Adeno-associated virus vector transduction of vascular smooth muscle cells in vivo.

abstract：:This study was the first to explore the potential role of the myostatin (GDF8) pathway in relation to muscle strength and estimated muscle cross-sectional area in humans using linkage analysis with a candidate gene approach. In young male sibs (n = 329) 11 polymorphic markers in or near 10 candidate genes from the myo...

journal_title：Physiological genomics

authors： Huygens W,Thomis MA,Peeters MW,Aerssens J,Janssen R,Vlietinck RF,Beunen G

更新日期：2004-05-19 00:00:00

abstract：:In mice, dystrophic cardiovascular calcification (DCC) is controlled by a major locus on proximal mouse chromosome 7 named Dyscalc1. Here we present a strategy that combines in silico analysis, expression analysis, and extensive sequencing for ultrafine mapping of the Dyscalc1 locus. We subjected 15 laboratory mouse s...

journal_title：Physiological genomics

authors： Aherrahrou Z,Doehring LC,Kaczmarek PM,Liptau H,Ehlers EM,Pomarino A,Wrobel S,Götz A,Mayer B,Erdmann J,Schunkert H

更新日期：2007-01-17 00:00:00

abstract：:Elastic fibers provide reversible elasticity to the large arteries and are assembled during development when hemodynamic forces are increasing. Mutations in elastic fiber genes are associated with cardiovascular disease. Mice lacking expression of the elastic fiber genes elastin ( Eln-/-), fibulin-4 ( Efemp2-/-), or l...

journal_title：Physiological genomics

authors： Staiculescu MC,Cocciolone AJ,Procknow JD,Kim J,Wagenseil JE

更新日期：2018-11-01 00:00:00

abstract：:11beta-Hydroxysteroid dehydrogenase type 2 (11betaHSD2) is a short-chain dehydrogenase/reductase (SDR) responsible for inactivating cortisol and preventing its binding to the mineralocorticoid receptor (MR). Nonfunctional mutations in HSD11B2, the gene encoding 11betaHSD2, cause the hypertensive syndrome of apparent m...

journal_title：Physiological genomics

authors： Manning JR,Bailey MA,Soares DC,Dunbar DR,Mullins JJ

更新日期：2010-08-01 00:00:00

abstract：:Mammalian heart development is built on highly conserved molecular mechanisms with polygenetic perturbations resulting in a spectrum of congenital heart diseases (CHD). However, knowledge of cardiogenic ontogeny that regulates proper cardiogenesis remains largely based on candidate-gene approaches. Mapping the dynamic...

journal_title：Physiological genomics

authors： Li X,Martinez-Fernandez A,Hartjes KA,Kocher JP,Olson TM,Terzic A,Nelson TJ

更新日期：2014-07-01 00:00:00

abstract：:Electrotaxis, directional cell movement in response to an electric potential, has been demonstrated in a wide range of cell types including lymphocytes. Exoelectrogens, microorganisms capable of generating electrical currents, have been identified in microbial fuel cells. However, no studies have investigated exoelect...

journal_title：Physiological genomics

authors： Ericsson AC,Davis DJ,Franklin CL,Hagan CE

更新日期：2015-07-01 00:00:00

abstract：:Little is known regarding the graft response to transplantation injury. This study investigates the posttransplantation response of genes that are constitutively expressed in the heart. Constitutive heart and lymph node tissue-restricted gene expression was first analyzed with DNA microarrays. To demonstrate changes f...

journal_title：Physiological genomics

authors： Christopher K,Mueller TF,DeFina R,Liang Y,Zhang J,Gentleman R,Perkins DL

更新日期：2003-09-29 00:00:00

abstract：:The p21 activated kinase 1(PAK1) gene encodes a serine/threonine kinase that is overexpressed in a subset of human breast carcinomas with poor prognosis. The laboratory rat (Rattus norvegicus)orthologous gene is located at Mammary carcinoma susceptibility 3 (Mcs3) QTL on rat chromosome 1. We used quantitative PCR to d...

journal_title：Physiological genomics

authors： Duderstadt EL,McQuaide SA,Sanders MA,Samuelson DJ

更新日期：2020-12-21 00:00:00

abstract：:Adenosine deaminase acting on RNA (ADAR) in Drosophila and mammals has recently become the target of numerous investigations. It is now clear that this protein has a number of functions in the nervous system. Indeed, the mutation of ADAR in Drosophila (dADAR) results in many pathological and physiological changes, suc...

journal_title：Physiological genomics

authors： Xia S,Yang J,Su Y,Qian J,Ma E,Haddad GG

更新日期：2005-01-20 00:00:00

abstract：:Chronic kidney disease (CKD), defined as reduced glomerular filtration rate, is increasingly becoming a major public health issue. At the histological level, renal fibrosis is the final common pathway leading to end-stage renal disease, irrespective of the initial injury. According to this view, antifibrotic agents sh...

journal_title：Physiological genomics

authors： Lv W,Fan F,Wang Y,Gonzalez-Fernandez E,Wang C,Yang L,Booz GW,Roman RJ

更新日期：2018-01-01 00:00:00

abstract：:Epigenetic differences between male and female bovine blastocysts provide a plausible link between physiological and gene transcription differences observed between male and female embryos. The aim of this study was to examine sex-related epigenetic differences in bovine blastocysts produced in vitro. Oocytes were mat...

journal_title：Physiological genomics

authors： Bermejo-Alvarez P,Rizos D,Rath D,Lonergan P,Gutierrez-Adan A

更新日期：2008-01-17 00:00:00

abstract：:Growth hormone is one of few pharmacologic agents known to augment milk production in humans. We hypothesized that recombinant human GH (rhGH) increases the expression of cell proliferation and milk protein synthesis genes. Sequential milk and blood samples collected over four days were obtained from five normal lacta...

journal_title：Physiological genomics

authors： Maningat PD,Sen P,Rijnkels M,Hadsell DL,Bray MS,Haymond MW

更新日期：2011-04-27 00:00:00

abstract：:Using CRISPR-Cas9 technology, we created a 5-HT7 receptor global knockout (KO) rat, on a Sprague-Dawley background, for use in cardiovascular physiology studies focused on blood pressure regulation. A stable line carrying indels in exons 1 and 2 of the rat Htr7 locus was established and validated. Surprisingly, 5-HT7 ...

journal_title：Physiological genomics

authors： Demireva EY,Xie H,Flood ED,Thompson JM,Seitz BM,Watts SW

更新日期：2019-07-01 00:00:00

abstract：:Regulation of iron absorption by duodenal enterocytes is essential for the maintenance of homeostasis by preventing iron deficiency or overload. Despite the identification of a number of genes implicated in iron absorption and its regulation, it is likely that further factors remain to be identified. For that purpose,...

journal_title：Physiological genomics

authors： Chicault C,Toutain B,Monnier A,Aubry M,Fergelot P,Le Treut A,Galibert MD,Mosser J

更新日期：2006-06-16 00:00:00

abstract：:We previously reported that mice deficient in stearoyl-CoA desaturase-1 (Scd1) and maintained on a very low-fat (VLF) diet for 10 days developed severe loss of body weight, hypoglycemia, hypercholesterolemia, and many cholestasis-like phenotypes. To better understand the metabolic changes associated with these phenoty...

journal_title：Physiological genomics

authors： Flowers MT,Keller MP,Choi Y,Lan H,Kendziorski C,Ntambi JM,Attie AD

更新日期：2008-05-13 00:00:00

abstract：:Mesodermal and epidermal precursor cells undergo phenotypic changes during differentiation to the smooth muscle cell (SMC) lineage that are relevant to pathophysiological processes in the adult. Molecular mechanisms that underlie lineage determination and terminal differentiation of this cell type have received much a...

journal_title：Physiological genomics

authors： Spin JM,Nallamshetty S,Tabibiazar R,Ashley EA,King JY,Chen M,Tsao PS,Quertermous T

更新日期：2004-11-17 00:00:00

abstract：:Sulfate plays an essential role during growth, development and cellular metabolism. In this study, we characterized the function and structure of the zebrafish (Danio rerio) Na+-sulfate cotransporter 1 (NaS1) cDNA and gene (slc13a1). Zebrafish NaS1 encodes a protein of 583 amino acids with 13 putative transmembrane do...

journal_title：Physiological genomics

authors： Markovich D,Romano A,Storelli C,Verri T

更新日期：2008-08-15 00:00:00

abstract：:We previously constructed a congenic mouse, B6.S-D2Mit194-D2Mit311 (B6.S-2) with 27 Mb of SPRET/Ei donor DNA on distal chromosome 2 in a C57BL/6J background that captured an obesity quantitative trait locus (QTL). Mice homozygous for SPRET/Ei alleles at the donor region had decreased body weight and obesity-related ph...

journal_title：Physiological genomics

authors： Chiu S,Kim K,Haus KA,Espinal GM,Millon LV,Warden CH

更新日期：2007-09-19 00:00:00

abstract：:Activation of NF-kappaB is essential for protease-activated receptor-1 (PAR-1)-mediated ICAM-1 expression in endothelial cells. Here we show that PAR-1 activation induces binding of both p65/RelA and NFATc1 to the NF-kappaB binding site localized in intron-1 of the ICAM-1 gene to initiate transcription in endothelial ...

journal_title：Physiological genomics

authors： Xue J,Thippegowda PB,Hu G,Bachmaier K,Christman JW,Malik AB,Tiruppathi C

更新日期：2009-06-10 00:00:00

abstract：:The zebrafish has become a popular model system for the study of vertebrate developmental biology because of its numerous strengths as a molecular genetic and embryological system. To determine the requirement for specific genes during embryogenesis, it is necessary to generate organisms carrying loss-of-function muta...

journal_title：Physiological genomics

authors： Lekven AC,Helde KA,Thorpe CJ,Rooke R,Moon RT

更新日期：2000-03-13 00:00:00

abstract：:Although increased vascular stiffness is more prominent in aging males than females, and males are more prone to vascular disease with aging, no study has investigated the genes potentially responsible for sex differences in vascular aging. We tested the hypothesis that the transcriptional adaptation to aging differs ...

journal_title：Physiological genomics

authors： Qiu H,Tian B,Resuello RG,Natividad FF,Peppas A,Shen YT,Vatner DE,Vatner SF,Depre C

更新日期：2007-04-24 00:00:00

abstract：:Valproic acid (VPA) and lithium are widely used in the treatment of bipolar disorder. However, the underlying mechanism of action of these drugs is not clearly understood. We used RNA-Seq analysis to examine the global profile of gene expression in a rat serotonergic cell line (RN46A) after exposure to these two mood ...

journal_title：Physiological genomics

authors： Balasubramanian D,Pearson JF,Kennedy MA

更新日期：2019-02-01 00:00:00

abstract：:Gene expression was measured during t10c12-CLA-induced body fat reduction in a polygenic obese line of mice. Adult mice (n = 185) were allotted to a 2 x 2 factorial experiment consisting of either nonobese (ICR-control) or obese (M16-selected) mice fed a 7% fat, purified diet containing either 1% linoleic acid (LA) or...

journal_title：Physiological genomics

authors： House RL,Cassady JP,Eisen EJ,Eling TE,Collins JB,Grissom SF,Odle J

更新日期：2005-05-11 00:00:00

abstract：:A cDNA microarray resource has been developed with the goal of providing integrated functional genomics resources for cattle. The National Bovine Functional Genomics Consortium's (NBFGC) expressed sequence tag (EST) collection was established in 2001 to develop resources for functional genomics research. The NBFGC EST...

journal_title：Physiological genomics

authors： Suchyta SP,Sipkovsky S,Kruska R,Jeffers A,McNulty A,Coussens MJ,Tempelman RJ,Halgren RG,Saama PM,Bauman DE,Boisclair YR,Burton JL,Collier RJ,DePeters EJ,Ferris TA,Lucy MC,McGuire MA,Medrano JF,Overton TR,Smith TP,

更新日期：2003-10-17 00:00:00

abstract：:To facilitate the development of assays for the discovery of pharmaceuticals capable of mimicking the effects of caloric restriction (CR) on life- and healthspan (CR mimetics), we evaluated the effectiveness of glucoregulatory and putative cancer chemopreventatives in reproducing the hepatic gene expression profile pr...

journal_title：Physiological genomics

authors： Dhahbi JM,Mote PL,Fahy GM,Spindler SR

更新日期：2005-11-17 00:00:00

abstract：:RNA viruses represent the predominant cause of many clinically relevant viral diseases in humans. Among several evolutionary advantages acquired by RNA viruses, the ability to usurp host cellular machinery and evade antiviral immune responses is imperative. During the past decade, RNA interference mechanisms, especial...

journal_title：Physiological genomics

authors： Swaminathan G,Martin-Garcia J,Navas-Martin S

更新日期：2013-11-15 00:00:00

abstract：:Large datasets from -omics studies need to be deeply investigated. The aim of this paper is to provide a new method (LEM method) for the search of transcriptome and metabolome connections. The heuristic algorithm here described extends the classical canonical correlation analysis (CCA) to a high number of variables (w...

journal_title：Physiological genomics

authors： Valour D,Hue I,Grimard B,Valour B

更新日期：2013-07-15 00:00:00

abstract：:Septa from sheep hearts at 130 days gestation, term, and 14-day-old lambs were used to model the changes in gene expression patterns during the perinatal period using Agilent 15k ovine microarrays. We used Bioconductor for R to model five major patterns of coexpressed genes. Gene ontology and transcription factor anal...

journal_title：Physiological genomics

authors： Richards EM,Rabaglino MB,Antolic A,Wood CE,Keller-Wood M

更新日期：2015-09-01 00:00:00

abstract：:The renin-angiotensin system (RAS), known for its roles in cardiovascular, metabolic, and developmental regulation, is present in both the circulation and in many individual tissues throughout the body. Substantial evidence supports the existence of a brain RAS, though quantification and localization of brain renin ha...

journal_title：Physiological genomics

authors： Xu D,Borges GR,Davis DR,Agassandian K,Sequeira Lopez ML,Gomez RA,Cassell MD,Grobe JL,Sigmund CD

更新日期：2011-03-29 00:00:00

abstract：:Since the discovery of the microbiome in humans, it has been studied in many mammalian species. Different microbiological communities with variable richness and diversity have been found among these species in distinct areas of the reproductive tract. Human studies have shown that the composition of the microbiome is ...

journal_title：Physiological genomics

authors： Heil BA,Paccamonti DL,Sones JL

更新日期：2019-08-01 00:00:00