In vivo measurement of lung volumes in mice.

abstract：:We previously reported that mice deficient in stearoyl-CoA desaturase-1 (Scd1) and maintained on a very low-fat (VLF) diet for 10 days developed severe loss of body weight, hypoglycemia, hypercholesterolemia, and many cholestasis-like phenotypes. To better understand the metabolic changes associated with these phenoty...

journal_title：Physiological genomics

authors： Flowers MT,Keller MP,Choi Y,Lan H,Kendziorski C,Ntambi JM,Attie AD

更新日期：2008-05-13 00:00:00

abstract：:Septa from sheep hearts at 130 days gestation, term, and 14-day-old lambs were used to model the changes in gene expression patterns during the perinatal period using Agilent 15k ovine microarrays. We used Bioconductor for R to model five major patterns of coexpressed genes. Gene ontology and transcription factor anal...

journal_title：Physiological genomics

authors： Richards EM,Rabaglino MB,Antolic A,Wood CE,Keller-Wood M

更新日期：2015-09-01 00:00:00

abstract：:Obesity is influenced by genetics and diet and has wide ranging comorbidities, including anxiety and depressive disorders. Outbred heterogeneous stock (HS) rats are used for fine-genetic mapping of complex traits and may be useful for understanding gene by diet interactions. In this study, HS rats were fed diets conta...

journal_title：Physiological genomics

authors： Deal AW,Seshie O,Lenzo A,Cooper N,Ozimek N,Solberg Woods LC

更新日期：2020-09-01 00:00:00

abstract：:Retinoid-related orphan receptor (ROR)α4 is the major RORα isoform expressed in adipose tissues and liver. In this study we demonstrate that RORα-deficient staggerer mice (RORα(sg/sg)) fed with a high-fat diet (HFD) exhibited reduced adiposity and hepatic triglyceride levels compared with wild-type (WT) littermates an...

journal_title：Physiological genomics

authors： Kang HS,Okamoto K,Takeda Y,Beak JY,Gerrish K,Bortner CD,DeGraff LM,Wada T,Xie W,Jetten AM

更新日期：2011-07-14 00:00:00

abstract：:In functional genomics, the high-throughput methods such as microarrays 1) allow analysis of the relationships between genes considering them as elements of a network and 2) lead to biological interpretations thanks to Gene Ontology. But up to now it has not been possible to find relationships between the functions an...

journal_title：Physiological genomics

authors： Gustin MP,Paultre CZ,Randon J,Bricca G,Cerutti C

更新日期：2008-06-12 00:00:00

abstract：:Survival of near-freezing body temperatures and reduced blood flow during hibernation is likely the result of changes in the expression of specific genes. In this study, we described a comprehensive survey of mRNAs in the heart of the thirteen-lined ground squirrel (Spermophilus tridecemlineatus) before and during hib...

journal_title：Physiological genomics

authors： Brauch KM,Dhruv ND,Hanse EA,Andrews MT

更新日期：2005-10-17 00:00:00

abstract：:Chronic kidney disease (CKD) is associated with increased cardiovascular morbidity and mortality. Previous studies indicated an impairment of ischemia-induced angiogenesis in skeletal muscle of rats with CKD. We performed a systematic comparison of early gene expression in response to ischemia in rats with or without ...

journal_title：Physiological genomics

authors： Heiss RU,Fahlbusch FB,Jacobi J,Daniel C,Ekici AB,Cordasic N,Amann K,Hartner A,Hilgers KF

更新日期：2017-04-01 00:00:00

abstract：:Hypertension (HTN) is a prevalent condition with complex etiology and pathophysiology. Evidence exists of significant communication between the nervous system and the immune system (IS), and there appears to be a direct role for inflammatory bone marrow (BM) cells in the pathophysiology of hypertension. However, the m...

journal_title：Physiological genomics

authors： Ahmari N,Schmidt JT,Krane GA,Malphurs W,Cunningham BE,Owen JL,Martyniuk CJ,Zubcevic J

更新日期：2016-07-01 00:00:00

abstract：:Dietary fructose intake has dramatically increased over recent decades and is implicated in the high rates of obesity, hypertension, and type 2 diabetes (metabolic syndrome) in Western societies. The molecular determinants of this epidemiologic correlation are incompletely defined, but high-flux fructose catabolism in...

journal_title：Physiological genomics

authors： Diggle CP,Shires M,McRae C,Crellin D,Fisher J,Carr IM,Markham AF,Hayward BE,Asipu A,Bonthron DT

更新日期：2010-11-29 00:00:00

abstract：:Chronic kidney disease (CKD), defined as reduced glomerular filtration rate, is increasingly becoming a major public health issue. At the histological level, renal fibrosis is the final common pathway leading to end-stage renal disease, irrespective of the initial injury. According to this view, antifibrotic agents sh...

journal_title：Physiological genomics

authors： Lv W,Fan F,Wang Y,Gonzalez-Fernandez E,Wang C,Yang L,Booz GW,Roman RJ

更新日期：2018-01-01 00:00:00

abstract：:Membrane-bound and membrane-associated proteins are difficult to analyze by mass spectrometry, since the association with lipids impedes the isolation and solubilization of the proteins in buffers suitable for mass spectrometry and the efficient generation of positively charged peptide ions by electrospray ionization....

journal_title：Physiological genomics

authors： Mirza SP,Halligan BD,Greene AS,Olivier M

更新日期：2007-06-19 00:00:00

abstract：:In this paper, two novel, powerful, and robust convolutional neural network (CNN) architectures are designed and proposed for two different classification tasks using publicly available data sets. The first architecture is able to decide whether a given chest X-ray image of a patient contains COVID-19 or not with 98.9...

journal_title：Physiological genomics

authors： Irmak E

更新日期：2020-12-01 00:00:00

abstract：:The renin-angiotensin system (RAS), known for its roles in cardiovascular, metabolic, and developmental regulation, is present in both the circulation and in many individual tissues throughout the body. Substantial evidence supports the existence of a brain RAS, though quantification and localization of brain renin ha...

journal_title：Physiological genomics

authors： Xu D,Borges GR,Davis DR,Agassandian K,Sequeira Lopez ML,Gomez RA,Cassell MD,Grobe JL,Sigmund CD

更新日期：2011-03-29 00:00:00

abstract：:An increased phospholamban (PLB)-to-sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA) ratio has been suggested to contribute to the slowing of relaxation in failing human ventricle. We have used an adenoviral vector carrying the sequence for PLB to increase this ratio in isolated adult rat ventricular myocytes, and w...

journal_title：Physiological genomics

authors： Davia K,Hajjar RJ,Terracciano CM,Kent NS,Ranu HK,O'Gara P,Rosenzweig A,Harding SE

更新日期：1999-08-31 00:00:00

abstract：:Intrinsic aerobic exercise capacity can influence many complex traits including obesity and aging. To study this connection we established two rat lines by divergent selection of untrained aerobic capacity. After 32 generations the high capacity runners (HCR) and low capacity runners (LCR) differed in endurance runnin...

journal_title：Physiological genomics

authors： Ren YY,Koch LG,Britton SL,Qi NR,Treutelaar MK,Burant CF,Li JZ

更新日期：2016-11-01 00:00:00

abstract：:Model organisms have been used over a century to understand basic, conserved biological processes. The study of these experimental systems began with genetics and development, moved into molecular and cellular biology, and most recently propelled into functional genomics and proteomics. The goal of this review is simp...

journal_title：Physiological genomics

authors： Barr MM

更新日期：2003-03-18 00:00:00

abstract：:Psoriasis is a chronic and common human skin disorder currently with no cure. Psoriatic skin displays inflammatory, raised, and scaly lesions with widely aberrant gene expression. Recent studies have revealed critical roles that microRNAs play as a class of posttranscriptional gene regulator in skin development and sk...

journal_title：Physiological genomics

authors： Xia J,Zhang W

更新日期：2014-02-15 00:00:00

abstract：:The structural organization of the brain is important for normal brain function and is critical to understand in order to evaluate changes that occur during disease processes. Three-dimensional (3D) imaging of the mouse brain is necessary to appreciate the spatial context of structures within the brain. In addition, t...

journal_title：Physiological genomics

authors： Gleave JA,Wong MD,Dazai J,Altaf M,Henkelman RM,Lerch JP,Nieman BJ

更新日期：2012-08-01 00:00:00

abstract：:Heterotrimeric G proteins (Galphabetagamma) play an essential role in coupling membrane receptors to effector proteins such as ion channels and enzymes. Among the five mammalian Gbeta-subunits cloned, the human G protein beta4 has not been described. The purpose of the present study was to functionally characterize th...

journal_title：Physiological genomics

authors： Ruiz-Velasco V,Ikeda SR,Puhl HL

更新日期：2002-02-11 00:00:00

abstract：:Physiological, morphological, and transcriptional alterations elicited by ethynyl estradiol in the uteri of Sprague-Dawley rats and C57BL/6 mice were assessed using comparable study designs, microarray platforms, and analysis methods to identify conserved estrogen signaling networks. Comparative analysis identified 15...

journal_title：Physiological genomics

authors： Kwekel JC,Burgoon LD,Burt JW,Harkema JR,Zacharewski TR

更新日期：2005-11-17 00:00:00

abstract：:Megakaryocyte (MK) development is critically informed by plasma membrane-localized receptors that integrate a multiplicity of environmental cues. Given that the current understanding about receptors and ligands involved in megakaryocytopoiesis is based on single targets, we performed a genome-wide search to identify a...

journal_title：Physiological genomics

authors： Sun S,Wang W,Latchman Y,Gao D,Aronow B,Reems JA

更新日期：2013-03-18 00:00:00

abstract：:There exists a sense of urgency to begin to generate a cohesive assembly of biomedical knowledge as the pace of knowledge accumulation accelerates. The urgency is in part driven by the emergence of systems molecular medicine that emphasizes the combination of systems analysis and molecular dissection in the future of ...

journal_title：Physiological genomics

authors： Liang M

更新日期：2007-08-20 00:00:00

abstract：:The Wfs1 gene codes for a protein with unknown function, but deficiency in this protein results in a range of neuropsychiatric and neuroendocrine syndromes. In the present study we aimed to find the functional networks influenced by Wfs1 in the hypothalamus. We performed gene expression profiling (Mouse Gene 1.0 ST Ar...

journal_title：Physiological genomics

authors： Kõks S,Soomets U,Plaas M,Terasmaa A,Noormets K,Tillmann V,Vasar E,Fernandes C,Schalkwyk LC

更新日期：2011-12-16 00:00:00

abstract：:High-frequency ultrasound biomicroscopy (UBM) has recently emerged as a high-resolution means of phenotyping genetically altered mice and has great potential to evaluate the cardiac morphology and hemodynamics of mouse mutants. However, there is no standard procedure of in vivo transthoracic cardiac imaging using UBM ...

journal_title：Physiological genomics

authors： Zhou YQ,Foster FS,Nieman BJ,Davidson L,Chen XJ,Henkelman RM

更新日期：2004-07-08 00:00:00

abstract：:Several vasoregulatory systems including the renin-angiotensin system, sympathetic vasoregulation, and cytokine release have been studied extensively. The aim of the present study was to establish a physiogenomic screening model for differentially expressed genes in the regulation of blood pressure that might give a h...

journal_title：Physiological genomics

authors： Westhoff TH,Scheid S,Tölle M,Kaynak B,Schmidt S,Zidek W,Sperling S,van der Giet M

更新日期：2005-09-21 00:00:00

abstract：:Metazoan akirin genes regulate innate immunity, myogenesis, and carcinogenesis. Invertebrates typically have one family member, while most tetrapod and teleost vertebrates have one to three. We demonstrate an expanded repertoire of eight family members in genomes of four salmonid fishes, owing to paralog preservation ...

journal_title：Physiological genomics

authors： Macqueen DJ,Kristjánsson BK,Johnston IA

更新日期：2010-06-01 00:00:00

abstract：:The mammalian liver works to keep the body in a state of homeostasis and plays an important role in systemic acute phase response to infections. In this study we investigated the bovine hepatic acute phase response at the gene transcription level in dairy cows with experimentally Escherichia coli-induced mastitis. At ...

journal_title：Physiological genomics

authors： Jørgensen HB,Buitenhuis B,Røntved CM,Jiang L,Ingvartsen KL,Sørensen P

更新日期：2012-06-01 00:00:00

abstract：:Mouse lines divergently selected for heat loss were evaluated for correlated responses in the hypothalamic transcriptome. High (MH) heat loss mice have approximately 50% greater heat loss, approximately 35% less body fat, approximately 20% greater feed intake, approximately 100% greater locomotor activity levels, and ...

journal_title：Physiological genomics

authors： Wesolowski SR,Allan MF,Nielsen MK,Pomp D

更新日期：2003-04-16 00:00:00

abstract：:We previously constructed a congenic mouse, B6.S-D2Mit194-D2Mit311 (B6.S-2) with 27 Mb of SPRET/Ei donor DNA on distal chromosome 2 in a C57BL/6J background that captured an obesity quantitative trait locus (QTL). Mice homozygous for SPRET/Ei alleles at the donor region had decreased body weight and obesity-related ph...

journal_title：Physiological genomics

authors： Chiu S,Kim K,Haus KA,Espinal GM,Millon LV,Warden CH

更新日期：2007-09-19 00:00:00

abstract：:Growth hormone (GH) controls the physiology and pathophysiology of the liver, and its signals are conducted by two members of the family of signal transducers and activators of transcription, STAT5A and STAT5B. Mice in which the Stat5a/b locus has been inactivated specifically in hepatocytes display GH resistance, the...

journal_title：Physiological genomics

authors： Hosui A,Hennighausen L

更新日期：2008-07-15 00:00:00