Endothelial transcriptomics reveals activation of fibrosis-related pathways in hypertension.

abstract：:Previous studies have indicated that hemorrhage may predispose the lung to respiratory distress syndrome. Gene expression profiling with oligonucleotide microarrays was used to evaluate the genetic responses of the lung to hemorrhage. Conscious rats, chronically instrumented with a catheter and telemetry device to rec...

journal_title：Physiological genomics

authors： Bowman PD,Sondeen JL,Zhao B,Coppes VG,Nelson JJ,Dubick MA,Vaughan GM

更新日期：2005-11-17 00:00:00

abstract：:Morbidity and mortality associated with acute lung injury (ALI) and acute respiratory distress syndrome remain substantial. Although many candidate genes have been tested, a clear understanding of the pathogenesis is lacking, as is our ability to predict individual outcome. Because ALI is a complex disease, single gen...

journal_title：Physiological genomics

authors： Prows DR,Winterberg AV,Gibbons WJ Jr,Burzynski BB,Liu C,Nick TG

更新日期：2009-07-09 00:00:00

abstract：:A high-resolution time series of transcript abundance was generated to describe global expression dynamics in response to nutrition in Drosophila. Nonparametric change-point statistics revealed that within 7 h of feeding upon yeast, transcript levels changed significantly for approximately 3,500 genes or 20% of the Dr...

journal_title：Physiological genomics

authors： Gershman B,Puig O,Hang L,Peitzsch RM,Tatar M,Garofalo RS

更新日期：2007-03-14 00:00:00

abstract：:The human miR-29 family of microRNAs has three mature members, miR-29a, miR-29b, and miR-29c. miR-29s are encoded by two gene clusters. Binding sites for several transcriptional factors have been identified in the promoter regions of miR-29 genes. The miR-29 family members share a common seed region sequence and are p...

journal_title：Physiological genomics

authors： Kriegel AJ,Liu Y,Fang Y,Ding X,Liang M

更新日期：2012-02-27 00:00:00

abstract：:Autosomal recessive mandibuloacral dysplasia [mandibuloacral dysplasia type A (MADA); Online Mendelian Inheritance in Man (OMIM) no. 248370] is caused by a mutation in LMNA encoding lamin A/C. Here we show that this mutation causes accumulation of the lamin A precursor protein, a marked alteration of the nuclear archi...

journal_title：Physiological genomics

authors： Filesi I,Gullotta F,Lattanzi G,D'Apice MR,Capanni C,Nardone AM,Columbaro M,Scarano G,Mattioli E,Sabatelli P,Maraldi NM,Biocca S,Novelli G

更新日期：2005-10-17 00:00:00

abstract：:Since inclusion of atherosclerotic tissues from different sources is often indispensable to study the full atherogenic spectrum, we investigated to what extent the expression profiles of advanced, stable atherosclerotic lesions obtained during autopsy and surgery are comparable. The gene expression profiles of human c...

journal_title：Physiological genomics

authors： Sluimer JC,Kisters N,Cleutjens KB,Volger OL,Horrevoets AJ,van den Akker LH,Bijnens AP,Daemen MJ

更新日期：2007-08-20 00:00:00

abstract：:It has been found that Arabian and Thoroughbred horses differ in muscle fiber structure and thus in physiological changes occurring in muscles during exercise. The aim of the present study was to identify the global gene expression modifications that occur in skeletal muscle following a training regime to prepare for ...

journal_title：Physiological genomics

authors： Ropka-Molik K,Stefaniuk-Szmukier M,Z Ukowski K,Piórkowska K,Bugno-Poniewierska M

更新日期：2017-06-01 00:00:00

abstract：:Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that regulates the oxygen-dependent expression of a number of genes. This transcription factor may contribute to the abundant expression of many genes in renal medullary cells that function normally under hypoxic conditions. The present study was d...

journal_title：Physiological genomics

authors： Zou AP,Yang ZZ,Li PL,Cowley AW JR

更新日期：2001-08-28 00:00:00

abstract：:Herbivores are predicted to evolve appropriate mechanisms to process the plant secondary compounds (PSCs) in their diet, and these mechanisms are likely specific to particular suites of PSCs. Changes in diet composition over evolutionary time should select for appropriate alterations in metabolism of the more recent d...

journal_title：Physiological genomics

authors： Magnanou E,Malenke JR,Dearing MD

更新日期：2013-09-03 00:00:00

abstract：:The influence of inducible heat stress proteins on protecting contracting skeletal muscle against fatigue-induced injury was investigated. A line of transgenic mice overexpressing the inducible form of the 72-kDa heat shock protein (HSP72) in skeletal muscles was used. We examined the relationship between muscle contr...

journal_title：Physiological genomics

authors： Nosek TM,Brotto MA,Essig DA,Mestril R,Conover RC,Dillmann WH,Kolbeck RC

更新日期：2000-11-09 00:00:00

abstract：:We used next-generation RNA sequencing (RNA-Seq) technology on the whole transcriptome to identify genes whose expression is consistently affected by obesity across multiple arteries. Specifically, we examined transcriptional profiles of the iliac artery as well as the feed artery, first, second, and third branch orde...

journal_title：Physiological genomics

authors： Padilla J,Jenkins NT,Thorne PK,Martin JS,Rector RS,Davis JW,Laughlin MH

更新日期：2014-11-15 00:00:00

abstract：:The gastric entero-chromaffin-like (ECL) cell plays a key regulatory role in peripheral regulation of acid secretion due to the release of histamine that stimulates acid secretion by the parietal cell. Studies in intact animals, gastric glands, and isolated cells after short-term culture have shown expression of stimu...

journal_title：Physiological genomics

authors： Lambrecht NW,Yakubov I,Zer C,Sachs G

更新日期：2006-03-13 00:00:00

abstract：:Despite an abundance of evidence to the contrary from animal studies, large clinical trials on humans have shown that estrogen administered to postmenopausal women increases the risk of cardiovascular disease. However, timing may be everything, as estrogen is often administered immediately after ovariectomy (Ovx) in a...

journal_title：Physiological genomics

authors： Pechenino AS,Lin L,Mbai FN,Lee AR,He XM,Stallone JN,Knowlton AA

更新日期：2011-09-22 00:00:00

abstract：:An increased phospholamban (PLB)-to-sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) ratio has been suggested to contribute to the slowing of relaxation in failing human ventricle. We have used an adenoviral vector carrying the sequence for PLB to increase this ratio in isolated adult rat ventricular myocytes, and w...

journal_title：Physiological genomics

authors： Davia K,Hajjar RJ,Terracciano CM,Kent NS,Ranu HK,O'Gara P,Rosenzweig A,Harding SE

更新日期：1999-08-31 00:00:00

abstract：:The mammary gland undergoes extensive remodeling between the beginning of pregnancy and lactation; this involves cellular processes including cell proliferation, differentiation, and apoptosis, all of which are under the control of numerous regulators. To unravel the role played by miRNA, we describe here 47 new ovine...

journal_title：Physiological genomics

authors： Galio L,Droineau S,Yeboah P,Boudiaf H,Bouet S,Truchet S,Devinoy E

更新日期：2013-02-15 00:00:00

abstract：:Although the genetics of rare, monogenic, forms of human hypertension are fairly well defined, the genetics of the common polygenic form of human essential hypertension is only emerging. With the ability to control environmental variables, animal models have provided valuable tools with which to study blood pressure (...

journal_title：Physiological genomics

authors： Woo DD,Kurtz I

更新日期：2003-11-11 00:00:00

abstract：:Both being dormant cellular states, quiescence and senescence are traditionally considered distinct. Quiescence is reversible to proliferation upon growth signals, whereas senescence is irreversible in physiological conditions. Recent findings, however, suggest that quiescence deepening with a decreased proliferative ...

journal_title：Physiological genomics

authors： Fujimaki K,Yao G

更新日期：2020-11-01 00:00:00

abstract：:To investigate the transcriptional response to oxidative stress in the heart and how it changes with age, we examined the cardiac gene expression profiles of young (5-mo-old), middle-aged (15-mo-old), and old (25-mo-old) C57BL/6 mice treated with a single intraperitoneal injection of paraquat (50 mg/kg). Mice were kil...

journal_title：Physiological genomics

authors： Edwards MG,Sarkar D,Klopp R,Morrow JD,Weindruch R,Prolla TA

更新日期：2003-04-16 00:00:00

abstract：:We analyzed the global transcriptional response of Saccharomyces cerevisiae cells exposed to different concentrations of CsCl in the growth medium and at different times after addition. Early responsive genes were mainly involved in cell wall structure and biosynthesis. About half of the induced genes were previously ...

journal_title：Physiological genomics

authors： Del Vescovo V,Casagrande V,Bianchi MM,Piccinni E,Frontali L,Militti C,Fardeau V,Devaux F,Di Sanza C,Presutti C,Negri R

更新日期：2008-03-14 00:00:00

abstract：:Snakes provide a unique and valuable model system for studying the extremes of physiological remodeling because of the ability of some species to rapidly upregulate organ form and function upon feeding. The predominant model species used to study such extreme responses has been the Burmese python because of the extrem...

journal_title：Physiological genomics

authors： Andrew AL,Card DC,Ruggiero RP,Schield DR,Adams RH,Pollock DD,Secor SM,Castoe TA

更新日期：2015-05-01 00:00:00

abstract：:The SMXA-5 recombinant inbred strain, which was established from nondiabetic parental SM/J and A/J mice, develops diabetic phenotypes such as impaired glucose tolerance. The combination of diabetogenic genes in the SM/J and A/J genomes impairs glucose tolerance in SMXA-5 mice. Using (SM/J x SMXA-5)F2 mice fed a high-f...

journal_title：Physiological genomics

authors： Hada N,Kobayashi M,Fujiyoshi M,Ishikawa A,Kuga M,Nishimura M,Ebihara S,Ohno T,Horio F

更新日期：2008-09-17 00:00:00

abstract：:To better understand the genetic basis of essential hypertension, we conducted a quantitative trait locus (QTL) analysis of a population of 207 (BALB/cJ x CBA/CaJ) F(2) male mice to identify genomic regions that regulate blood pressure, heart rate, and heart weight. We identified two loci, Bpq6 (blood pressure quantit...

journal_title：Physiological genomics

authors： Sugiyama F,Churchill GA,Li R,Libby LJ,Carver T,Yagami K,John SW,Paigen B

更新日期：2002-07-12 00:00:00

abstract：:Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity and mortality. Previous studies indicated an impairment of ischemia-induced angiogenesis in skeletal muscle of rats with CKD. We performed a systematic comparison of early gene expression in response to ischemia in rats with or without ...

journal_title：Physiological genomics

authors： Heiss RU,Fahlbusch FB,Jacobi J,Daniel C,Ekici AB,Cordasic N,Amann K,Hartner A,Hilgers KF

更新日期：2017-04-01 00:00:00

abstract：:We previously reported that markers on rat chromosome 1 are genetically linked to blood pressure in an F(2) population derived from Dahl salt hypertension-sensitive (S) and Lewis (LEW) rats. Because there was evidence for more than one blood pressure quantitative trait locus (QTL) on chromosome 1, an initial congenic ...

journal_title：Physiological genomics

authors： Saad Y,Garrett MR,Lee SJ,Dene H,Rapp JP

更新日期：1999-11-11 00:00:00

abstract：:Retinoid-related orphan receptor (ROR)α4 is the major RORα isoform expressed in adipose tissues and liver. In this study we demonstrate that RORα-deficient staggerer mice (RORα(sg/sg)) fed with a high-fat diet (HFD) exhibited reduced adiposity and hepatic triglyceride levels compared with wild-type (WT) littermates an...

journal_title：Physiological genomics

authors： Kang HS,Okamoto K,Takeda Y,Beak JY,Gerrish K,Bortner CD,DeGraff LM,Wada T,Xie W,Jetten AM

更新日期：2011-07-14 00:00:00

abstract：:We previously generated a conditional floxed mouse line to study androgen action, in which exon 3 of the androgen receptor (AR) gene is flanked by loxP sites, with the neomycin resistance gene present in intron 3. Deletion of exon 3 in global AR knockout mice causes androgen insensitivity syndrome, characterized by ge...

journal_title：Physiological genomics

authors： MacLean HE,Chiu WS,Ma C,McManus JF,Davey RA,Cameron R,Notini AJ,Zajac JD

更新日期：2008-03-14 00:00:00

abstract：:Although Escherichia coli LPS is known to elicit various proinflammatory responses in macrophages, its effect on the translational states of transcripts has not yet been explored on a genome-wide scale. To address this, we investigated the mRNA profiles in polysomal and free messenger ribonucleoprotein particle (mRNP)...

journal_title：Physiological genomics

authors： Kitamura H,Ito M,Yuasa T,Kikuguchi C,Hijikata A,Takayama M,Kimura Y,Yokoyama R,Kaji T,Ohara O

更新日期：2008-03-14 00:00:00

abstract：:Abnormalities in dopamine production and receptor function have been described in human essential hypertension and rodent models of genetic hypertension. Under normal conditions, D(1)-like receptors (D(1) and D(5)) inhibit sodium transport in the kidney and intestine. However, in the Dahl salt-sensitive and spontaneou...

journal_title：Physiological genomics

authors： Zeng C,Sanada H,Watanabe H,Eisner GM,Felder RA,Jose PA

更新日期：2004-11-17 00:00:00

abstract：:Cardiomyocytes derived from pluripotent embryonic stem cells (ESC) have the advantage of providing a source for standardized cell cultures. However, little is known on the regulation of the genome during differentiation of ESC to cardiomyocytes. Here, we characterize the transcriptome of the mouse ESC line CM7/1 durin...

journal_title：Physiological genomics

authors： Seewald MJ,Ellinghaus P,Kassner A,Stork I,Barg M,Niebrügge S,Golz S,Summer H,Zweigerdt R,Schräder EM,Feicht S,Jaquet K,Reis S,Körfer R,Milting H

更新日期：2009-06-10 00:00:00

abstract：:Cultured shrimp are continuously exposed to variable environmental conditions that have been associated with stress and subsequent outbreaks of disease. To investigate the effect of environmental stress on Penaeus monodon gene expression, a 3,853 random cDNA microarray chip was generated with clones originating from s...

journal_title：Physiological genomics

authors： de la Vega E,Hall MR,Wilson KJ,Reverter A,Woods RG,Degnan BM

更新日期：2007-09-19 00:00:00