Influence of the microenvironment on cell fate determination and migration.

abstract：:Since inclusion of atherosclerotic tissues from different sources is often indispensable to study the full atherogenic spectrum, we investigated to what extent the expression profiles of advanced, stable atherosclerotic lesions obtained during autopsy and surgery are comparable. The gene expression profiles of human c...

journal_title：Physiological genomics

authors： Sluimer JC,Kisters N,Cleutjens KB,Volger OL,Horrevoets AJ,van den Akker LH,Bijnens AP,Daemen MJ

更新日期：2007-08-20 00:00:00

abstract：:The objectives of this study were to examine systemic insulin response to a glucose tolerance test (GTT) and transcript abundance of genes of the insulin signaling pathway in skeletal muscle, during both dietary restriction and re-alimentation-induced compensatory growth. Holstein Friesian bulls were blocked to one of...

journal_title：Physiological genomics

authors： Keogh K,Kenny DA,Kelly AK,Waters SM

更新日期：2015-08-01 00:00:00

abstract：:Carotid atherosclerosis is the primary cause of ischemic stroke. To identify genetic factors contributing to carotid atherosclerosis, we performed quantitative trait locus (QTL) analysis using female mice derived from an intercross between C57BL/6J (B6) and BALB/cJ (BALB) apolipoprotein E (Apoe(-/-)) mice. We started ...

journal_title：Physiological genomics

authors： Rowlan JS,Zhang Z,Wang Q,Fang Y,Shi W

更新日期：2013-04-16 00:00:00

abstract：:Bioaccumulative environmental estrogen, nonylphenol (NP; 4-nonylphenol), is widely used as a nonionic surfactant and can affect human health. Since genomes of Saccharomyces cerevisiae and higher eukaryotes share many structural and functional similarities, we investigated subcellular effects of NP on S. cerevisiae BY4...

journal_title：Physiological genomics

authors： Bereketoglu C,Arga KY,Eraslan S,Mertoglu B

更新日期：2017-10-01 00:00:00

abstract：:Understanding how vertebrates respond to hypoxia can have important clinical implications. Fish have evolved the ability to survive long exposure to low oxygen levels. However, little is known about the specific changes in gene expression that result from hypoxia. In this study we used a zebrafish cDNA microarray to e...

journal_title：Physiological genomics

authors： Ton C,Stamatiou D,Liew CC

更新日期：2003-04-16 00:00:00

abstract：:In the mouse model of permanent, middle cerebral artery occlusion, infarct volume varies widely across inbred strains but generally is inversely correlated with collateral vessel number. However, we also observed certain mouse strains that share similar collateral vessel anatomy but exhibit significantly different inf...

journal_title：Physiological genomics

authors： Chu PL,Keum S,Marchuk DA

更新日期：2013-09-03 00:00:00

abstract：:We in this study investigated the role of imatinib-upregulated lncRNA (IUR) in prostate carcinoma (PC). We observed that IUR was downregulated in PC, and its expression levels decreased with the increase of clinical stages. In PC tissues, microRNA (miR)-200 was positively, while ZEB1 was inversely correlated with IUR....

journal_title：Physiological genomics

authors： Sun L,Chen T,Li T,Yu J

更新日期：2019-11-01 00:00:00

abstract：:Immobilization, bed rest, or denervation leads to muscle disuse and subsequent skeletal muscle atrophy. Muscle atrophy can also occur as a component of various chronic diseases such as cancer, AIDS, sepsis, diabetes, and chronic heart failure or as a direct result of genetic muscle disorders. In addition to this atrop...

journal_title：Physiological genomics

authors： Cho Y,Ross RS

更新日期：2018-09-01 00:00:00

abstract：:Intracranial aneurysm (IA) is a complex genetic disease for which, to date, 10 loci have been identified by linkage. Identification of the risk-conferring genes in the loci has proven difficult, since the regions often contain several hundreds of genes. An approach to prioritize positional candidate genes for further ...

journal_title：Physiological genomics

authors： Weinsheimer S,Lenk GM,van der Voet M,Land S,Ronkainen A,Alafuzoff I,Kuivaniemi H,Tromp G

更新日期：2007-12-19 00:00:00

abstract：:In recent years, it has become evident that the adult mammalian CNS contains a population of neural stem cells (NSCs) described as immature, undifferentiated, multipotent cells, that may be called upon for repair in neurodegenerative and demyelinating diseases. NSCs may give rise to oligodendrocyte progenitor cells (O...

journal_title：Physiological genomics

authors： Imitola J,Snyder EY,Khoury SJ

更新日期：2003-08-15 00:00:00

abstract：:High-frequency ultrasound biomicroscopy (UBM) has recently emerged as a high-resolution means of phenotyping genetically altered mice and has great potential to evaluate the cardiac morphology and hemodynamics of mouse mutants. However, there is no standard procedure of in vivo transthoracic cardiac imaging using UBM ...

journal_title：Physiological genomics

authors： Zhou YQ,Foster FS,Nieman BJ,Davidson L,Chen XJ,Henkelman RM

更新日期：2004-07-08 00:00:00

abstract：:Gene expression was evaluated in mice divergently selected for 16 generations for heat loss, measured by direct calorimetry. The high (MH) heat loss line has approximately 50% greater heat loss, approximately 35% less body fat, approximately 20% greater feed intake, and twofold greater activity levels than the low (ML...

journal_title：Physiological genomics

authors： Allan MF,Nielsen MK,Pomp D

更新日期：2000-09-08 00:00:00

abstract：:Valve formation during embryonic heart development involves a complex interplay of regional specification, cell transformations, and remodeling events. While many studies have addressed the role of specific genes during this process, a global understanding of the genetic basis for the regional specification and develo...

journal_title：Physiological genomics

authors： Vrljicak P,Chang AC,Morozova O,Wederell ED,Niessen K,Marra MA,Karsan A,Hoodless PA

更新日期：2010-02-04 00:00:00

abstract：:Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that regulates the oxygen-dependent expression of a number of genes. This transcription factor may contribute to the abundant expression of many genes in renal medullary cells that function normally under hypoxic conditions. The present study was d...

journal_title：Physiological genomics

authors： Zou AP,Yang ZZ,Li PL,Cowley AW JR

更新日期：2001-08-28 00:00:00

abstract：:A high-resolution time series of transcript abundance was generated to describe global expression dynamics in response to nutrition in Drosophila. Nonparametric change-point statistics revealed that within 7 h of feeding upon yeast, transcript levels changed significantly for approximately 3,500 genes or 20% of the Dr...

journal_title：Physiological genomics

authors： Gershman B,Puig O,Hang L,Peitzsch RM,Tatar M,Garofalo RS

更新日期：2007-03-14 00:00:00

abstract：:The structural organization of the brain is important for normal brain function and is critical to understand in order to evaluate changes that occur during disease processes. Three-dimensional (3D) imaging of the mouse brain is necessary to appreciate the spatial context of structures within the brain. In addition, t...

journal_title：Physiological genomics

authors： Gleave JA,Wong MD,Dazai J,Altaf M,Henkelman RM,Lerch JP,Nieman BJ

更新日期：2012-08-01 00:00:00

abstract：:Vasopressin is a peptide hormone that regulates renal water excretion in part through its actions on the collecting duct. The regulation occurs in part via control of transcription of genes coding for the water channels aquaporin-2 (Aqp2) and aquaporin-3 (Aqp3). To identify transcription factors expressed in collectin...

journal_title：Physiological genomics

authors： Tchapyjnikov D,Li Y,Pisitkun T,Hoffert JD,Yu MJ,Knepper MA

更新日期：2010-02-04 00:00:00

abstract：:Mouse lines divergently selected for heat loss were evaluated for correlated responses in the hypothalamic transcriptome. High (MH) heat loss mice have approximately 50% greater heat loss, approximately 35% less body fat, approximately 20% greater feed intake, approximately 100% greater locomotor activity levels, and ...

journal_title：Physiological genomics

authors： Wesolowski SR,Allan MF,Nielsen MK,Pomp D

更新日期：2003-04-16 00:00:00

abstract：:Protein restriction and hypercalcemia result in a urinary concentrating defect in rats and humans. Previous tubular perfusion studies show that there is an increased active urea transport activity in the initial inner medullary (IM) collecting duct in low-protein diet (LPD) and vitamin D (Vit D) animal models. To inve...

journal_title：Physiological genomics

authors： Chen G,Yang Y,Fröhlich O,Klein JD,Sands JM

更新日期：2010-05-01 00:00:00

abstract：:The purpose of this study was to identify novel transcriptional events occurring in the aortic wall before angiogenesis. We used a defined tissue culture system that takes advantage of the capacity of rat aortic rings to generate neovessels ex vivo in response to angiogenic factor stimulation. Total RNA isolated from ...

journal_title：Physiological genomics

authors： Aplin AC,Gelati M,Fogel E,Carnevale E,Nicosia RF

更新日期：2006-10-03 00:00:00

abstract：:Repair and regeneration are key processes for tissue maintenance, and their disruption may lead to disease states. Little is known about the molecular mechanisms that underline the repair and regeneration of the digestive tract. The sea cucumber Holothuria glaberrima represents an excellent model to dissect and charac...

journal_title：Physiological genomics

authors： Rojas-Cartagena C,Ortíz-Pineda P,Ramírez-Gómez F,Suárez-Castillo EC,Matos-Cruz V,Rodríguez C,Ortíz-Zuazaga H,García-Arrarás JE

更新日期：2007-10-22 00:00:00

abstract：:Peripheral blood cells are an accessible environment in which to visualize exercise-induced alterations in global gene expression patterns. We aimed to identify a peripheral blood mononuclear cell (PBMC) signature represented by alterations in gene expression, in response to a standardized endurance exercise training ...

journal_title：Physiological genomics

authors： Dias RG,Silva MS,Duarte NE,Bolani W,Alves CR,Junior JR,da Silva JL,de Oliveira PA,Alves GB,de Oliveira EM,Rocha CS,Marsiglia JD,Negrao CE,Krieger EM,Krieger JE,Pereira AC

更新日期：2015-02-01 00:00:00

abstract：:The renin-angiotensin system (RAS), known for its roles in cardiovascular, metabolic, and developmental regulation, is present in both the circulation and in many individual tissues throughout the body. Substantial evidence supports the existence of a brain RAS, though quantification and localization of brain renin ha...

journal_title：Physiological genomics

authors： Xu D,Borges GR,Davis DR,Agassandian K,Sequeira Lopez ML,Gomez RA,Cassell MD,Grobe JL,Sigmund CD

更新日期：2011-03-29 00:00:00

abstract：:microRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through posttranscriptional repression of target genes. miRNAs exert a fundamental level of control over many developmental processes, but their role in the differentiation and development of skeletal muscle from myogenic progenitor cells in hum...

journal_title：Physiological genomics

authors： Sjögren RJ,Egan B,Katayama M,Zierath JR,Krook A

更新日期：2015-03-01 00:00:00

abstract：:This study investigated the use of the hindlimb suspension (HS) and reloading model of mice for the mapping of ultrastructural and gene expressional alterations underlying load-dependent muscular adaptations. Mice were hindlimb suspended for 7 days or kept as controls (n = 12). Soleus muscles were harvested after HS (...

journal_title：Physiological genomics

authors： Däpp C,Schmutz S,Hoppeler H,Flück M

更新日期：2004-12-15 00:00:00

abstract：:Both being dormant cellular states, quiescence and senescence are traditionally considered distinct. Quiescence is reversible to proliferation upon growth signals, whereas senescence is irreversible in physiological conditions. Recent findings, however, suggest that quiescence deepening with a decreased proliferative ...

journal_title：Physiological genomics

authors： Fujimaki K,Yao G

更新日期：2020-11-01 00:00:00

abstract：:This study was the first to explore the potential role of the myostatin (GDF8) pathway in relation to muscle strength and estimated muscle cross-sectional area in humans using linkage analysis with a candidate gene approach. In young male sibs (n = 329) 11 polymorphic markers in or near 10 candidate genes from the myo...

journal_title：Physiological genomics

authors： Huygens W,Thomis MA,Peeters MW,Aerssens J,Janssen R,Vlietinck RF,Beunen G

更新日期：2004-05-19 00:00:00

abstract：:Aside from abnormal angiogenesis, dual endothelin-1/VEGF signal peptide-activated receptor deficiency (DEspR(-/-)) results in aberrant neuroepithelium and neural tube differentiation, thus elucidating DEspR's role in neurogenesis. With the emerging importance of neurogenesis in adulthood, we tested the hypothesis that...

journal_title：Physiological genomics

authors： Herrera VL,Decano JL,Bagamasbad P,Kufahl T,Steffen M,Ruiz-Opazo N

更新日期：2008-11-12 00:00:00

abstract：:alpha-Sarcoglycan-deficient (Sgca-null) mice provide potential for elucidating the pathogenesis of limb girdle muscular dystrophy type 2D (LGMD 2D) as well as for studying the effectiveness of therapeutic strategies. Skeletal muscles of Sgca-null mice demonstrate an early onset of extensive fiber necrosis, degeneratio...

journal_title：Physiological genomics

authors： Consolino CM,Duclos F,Lee J,Williamson RA,Campbell KP,Brooks SV

更新日期：2005-07-14 00:00:00

abstract：:To better understand the genetic basis of essential hypertension, we conducted a quantitative trait locus (QTL) analysis of a population of 207 (BALB/cJ x CBA/CaJ) F(2) male mice to identify genomic regions that regulate blood pressure, heart rate, and heart weight. We identified two loci, Bpq6 (blood pressure quantit...

journal_title：Physiological genomics

authors： Sugiyama F,Churchill GA,Li R,Libby LJ,Carver T,Yagami K,John SW,Paigen B

更新日期：2002-07-12 00:00:00