Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study.

abstract：:The full extent to which 1,25-dihydroxyvitamin D(3) affects gene expression in human intestinal epithelial cells is unknown. We used oligonucleotide arrays to catalog vitamin D-induced changes in gene expression in Caco-2 cells, a human colon carcinoma cell line. Five paired sets of Caco-2 cell cultures were subjected...

journal_title：Physiological genomics

authors： Wood RJ,Tchack L,Angelo G,Pratt RE,Sonna LA

更新日期：2004-04-13 00:00:00

abstract：:Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity and mortality. Previous studies indicated an impairment of ischemia-induced angiogenesis in skeletal muscle of rats with CKD. We performed a systematic comparison of early gene expression in response to ischemia in rats with or without ...

journal_title：Physiological genomics

authors： Heiss RU,Fahlbusch FB,Jacobi J,Daniel C,Ekici AB,Cordasic N,Amann K,Hartner A,Hilgers KF

更新日期：2017-04-01 00:00:00

abstract：:Several vasoregulatory systems including the renin-angiotensin system, sympathetic vasoregulation, and cytokine release have been studied extensively. The aim of the present study was to establish a physiogenomic screening model for differentially expressed genes in the regulation of blood pressure that might give a h...

journal_title：Physiological genomics

authors： Westhoff TH,Scheid S,Tölle M,Kaynak B,Schmidt S,Zidek W,Sperling S,van der Giet M

更新日期：2005-09-21 00:00:00

abstract：:Heart disease is the major cause of death in diabetes, a disorder characterized by chronic hyperglycemia and cardiovascular complications. Diabetic cardiomyopathy (DCM) is increasingly recognized as a major contributor to diastolic dysfunction and heart failure in diabetes, but its molecular basis has remained obscure...

journal_title：Physiological genomics

authors： Glyn-Jones S,Song S,Black MA,Phillips AR,Choong SY,Cooper GJ

更新日期：2007-02-12 00:00:00

abstract：:microRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through posttranscriptional repression of target genes. miRNAs exert a fundamental level of control over many developmental processes, but their role in the differentiation and development of skeletal muscle from myogenic progenitor cells in hum...

journal_title：Physiological genomics

authors： Sjögren RJ,Egan B,Katayama M,Zierath JR,Krook A

更新日期：2015-03-01 00:00:00

abstract：:The Ala allele of PPARG Pro12Ala ( rs1801282 ) is associated with greater improvements to the glucose metabolism in exercise studies, but whether this extends to peripheral insulin sensitivity is unknown. Our objective was to investigate the effect of PPARG Pro12Ala on exercise-induced changes in peripheral insulin se...

journal_title：Physiological genomics

authors： Blond MB,Schnurr TM,Rosenkilde M,Quist JS,Gram AS,Reichkendler MH,Auerbach PL,Nordby P,Skovgaard LT,Ribel-Madsen R,Justesen JM,Kilpeläinen TO,Ploug T,Stallknecht BM,Hansen T

更新日期：2019-06-01 00:00:00

abstract：:Intrinsic aerobic exercise capacity can influence many complex traits including obesity and aging. To study this connection we established two rat lines by divergent selection of untrained aerobic capacity. After 32 generations the high capacity runners (HCR) and low capacity runners (LCR) differed in endurance runnin...

journal_title：Physiological genomics

authors： Ren YY,Koch LG,Britton SL,Qi NR,Treutelaar MK,Burant CF,Li JZ

更新日期：2016-11-01 00:00:00

abstract：:Using CRISPR-Cas9 technology, we created a 5-HT7 receptor global knockout (KO) rat, on a Sprague-Dawley background, for use in cardiovascular physiology studies focused on blood pressure regulation. A stable line carrying indels in exons 1 and 2 of the rat Htr7 locus was established and validated. Surprisingly, 5-HT7 ...

journal_title：Physiological genomics

authors： Demireva EY,Xie H,Flood ED,Thompson JM,Seitz BM,Watts SW

更新日期：2019-07-01 00:00:00

abstract：:Cardiac microvascular endothelial cells (CMVECs) are the most numerous cells in the myocardium and orchestrate cardiogenesis during development, regulate adult cardiac function, and modulate pathophysiology of heart failure. It has been shown that the transcriptome of CMVECs differs from other endothelial cell types, ...

journal_title：Physiological genomics

authors： Vermeulen Z,Mateiu L,Dugaucquier L,De Keulenaer GW,Segers VFM

更新日期：2019-06-01 00:00:00

abstract：:Consumption of a protein-containing meal by a fasted animal promotes protein accretion in skeletal muscle, in part through leucine stimulation of protein synthesis and indirectly through repression of protein degradation mediated by its metabolite, α-ketoisocaproate. Mice lacking the mitochondrial branched-chain amino...

journal_title：Physiological genomics

authors： Lynch CJ,Kimball SR,Xu Y,Salzberg AC,Kawasawa YI

更新日期：2015-11-01 00:00:00

abstract：:Myosin heavy chain genes (MYHs) are the most important functional domains of myosins, which are highly conserved throughout evolution. The human genome contains 15 MYHs, whereas the corresponding number in teleost appears to be much higher. Although teleosts comprise more than one-half of all vertebrate species, our k...

journal_title：Physiological genomics

authors： Ikeda D,Ono Y,Snell P,Edwards YJ,Elgar G,Watabe S

更新日期：2007-12-19 00:00:00

abstract：:Experimental rat models of arthritis are extensively studied with a view to understand the genetic underpinnings of rheumatoid arthritis (RA). Genome scans using these models have led to the detection of arthritis regulatory quantitative trait loci (QTLs) on all but three chromosomes of the rat. Whereas some of the QT...

journal_title：Physiological genomics

authors： Joe B

更新日期：2006-10-03 00:00:00

abstract：:alpha-Sarcoglycan-deficient (Sgca-null) mice provide potential for elucidating the pathogenesis of limb girdle muscular dystrophy type 2D (LGMD 2D) as well as for studying the effectiveness of therapeutic strategies. Skeletal muscles of Sgca-null mice demonstrate an early onset of extensive fiber necrosis, degeneratio...

journal_title：Physiological genomics

authors： Consolino CM,Duclos F,Lee J,Williamson RA,Campbell KP,Brooks SV

更新日期：2005-07-14 00:00:00

abstract：:To examine differences in cytokine profiles that may confer tolerance/susceptibility to bovine African trypanosomiasis, N'Dama (trypanotolerant, n = 8) and Boran (trypanosusceptible, n = 8) cattle were experimentally challenged with Trypanosoma congolense. Blood samples were collected over a 34-day period, and RNA was...

journal_title：Physiological genomics

authors： O'Gorman GM,Park SD,Hill EW,Meade KG,Mitchell LC,Agaba M,Gibson JP,Hanotte O,Naessens J,Kemp SJ,MacHugh DE

更新日期：2006-12-13 00:00:00

abstract：:The mammalian liver works to keep the body in a state of homeostasis and plays an important role in systemic acute phase response to infections. In this study we investigated the bovine hepatic acute phase response at the gene transcription level in dairy cows with experimentally Escherichia coli-induced mastitis. At ...

journal_title：Physiological genomics

authors： Jørgensen HB,Buitenhuis B,Røntved CM,Jiang L,Ingvartsen KL,Sørensen P

更新日期：2012-06-01 00:00:00

abstract：:In recent years, it has become evident that the adult mammalian CNS contains a population of neural stem cells (NSCs) described as immature, undifferentiated, multipotent cells, that may be called upon for repair in neurodegenerative and demyelinating diseases. NSCs may give rise to oligodendrocyte progenitor cells (O...

journal_title：Physiological genomics

authors： Imitola J,Snyder EY,Khoury SJ

更新日期：2003-08-15 00:00:00

abstract：:Aortic banding in the rat has become a popular method to induce left ventricular (LV) hypertrophy and heart failure. However, because of often extensive intrathoracic adhesions and inflammatory cell infiltrates resulting from the traditional surgical approach, an uncomplicated second thoracic incision for genetic mani...

journal_title：Physiological genomics

authors： Del Monte F,Butler K,Boecker W,Gwathmey JK,Hajjar RJ

更新日期：2002-01-01 00:00:00

abstract：:It is generally accepted that exhausting endurance exercise exhibits strong effects on the immune system. Such effects have been attributed to changes in the cellular composition of peripheral blood as well as to changes in the expression of plausible candidate genes. The list of candidate genes is far from being comp...

journal_title：Physiological genomics

authors： Zieker D,Fehrenbach E,Dietzsch J,Fliegner J,Waidmann M,Nieselt K,Gebicke-Haerter P,Spanagel R,Simon P,Niess AM,Northoff H

更新日期：2005-11-17 00:00:00

abstract：:Its accessibility, unique evolutionary position, and recently assembled genome sequence have advanced the chicken to the forefront of comparative genomics and developmental biology research as a model organism. Several chicken expressed sequence tag (EST) projects have placed the chicken in 10th place for accrued ESTs...

journal_title：Physiological genomics

authors： Carre W,Wang X,Porter TE,Nys Y,Tang J,Bernberg E,Morgan R,Burnside J,Aggrey SE,Simon J,Cogburn LA

更新日期：2006-05-16 00:00:00

abstract：:11beta-Hydroxysteroid dehydrogenase type 2 (11betaHSD2) is a short-chain dehydrogenase/reductase (SDR) responsible for inactivating cortisol and preventing its binding to the mineralocorticoid receptor (MR). Nonfunctional mutations in HSD11B2, the gene encoding 11betaHSD2, cause the hypertensive syndrome of apparent m...

journal_title：Physiological genomics

authors： Manning JR,Bailey MA,Soares DC,Dunbar DR,Mullins JJ

更新日期：2010-08-01 00:00:00

abstract：:Metazoan akirin genes regulate innate immunity, myogenesis, and carcinogenesis. Invertebrates typically have one family member, while most tetrapod and teleost vertebrates have one to three. We demonstrate an expanded repertoire of eight family members in genomes of four salmonid fishes, owing to paralog preservation ...

journal_title：Physiological genomics

authors： Macqueen DJ,Kristjánsson BK,Johnston IA

更新日期：2010-06-01 00:00:00

abstract：:Intracranial aneurysm (IA) is a complex genetic disease for which, to date, 10 loci have been identified by linkage. Identification of the risk-conferring genes in the loci has proven difficult, since the regions often contain several hundreds of genes. An approach to prioritize positional candidate genes for further ...

journal_title：Physiological genomics

authors： Weinsheimer S,Lenk GM,van der Voet M,Land S,Ronkainen A,Alafuzoff I,Kuivaniemi H,Tromp G

更新日期：2007-12-19 00:00:00

abstract：:It has been found that Arabian and Thoroughbred horses differ in muscle fiber structure and thus in physiological changes occurring in muscles during exercise. The aim of the present study was to identify the global gene expression modifications that occur in skeletal muscle following a training regime to prepare for ...

journal_title：Physiological genomics

authors： Ropka-Molik K,Stefaniuk-Szmukier M,Z Ukowski K,Piórkowska K,Bugno-Poniewierska M

更新日期：2017-06-01 00:00:00

abstract：:Myocardial infarction (MI) induced by acute coronary arterial occlusion is usually secondary to atherosclerotic plaque rupture. Dysregulated response of vascular smooth muscle cells (VSMCs) in atherosclerotic plaques may promote plaque rupture. Cadherins (CDHs) form adherens junctions and are known stabilizers of athe...

journal_title：Physiological genomics

authors： Derda AA,Woo CC,Wongsurawat T,Richards M,Lee CN,Kofidis T,Kuznetsov VA,Sorokin VA

更新日期：2018-08-01 00:00:00

abstract：:The objectives of this study were to examine systemic insulin response to a glucose tolerance test (GTT) and transcript abundance of genes of the insulin signaling pathway in skeletal muscle, during both dietary restriction and re-alimentation-induced compensatory growth. Holstein Friesian bulls were blocked to one of...

journal_title：Physiological genomics

authors： Keogh K,Kenny DA,Kelly AK,Waters SM

更新日期：2015-08-01 00:00:00

abstract：:Epigenetic differences between male and female bovine blastocysts provide a plausible link between physiological and gene transcription differences observed between male and female embryos. The aim of this study was to examine sex-related epigenetic differences in bovine blastocysts produced in vitro. Oocytes were mat...

journal_title：Physiological genomics

authors： Bermejo-Alvarez P,Rizos D,Rath D,Lonergan P,Gutierrez-Adan A

更新日期：2008-01-17 00:00:00

abstract：:Since the discovery of the microbiome in humans, it has been studied in many mammalian species. Different microbiological communities with variable richness and diversity have been found among these species in distinct areas of the reproductive tract. Human studies have shown that the composition of the microbiome is ...

journal_title：Physiological genomics

authors： Heil BA,Paccamonti DL,Sones JL

更新日期：2019-08-01 00:00:00

abstract：:Although increased vascular stiffness is more prominent in aging males than females, and males are more prone to vascular disease with aging, no study has investigated the genes potentially responsible for sex differences in vascular aging. We tested the hypothesis that the transcriptional adaptation to aging differs ...

journal_title：Physiological genomics

authors： Qiu H,Tian B,Resuello RG,Natividad FF,Peppas A,Shen YT,Vatner DE,Vatner SF,Depre C

更新日期：2007-04-24 00:00:00

abstract：:Aside from abnormal angiogenesis, dual endothelin-1/VEGF signal peptide-activated receptor deficiency (DEspR(-/-)) results in aberrant neuroepithelium and neural tube differentiation, thus elucidating DEspR's role in neurogenesis. With the emerging importance of neurogenesis in adulthood, we tested the hypothesis that...

journal_title：Physiological genomics

authors： Herrera VL,Decano JL,Bagamasbad P,Kufahl T,Steffen M,Ruiz-Opazo N

更新日期：2008-11-12 00:00:00

abstract：:Gene expression was evaluated in mice divergently selected for 16 generations for heat loss, measured by direct calorimetry. The high (MH) heat loss line has approximately 50% greater heat loss, approximately 35% less body fat, approximately 20% greater feed intake, and twofold greater activity levels than the low (ML...

journal_title：Physiological genomics

authors： Allan MF,Nielsen MK,Pomp D

更新日期：2000-09-08 00:00:00