Serum response factor induces endothelial-mesenchymal transition in glomerular endothelial cells to aggravate proteinuria in diabetic nephropathy.

abstract：:Valve formation during embryonic heart development involves a complex interplay of regional specification, cell transformations, and remodeling events. While many studies have addressed the role of specific genes during this process, a global understanding of the genetic basis for the regional specification and develo...

journal_title：Physiological genomics

authors： Vrljicak P,Chang AC,Morozova O,Wederell ED,Niessen K,Marra MA,Karsan A,Hoodless PA

更新日期：2010-02-04 00:00:00

abstract：:Creatine monohydrate (CrM) supplementation has been shown to increase fat-free mass and muscle power output possibly via cell swelling. Little is known about the cellular response to CrM. We investigated the effect of short-term CrM supplementation on global and targeted mRNA expression and protein content in human sk...

journal_title：Physiological genomics

authors： Safdar A,Yardley NJ,Snow R,Melov S,Tarnopolsky MA

更新日期：2008-01-17 00:00:00

abstract：:Electrotaxis, directional cell movement in response to an electric potential, has been demonstrated in a wide range of cell types including lymphocytes. Exoelectrogens, microorganisms capable of generating electrical currents, have been identified in microbial fuel cells. However, no studies have investigated exoelect...

journal_title：Physiological genomics

authors： Ericsson AC,Davis DJ,Franklin CL,Hagan CE

更新日期：2015-07-01 00:00:00

abstract：:As the amount of information available to biologists increases exponentially, data analysis becomes progressively more challenging. Sequence homology has been a traditional tool in the researchers' armamentarium; it is a very versatile instrument and can be employed to assist in numerous tasks, from establishing the f...

journal_title：Physiological genomics

authors： Turchin A,Kohane IS

更新日期：2002-12-03 00:00:00

abstract：:Cardiac microvascular endothelial cells (CMVECs) are the most numerous cells in the myocardium and orchestrate cardiogenesis during development, regulate adult cardiac function, and modulate pathophysiology of heart failure. It has been shown that the transcriptome of CMVECs differs from other endothelial cell types, ...

journal_title：Physiological genomics

authors： Vermeulen Z,Mateiu L,Dugaucquier L,De Keulenaer GW,Segers VFM

更新日期：2019-06-01 00:00:00

abstract：:Functional proteomic strategies offer unique advantages over current molecular array approaches, as the epitopes identified can directly provide bioactive peptides for investigational and/or translational applications. The vascular endothelium is well suited to proteomic assessment by in vivo phage display, but extens...

journal_title：Physiological genomics

authors： Ballard VL,Holm JM,Edelberg JM

更新日期：2006-08-16 00:00:00

abstract：:The bacterium Piscirickettsia salmonis is the etiological agent of salmonid rickettsial septicemia (SRS), a severe disease that causes major economic losses to the Atlantic salmon aquaculture industry every year. Little is known about the infective strategy of P. salmonis, which is able to infect, survive within, and ...

journal_title：Physiological genomics

authors： Tacchi L,Bron JE,Taggart JB,Secombes CJ,Bickerdike R,Adler MA,Takle H,Martin SA

更新日期：2011-11-07 00:00:00

abstract：:The recent development of genetic mouse models presenting life-long alterations in expression of the genes for atrial natriuretic peptide (ANP) or its receptors (NPR-A, NPR-C) has uncovered a physiological role of this hormone in chronic blood pressure homeostasis. Transgenic mice overexpressing a transthyretin-ANP fu...

journal_title：Physiological genomics

authors： Melo LG,Steinhelper ME,Pang SC,Tse Y,Ackermann U

更新日期：2000-06-29 00:00:00

abstract：:Previous in vitro studies found that nuclear factor erythroid-derived 2-like 1 (NFE2L1) was involved in mediating ascorbic acid-induced osterix expression and osteoblast differentiation via binding to the antioxidant response element of the osterix promoter. To test the role of NFE2L1 in regulating bone formation in v...

journal_title：Physiological genomics

authors： Kim J,Xing W,Wergedal J,Chan JY,Mohan S

更新日期：2010-01-08 00:00:00

abstract：:Dahl salt-sensitive SS and consomic, salt-resistant SS-13(BN)/Mcw rats possess a highly similar genetic background but exhibit substantial differences in blood pressure salt sensitivity. We used cDNA microarrays to examine sequential changes of mRNA expression of approximately 2,000 currently known rat genes in the re...

journal_title：Physiological genomics

authors： Liang M,Yuan B,Rute E,Greene AS,Olivier M,Cowley AW Jr

更新日期：2003-02-06 00:00:00

abstract：:To date, physical exercise is the only intervention consistently demonstrated to attenuate age-related declines in physical function. However, variability exists in seniors' responsiveness to training. One potential source of variability is the insertion (I allele) or deletion (D allele) of a 287 bp fragment in intron...

journal_title：Physiological genomics

authors： Buford TW,Hsu FC,Brinkley TE,Carter CS,Church TS,Dodson JA,Goodpaster BH,McDermott MM,Nicklas BJ,Yank V,Johnson JA,Pahor M,LIFE Research Group.

更新日期：2014-03-01 00:00:00

abstract：:alpha-Sarcoglycan-deficient (Sgca-null) mice provide potential for elucidating the pathogenesis of limb girdle muscular dystrophy type 2D (LGMD 2D) as well as for studying the effectiveness of therapeutic strategies. Skeletal muscles of Sgca-null mice demonstrate an early onset of extensive fiber necrosis, degeneratio...

journal_title：Physiological genomics

authors： Consolino CM,Duclos F,Lee J,Williamson RA,Campbell KP,Brooks SV

更新日期：2005-07-14 00:00:00

abstract：:Phospholamban (PLN), the reversible inhibitor of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2a), is a key regulator of myocyte Ca(2+) cycling with a significant role in heart failure. We previously showed that the single amino acid difference between human and mouse PLN results in increased inhibition of Ca(...

journal_title：Physiological genomics

authors： Wang HS,Arvanitis DA,Dong M,Niklewski PJ,Zhao W,Lam CK,Kranias EG,Sanoudou D

更新日期：2011-04-12 00:00:00

abstract：:Little is known regarding the graft response to transplantation injury. This study investigates the posttransplantation response of genes that are constitutively expressed in the heart. Constitutive heart and lymph node tissue-restricted gene expression was first analyzed with DNA microarrays. To demonstrate changes f...

journal_title：Physiological genomics

authors： Christopher K,Mueller TF,DeFina R,Liang Y,Zhang J,Gentleman R,Perkins DL

更新日期：2003-09-29 00:00:00

abstract：:Peroxisome proliferator-activated receptor type gamma (PPARgamma) is a subgroup of the PPAR transcription factor family. Recent studies indicate that loss of PPARgamma is associated with the development of pulmonary hypertension (PH). We hypothesized that the endothelial dysfunction associated with PPARgamma inhibitio...

journal_title：Physiological genomics

authors： Tian J,Smith A,Nechtman J,Podolsky R,Aggarwal S,Snead C,Kumar S,Elgaish M,Oishi P,Göerlach A,Fratz S,Hess J,Catravas JD,Verin AD,Fineman JR,She JX,Black SM

更新日期：2009-12-30 00:00:00

abstract：:To account for sex as a biological variable, it is sometimes necessary to identify the sex of an embryo or embryonic cell that was used to generate libraries for RNA sequencing, without the sex being known a priori. The preferred approach for this would take advantage of the mRNA data, rather than relying on other met...

journal_title：Physiological genomics

authors： Midic U,VandeVoort CA,Latham KE

更新日期：2018-08-01 00:00:00

abstract：:Essential hypertension is highly prevalent in the elderly population, exceeding 70% in people older than 60 yr of age, and remains a leading risk factor for heart disease, stroke, and chronic renal disease. Elucidation of genetic determinants is critical but remains a challenge due to its complex, multifactorial patho...

journal_title：Physiological genomics

authors： Glorioso N,Herrera VL,Didishvili T,Argiolas G,Troffa C,Bulla P,Bulla E,Ruiz-Opazo N

更新日期：2011-11-07 00:00:00

abstract：:Obesity is influenced by genetics and diet and has wide ranging comorbidities, including anxiety and depressive disorders. Outbred heterogeneous stock (HS) rats are used for fine-genetic mapping of complex traits and may be useful for understanding gene by diet interactions. In this study, HS rats were fed diets conta...

journal_title：Physiological genomics

authors： Deal AW,Seshie O,Lenzo A,Cooper N,Ozimek N,Solberg Woods LC

更新日期：2020-09-01 00:00:00

abstract：:Although increased vascular stiffness is more prominent in aging males than females, and males are more prone to vascular disease with aging, no study has investigated the genes potentially responsible for sex differences in vascular aging. We tested the hypothesis that the transcriptional adaptation to aging differs ...

journal_title：Physiological genomics

authors： Qiu H,Tian B,Resuello RG,Natividad FF,Peppas A,Shen YT,Vatner DE,Vatner SF,Depre C

更新日期：2007-04-24 00:00:00

abstract：:Myosin heavy chain genes (MYHs) are the most important functional domains of myosins, which are highly conserved throughout evolution. The human genome contains 15 MYHs, whereas the corresponding number in teleost appears to be much higher. Although teleosts comprise more than one-half of all vertebrate species, our k...

journal_title：Physiological genomics

authors： Ikeda D,Ono Y,Snell P,Edwards YJ,Elgar G,Watabe S

更新日期：2007-12-19 00:00:00

abstract：:We in this study investigated the role of imatinib-upregulated lncRNA (IUR) in prostate carcinoma (PC). We observed that IUR was downregulated in PC, and its expression levels decreased with the increase of clinical stages. In PC tissues, microRNA (miR)-200 was positively, while ZEB1 was inversely correlated with IUR....

journal_title：Physiological genomics

authors： Sun L,Chen T,Li T,Yu J

更新日期：2019-11-01 00:00:00

abstract：:Bone marrow mononuclear cells (BMMNCs) increase capillary density and reduce fibrosis in rodents after myocardial infarction, resulting in an overall improvement in left ventricular function. Little is known about the effectiveness of BMMNC therapy in hypertensive heart disease. In the current study, we show that deli...

journal_title：Physiological genomics

authors： Parker SJ,Didier DN,Karcher JR,Stodola TJ,Endres B,Greene AS

更新日期：2012-10-02 00:00:00

abstract：:Mammalian heart development is built on highly conserved molecular mechanisms with polygenetic perturbations resulting in a spectrum of congenital heart diseases (CHD). However, knowledge of cardiogenic ontogeny that regulates proper cardiogenesis remains largely based on candidate-gene approaches. Mapping the dynamic...

journal_title：Physiological genomics

authors： Li X,Martinez-Fernandez A,Hartjes KA,Kocher JP,Olson TM,Terzic A,Nelson TJ

更新日期：2014-07-01 00:00:00

abstract：:This study was the first to explore the potential role of the myostatin (GDF8) pathway in relation to muscle strength and estimated muscle cross-sectional area in humans using linkage analysis with a candidate gene approach. In young male sibs (n = 329) 11 polymorphic markers in or near 10 candidate genes from the myo...

journal_title：Physiological genomics

authors： Huygens W,Thomis MA,Peeters MW,Aerssens J,Janssen R,Vlietinck RF,Beunen G

更新日期：2004-05-19 00:00:00

abstract：:Higher fat and lower carbohydrate and amino acid oxidation are observed in women compared with men during endurance exercise. We hypothesized that the observed sex difference is due to estrogen and that menstrual cycle phase or supplementation of men with 17beta-estradiol (E(2)) would coordinately influence the mRNA c...

journal_title：Physiological genomics

authors： Fu MH,Maher AC,Hamadeh MJ,Ye C,Tarnopolsky MA

更新日期：2009-12-30 00:00:00

abstract：:Hypoxia is an important ecological, evolutionary, and biomedical stressor. While physiological acclimatization of mammals to hypoxia is well studied, the variation in gene expression that underlies acclimatization is not well studied. We acclimatized inbred mice for 32 days to hypoxic conditions that simulated altitud...

journal_title：Physiological genomics

authors： Baze MM,Schlauch K,Hayes JP

更新日期：2010-05-01 00:00:00

abstract：:Cultured shrimp are continuously exposed to variable environmental conditions that have been associated with stress and subsequent outbreaks of disease. To investigate the effect of environmental stress on Penaeus monodon gene expression, a 3,853 random cDNA microarray chip was generated with clones originating from s...

journal_title：Physiological genomics

authors： de la Vega E,Hall MR,Wilson KJ,Reverter A,Woods RG,Degnan BM

更新日期：2007-09-19 00:00:00

abstract：:Retinoid-related orphan receptor (ROR)α4 is the major RORα isoform expressed in adipose tissues and liver. In this study we demonstrate that RORα-deficient staggerer mice (RORα(sg/sg)) fed with a high-fat diet (HFD) exhibited reduced adiposity and hepatic triglyceride levels compared with wild-type (WT) littermates an...

journal_title：Physiological genomics

authors： Kang HS,Okamoto K,Takeda Y,Beak JY,Gerrish K,Bortner CD,DeGraff LM,Wada T,Xie W,Jetten AM

更新日期：2011-07-14 00:00:00

abstract：:Large datasets from -omics studies need to be deeply investigated. The aim of this paper is to provide a new method (LEM method) for the search of transcriptome and metabolome connections. The heuristic algorithm here described extends the classical canonical correlation analysis (CCA) to a high number of variables (w...

journal_title：Physiological genomics

authors： Valour D,Hue I,Grimard B,Valour B

更新日期：2013-07-15 00:00:00

abstract：:Consumption of a protein-containing meal by a fasted animal promotes protein accretion in skeletal muscle, in part through leucine stimulation of protein synthesis and indirectly through repression of protein degradation mediated by its metabolite, α-ketoisocaproate. Mice lacking the mitochondrial branched-chain amino...

journal_title：Physiological genomics

authors： Lynch CJ,Kimball SR,Xu Y,Salzberg AC,Kawasawa YI

更新日期：2015-11-01 00:00:00