Short-term administration of rhGH increases markers of cellular proliferation but not milk protein gene expression in normal lactating women.

abstract：:We in this study investigated the role of imatinib-upregulated lncRNA (IUR) in prostate carcinoma (PC). We observed that IUR was downregulated in PC, and its expression levels decreased with the increase of clinical stages. In PC tissues, microRNA (miR)-200 was positively, while ZEB1 was inversely correlated with IUR....

journal_title：Physiological genomics

authors： Sun L,Chen T,Li T,Yu J

更新日期：2019-11-01 00:00:00

abstract：:Heterotrimeric G proteins (Galphabetagamma) play an essential role in coupling membrane receptors to effector proteins such as ion channels and enzymes. Among the five mammalian Gbeta-subunits cloned, the human G protein beta4 has not been described. The purpose of the present study was to functionally characterize th...

journal_title：Physiological genomics

authors： Ruiz-Velasco V,Ikeda SR,Puhl HL

更新日期：2002-02-11 00:00:00

abstract：:To date, physical exercise is the only intervention consistently demonstrated to attenuate age-related declines in physical function. However, variability exists in seniors' responsiveness to training. One potential source of variability is the insertion (I allele) or deletion (D allele) of a 287 bp fragment in intron...

journal_title：Physiological genomics

authors： Buford TW,Hsu FC,Brinkley TE,Carter CS,Church TS,Dodson JA,Goodpaster BH,McDermott MM,Nicklas BJ,Yank V,Johnson JA,Pahor M,LIFE Research Group.

更新日期：2014-03-01 00:00:00

abstract：:To better understand the genetic basis of essential hypertension, we conducted a quantitative trait locus (QTL) analysis of a population of 207 (BALB/cJ x CBA/CaJ) F(2) male mice to identify genomic regions that regulate blood pressure, heart rate, and heart weight. We identified two loci, Bpq6 (blood pressure quantit...

journal_title：Physiological genomics

authors： Sugiyama F,Churchill GA,Li R,Libby LJ,Carver T,Yagami K,John SW,Paigen B

更新日期：2002-07-12 00:00:00

abstract：:The objectives of this study were to examine systemic insulin response to a glucose tolerance test (GTT) and transcript abundance of genes of the insulin signaling pathway in skeletal muscle, during both dietary restriction and re-alimentation-induced compensatory growth. Holstein Friesian bulls were blocked to one of...

journal_title：Physiological genomics

authors： Keogh K,Kenny DA,Kelly AK,Waters SM

更新日期：2015-08-01 00:00:00

abstract：:We used next-generation RNA sequencing (RNA-Seq) technology on the whole transcriptome to identify genes whose expression is consistently affected by obesity across multiple arteries. Specifically, we examined transcriptional profiles of the iliac artery as well as the feed artery, first, second, and third branch orde...

journal_title：Physiological genomics

authors： Padilla J,Jenkins NT,Thorne PK,Martin JS,Rector RS,Davis JW,Laughlin MH

更新日期：2014-11-15 00:00:00

abstract：:To further define genes that are differentially expressed during cysteine deprivation and to evaluate the roles of amino acid deprivation vs. oxidative stress in the response to cysteine deprivation, we assessed gene expression in human hepatoma cells cultured in complete or cysteine-deficient medium. Overall, C3A cel...

journal_title：Physiological genomics

authors： Lee JI,Dominy JE Jr,Sikalidis AK,Hirschberger LL,Wang W,Stipanuk MH

更新日期：2008-04-22 00:00:00

abstract：:Cardiomyocytes derived from pluripotent embryonic stem cells (ESC) have the advantage of providing a source for standardized cell cultures. However, little is known on the regulation of the genome during differentiation of ESC to cardiomyocytes. Here, we characterize the transcriptome of the mouse ESC line CM7/1 durin...

journal_title：Physiological genomics

authors： Seewald MJ,Ellinghaus P,Kassner A,Stork I,Barg M,Niebrügge S,Golz S,Summer H,Zweigerdt R,Schräder EM,Feicht S,Jaquet K,Reis S,Körfer R,Milting H

更新日期：2009-06-10 00:00:00

abstract：:We previously mapped several gene loci influencing cancer risk of inbred BDIV and BDIX rats, resistant and susceptible, respectively, to N-ethyl-N-nitrosourea (ENU)-induced malignant peripheral nerve sheath tumors (MPNSTs). On the basis of a genomewide association analysis using a (BDIV × BDIX) F(2) generation the Mss...

journal_title：Physiological genomics

authors： Koelsch B,Winzen-Reichert B,Fischer C,Kutritz A,van den Berg L,Kindler-Röhrborn A

更新日期：2011-05-01 00:00:00

abstract：:microRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through posttranscriptional repression of target genes. miRNAs exert a fundamental level of control over many developmental processes, but their role in the differentiation and development of skeletal muscle from myogenic progenitor cells in hum...

journal_title：Physiological genomics

authors： Sjögren RJ,Egan B,Katayama M,Zierath JR,Krook A

更新日期：2015-03-01 00:00:00

abstract：:There exists a sense of urgency to begin to generate a cohesive assembly of biomedical knowledge as the pace of knowledge accumulation accelerates. The urgency is in part driven by the emergence of systems molecular medicine that emphasizes the combination of systems analysis and molecular dissection in the future of ...

journal_title：Physiological genomics

authors： Liang M

更新日期：2007-08-20 00:00:00

abstract：:We previously constructed a congenic mouse, B6.S-D2Mit194-D2Mit311 (B6.S-2) with 27 Mb of SPRET/Ei donor DNA on distal chromosome 2 in a C57BL/6J background that captured an obesity quantitative trait locus (QTL). Mice homozygous for SPRET/Ei alleles at the donor region had decreased body weight and obesity-related ph...

journal_title：Physiological genomics

authors： Chiu S,Kim K,Haus KA,Espinal GM,Millon LV,Warden CH

更新日期：2007-09-19 00:00:00

abstract：:The genetically hypertensive fawn-hooded (FHH/Eur) rat is characterized by the early presence of systolic and glomerular hypertension, progressive proteinuria (UPV), and albuminuria (UAV), and focal glomerulosclerosis, resulting in premature death from renal failure. Previous studies showed that at least five genetic ...

journal_title：Physiological genomics

authors： Provoost AP,Shiozawa M,Van Dokkum RP,Jacob HJ

更新日期：2002-02-28 00:00:00

abstract：:The nucleus tractus solitarii (NTS) controls the cardiovascular system during exercise, and alteration of its function may underlie exercise-induced cardiovascular adaptation. To understand the molecular basis of the NTS's plasticity in regulating blood pressure (BP) and its potential contribution to the antihypertens...

journal_title：Physiological genomics

authors： Waki H,Gouraud SS,Bhuiyan ME,Takagishi M,Yamazaki T,Kohsaka A,Maeda M

更新日期：2013-01-07 00:00:00

abstract：:Dietary fructose intake has dramatically increased over recent decades and is implicated in the high rates of obesity, hypertension, and type 2 diabetes (metabolic syndrome) in Western societies. The molecular determinants of this epidemiologic correlation are incompletely defined, but high-flux fructose catabolism in...

journal_title：Physiological genomics

authors： Diggle CP,Shires M,McRae C,Crellin D,Fisher J,Carr IM,Markham AF,Hayward BE,Asipu A,Bonthron DT

更新日期：2010-11-29 00:00:00

abstract：:Exercise as well as hypoxia cause an increase in angiogenesis, changes in mitochondrial density and alterations in metabolism, but it is still under debate whether the hypoxia inducible factor (HIF) is active during both situations. In this study gene expression analysis of zebrafish larvae that were raised under norm...

journal_title：Physiological genomics

authors： Kopp R,Köblitz L,Egg M,Pelster B

更新日期：2011-05-13 00:00:00

abstract：:Myocardial infarction (MI) induced by acute coronary arterial occlusion is usually secondary to atherosclerotic plaque rupture. Dysregulated response of vascular smooth muscle cells (VSMCs) in atherosclerotic plaques may promote plaque rupture. Cadherins (CDHs) form adherens junctions and are known stabilizers of athe...

journal_title：Physiological genomics

authors： Derda AA,Woo CC,Wongsurawat T,Richards M,Lee CN,Kofidis T,Kuznetsov VA,Sorokin VA

更新日期：2018-08-01 00:00:00

abstract：:Adeno-associated virus (AAV) vectors might offer solutions for restenosis and angiogenesis by transducing nondividing cells and providing long-term gene expression. We investigated the feasibility of vascular cell transduction by AAV vectors in an in vivo rabbit carotid artery model. Time course of gene expression, in...

journal_title：Physiological genomics

authors： Richter M,Iwata A,Nyhuis J,Nitta Y,Miller AD,Halbert CL,Allen MD

更新日期：2000-04-27 00:00:00

abstract：:The genetic relationship between immune responsiveness and performance is not well understood, but a major topic of the evolution of resource allocation and of relevance in human medicine and livestock breeding, for instance. This study aims to show differences of transcript abundance changes during the time intervals...

journal_title：Physiological genomics

authors： Adler M,Murani E,Ponsuksili S,Wimmers K

更新日期：2015-10-01 00:00:00

abstract：:The relative importance of regulatory versus structural evolution for the evolution of different biological systems is a subject of controversy. The primacy of regulatory evolution in the diversification of morphological traits has been promoted by many evolutionary developmental biologists. For physiological traits, ...

journal_title：Physiological genomics

authors： Rosati B,Dong M,Cheng L,Liou SR,Yan Q,Park JY,Shiang E,Sanguinetti M,Wang HS,McKinnon D

更新日期：2008-11-12 00:00:00

abstract：:Since the discovery of the microbiome in humans, it has been studied in many mammalian species. Different microbiological communities with variable richness and diversity have been found among these species in distinct areas of the reproductive tract. Human studies have shown that the composition of the microbiome is ...

journal_title：Physiological genomics

authors： Heil BA,Paccamonti DL,Sones JL

更新日期：2019-08-01 00:00:00

abstract：:The Ala allele of PPARG Pro12Ala ( rs1801282 ) is associated with greater improvements to the glucose metabolism in exercise studies, but whether this extends to peripheral insulin sensitivity is unknown. Our objective was to investigate the effect of PPARG Pro12Ala on exercise-induced changes in peripheral insulin se...

journal_title：Physiological genomics

authors： Blond MB,Schnurr TM,Rosenkilde M,Quist JS,Gram AS,Reichkendler MH,Auerbach PL,Nordby P,Skovgaard LT,Ribel-Madsen R,Justesen JM,Kilpeläinen TO,Ploug T,Stallknecht BM,Hansen T

更新日期：2019-06-01 00:00:00

abstract：:A single point mutation in a novel immune-associated nucleotide gene 5 (Ian5) coincides with severe T cell lymphopenia in BB rats. We used a transgenic rescue approach in lymphopenic BB-derived congenic F344.lyp/lyp rats to determine whether this mutation is responsible for lymphopenia and to establish the functional ...

journal_title：Physiological genomics

authors： Michalkiewicz M,Michalkiewicz T,Ettinger RA,Rutledge EA,Fuller JM,Moralejo DH,Van Yserloo B,MacMurray AJ,Kwitek AE,Jacob HJ,Lander ES,Lernmark A

更新日期：2004-10-04 00:00:00

abstract：:To investigate the transcriptional response to oxidative stress in the heart and how it changes with age, we examined the cardiac gene expression profiles of young (5-mo-old), middle-aged (15-mo-old), and old (25-mo-old) C57BL/6 mice treated with a single intraperitoneal injection of paraquat (50 mg/kg). Mice were kil...

journal_title：Physiological genomics

authors： Edwards MG,Sarkar D,Klopp R,Morrow JD,Weindruch R,Prolla TA

更新日期：2003-04-16 00:00:00

abstract：:Mast cell numbers are significantly increased in bladder disorders including malignancy and interstitial cystitis, but their precise role has been difficult to determine. We characterized the role of mast cells on gene regulation associated with antigen-induced bladder inflammation in mice. For this purpose, we examin...

journal_title：Physiological genomics

authors： Saban R,Saban MR,Nguyen NB,Hammond TG,Wershil BK

更新日期：2001-10-10 00:00:00

abstract：:To examine differences in cytokine profiles that may confer tolerance/susceptibility to bovine African trypanosomiasis, N'Dama (trypanotolerant, n = 8) and Boran (trypanosusceptible, n = 8) cattle were experimentally challenged with Trypanosoma congolense. Blood samples were collected over a 34-day period, and RNA was...

journal_title：Physiological genomics

authors： O'Gorman GM,Park SD,Hill EW,Meade KG,Mitchell LC,Agaba M,Gibson JP,Hanotte O,Naessens J,Kemp SJ,MacHugh DE

更新日期：2006-12-13 00:00:00

abstract：:Mesodermal and epidermal precursor cells undergo phenotypic changes during differentiation to the smooth muscle cell (SMC) lineage that are relevant to pathophysiological processes in the adult. Molecular mechanisms that underlie lineage determination and terminal differentiation of this cell type have received much a...

journal_title：Physiological genomics

authors： Spin JM,Nallamshetty S,Tabibiazar R,Ashley EA,King JY,Chen M,Tsao PS,Quertermous T

更新日期：2004-11-17 00:00:00

abstract：:We describe longitudinal measurements of functional residual capacity (FRC) in breathing mice using a clinical computed tomography (CT) scanner. Lungs of anesthetized mice from the A/J and C3H/HeJ strains were scanned over a 10-s period. Using a fixed threshold for CT density, we could accurately and reproducibly obta...

journal_title：Physiological genomics

authors： Mitzner W,Brown R,Lee W

更新日期：2001-01-19 00:00:00

abstract：:This study analyzes the electrophysiological cause and behavioral consequence of dopaminergic cell loss in a knockin mouse strain bearing hypersensitive nicotinic alpha4-receptor subunits ("L9'S mice"). Adult brains of L9'S mice show moderate loss of substantia nigra dopaminergic neurons and of striatal dopaminergic i...

journal_title：Physiological genomics

authors： Orb S,Wieacker J,Labarca C,Fonck C,Lester HA,Schwarz J

更新日期：2004-08-11 00:00:00

abstract：:Regulation of iron absorption by duodenal enterocytes is essential for the maintenance of homeostasis by preventing iron deficiency or overload. Despite the identification of a number of genes implicated in iron absorption and its regulation, it is likely that further factors remain to be identified. For that purpose,...

journal_title：Physiological genomics

authors： Chicault C,Toutain B,Monnier A,Aubry M,Fergelot P,Le Treut A,Galibert MD,Mosser J

更新日期：2006-06-16 00:00:00