Abstract:
:Chronic kidney disease (CKD), defined as reduced glomerular filtration rate, is increasingly becoming a major public health issue. At the histological level, renal fibrosis is the final common pathway leading to end-stage renal disease, irrespective of the initial injury. According to this view, antifibrotic agents should slow or halt the progression of CKD. However, due to multiple overlapping pathways stimulating fibrosis, it has been difficult to develop antifibrotic drugs that delay or reverse the progression of CKD. MicroRNAs (miRNAs) are small noncoding RNA molecules, 18-22 nucleotides in length, that control many developmental and cellular processes as posttranscriptional regulators of gene expression. Emerging evidence suggests that miRNAs targeted against genes involved in renal fibrosis might be potential candidates for the development of antifibrotic therapies for CKD. This review will discuss some of the miRNAs, such as Let-7, miR-21,-29, -192, -200,-324, -132, -212, -30, -126, -433, -214, and -199a, that are implicated in renal fibrosis and the potential to exploit these molecular targets for the treatment of CKD.
journal_name
Physiol Genomicsjournal_title
Physiological genomicsauthors
Lv W,Fan F,Wang Y,Gonzalez-Fernandez E,Wang C,Yang L,Booz GW,Roman RJdoi
10.1152/physiolgenomics.00039.2017subject
Has Abstractpub_date
2018-01-01 00:00:00pages
20-34issue
1eissn
1094-8341issn
1531-2267pii
physiolgenomics.00039.2017journal_volume
50pub_type
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