Kenny DA,Kelly AK,Waters SM

更新日期：2015-08-01 00:00:00

abstract：:As the amount of information available to biologists increases exponentially, data analysis becomes progressively more challenging. Sequence homology has been a traditional tool in the researchers' armamentarium; it is a very versatile instrument and can be employed to assist in numerous tasks, from establishing the f...

journal_title：Physiological genomics

authors： Turchin A,Kohane IS

更新日期：2002-12-03 00:00:00

abstract：:The relative importance of regulatory versus structural evolution for the evolution of different biological systems is a subject of controversy. The primacy of regulatory evolution in the diversification of morphological traits has been promoted by many evolutionary developmental biologists. For physiological traits, ...

journal_title：Physiological genomics

authors： Rosati B,Dong M,Cheng L,Liou SR,Yan Q,Park JY,Shiang E,Sanguinetti M,Wang HS,McKinnon D

更新日期：2008-11-12 00:00:00

abstract：:Teleost fish represent unique models to study the role of neuroestrogens because of the extremely high activity of brain aromatase (AroB; the product of cyp19a1b). Aromatase respectively converts androstenedione and testosterone to estrone and 17beta-estradiol (E2). Specific inhibition of aromatase activity by fadrozo...

journal_title：Physiological genomics

authors： Zhang D,Popesku JT,Martyniuk CJ,Xiong H,Duarte-Guterman P,Yao L,Xia X,Trudeau VL

更新日期：2009-08-07 00:00:00

abstract：:Uncoupling protein 1 (UCP1) is the first UCP described. It belongs to the family of mitochondrial carrier proteins and is expressed mainly in brown adipose tissue. Recently, the family of the UCPs has rapidly been growing due to the successive cloning of UCP2, UCP3, UCP4, and UCP5, also called brain mitochondrial carr...

journal_title：Physiological genomics

authors： Keller PA,Lehr L,Giacobino JP,Charnay Y,Assimacopoulos-Jeannet F,Giovannini N

更新日期：2005-08-11 00:00:00

abstract：:Cardiac microvascular endothelial cells (CMVECs) are the most numerous cells in the myocardium and orchestrate cardiogenesis during development, regulate adult cardiac function, and modulate pathophysiology of heart failure. It has been shown that the transcriptome of CMVECs differs from other endothelial cell types, ...

journal_title：Physiological genomics

authors： Vermeulen Z,Mateiu L,Dugaucquier L,De Keulenaer GW,Segers VFM

更新日期：2019-06-01 00:00:00

abstract：:The bacterium Piscirickettsia salmonis is the etiological agent of salmonid rickettsial septicemia (SRS), a severe disease that causes major economic losses to the Atlantic salmon aquaculture industry every year. Little is known about the infective strategy of P. salmonis, which is able to infect, survive within, and ...

journal_title：Physiological genomics

authors： Tacchi L,Bron JE,Taggart JB,Secombes CJ,Bickerdike R,Adler MA,Takle H,Martin SA

更新日期：2011-11-07 00:00:00

abstract：:A single point mutation in a novel immune-associated nucleotide gene 5 (Ian5) coincides with severe T cell lymphopenia in BB rats. We used a transgenic rescue approach in lymphopenic BB-derived congenic F344.lyp/lyp rats to determine whether this mutation is responsible for lymphopenia and to establish the functional ...

journal_title：Physiological genomics

authors： Michalkiewicz M,Michalkiewicz T,Ettinger RA,Rutledge EA,Fuller JM,Moralejo DH,Van Yserloo B,MacMurray AJ,Kwitek AE,Jacob HJ,Lander ES,Lernmark A

更新日期：2004-10-04 00:00:00

abstract：:Valve formation during embryonic heart development involves a complex interplay of regional specification, cell transformations, and remodeling events. While many studies have addressed the role of specific genes during this process, a global understanding of the genetic basis for the regional specification and develo...

journal_title：Physiological genomics

authors： Vrljicak P,Chang AC,Morozova O,Wederell ED,Niessen K,Marra MA,Karsan A,Hoodless PA

更新日期：2010-02-04 00:00:00

abstract：:The process of parturition involves the complex interplay of factors that change the excitability and contractile activity of the uterus. We have compared the relative gene expression profile of myometrium from rats before parturition (21 days pregnant) and during delivery, using high-density DNA microarray. Of 8,740 ...

journal_title：Physiological genomics

authors： Helguera G,Eghbali M,Sforza D,Minosyan TY,Toro L,Stefani E

更新日期：2009-01-08 00:00:00

abstract：:The nucleus tractus solitarii (NTS) controls the cardiovascular system during exercise, and alteration of its function may underlie exercise-induced cardiovascular adaptation. To understand the molecular basis of the NTS's plasticity in regulating blood pressure (BP) and its potential contribution to the antihypertens...

journal_title：Physiological genomics

authors： Waki H,Gouraud SS,Bhuiyan ME,Takagishi M,Yamazaki T,Kohsaka A,Maeda M

更新日期：2013-01-07 00:00:00

abstract：:Dynamic, epigenetic mechanisms can regulate macrophage phenotypes following exposure to different stimulating conditions and environments. However, temporal patterns of microRNAs (miRNAs or miRs) across multiple macrophage polarization phenotypes have not been defined. We determined miRNA expression in bone marrow-der...

journal_title：Physiological genomics

authors： Melton DW,Lei X,Gelfond JA,Shireman PK

更新日期：2016-05-01 00:00:00

abstract：:Functional proteomic strategies offer unique advantages over current molecular array approaches, as the epitopes identified can directly provide bioactive peptides for investigational and/or translational applications. The vascular endothelium is well suited to proteomic assessment by in vivo phage display, but extens...

journal_title：Physiological genomics

authors： Ballard VL,Holm JM,Edelberg JM

更新日期：2006-08-16 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChR) are assembled from a pool of nine alpha-subunits and three beta-subunits into functional pentamers in peripheral autonomic neurons. The contribution of different subunits to native, physiologically important nAChR for synaptic transmission in autonomic ganglia is unclear. Here...

journal_title：Physiological genomics

authors： Deck J,Bibevski S,Gnecchi-Ruscone T,Bellina V,Montano N,Dunlap ME

更新日期：2005-06-16 00:00:00

abstract：:A high-resolution time series of transcript abundance was generated to describe global expression dynamics in response to nutrition in Drosophila. Nonparametric change-point statistics revealed that within 7 h of feeding upon yeast, transcript levels changed significantly for approximately 3,500 genes or 20% of the Dr...

journal_title：Physiological genomics

authors： Gershman B,Puig O,Hang L,Peitzsch RM,Tatar M,Garofalo RS

更新日期：2007-03-14 00:00:00

abstract：:Valproic acid (VPA) and lithium are widely used in the treatment of bipolar disorder. However, the underlying mechanism of action of these drugs is not clearly understood. We used RNA-Seq analysis to examine the global profile of gene expression in a rat serotonergic cell line (RN46A) after exposure to these two mood ...

journal_title：Physiological genomics

authors： Balasubramanian D,Pearson JF,Kennedy MA

更新日期：2019-02-01 00:00:00

abstract：:This study was the first to explore the potential role of the myostatin (GDF8) pathway in relation to muscle strength and estimated muscle cross-sectional area in humans using linkage analysis with a candidate gene approach. In young male sibs (n = 329) 11 polymorphic markers in or near 10 candidate genes from the myo...

journal_title：Physiological genomics

authors： Huygens W,Thomis MA,Peeters MW,Aerssens J,Janssen R,Vlietinck RF,Beunen G

更新日期：2004-05-19 00:00:00

abstract：:Cultured shrimp are continuously exposed to variable environmental conditions that have been associated with stress and subsequent outbreaks of disease. To investigate the effect of environmental stress on Penaeus monodon gene expression, a 3,853 random cDNA microarray chip was generated with clones originating from s...

journal_title：Physiological genomics

authors： de la Vega E,Hall MR,Wilson KJ,Reverter A,Woods RG,Degnan BM

更新日期：2007-09-19 00:00:00

abstract：:Despite an abundance of evidence to the contrary from animal studies, large clinical trials on humans have shown that estrogen administered to postmenopausal women increases the risk of cardiovascular disease. However, timing may be everything, as estrogen is often administered immediately after ovariectomy (Ovx) in a...

journal_title：Physiological genomics

authors： Pechenino AS,Lin L,Mbai FN,Lee AR,He XM,Stallone JN,Knowlton AA

更新日期：2011-09-22 00:00:00

abstract：:In this paper, two novel, powerful, and robust convolutional neural network (CNN) architectures are designed and proposed for two different classification tasks using publicly available data sets. The first architecture is able to decide whether a given chest X-ray image of a patient contains COVID-19 or not with 98.9...

journal_title：Physiological genomics

authors： Irmak E

更新日期：2020-12-01 00:00:00

abstract：:A novel coronavirus disease, COVID-19, has created a global pandemic in 2020, posing an enormous challenge to healthcare systems and affected communities. COVID-19 is caused by Severe Acute Respiratory Syndrome (SARS)-CoronaVirus-2 (CoV-2) that manifests as bronchitis, pneumonia, or a severe respiratory illness. SARS-...

journal_title：Physiological genomics

authors： Ashraf UM,Abokor AA,Edwards JM,Waigi EW,Royfman RS,Hasan SA,Smedlund KB,Hardy AMG,Chakravarti R,Koch LG

更新日期：2020-12-04 00:00:00

abstract：:Sulfate plays an essential role during growth, development and cellular metabolism. In this study, we characterized the function and structure of the zebrafish (Danio rerio) Na+-sulfate cotransporter 1 (NaS1) cDNA and gene (slc13a1). Zebrafish NaS1 encodes a protein of 583 amino acids with 13 putative transmembrane do...

journal_title：Physiological genomics

authors： Markovich D,Romano A,Storelli C,Verri T

更新日期：2008-08-15 00:00:00