Abstract:
:Model organisms have been used over a century to understand basic, conserved biological processes. The study of these experimental systems began with genetics and development, moved into molecular and cellular biology, and most recently propelled into functional genomics and proteomics. The goal of this review is simple: to discuss the place of model organisms in "The Age of the Ome": the genome, the transcriptome, and the proteome. This review will address the following questions. What exactly is a model organism? What characteristics make an excellent model system? Using the yeast Saccharomyces cerevisiae and the nematode Caenorhabditis elegans as examples, this review will discuss these issues with the aim of demonstrating how model organisms remain indispensable scientific tools for understanding complex biological pathways and human disease.
journal_name
Physiol Genomicsjournal_title
Physiological genomicsauthors
Barr MMdoi
10.1152/physiolgenomics.00075.2002subject
Has Abstractpub_date
2003-03-18 00:00:00pages
15-24issue
1eissn
1094-8341issn
1531-2267pii
13/1/15journal_volume
13pub_type
杂志文章abstract::As the amount of information available to biologists increases exponentially, data analysis becomes progressively more challenging. Sequence homology has been a traditional tool in the researchers' armamentarium; it is a very versatile instrument and can be employed to assist in numerous tasks, from establishing the f...
journal_title:Physiological genomics
pub_type: 杂志文章,评审
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journal_title:Physiological genomics
pub_type: 杂志文章,评审
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journal_title:Physiological genomics
pub_type: 杂志文章,评审
doi:10.1152/physiolgenomics.00170.2013
更新日期:2014-05-01 00:00:00
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journal_title:Physiological genomics
pub_type: 杂志文章
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更新日期:2013-02-15 00:00:00
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journal_title:Physiological genomics
pub_type: 杂志文章
doi:10.1152/physiolgenomics.00072.2014
更新日期:2015-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1152/physiolgenomics.00015.2015
更新日期:2015-10-01 00:00:00
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journal_title:Physiological genomics
pub_type: 杂志文章
doi:10.1152/physiolgenomics.00172.2002
更新日期:2003-04-16 00:00:00
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journal_title:Physiological genomics
pub_type: 杂志文章
doi:10.1152/physiolgenomics.00277.2006
更新日期:2007-06-19 00:00:00
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journal_title:Physiological genomics
pub_type: 杂志文章
doi:10.1152/physiolgenomics.00112.2020
更新日期:2020-12-21 00:00:00
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journal_title:Physiological genomics
pub_type: 杂志文章
doi:10.1152/physiolgenomics.00002.2015
更新日期:2015-08-01 00:00:00
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journal_title:Physiological genomics
pub_type: 杂志文章
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journal_title:Physiological genomics
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journal_title:Physiological genomics
pub_type: 杂志文章
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journal_title:Physiological genomics
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更新日期:2008-04-22 00:00:00
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journal_title:Physiological genomics
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更新日期:2019-06-01 00:00:00
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journal_title:Physiological genomics
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更新日期:2007-09-19 00:00:00
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journal_title:Physiological genomics
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更新日期:2005-01-20 00:00:00
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journal_title:Physiological genomics
pub_type: 杂志文章
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更新日期:2008-03-14 00:00:00