HIF signaling and overall gene expression changes during hypoxia and prolonged exercise differ considerably.

abstract：:We evaluated the association between insulin resistance and the angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) gene polymorphism in a group of older hypertensive subjects (63 +/- 1 yr, n = 35) before and after a 6-mo aerobic exercise program (AEX). Insulin sensitivity index (S(I)), assessed by the freq...

journal_title：Physiological genomics

authors： Dengel DR,Brown MD,Ferrell RE,Reynolds TH 4th,Supiano MA

更新日期：2002-10-29 00:00:00

abstract：:Branchial ammonia transport in freshwater teleosts is not well understood. Most studies conclude that NH(3) diffuses out of the gill and becomes protonated to NH(4)(+) in an acidified gill boundary layer. Rhesus (Rh) proteins are new members of the ammonia transporter superfamily and rainbow trout possess genes encodi...

journal_title：Physiological genomics

authors： Nawata CM,Hung CC,Tsui TK,Wilson JM,Wright PA,Wood CM

更新日期：2007-11-14 00:00:00

abstract：:Obesity is influenced by genetics and diet and has wide ranging comorbidities, including anxiety and depressive disorders. Outbred heterogeneous stock (HS) rats are used for fine-genetic mapping of complex traits and may be useful for understanding gene by diet interactions. In this study, HS rats were fed diets conta...

journal_title：Physiological genomics

authors： Deal AW,Seshie O,Lenzo A,Cooper N,Ozimek N,Solberg Woods LC

更新日期：2020-09-01 00:00:00

abstract：:Growth hormone is one of few pharmacologic agents known to augment milk production in humans. We hypothesized that recombinant human GH (rhGH) increases the expression of cell proliferation and milk protein synthesis genes. Sequential milk and blood samples collected over four days were obtained from five normal lacta...

journal_title：Physiological genomics

authors： Maningat PD,Sen P,Rijnkels M,Hadsell DL,Bray MS,Haymond MW

更新日期：2011-04-27 00:00:00

abstract：:The relative importance of regulatory versus structural evolution for the evolution of different biological systems is a subject of controversy. The primacy of regulatory evolution in the diversification of morphological traits has been promoted by many evolutionary developmental biologists. For physiological traits, ...

journal_title：Physiological genomics

authors： Rosati B,Dong M,Cheng L,Liou SR,Yan Q,Park JY,Shiang E,Sanguinetti M,Wang HS,McKinnon D

更新日期：2008-11-12 00:00:00

abstract：:Essential hypertension is highly prevalent in the elderly population, exceeding 70% in people older than 60 yr of age, and remains a leading risk factor for heart disease, stroke, and chronic renal disease. Elucidation of genetic determinants is critical but remains a challenge due to its complex, multifactorial patho...

journal_title：Physiological genomics

authors： Glorioso N,Herrera VL,Didishvili T,Argiolas G,Troffa C,Bulla P,Bulla E,Ruiz-Opazo N

更新日期：2011-11-07 00:00:00

abstract：:The human miR-29 family of microRNAs has three mature members, miR-29a, miR-29b, and miR-29c. miR-29s are encoded by two gene clusters. Binding sites for several transcriptional factors have been identified in the promoter regions of miR-29 genes. The miR-29 family members share a common seed region sequence and are p...

journal_title：Physiological genomics

authors： Kriegel AJ,Liu Y,Fang Y,Ding X,Liang M

更新日期：2012-02-27 00:00:00

abstract：:We previously constructed a congenic mouse, B6.S-D2Mit194-D2Mit311 (B6.S-2) with 27 Mb of SPRET/Ei donor DNA on distal chromosome 2 in a C57BL/6J background that captured an obesity quantitative trait locus (QTL). Mice homozygous for SPRET/Ei alleles at the donor region had decreased body weight and obesity-related ph...

journal_title：Physiological genomics

authors： Chiu S,Kim K,Haus KA,Espinal GM,Millon LV,Warden CH

更新日期：2007-09-19 00:00:00

abstract：:Valproic acid (VPA) and lithium are widely used in the treatment of bipolar disorder. However, the underlying mechanism of action of these drugs is not clearly understood. We used RNA-Seq analysis to examine the global profile of gene expression in a rat serotonergic cell line (RN46A) after exposure to these two mood ...

journal_title：Physiological genomics

authors： Balasubramanian D,Pearson JF,Kennedy MA

更新日期：2019-02-01 00:00:00

abstract：:Large datasets from -omics studies need to be deeply investigated. The aim of this paper is to provide a new method (LEM method) for the search of transcriptome and metabolome connections. The heuristic algorithm here described extends the classical canonical correlation analysis (CCA) to a high number of variables (w...

journal_title：Physiological genomics

authors： Valour D,Hue I,Grimard B,Valour B

更新日期：2013-07-15 00:00:00

abstract：:Sulfate plays an essential role during growth, development and cellular metabolism. In this study, we characterized the function and structure of the zebrafish (Danio rerio) Na+-sulfate cotransporter 1 (NaS1) cDNA and gene (slc13a1). Zebrafish NaS1 encodes a protein of 583 amino acids with 13 putative transmembrane do...

journal_title：Physiological genomics

authors： Markovich D,Romano A,Storelli C,Verri T

更新日期：2008-08-15 00:00:00

abstract：:Bone marrow mononuclear cells (BMMNCs) increase capillary density and reduce fibrosis in rodents after myocardial infarction, resulting in an overall improvement in left ventricular function. Little is known about the effectiveness of BMMNC therapy in hypertensive heart disease. In the current study, we show that deli...

journal_title：Physiological genomics

authors： Parker SJ,Didier DN,Karcher JR,Stodola TJ,Endres B,Greene AS

更新日期：2012-10-02 00:00:00

abstract：:Genetic analysis of polygenic traits in rats and mice has been very useful for finding the approximate chromosomal locations of the genes causing quantitative phenotypic variation, so-called quantitative trait loci (QTL). Further localization of the causative genes and their ultimate identification has, however, prove...

journal_title：Physiological genomics

authors： Rapp JP,Joe B

更新日期：2012-02-01 00:00:00

abstract：:Hypertension is a condition with major cardiovascular and renal complications, affecting nearly a billion patients worldwide. Few validated gene targets are available for pharmacological intervention, so there is a need to identify new biological pathways regulating blood pressure and containing novel targets for trea...

journal_title：Physiological genomics

authors： Puig O,Wang IM,Cheng P,Zhou P,Roy S,Cully D,Peters M,Benita Y,Thompson J,Cai TQ

更新日期：2010-09-01 00:00:00

abstract：:The genetically hypertensive fawn-hooded (FHH/Eur) rat is characterized by the early presence of systolic and glomerular hypertension, progressive proteinuria (UPV), and albuminuria (UAV), and focal glomerulosclerosis, resulting in premature death from renal failure. Previous studies showed that at least five genetic ...

journal_title：Physiological genomics

authors： Provoost AP,Shiozawa M,Van Dokkum RP,Jacob HJ

更新日期：2002-02-28 00:00:00

abstract：:Our objective was to resequence insulin receptor substrate 2 (IRS2) to identify variants associated with obesity- and diabetes-related traits in Hispanic children. Exonic and intronic segments, 5' and 3' flanking regions of IRS2 (∼14.5 kb), were bidirectionally sequenced for single nucleotide polymorphism (SNP) discov...

journal_title：Physiological genomics

authors： Butte NF,Voruganti VS,Cole SA,Haack K,Comuzzie AG,Muzny DM,Wheeler DA,Chang K,Hawes A,Gibbs RA

更新日期：2011-09-22 00:00:00

abstract：:The cardiovascular restricted transcription factor CHF1/Hey2 has been previously shown to regulate the smooth muscle response to growth factors. To determine how CHF1/Hey2 affects the smooth muscle response to growth factors, we performed a genomic screen for transcripts that are differentially expressed in wild-type ...

journal_title：Physiological genomics

authors： Shirvani SM,Mookanamparambil L,Ramoni MF,Chin MT

更新日期：2007-06-19 00:00:00

abstract：:This study investigated the use of the hindlimb suspension (HS) and reloading model of mice for the mapping of ultrastructural and gene expressional alterations underlying load-dependent muscular adaptations. Mice were hindlimb suspended for 7 days or kept as controls (n = 12). Soleus muscles were harvested after HS (...

journal_title：Physiological genomics

authors： Däpp C,Schmutz S,Hoppeler H,Flück M

更新日期：2004-12-15 00:00:00

abstract：:Intracranial aneurysm (IA) is a complex genetic disease for which, to date, 10 loci have been identified by linkage. Identification of the risk-conferring genes in the loci has proven difficult, since the regions often contain several hundreds of genes. An approach to prioritize positional candidate genes for further ...

journal_title：Physiological genomics

authors： Weinsheimer S,Lenk GM,van der Voet M,Land S,Ronkainen A,Alafuzoff I,Kuivaniemi H,Tromp G

更新日期：2007-12-19 00:00:00

abstract：:In the mouse model of permanent, middle cerebral artery occlusion, infarct volume varies widely across inbred strains but generally is inversely correlated with collateral vessel number. However, we also observed certain mouse strains that share similar collateral vessel anatomy but exhibit significantly different inf...

journal_title：Physiological genomics

authors： Chu PL,Keum S,Marchuk DA

更新日期：2013-09-03 00:00:00

abstract：:Hypoxia is a widely occurring condition experienced by diverse organisms under numerous physiological and disease conditions. To probe the molecular mechanisms underlying hypoxia responses and tolerance, we performed a genome-wide screen to identify mutants with enhanced hypoxia tolerance in the model eukaryote, the y...

journal_title：Physiological genomics

authors： Shah AN,Cadinu D,Henke RM,Xin X,Dastidar RG,Zhang L

更新日期：2011-07-27 00:00:00

abstract：:The Wfs1 gene codes for a protein with unknown function, but deficiency in this protein results in a range of neuropsychiatric and neuroendocrine syndromes. In the present study we aimed to find the functional networks influenced by Wfs1 in the hypothalamus. We performed gene expression profiling (Mouse Gene 1.0 ST Ar...

journal_title：Physiological genomics

authors： Kõks S,Soomets U,Plaas M,Terasmaa A,Noormets K,Tillmann V,Vasar E,Fernandes C,Schalkwyk LC

更新日期：2011-12-16 00:00:00

abstract：:In Drosophila larvae, acquired synaptic thermotolerance after heat shock has previously been shown to correlate with the induction of heat shock proteins (Hsps) including HSP70. We tested the hypothesis that synaptic thermotolerance would be significantly diminished in a temperature-sensitive strain (Drosophila heat s...

journal_title：Physiological genomics

authors： Neal SJ,Karunanithi S,Best A,So AK,Tanguay RM,Atwood HL,Westwood JT

更新日期：2006-05-16 00:00:00

abstract：:The gastric entero-chromaffin-like (ECL) cell plays a key regulatory role in peripheral regulation of acid secretion due to the release of histamine that stimulates acid secretion by the parietal cell. Studies in intact animals, gastric glands, and isolated cells after short-term culture have shown expression of stimu...

journal_title：Physiological genomics

authors： Lambrecht NW,Yakubov I,Zer C,Sachs G

更新日期：2006-03-13 00:00:00

abstract：:Abnormalities in dopamine production and receptor function have been described in human essential hypertension and rodent models of genetic hypertension. Under normal conditions, D(1)-like receptors (D(1) and D(5)) inhibit sodium transport in the kidney and intestine. However, in the Dahl salt-sensitive and spontaneou...

journal_title：Physiological genomics

authors： Zeng C,Sanada H,Watanabe H,Eisner GM,Felder RA,Jose PA

更新日期：2004-11-17 00:00:00

abstract：:Slc22 family organic anion and cation transporters (OATs, OCTs, and OCTNs) are transmembrane proteins expressed predominantly in kidney and liver. These proteins mediate the uptake or excretion of numerous physiologically (and pharmacologically) important compounds, and accordingly have been the focus of intensive stu...

journal_title：Physiological genomics

authors： Eraly SA,Monte JC,Nigam SK

更新日期：2004-06-17 00:00:00

abstract：:This study analyzes the electrophysiological cause and behavioral consequence of dopaminergic cell loss in a knockin mouse strain bearing hypersensitive nicotinic alpha4-receptor subunits ("L9'S mice"). Adult brains of L9'S mice show moderate loss of substantia nigra dopaminergic neurons and of striatal dopaminergic i...

journal_title：Physiological genomics

authors： Orb S,Wieacker J,Labarca C,Fonck C,Lester HA,Schwarz J

更新日期：2004-08-11 00:00:00

abstract：:Genetic influences and endurance exercise have been shown to alter circulating concentrations of dehydroepiandrosterone (DHEA) and its sulfated conjugate, DHEAS. We hypothesized that acute resistance exercise (RE) and training (RET) would increase DHEA steroids, and the magnitude of the increase would be influenced by...

journal_title：Physiological genomics

authors： Riechman SE,Fabian TJ,Kroboth PD,Ferrell RE

更新日期：2004-05-19 00:00:00

abstract：:Metazoan akirin genes regulate innate immunity, myogenesis, and carcinogenesis. Invertebrates typically have one family member, while most tetrapod and teleost vertebrates have one to three. We demonstrate an expanded repertoire of eight family members in genomes of four salmonid fishes, owing to paralog preservation ...

journal_title：Physiological genomics

authors： Macqueen DJ,Kristjánsson BK,Johnston IA

更新日期：2010-06-01 00:00:00

abstract：:Carotid atherosclerosis is the primary cause of ischemic stroke. To identify genetic factors contributing to carotid atherosclerosis, we performed quantitative trait locus (QTL) analysis using female mice derived from an intercross between C57BL/6J (B6) and BALB/cJ (BALB) apolipoprotein E (Apoe(-/-)) mice. We started ...

journal_title：Physiological genomics

authors： Rowlan JS,Zhang Z,Wang Q,Fang Y,Shi W

更新日期：2013-04-16 00:00:00