Functional properties of skeletal muscle from transgenic animals with upregulated heat shock protein 70.

abstract：:Bioaccumulative environmental estrogen, nonylphenol (NP; 4-nonylphenol), is widely used as a nonionic surfactant and can affect human health. Since genomes of Saccharomyces cerevisiae and higher eukaryotes share many structural and functional similarities, we investigated subcellular effects of NP on S. cerevisiae BY4...

journal_title：Physiological genomics

authors： Bereketoglu C,Arga KY,Eraslan S,Mertoglu B

更新日期：2017-10-01 00:00:00

abstract：:Although Escherichia coli LPS is known to elicit various proinflammatory responses in macrophages, its effect on the translational states of transcripts has not yet been explored on a genome-wide scale. To address this, we investigated the mRNA profiles in polysomal and free messenger ribonucleoprotein particle (mRNP)...

journal_title：Physiological genomics

authors： Kitamura H,Ito M,Yuasa T,Kikuguchi C,Hijikata A,Takayama M,Kimura Y,Yokoyama R,Kaji T,Ohara O

更新日期：2008-03-14 00:00:00

abstract：:Adenosine deaminase acting on RNA (ADAR) in Drosophila and mammals has recently become the target of numerous investigations. It is now clear that this protein has a number of functions in the nervous system. Indeed, the mutation of ADAR in Drosophila (dADAR) results in many pathological and physiological changes, suc...

journal_title：Physiological genomics

authors： Xia S,Yang J,Su Y,Qian J,Ma E,Haddad GG

更新日期：2005-01-20 00:00:00

abstract：:Adeno-associated virus (AAV) vectors might offer solutions for restenosis and angiogenesis by transducing nondividing cells and providing long-term gene expression. We investigated the feasibility of vascular cell transduction by AAV vectors in an in vivo rabbit carotid artery model. Time course of gene expression, in...

journal_title：Physiological genomics

authors： Richter M,Iwata A,Nyhuis J,Nitta Y,Miller AD,Halbert CL,Allen MD

更新日期：2000-04-27 00:00:00

abstract：:microRNAs (miRNAs) are short noncoding RNAs that regulate gene expression through posttranscriptional repression of target genes. miRNAs exert a fundamental level of control over many developmental processes, but their role in the differentiation and development of skeletal muscle from myogenic progenitor cells in hum...

journal_title：Physiological genomics

authors： Sjögren RJ,Egan B,Katayama M,Zierath JR,Krook A

更新日期：2015-03-01 00:00:00

abstract：:Several vasoregulatory systems including the renin-angiotensin system, sympathetic vasoregulation, and cytokine release have been studied extensively. The aim of the present study was to establish a physiogenomic screening model for differentially expressed genes in the regulation of blood pressure that might give a h...

journal_title：Physiological genomics

authors： Westhoff TH,Scheid S,Tölle M,Kaynak B,Schmidt S,Zidek W,Sperling S,van der Giet M

更新日期：2005-09-21 00:00:00

abstract：:Peripheral blood cells are an accessible environment in which to visualize exercise-induced alterations in global gene expression patterns. We aimed to identify a peripheral blood mononuclear cell (PBMC) signature represented by alterations in gene expression, in response to a standardized endurance exercise training ...

journal_title：Physiological genomics

authors： Dias RG,Silva MS,Duarte NE,Bolani W,Alves CR,Junior JR,da Silva JL,de Oliveira PA,Alves GB,de Oliveira EM,Rocha CS,Marsiglia JD,Negrao CE,Krieger EM,Krieger JE,Pereira AC

更新日期：2015-02-01 00:00:00

abstract：:In recent years, it has become evident that the adult mammalian CNS contains a population of neural stem cells (NSCs) described as immature, undifferentiated, multipotent cells, that may be called upon for repair in neurodegenerative and demyelinating diseases. NSCs may give rise to oligodendrocyte progenitor cells (O...

journal_title：Physiological genomics

authors： Imitola J,Snyder EY,Khoury SJ

更新日期：2003-08-15 00:00:00

abstract：:Understanding how vertebrates respond to hypoxia can have important clinical implications. Fish have evolved the ability to survive long exposure to low oxygen levels. However, little is known about the specific changes in gene expression that result from hypoxia. In this study we used a zebrafish cDNA microarray to e...

journal_title：Physiological genomics

authors： Ton C,Stamatiou D,Liew CC

更新日期：2003-04-16 00:00:00

abstract：:Studies were performed to examine the extent to which mechanical stimuli mediate control of angiogenesis in bladder cells both in vitro and in vivo. Differential gene expression between control nonstretched and cyclically stretched bladder smooth muscle cells was assessed using oligonucleotide microarrays and pathway ...

journal_title：Physiological genomics

authors： Yang R,Amir J,Liu H,Chaqour B

更新日期：2008-12-12 00:00:00

abstract：:A cDNA microarray resource has been developed with the goal of providing integrated functional genomics resources for cattle. The National Bovine Functional Genomics Consortium's (NBFGC) expressed sequence tag (EST) collection was established in 2001 to develop resources for functional genomics research. The NBFGC EST...

journal_title：Physiological genomics

authors： Suchyta SP,Sipkovsky S,Kruska R,Jeffers A,McNulty A,Coussens MJ,Tempelman RJ,Halgren RG,Saama PM,Bauman DE,Boisclair YR,Burton JL,Collier RJ,DePeters EJ,Ferris TA,Lucy MC,McGuire MA,Medrano JF,Overton TR,Smith TP,

更新日期：2003-10-17 00:00:00

abstract：:We used next-generation RNA sequencing (RNA-Seq) technology on the whole transcriptome to identify genes whose expression is consistently affected by obesity across multiple arteries. Specifically, we examined transcriptional profiles of the iliac artery as well as the feed artery, first, second, and third branch orde...

journal_title：Physiological genomics

authors： Padilla J,Jenkins NT,Thorne PK,Martin JS,Rector RS,Davis JW,Laughlin MH

更新日期：2014-11-15 00:00:00

abstract：:The cardiovascular restricted transcription factor CHF1/Hey2 has been previously shown to regulate the smooth muscle response to growth factors. To determine how CHF1/Hey2 affects the smooth muscle response to growth factors, we performed a genomic screen for transcripts that are differentially expressed in wild-type ...

journal_title：Physiological genomics

authors： Shirvani SM,Mookanamparambil L,Ramoni MF,Chin MT

更新日期：2007-06-19 00:00:00

abstract：:Bone marrow mononuclear cells (BMMNCs) increase capillary density and reduce fibrosis in rodents after myocardial infarction, resulting in an overall improvement in left ventricular function. Little is known about the effectiveness of BMMNC therapy in hypertensive heart disease. In the current study, we show that deli...

journal_title：Physiological genomics

authors： Parker SJ,Didier DN,Karcher JR,Stodola TJ,Endres B,Greene AS

更新日期：2012-10-02 00:00:00

abstract：:Hypoxia is a widely occurring condition experienced by diverse organisms under numerous physiological and disease conditions. To probe the molecular mechanisms underlying hypoxia responses and tolerance, we performed a genome-wide screen to identify mutants with enhanced hypoxia tolerance in the model eukaryote, the y...

journal_title：Physiological genomics

authors： Shah AN,Cadinu D,Henke RM,Xin X,Dastidar RG,Zhang L

更新日期：2011-07-27 00:00:00

abstract：:Preeclampsia (PE) is a devastating adverse outcome of pregnancy. Characterized by maternal hypertension, PE, when left untreated, can result in death of both mother and baby. The cause of PE remains unknown, and there is no way to predict which women will develop PE during pregnancy. The only known treatment is delive...

journal_title：Physiological genomics

authors： Olson KN,Redman LM,Sones JL

更新日期：2019-03-01 00:00:00

abstract：:Stearoyl-CoA desaturases (SCDs) are key enzymes of fatty acid biosynthesis whose regulation underpins responses to dietary, thermal, and hormonal treatment. Although two isoforms are known to exist in the common carp and human and four in mouse, there is no coherent view on how this gene family evolved to generate fun...

journal_title：Physiological genomics

authors： Evans H,De Tomaso T,Quail M,Rogers J,Gracey AY,Cossins AR,Berenbrink M

更新日期：2008-09-17 00:00:00

abstract：:The renin-angiotensin system (RAS), known for its roles in cardiovascular, metabolic, and developmental regulation, is present in both the circulation and in many individual tissues throughout the body. Substantial evidence supports the existence of a brain RAS, though quantification and localization of brain renin ha...

journal_title：Physiological genomics

authors： Xu D,Borges GR,Davis DR,Agassandian K,Sequeira Lopez ML,Gomez RA,Cassell MD,Grobe JL,Sigmund CD

更新日期：2011-03-29 00:00:00

abstract：:The purpose of this study was to identify novel transcriptional events occurring in the aortic wall before angiogenesis. We used a defined tissue culture system that takes advantage of the capacity of rat aortic rings to generate neovessels ex vivo in response to angiogenic factor stimulation. Total RNA isolated from ...

journal_title：Physiological genomics

authors： Aplin AC,Gelati M,Fogel E,Carnevale E,Nicosia RF

更新日期：2006-10-03 00:00:00

abstract：:Herbivores are predicted to evolve appropriate mechanisms to process the plant secondary compounds (PSCs) in their diet, and these mechanisms are likely specific to particular suites of PSCs. Changes in diet composition over evolutionary time should select for appropriate alterations in metabolism of the more recent d...

journal_title：Physiological genomics

authors： Magnanou E,Malenke JR,Dearing MD

更新日期：2013-09-03 00:00:00

abstract：:Chronic kidney disease (CKD) is accompanied by cardiac fibrosis, hypertrophy, and dysfunction, which are commonly referred to as uremic cardiomyopathy. Our previous studies found that Na/K-ATPase ligands or 5/6th partial nephrectomy (PNx) induces cardiac fibrosis in rats and mice. The current study used in vitro and i...

journal_title：Physiological genomics

authors： Drummond CA,Hill MC,Shi H,Fan X,Xie JX,Haller ST,Kennedy DJ,Liu J,Garrett MR,Xie Z,Cooper CJ,Shapiro JI,Tian J

更新日期：2016-03-01 00:00:00

abstract：:11beta-Hydroxysteroid dehydrogenase type 2 (11betaHSD2) is a short-chain dehydrogenase/reductase (SDR) responsible for inactivating cortisol and preventing its binding to the mineralocorticoid receptor (MR). Nonfunctional mutations in HSD11B2, the gene encoding 11betaHSD2, cause the hypertensive syndrome of apparent m...

journal_title：Physiological genomics

authors： Manning JR,Bailey MA,Soares DC,Dunbar DR,Mullins JJ

更新日期：2010-08-01 00:00:00

abstract：:The recent development of genetic mouse models presenting life-long alterations in expression of the genes for atrial natriuretic peptide (ANP) or its receptors (NPR-A, NPR-C) has uncovered a physiological role of this hormone in chronic blood pressure homeostasis. Transgenic mice overexpressing a transthyretin-ANP fu...

journal_title：Physiological genomics

authors： Melo LG,Steinhelper ME,Pang SC,Tse Y,Ackermann U

更新日期：2000-06-29 00:00:00

abstract：:Myocardial infarction (MI) induced by acute coronary arterial occlusion is usually secondary to atherosclerotic plaque rupture. Dysregulated response of vascular smooth muscle cells (VSMCs) in atherosclerotic plaques may promote plaque rupture. Cadherins (CDHs) form adherens junctions and are known stabilizers of athe...

journal_title：Physiological genomics

authors： Derda AA,Woo CC,Wongsurawat T,Richards M,Lee CN,Kofidis T,Kuznetsov VA,Sorokin VA

更新日期：2018-08-01 00:00:00

abstract：:The human miR-29 family of microRNAs has three mature members, miR-29a, miR-29b, and miR-29c. miR-29s are encoded by two gene clusters. Binding sites for several transcriptional factors have been identified in the promoter regions of miR-29 genes. The miR-29 family members share a common seed region sequence and are p...

journal_title：Physiological genomics

authors： Kriegel AJ,Liu Y,Fang Y,Ding X,Liang M

更新日期：2012-02-27 00:00:00

abstract：:Little is known regarding the graft response to transplantation injury. This study investigates the posttransplantation response of genes that are constitutively expressed in the heart. Constitutive heart and lymph node tissue-restricted gene expression was first analyzed with DNA microarrays. To demonstrate changes f...

journal_title：Physiological genomics

authors： Christopher K,Mueller TF,DeFina R,Liang Y,Zhang J,Gentleman R,Perkins DL

更新日期：2003-09-29 00:00:00

abstract：:We previously constructed a congenic mouse, B6.S-D2Mit194-D2Mit311 (B6.S-2) with 27 Mb of SPRET/Ei donor DNA on distal chromosome 2 in a C57BL/6J background that captured an obesity quantitative trait locus (QTL). Mice homozygous for SPRET/Ei alleles at the donor region had decreased body weight and obesity-related ph...

journal_title：Physiological genomics

authors： Chiu S,Kim K,Haus KA,Espinal GM,Millon LV,Warden CH

更新日期：2007-09-19 00:00:00

abstract：:The aims of this study were to 1) identify the earliest transcriptional response of the bovine endometrium to the presence of the conceptus (using RNAseq), 2) investigate if these genes are regulated by interferon tau (IFNT) in vivo, and 3) determine if they are predictive of the pregnancy status of postpartum dairy c...

journal_title：Physiological genomics

authors： Forde N,Duffy GB,McGettigan PA,Browne JA,Mehta JP,Kelly AK,Mansouri-Attia N,Sandra O,Loftus BJ,Crowe MA,Fair T,Roche JF,Lonergan P,Evans AC

更新日期：2012-08-17 00:00:00

abstract：:Survival of near-freezing body temperatures and reduced blood flow during hibernation is likely the result of changes in the expression of specific genes. In this study, we described a comprehensive survey of mRNAs in the heart of the thirteen-lined ground squirrel (Spermophilus tridecemlineatus) before and during hib...

journal_title：Physiological genomics

authors： Brauch KM,Dhruv ND,Hanse EA,Andrews MT

更新日期：2005-10-17 00:00:00

abstract：:We previously generated a conditional floxed mouse line to study androgen action, in which exon 3 of the androgen receptor (AR) gene is flanked by loxP sites, with the neomycin resistance gene present in intron 3. Deletion of exon 3 in global AR knockout mice causes androgen insensitivity syndrome, characterized by ge...

journal_title：Physiological genomics

authors： MacLean HE,Chiu WS,Ma C,McManus JF,Davey RA,Cameron R,Notini AJ,Zajac JD

更新日期：2008-03-14 00:00:00