Localization of a blood pressure QTL on rat chromosome 1 using Dahl rat congenic strains.

abstract：:A cDNA microarray resource has been developed with the goal of providing integrated functional genomics resources for cattle. The National Bovine Functional Genomics Consortium's (NBFGC) expressed sequence tag (EST) collection was established in 2001 to develop resources for functional genomics research. The NBFGC EST...

journal_title：Physiological genomics

authors： Suchyta SP,Sipkovsky S,Kruska R,Jeffers A,McNulty A,Coussens MJ,Tempelman RJ,Halgren RG,Saama PM,Bauman DE,Boisclair YR,Burton JL,Collier RJ,DePeters EJ,Ferris TA,Lucy MC,McGuire MA,Medrano JF,Overton TR,Smith TP,

更新日期：2003-10-17 00:00:00

abstract：:Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that regulates the oxygen-dependent expression of a number of genes. This transcription factor may contribute to the abundant expression of many genes in renal medullary cells that function normally under hypoxic conditions. The present study was d...

journal_title：Physiological genomics

authors： Zou AP,Yang ZZ,Li PL,Cowley AW JR

更新日期：2001-08-28 00:00:00

abstract：:Herbivores are predicted to evolve appropriate mechanisms to process the plant secondary compounds (PSCs) in their diet, and these mechanisms are likely specific to particular suites of PSCs. Changes in diet composition over evolutionary time should select for appropriate alterations in metabolism of the more recent d...

journal_title：Physiological genomics

authors： Magnanou E,Malenke JR,Dearing MD

更新日期：2013-09-03 00:00:00

abstract：:We describe longitudinal measurements of functional residual capacity (FRC) in breathing mice using a clinical computed tomography (CT) scanner. Lungs of anesthetized mice from the A/J and C3H/HeJ strains were scanned over a 10-s period. Using a fixed threshold for CT density, we could accurately and reproducibly obta...

journal_title：Physiological genomics

authors： Mitzner W,Brown R,Lee W

更新日期：2001-01-19 00:00:00

abstract：:In recent years, it has become evident that the adult mammalian CNS contains a population of neural stem cells (NSCs) described as immature, undifferentiated, multipotent cells, that may be called upon for repair in neurodegenerative and demyelinating diseases. NSCs may give rise to oligodendrocyte progenitor cells (O...

journal_title：Physiological genomics

authors： Imitola J,Snyder EY,Khoury SJ

更新日期：2003-08-15 00:00:00

abstract：:Immobilization, bed rest, or denervation leads to muscle disuse and subsequent skeletal muscle atrophy. Muscle atrophy can also occur as a component of various chronic diseases such as cancer, AIDS, sepsis, diabetes, and chronic heart failure or as a direct result of genetic muscle disorders. In addition to this atrop...

journal_title：Physiological genomics

authors： Cho Y,Ross RS

更新日期：2018-09-01 00:00:00

abstract：:Since inclusion of atherosclerotic tissues from different sources is often indispensable to study the full atherogenic spectrum, we investigated to what extent the expression profiles of advanced, stable atherosclerotic lesions obtained during autopsy and surgery are comparable. The gene expression profiles of human c...

journal_title：Physiological genomics

authors： Sluimer JC,Kisters N,Cleutjens KB,Volger OL,Horrevoets AJ,van den Akker LH,Bijnens AP,Daemen MJ

更新日期：2007-08-20 00:00:00

abstract：:We investigated the expression and function of serum response factor (SRF) in endothelial-mesenchymal transition (EndMT) in glomerular endothelial cells (GEnCs) of diabetic nephropathy (DN). The expression of SRF, endothelial markers (VE-cadherin, CD31), and mesenchymal markers (α-SMA, FSP-1, fibronectin) was examined...

journal_title：Physiological genomics

authors： Zhao L,Zhao J,Wang X,Chen Z,Peng K,Lu X,Meng L,Liu G,Guan G,Wang F

更新日期：2016-10-01 00:00:00

abstract：:Peripheral blood cells are an accessible environment in which to visualize exercise-induced alterations in global gene expression patterns. We aimed to identify a peripheral blood mononuclear cell (PBMC) signature represented by alterations in gene expression, in response to a standardized endurance exercise training ...

journal_title：Physiological genomics

authors： Dias RG,Silva MS,Duarte NE,Bolani W,Alves CR,Junior JR,da Silva JL,de Oliveira PA,Alves GB,de Oliveira EM,Rocha CS,Marsiglia JD,Negrao CE,Krieger EM,Krieger JE,Pereira AC

更新日期：2015-02-01 00:00:00

abstract：:Mouse lines divergently selected for heat loss were evaluated for correlated responses in the hypothalamic transcriptome. High (MH) heat loss mice have approximately 50% greater heat loss, approximately 35% less body fat, approximately 20% greater feed intake, approximately 100% greater locomotor activity levels, and ...

journal_title：Physiological genomics

authors： Wesolowski SR,Allan MF,Nielsen MK,Pomp D

更新日期：2003-04-16 00:00:00

abstract：:Genetic influences and endurance exercise have been shown to alter circulating concentrations of dehydroepiandrosterone (DHEA) and its sulfated conjugate, DHEAS. We hypothesized that acute resistance exercise (RE) and training (RET) would increase DHEA steroids, and the magnitude of the increase would be influenced by...

journal_title：Physiological genomics

authors： Riechman SE,Fabian TJ,Kroboth PD,Ferrell RE

更新日期：2004-05-19 00:00:00

abstract：:The human miR-29 family of microRNAs has three mature members, miR-29a, miR-29b, and miR-29c. miR-29s are encoded by two gene clusters. Binding sites for several transcriptional factors have been identified in the promoter regions of miR-29 genes. The miR-29 family members share a common seed region sequence and are p...

journal_title：Physiological genomics

authors： Kriegel AJ,Liu Y,Fang Y,Ding X,Liang M

更新日期：2012-02-27 00:00:00

abstract：:Recombinant human erythropoietin (rHuEPO) is frequently abused by athletes as a performance-enhancing drug, despite being prohibited by the World Anti-Doping Agency. Although the methods to detect blood doping, including rHuEPO injections, have improved in recent years, they remain imperfect. In a proof-of-principle s...

journal_title：Physiological genomics

authors： Durussel J,Haile DW,Mooses K,Daskalaki E,Beattie W,Mooses M,Mekonen W,Ongaro N,Anjila E,Patel RK,Padmanabhan N,McBride MW,McClure JD,Pitsiladis YP

更新日期：2016-03-01 00:00:00

abstract：:Membrane-bound and membrane-associated proteins are difficult to analyze by mass spectrometry, since the association with lipids impedes the isolation and solubilization of the proteins in buffers suitable for mass spectrometry and the efficient generation of positively charged peptide ions by electrospray ionization....

journal_title：Physiological genomics

authors： Mirza SP,Halligan BD,Greene AS,Olivier M

更新日期：2007-06-19 00:00:00

abstract：:The aims of this study were to 1) identify the earliest transcriptional response of the bovine endometrium to the presence of the conceptus (using RNAseq), 2) investigate if these genes are regulated by interferon tau (IFNT) in vivo, and 3) determine if they are predictive of the pregnancy status of postpartum dairy c...

journal_title：Physiological genomics

authors： Forde N,Duffy GB,McGettigan PA,Browne JA,Mehta JP,Kelly AK,Mansouri-Attia N,Sandra O,Loftus BJ,Crowe MA,Fair T,Roche JF,Lonergan P,Evans AC

更新日期：2012-08-17 00:00:00

abstract：:Cardiac microvascular endothelial cells (CMVECs) are the most numerous cells in the myocardium and orchestrate cardiogenesis during development, regulate adult cardiac function, and modulate pathophysiology of heart failure. It has been shown that the transcriptome of CMVECs differs from other endothelial cell types, ...

journal_title：Physiological genomics

authors： Vermeulen Z,Mateiu L,Dugaucquier L,De Keulenaer GW,Segers VFM

更新日期：2019-06-01 00:00:00

abstract：:Physiological, morphological, and transcriptional alterations elicited by ethynyl estradiol in the uteri of Sprague-Dawley rats and C57BL/6 mice were assessed using comparable study designs, microarray platforms, and analysis methods to identify conserved estrogen signaling networks. Comparative analysis identified 15...

journal_title：Physiological genomics

authors： Kwekel JC,Burgoon LD,Burt JW,Harkema JR,Zacharewski TR

更新日期：2005-11-17 00:00:00

abstract：:Both being dormant cellular states, quiescence and senescence are traditionally considered distinct. Quiescence is reversible to proliferation upon growth signals, whereas senescence is irreversible in physiological conditions. Recent findings, however, suggest that quiescence deepening with a decreased proliferative ...

journal_title：Physiological genomics

authors： Fujimaki K,Yao G

更新日期：2020-11-01 00:00:00

abstract：:Metazoan akirin genes regulate innate immunity, myogenesis, and carcinogenesis. Invertebrates typically have one family member, while most tetrapod and teleost vertebrates have one to three. We demonstrate an expanded repertoire of eight family members in genomes of four salmonid fishes, owing to paralog preservation ...

journal_title：Physiological genomics

authors： Macqueen DJ,Kristjánsson BK,Johnston IA

更新日期：2010-06-01 00:00:00

abstract：:Branchial ammonia transport in freshwater teleosts is not well understood. Most studies conclude that NH(3) diffuses out of the gill and becomes protonated to NH(4)(+) in an acidified gill boundary layer. Rhesus (Rh) proteins are new members of the ammonia transporter superfamily and rainbow trout possess genes encodi...

journal_title：Physiological genomics

authors： Nawata CM,Hung CC,Tsui TK,Wilson JM,Wright PA,Wood CM

更新日期：2007-11-14 00:00:00

abstract：:Mammalian heart development is built on highly conserved molecular mechanisms with polygenetic perturbations resulting in a spectrum of congenital heart diseases (CHD). However, knowledge of cardiogenic ontogeny that regulates proper cardiogenesis remains largely based on candidate-gene approaches. Mapping the dynamic...

journal_title：Physiological genomics

authors： Li X,Martinez-Fernandez A,Hartjes KA,Kocher JP,Olson TM,Terzic A,Nelson TJ

更新日期：2014-07-01 00:00:00

abstract：:The mammary gland undergoes extensive remodeling between the beginning of pregnancy and lactation; this involves cellular processes including cell proliferation, differentiation, and apoptosis, all of which are under the control of numerous regulators. To unravel the role played by miRNA, we describe here 47 new ovine...

journal_title：Physiological genomics

authors： Galio L,Droineau S,Yeboah P,Boudiaf H,Bouet S,Truchet S,Devinoy E

更新日期：2013-02-15 00:00:00

abstract：:The airway epithelium represents an important barrier between the host and the environment. It is a first site of contact with pathogens, particulates, and other stimuli, and has evolved the means to dynamically respond to these challenges. In an effort to define the transcript profile of airway epithelia, we created ...

journal_title：Physiological genomics

authors： Scheetz TE,Zabner J,Welsh MJ,Coco J,Eyestone Mde F,Bonaldo M,Kucaba T,Casavant TL,Soares MB,McCray PB Jr

更新日期：2004-03-12 00:00:00

abstract：:The objective of this study was to identify prostaglandin F(2α) (PG)-induced changes in the transcriptome of bovine corpora lutea (CL) that are specific to mature, PG-responsive (day 11) CL vs. developing (day 4) CL, which do not undergo luteolysis in response to PG administration. CL were collected at 0, 4, and 24 h ...

journal_title：Physiological genomics

authors： Mondal M,Schilling B,Folger J,Steibel JP,Buchnick H,Zalman Y,Ireland JJ,Meidan R,Smith GW

更新日期：2011-04-27 00:00:00

abstract：:The p21 activated kinase 1(PAK1) gene encodes a serine/threonine kinase that is overexpressed in a subset of human breast carcinomas with poor prognosis. The laboratory rat (Rattus norvegicus)orthologous gene is located at Mammary carcinoma susceptibility 3 (Mcs3) QTL on rat chromosome 1. We used quantitative PCR to d...

journal_title：Physiological genomics

authors： Duderstadt EL,McQuaide SA,Sanders MA,Samuelson DJ

更新日期：2020-12-21 00:00:00

abstract：:The liver of dairy cows is involved in signaling the current hepatic metabolic state to the brain via metabolites and nerval afferents to control and adjust feed intake. Feed deprivation may result in mobilization of body reserves favoring hepatic steatosis. While the overall metabolic changes are well characterized, ...

journal_title：Physiological genomics

authors： Kuhla B,Albrecht D,Kuhla S,Metges CC

更新日期：2009-04-10 00:00:00

abstract：:We previously reported that mice deficient in stearoyl-CoA desaturase-1 (Scd1) and maintained on a very low-fat (VLF) diet for 10 days developed severe loss of body weight, hypoglycemia, hypercholesterolemia, and many cholestasis-like phenotypes. To better understand the metabolic changes associated with these phenoty...

journal_title：Physiological genomics

authors： Flowers MT,Keller MP,Choi Y,Lan H,Kendziorski C,Ntambi JM,Attie AD

更新日期：2008-05-13 00:00:00

abstract：:Consumption of a protein-containing meal by a fasted animal promotes protein accretion in skeletal muscle, in part through leucine stimulation of protein synthesis and indirectly through repression of protein degradation mediated by its metabolite, α-ketoisocaproate. Mice lacking the mitochondrial branched-chain amino...

journal_title：Physiological genomics

authors： Lynch CJ,Kimball SR,Xu Y,Salzberg AC,Kawasawa YI

更新日期：2015-11-01 00:00:00

abstract：:alpha-Sarcoglycan-deficient (Sgca-null) mice provide potential for elucidating the pathogenesis of limb girdle muscular dystrophy type 2D (LGMD 2D) as well as for studying the effectiveness of therapeutic strategies. Skeletal muscles of Sgca-null mice demonstrate an early onset of extensive fiber necrosis, degeneratio...

journal_title：Physiological genomics

authors： Consolino CM,Duclos F,Lee J,Williamson RA,Campbell KP,Brooks SV

更新日期：2005-07-14 00:00:00

abstract：:Expression patterns of monocarboxylate transporter 2 (MCT2) display mRNA diversity in a tissue-specific fashion. We cloned and characterized multiple mct2 5'-cDNA ends from the mouse and determined the structural organization of the mct2 gene. We found that transcription of this gene was initiated from five independen...

journal_title：Physiological genomics

authors： Zhang SX,Searcy TR,Wu Y,Gozal D,Wang Y

更新日期：2007-12-19 00:00:00