Gene expression profile of zebrafish exposed to hypoxia during development.

abstract：:Abnormalities in dopamine production and receptor function have been described in human essential hypertension and rodent models of genetic hypertension. Under normal conditions, D(1)-like receptors (D(1) and D(5)) inhibit sodium transport in the kidney and intestine. However, in the Dahl salt-sensitive and spontaneou...

journal_title：Physiological genomics

authors： Zeng C,Sanada H,Watanabe H,Eisner GM,Felder RA,Jose PA

更新日期：2004-11-17 00:00:00

abstract：:It is generally accepted that exhausting endurance exercise exhibits strong effects on the immune system. Such effects have been attributed to changes in the cellular composition of peripheral blood as well as to changes in the expression of plausible candidate genes. The list of candidate genes is far from being comp...

journal_title：Physiological genomics

authors： Zieker D,Fehrenbach E,Dietzsch J,Fliegner J,Waidmann M,Nieselt K,Gebicke-Haerter P,Spanagel R,Simon P,Niess AM,Northoff H

更新日期：2005-11-17 00:00:00

abstract：:Disordered angiogenesis is implicated in pulmonary vascular remodeling secondary to congenital heart diseases (CHD). However, the underlying genes are not well delineated. We showed previously that an ovine model of CHD with increased pulmonary blood flow (PBF, Shunt) has an "angiogenesis burst" between 1 and 4 wk of ...

journal_title：Physiological genomics

authors： Tian J,Fratz S,Hou Y,Lu Q,Görlach A,Hess J,Schreiber C,Datar SA,Oishi P,Nechtman J,Podolsky R,She JX,Fineman JR,Black SM

更新日期：2011-01-01 00:00:00

abstract：:Mechanical ventilation is a life-saving intervention in patients with respiratory failure. However, human and animal studies have demonstrated that mechanical ventilation using large tidal volumes (>or=12 ml/kg) induces a potent inflammatory response and can cause acute lung injury. We hypothesized that mechanical ven...

journal_title：Physiological genomics

authors： Gharib SA,Liles WC,Klaff LS,Altemeier WA

更新日期：2009-05-13 00:00:00

abstract：:Preeclampsia (PE) is a devastating adverse outcome of pregnancy. Characterized by maternal hypertension, PE, when left untreated, can result in death of both mother and baby. The cause of PE remains unknown, and there is no way to predict which women will develop PE during pregnancy. The only known treatment is delive...

journal_title：Physiological genomics

authors： Olson KN,Redman LM,Sones JL

更新日期：2019-03-01 00:00:00

abstract：:We analyzed the global transcriptional response of Saccharomyces cerevisiae cells exposed to different concentrations of CsCl in the growth medium and at different times after addition. Early responsive genes were mainly involved in cell wall structure and biosynthesis. About half of the induced genes were previously ...

journal_title：Physiological genomics

authors： Del Vescovo V,Casagrande V,Bianchi MM,Piccinni E,Frontali L,Militti C,Fardeau V,Devaux F,Di Sanza C,Presutti C,Negri R

更新日期：2008-03-14 00:00:00

abstract：:The Wfs1 gene codes for a protein with unknown function, but deficiency in this protein results in a range of neuropsychiatric and neuroendocrine syndromes. In the present study we aimed to find the functional networks influenced by Wfs1 in the hypothalamus. We performed gene expression profiling (Mouse Gene 1.0 ST Ar...

journal_title：Physiological genomics

authors： Kõks S,Soomets U,Plaas M,Terasmaa A,Noormets K,Tillmann V,Vasar E,Fernandes C,Schalkwyk LC

更新日期：2011-12-16 00:00:00

abstract：:Little is known regarding the graft response to transplantation injury. This study investigates the posttransplantation response of genes that are constitutively expressed in the heart. Constitutive heart and lymph node tissue-restricted gene expression was first analyzed with DNA microarrays. To demonstrate changes f...

journal_title：Physiological genomics

authors： Christopher K,Mueller TF,DeFina R,Liang Y,Zhang J,Gentleman R,Perkins DL

更新日期：2003-09-29 00:00:00

abstract：:Cultured shrimp are continuously exposed to variable environmental conditions that have been associated with stress and subsequent outbreaks of disease. To investigate the effect of environmental stress on Penaeus monodon gene expression, a 3,853 random cDNA microarray chip was generated with clones originating from s...

journal_title：Physiological genomics

authors： de la Vega E,Hall MR,Wilson KJ,Reverter A,Woods RG,Degnan BM

更新日期：2007-09-19 00:00:00

abstract：:Psoriasis is a chronic and common human skin disorder currently with no cure. Psoriatic skin displays inflammatory, raised, and scaly lesions with widely aberrant gene expression. Recent studies have revealed critical roles that microRNAs play as a class of posttranscriptional gene regulator in skin development and sk...

journal_title：Physiological genomics

authors： Xia J,Zhang W

更新日期：2014-02-15 00:00:00

abstract：:Recombinant human erythropoietin (rHuEPO) is frequently abused by athletes as a performance-enhancing drug, despite being prohibited by the World Anti-Doping Agency. Although the methods to detect blood doping, including rHuEPO injections, have improved in recent years, they remain imperfect. In a proof-of-principle s...

journal_title：Physiological genomics

authors： Durussel J,Haile DW,Mooses K,Daskalaki E,Beattie W,Mooses M,Mekonen W,Ongaro N,Anjila E,Patel RK,Padmanabhan N,McBride MW,McClure JD,Pitsiladis YP

更新日期：2016-03-01 00:00:00

abstract：:Obesity is influenced by genetics and diet and has wide ranging comorbidities, including anxiety and depressive disorders. Outbred heterogeneous stock (HS) rats are used for fine-genetic mapping of complex traits and may be useful for understanding gene by diet interactions. In this study, HS rats were fed diets conta...

journal_title：Physiological genomics

authors： Deal AW,Seshie O,Lenzo A,Cooper N,Ozimek N,Solberg Woods LC

更新日期：2020-09-01 00:00:00

abstract：:The aim of the study was to explore the genetic architecture influencing weight of fast- and slow-twitch skeletal muscles. The weights of the slow-twitch soleus, the mixed gastrocnemius, the fast-twitch tibialis anterior (TA), and extensor digitorum longus (EDL) muscles were 11-34% greater (P < 0.001) in 200-day-old C...

journal_title：Physiological genomics

authors： Lionikas A,Blizard DA,Vandenbergh DJ,Glover MG,Stout JT,Vogler GP,McClearn GE,Larsson L

更新日期：2003-12-16 00:00:00

abstract：:The bacterium Piscirickettsia salmonis is the etiological agent of salmonid rickettsial septicemia (SRS), a severe disease that causes major economic losses to the Atlantic salmon aquaculture industry every year. Little is known about the infective strategy of P. salmonis, which is able to infect, survive within, and ...

journal_title：Physiological genomics

authors： Tacchi L,Bron JE,Taggart JB,Secombes CJ,Bickerdike R,Adler MA,Takle H,Martin SA

更新日期：2011-11-07 00:00:00

abstract：:The relative importance of regulatory versus structural evolution for the evolution of different biological systems is a subject of controversy. The primacy of regulatory evolution in the diversification of morphological traits has been promoted by many evolutionary developmental biologists. For physiological traits, ...

journal_title：Physiological genomics

authors： Rosati B,Dong M,Cheng L,Liou SR,Yan Q,Park JY,Shiang E,Sanguinetti M,Wang HS,McKinnon D

更新日期：2008-11-12 00:00:00

abstract：:Aside from abnormal angiogenesis, dual endothelin-1/VEGF signal peptide-activated receptor deficiency (DEspR(-/-)) results in aberrant neuroepithelium and neural tube differentiation, thus elucidating DEspR's role in neurogenesis. With the emerging importance of neurogenesis in adulthood, we tested the hypothesis that...

journal_title：Physiological genomics

authors： Herrera VL,Decano JL,Bagamasbad P,Kufahl T,Steffen M,Ruiz-Opazo N

更新日期：2008-11-12 00:00:00

abstract：:Alzheimer's Disease (AD) is the most widespread form of dementia during the later stages of life. If improved therapeutics are not developed, the prevalence of AD will drastically increase in the coming years as the world's population ages. By identifying differences in neuronal gene expression profiles between health...

journal_title：Physiological genomics

authors： Liang WS,Dunckley T,Beach TG,Grover A,Mastroeni D,Ramsey K,Caselli RJ,Kukull WA,McKeel D,Morris JC,Hulette CM,Schmechel D,Reiman EM,Rogers J,Stephan DA

更新日期：2008-04-22 00:00:00

abstract：:Mouse lines divergently selected for heat loss were evaluated for correlated responses in the hypothalamic transcriptome. High (MH) heat loss mice have approximately 50% greater heat loss, approximately 35% less body fat, approximately 20% greater feed intake, approximately 100% greater locomotor activity levels, and ...

journal_title：Physiological genomics

authors： Wesolowski SR,Allan MF,Nielsen MK,Pomp D

更新日期：2003-04-16 00:00:00

abstract：:The gut microbiome plays a critical role in the onset and progression of obesity and the metabolic syndrome. However, it is not well documented whether the cecal vs. the fecal microbiome is more relevant when assessing their contributions to these diseases. Here, we amplified the V4 region of the 16S rRNA gene from ce...

journal_title：Physiological genomics

authors： Panasevich MR,Wankhade UD,Chintapalli SV,Shankar K,Rector RS

更新日期：2018-05-01 00:00:00

abstract：:A high-resolution time series of transcript abundance was generated to describe global expression dynamics in response to nutrition in Drosophila. Nonparametric change-point statistics revealed that within 7 h of feeding upon yeast, transcript levels changed significantly for approximately 3,500 genes or 20% of the Dr...

journal_title：Physiological genomics

authors： Gershman B,Puig O,Hang L,Peitzsch RM,Tatar M,Garofalo RS

更新日期：2007-03-14 00:00:00

abstract：:Adeno-associated virus (AAV) vectors might offer solutions for restenosis and angiogenesis by transducing nondividing cells and providing long-term gene expression. We investigated the feasibility of vascular cell transduction by AAV vectors in an in vivo rabbit carotid artery model. Time course of gene expression, in...

journal_title：Physiological genomics

authors： Richter M,Iwata A,Nyhuis J,Nitta Y,Miller AD,Halbert CL,Allen MD

更新日期：2000-04-27 00:00:00

abstract：:Uncoupling protein 1 (UCP1) is the first UCP described. It belongs to the family of mitochondrial carrier proteins and is expressed mainly in brown adipose tissue. Recently, the family of the UCPs has rapidly been growing due to the successive cloning of UCP2, UCP3, UCP4, and UCP5, also called brain mitochondrial carr...

journal_title：Physiological genomics

authors： Keller PA,Lehr L,Giacobino JP,Charnay Y,Assimacopoulos-Jeannet F,Giovannini N

更新日期：2005-08-11 00:00:00

abstract：:Mast cell numbers are significantly increased in bladder disorders including malignancy and interstitial cystitis, but their precise role has been difficult to determine. We characterized the role of mast cells on gene regulation associated with antigen-induced bladder inflammation in mice. For this purpose, we examin...

journal_title：Physiological genomics

authors： Saban R,Saban MR,Nguyen NB,Hammond TG,Wershil BK

更新日期：2001-10-10 00:00:00

abstract：:Epistasis effects (gene interactions) have been increasingly recognized as important genetic factors underlying complex traits. The existence of a large number of single nucleotide polymorphisms (SNPs) provides opportunities and challenges to screen DNA variations affecting complex traits using a candidate gene analys...

journal_title：Physiological genomics

authors： Mao Y,London NR,Ma L,Dvorkin D,Da Y

更新日期：2006-12-13 00:00:00

abstract：:Large datasets from -omics studies need to be deeply investigated. The aim of this paper is to provide a new method (LEM method) for the search of transcriptome and metabolome connections. The heuristic algorithm here described extends the classical canonical correlation analysis (CCA) to a high number of variables (w...

journal_title：Physiological genomics

authors： Valour D,Hue I,Grimard B,Valour B

更新日期：2013-07-15 00:00:00

abstract：:A single point mutation in a novel immune-associated nucleotide gene 5 (Ian5) coincides with severe T cell lymphopenia in BB rats. We used a transgenic rescue approach in lymphopenic BB-derived congenic F344.lyp/lyp rats to determine whether this mutation is responsible for lymphopenia and to establish the functional ...

journal_title：Physiological genomics

authors： Michalkiewicz M,Michalkiewicz T,Ettinger RA,Rutledge EA,Fuller JM,Moralejo DH,Van Yserloo B,MacMurray AJ,Kwitek AE,Jacob HJ,Lander ES,Lernmark A

更新日期：2004-10-04 00:00:00

abstract：:Loss of innervation in skeletal muscles leads to degeneration, atrophy, and loss of force. These dramatic changes are reflected in modifications of the mRNA expression of a large number of genes. Our goal was to clarify the broad spectrum of molecular events associated with long-term denervation of skeletal muscles. A...

journal_title：Physiological genomics

authors： Kostrominova TY,Dow DE,Dennis RG,Miller RA,Faulkner JA

更新日期：2005-07-14 00:00:00

abstract：:Insulin resistance is a heterogeneous disorder caused by a range of genetic and environmental factors, and we hypothesize that its etiology varies considerably between individuals. This heterogeneity provides significant challenges to the development of effective therapeutic regimes for long-term management of type 2 ...

journal_title：Physiological genomics

authors： Konstantopoulos N,Foletta VC,Segal DH,Shields KA,Sanigorski A,Windmill K,Swinton C,Connor T,Wanyonyi S,Dyer TD,Fahey RP,Watt RA,Curran JE,Molero JC,Krippner G,Collier GR,James DE,Blangero J,Jowett JB,Walder KR

更新日期：2011-02-11 00:00:00

abstract：:Establishing standard operating procedures (SOPs) as tools for the analysis of behavioral phenotypes is fundamental to mouse functional genomics. It is essential that the tests designed provide reliable measures of the process under investigation but most importantly that these are reproducible across both time and la...

journal_title：Physiological genomics

authors： Mandillo S,Tucci V,Hölter SM,Meziane H,Banchaabouchi MA,Kallnik M,Lad HV,Nolan PM,Ouagazzal AM,Coghill EL,Gale K,Golini E,Jacquot S,Krezel W,Parker A,Riet F,Schneider I,Marazziti D,Auwerx J,Brown SD,Chambon P,Ro

更新日期：2008-08-15 00:00:00

abstract：:The nucleus tractus solitarii (NTS) controls the cardiovascular system during exercise, and alteration of its function may underlie exercise-induced cardiovascular adaptation. To understand the molecular basis of the NTS's plasticity in regulating blood pressure (BP) and its potential contribution to the antihypertens...

journal_title：Physiological genomics

authors： Waki H,Gouraud SS,Bhuiyan ME,Takagishi M,Yamazaki T,Kohsaka A,Maeda M

更新日期：2013-01-07 00:00:00