Iron-related transcriptomic variations in CaCo-2 cells, an in vitro model of intestinal absorptive cells.

abstract：:Hypertension poses a significant challenge to vasculature homeostasis and stands as the most common cardiovascular disease in the world. Its effects are especially profound on endothelial cells that form the inner lining of the vasculature and are directly exposed to the effects of excess pressure. Here, we characteri...

journal_title：Physiological genomics

authors： Nelson JW,Ferdaus MZ,McCormick JA,Minnier J,Kaul S,Ellison DH,Barnes AP

更新日期：2018-02-01 00:00:00

abstract：:Dynamic, epigenetic mechanisms can regulate macrophage phenotypes following exposure to different stimulating conditions and environments. However, temporal patterns of microRNAs (miRNAs or miRs) across multiple macrophage polarization phenotypes have not been defined. We determined miRNA expression in bone marrow-der...

journal_title：Physiological genomics

authors： Melton DW,Lei X,Gelfond JA,Shireman PK

更新日期：2016-05-01 00:00:00

abstract：:Epigenetic differences between male and female bovine blastocysts provide a plausible link between physiological and gene transcription differences observed between male and female embryos. The aim of this study was to examine sex-related epigenetic differences in bovine blastocysts produced in vitro. Oocytes were mat...

journal_title：Physiological genomics

authors： Bermejo-Alvarez P,Rizos D,Rath D,Lonergan P,Gutierrez-Adan A

更新日期：2008-01-17 00:00:00

abstract：:The full extent to which 1,25-dihydroxyvitamin D(3) affects gene expression in human intestinal epithelial cells is unknown. We used oligonucleotide arrays to catalog vitamin D-induced changes in gene expression in Caco-2 cells, a human colon carcinoma cell line. Five paired sets of Caco-2 cell cultures were subjected...

journal_title：Physiological genomics

authors： Wood RJ,Tchack L,Angelo G,Pratt RE,Sonna LA

更新日期：2004-04-13 00:00:00

abstract：:Adenosine deaminase acting on RNA (ADAR) in Drosophila and mammals has recently become the target of numerous investigations. It is now clear that this protein has a number of functions in the nervous system. Indeed, the mutation of ADAR in Drosophila (dADAR) results in many pathological and physiological changes, suc...

journal_title：Physiological genomics

authors： Xia S,Yang J,Su Y,Qian J,Ma E,Haddad GG

更新日期：2005-01-20 00:00:00

abstract：:The objectives of this study were to examine systemic insulin response to a glucose tolerance test (GTT) and transcript abundance of genes of the insulin signaling pathway in skeletal muscle, during both dietary restriction and re-alimentation-induced compensatory growth. Holstein Friesian bulls were blocked to one of...

journal_title：Physiological genomics

authors： Keogh K,Kenny DA,Kelly AK,Waters SM

更新日期：2015-08-01 00:00:00

abstract：:Physiological, morphological, and transcriptional alterations elicited by ethynyl estradiol in the uteri of Sprague-Dawley rats and C57BL/6 mice were assessed using comparable study designs, microarray platforms, and analysis methods to identify conserved estrogen signaling networks. Comparative analysis identified 15...

journal_title：Physiological genomics

authors： Kwekel JC,Burgoon LD,Burt JW,Harkema JR,Zacharewski TR

更新日期：2005-11-17 00:00:00

abstract：:Understanding how vertebrates respond to hypoxia can have important clinical implications. Fish have evolved the ability to survive long exposure to low oxygen levels. However, little is known about the specific changes in gene expression that result from hypoxia. In this study we used a zebrafish cDNA microarray to e...

journal_title：Physiological genomics

authors： Ton C,Stamatiou D,Liew CC

更新日期：2003-04-16 00:00:00

abstract：:Immobilization, bed rest, or denervation leads to muscle disuse and subsequent skeletal muscle atrophy. Muscle atrophy can also occur as a component of various chronic diseases such as cancer, AIDS, sepsis, diabetes, and chronic heart failure or as a direct result of genetic muscle disorders. In addition to this atrop...

journal_title：Physiological genomics

authors： Cho Y,Ross RS

更新日期：2018-09-01 00:00:00

abstract：:Although some single polymorphism analyses of the angiotensinogen (AGT) gene have been found to be associated with hypertension, the results are still inconsistent. The objectives of this study are to evaluate the association of the genotype and haplotype distributions of three single-nucleotide polymorphisms (SNPs) (...

journal_title：Physiological genomics

authors： Wu SJ,Chiang FT,Chen WJ,Liu PH,Hsu KL,Hwang JJ,Lai LP,Lin JL,Tseng CD,Tseng YZ

更新日期：2004-04-13 00:00:00

abstract：:Cardiac microvascular endothelial cells (CMVECs) are the most numerous cells in the myocardium and orchestrate cardiogenesis during development, regulate adult cardiac function, and modulate pathophysiology of heart failure. It has been shown that the transcriptome of CMVECs differs from other endothelial cell types, ...

journal_title：Physiological genomics

authors： Vermeulen Z,Mateiu L,Dugaucquier L,De Keulenaer GW,Segers VFM

更新日期：2019-06-01 00:00:00

abstract：:RNA viruses represent the predominant cause of many clinically relevant viral diseases in humans. Among several evolutionary advantages acquired by RNA viruses, the ability to usurp host cellular machinery and evade antiviral immune responses is imperative. During the past decade, RNA interference mechanisms, especial...

journal_title：Physiological genomics

authors： Swaminathan G,Martin-Garcia J,Navas-Martin S

更新日期：2013-11-15 00:00:00

abstract：:We investigated the expression and function of serum response factor (SRF) in endothelial-mesenchymal transition (EndMT) in glomerular endothelial cells (GEnCs) of diabetic nephropathy (DN). The expression of SRF, endothelial markers (VE-cadherin, CD31), and mesenchymal markers (α-SMA, FSP-1, fibronectin) was examined...

journal_title：Physiological genomics

authors： Zhao L,Zhao J,Wang X,Chen Z,Peng K,Lu X,Meng L,Liu G,Guan G,Wang F

更新日期：2016-10-01 00:00:00

abstract：:Higher fat and lower carbohydrate and amino acid oxidation are observed in women compared with men during endurance exercise. We hypothesized that the observed sex difference is due to estrogen and that menstrual cycle phase or supplementation of men with 17beta-estradiol (E(2)) would coordinately influence the mRNA c...

journal_title：Physiological genomics

authors： Fu MH,Maher AC,Hamadeh MJ,Ye C,Tarnopolsky MA

更新日期：2009-12-30 00:00:00

abstract：:Cardiomyocytes derived from pluripotent embryonic stem cells (ESC) have the advantage of providing a source for standardized cell cultures. However, little is known on the regulation of the genome during differentiation of ESC to cardiomyocytes. Here, we characterize the transcriptome of the mouse ESC line CM7/1 durin...

journal_title：Physiological genomics

authors： Seewald MJ,Ellinghaus P,Kassner A,Stork I,Barg M,Niebrügge S,Golz S,Summer H,Zweigerdt R,Schräder EM,Feicht S,Jaquet K,Reis S,Körfer R,Milting H

更新日期：2009-06-10 00:00:00

abstract：:Besides neuronal plasticity, the neurotrophin brain-derived neurotrophic factor (BDNF) is also important in vascular function. The BDNF has been associated with angiogenesis through its specific receptor tropomyosin-related kinase B (TrkB). Additionally, Val66Met polymorphism decreases activity-induced BDNF. Since BDN...

journal_title：Physiological genomics

authors： Lemos JR Jr,Alves CR,de Souza SB,Marsiglia JD,Silva MS,Pereira AC,Teixeira AL,Vieira EL,Krieger JE,Negrão CE,Alves GB,de Oliveira EM,Bolani W,Dias RG,Trombetta IC

更新日期：2016-02-01 00:00:00

abstract：:High-frequency ultrasound biomicroscopy (UBM) has recently emerged as a high-resolution means of phenotyping genetically altered mice and has great potential to evaluate the cardiac morphology and hemodynamics of mouse mutants. However, there is no standard procedure of in vivo transthoracic cardiac imaging using UBM ...

journal_title：Physiological genomics

authors： Zhou YQ,Foster FS,Nieman BJ,Davidson L,Chen XJ,Henkelman RM

更新日期：2004-07-08 00:00:00

abstract：:Slc22 family organic anion and cation transporters (OATs, OCTs, and OCTNs) are transmembrane proteins expressed predominantly in kidney and liver. These proteins mediate the uptake or excretion of numerous physiologically (and pharmacologically) important compounds, and accordingly have been the focus of intensive stu...

journal_title：Physiological genomics

authors： Eraly SA,Monte JC,Nigam SK

更新日期：2004-06-17 00:00:00

abstract：:Intrinsic aerobic exercise capacity can influence many complex traits including obesity and aging. To study this connection we established two rat lines by divergent selection of untrained aerobic capacity. After 32 generations the high capacity runners (HCR) and low capacity runners (LCR) differed in endurance runnin...

journal_title：Physiological genomics

authors： Ren YY,Koch LG,Britton SL,Qi NR,Treutelaar MK,Burant CF,Li JZ

更新日期：2016-11-01 00:00:00

abstract：:Septa from sheep hearts at 130 days gestation, term, and 14-day-old lambs were used to model the changes in gene expression patterns during the perinatal period using Agilent 15k ovine microarrays. We used Bioconductor for R to model five major patterns of coexpressed genes. Gene ontology and transcription factor anal...

journal_title：Physiological genomics

authors： Richards EM,Rabaglino MB,Antolic A,Wood CE,Keller-Wood M

更新日期：2015-09-01 00:00:00

abstract：:Mouse lines divergently selected for heat loss were evaluated for correlated responses in the hypothalamic transcriptome. High (MH) heat loss mice have approximately 50% greater heat loss, approximately 35% less body fat, approximately 20% greater feed intake, approximately 100% greater locomotor activity levels, and ...

journal_title：Physiological genomics

authors： Wesolowski SR,Allan MF,Nielsen MK,Pomp D

更新日期：2003-04-16 00:00:00

abstract：:Valve formation during embryonic heart development involves a complex interplay of regional specification, cell transformations, and remodeling events. While many studies have addressed the role of specific genes during this process, a global understanding of the genetic basis for the regional specification and develo...

journal_title：Physiological genomics

authors： Vrljicak P,Chang AC,Morozova O,Wederell ED,Niessen K,Marra MA,Karsan A,Hoodless PA

更新日期：2010-02-04 00:00:00

abstract：:The Ala allele of PPARG Pro12Ala ( rs1801282 ) is associated with greater improvements to the glucose metabolism in exercise studies, but whether this extends to peripheral insulin sensitivity is unknown. Our objective was to investigate the effect of PPARG Pro12Ala on exercise-induced changes in peripheral insulin se...

journal_title：Physiological genomics

authors： Blond MB,Schnurr TM,Rosenkilde M,Quist JS,Gram AS,Reichkendler MH,Auerbach PL,Nordby P,Skovgaard LT,Ribel-Madsen R,Justesen JM,Kilpeläinen TO,Ploug T,Stallknecht BM,Hansen T

更新日期：2019-06-01 00:00:00

abstract：:Myocardial infarction (MI) induced by acute coronary arterial occlusion is usually secondary to atherosclerotic plaque rupture. Dysregulated response of vascular smooth muscle cells (VSMCs) in atherosclerotic plaques may promote plaque rupture. Cadherins (CDHs) form adherens junctions and are known stabilizers of athe...

journal_title：Physiological genomics

authors： Derda AA,Woo CC,Wongsurawat T,Richards M,Lee CN,Kofidis T,Kuznetsov VA,Sorokin VA

更新日期：2018-08-01 00:00:00

abstract：:Studies were performed to examine the extent to which mechanical stimuli mediate control of angiogenesis in bladder cells both in vitro and in vivo. Differential gene expression between control nonstretched and cyclically stretched bladder smooth muscle cells was assessed using oligonucleotide microarrays and pathway ...

journal_title：Physiological genomics

authors： Yang R,Amir J,Liu H,Chaqour B

更新日期：2008-12-12 00:00:00

abstract：:Membrane-bound and membrane-associated proteins are difficult to analyze by mass spectrometry, since the association with lipids impedes the isolation and solubilization of the proteins in buffers suitable for mass spectrometry and the efficient generation of positively charged peptide ions by electrospray ionization....

journal_title：Physiological genomics

authors： Mirza SP,Halligan BD,Greene AS,Olivier M

更新日期：2007-06-19 00:00:00

abstract：:ATP-sensitive K+ (KATP) channels play a crucial role in coupling cellular metabolism to membrane potential. In addition to the orthologs corresponding to Kir6.1 and Kir6.2 of mammals, we have identified a novel member, designated Kir6.3 (zKir6.3), of the inward rectifier K+ channel subfamily Kir6.x in zebrafish. zKir6...

journal_title：Physiological genomics

authors： Zhang C,Miki T,Shibasaki T,Yokokura M,Saraya A,Seino S

更新日期：2006-02-14 00:00:00

abstract：:The bacterium Piscirickettsia salmonis is the etiological agent of salmonid rickettsial septicemia (SRS), a severe disease that causes major economic losses to the Atlantic salmon aquaculture industry every year. Little is known about the infective strategy of P. salmonis, which is able to infect, survive within, and ...

journal_title：Physiological genomics

authors： Tacchi L,Bron JE,Taggart JB,Secombes CJ,Bickerdike R,Adler MA,Takle H,Martin SA

更新日期：2011-11-07 00:00:00

abstract：:Teleost fish represent unique models to study the role of neuroestrogens because of the extremely high activity of brain aromatase (AroB; the product of cyp19a1b). Aromatase respectively converts androstenedione and testosterone to estrone and 17beta-estradiol (E2). Specific inhibition of aromatase activity by fadrozo...

journal_title：Physiological genomics

authors： Zhang D,Popesku JT,Martyniuk CJ,Xiong H,Duarte-Guterman P,Yao L,Xia X,Trudeau VL

更新日期：2009-08-07 00:00:00

abstract：:The zebrafish has become a popular model system for the study of vertebrate developmental biology because of its numerous strengths as a molecular genetic and embryological system. To determine the requirement for specific genes during embryogenesis, it is necessary to generate organisms carrying loss-of-function muta...

journal_title：Physiological genomics

authors： Lekven AC,Helde KA,Thorpe CJ,Rooke R,Moon RT

更新日期：2000-03-13 00:00:00