Identification of MEF2-regulated genes during muscle differentiation.

abstract：:In this paper, two novel, powerful, and robust convolutional neural network (CNN) architectures are designed and proposed for two different classification tasks using publicly available data sets. The first architecture is able to decide whether a given chest X-ray image of a patient contains COVID-19 or not with 98.9...

journal_title：Physiological genomics

authors： Irmak E

更新日期：2020-12-01 00:00:00

abstract：:It has been found that Arabian and Thoroughbred horses differ in muscle fiber structure and thus in physiological changes occurring in muscles during exercise. The aim of the present study was to identify the global gene expression modifications that occur in skeletal muscle following a training regime to prepare for ...

journal_title：Physiological genomics

authors： Ropka-Molik K,Stefaniuk-Szmukier M,Z Ukowski K,Piórkowska K,Bugno-Poniewierska M

更新日期：2017-06-01 00:00:00

abstract：:We previously reported that markers on rat chromosome 1 are genetically linked to blood pressure in an F(2) population derived from Dahl salt hypertension-sensitive (S) and Lewis (LEW) rats. Because there was evidence for more than one blood pressure quantitative trait locus (QTL) on chromosome 1, an initial congenic ...

journal_title：Physiological genomics

authors： Saad Y,Garrett MR,Lee SJ,Dene H,Rapp JP

更新日期：1999-11-11 00:00:00

abstract：:The aim of the study was to explore the genetic architecture influencing weight of fast- and slow-twitch skeletal muscles. The weights of the slow-twitch soleus, the mixed gastrocnemius, the fast-twitch tibialis anterior (TA), and extensor digitorum longus (EDL) muscles were 11-34% greater (P < 0.001) in 200-day-old C...

journal_title：Physiological genomics

authors： Lionikas A,Blizard DA,Vandenbergh DJ,Glover MG,Stout JT,Vogler GP,McClearn GE,Larsson L

更新日期：2003-12-16 00:00:00

abstract：:Preeclampsia (PE) is a devastating adverse outcome of pregnancy. Characterized by maternal hypertension, PE, when left untreated, can result in death of both mother and baby. The cause of PE remains unknown, and there is no way to predict which women will develop PE during pregnancy. The only known treatment is delive...

journal_title：Physiological genomics

authors： Olson KN,Redman LM,Sones JL

更新日期：2019-03-01 00:00:00

abstract：:We used next-generation RNA sequencing (RNA-Seq) technology on the whole transcriptome to identify genes whose expression is consistently affected by obesity across multiple arteries. Specifically, we examined transcriptional profiles of the iliac artery as well as the feed artery, first, second, and third branch orde...

journal_title：Physiological genomics

authors： Padilla J,Jenkins NT,Thorne PK,Martin JS,Rector RS,Davis JW,Laughlin MH

更新日期：2014-11-15 00:00:00

abstract：:Epigenetic differences between male and female bovine blastocysts provide a plausible link between physiological and gene transcription differences observed between male and female embryos. The aim of this study was to examine sex-related epigenetic differences in bovine blastocysts produced in vitro. Oocytes were mat...

journal_title：Physiological genomics

authors： Bermejo-Alvarez P,Rizos D,Rath D,Lonergan P,Gutierrez-Adan A

更新日期：2008-01-17 00:00:00

abstract：:Mast cell numbers are significantly increased in bladder disorders including malignancy and interstitial cystitis, but their precise role has been difficult to determine. We characterized the role of mast cells on gene regulation associated with antigen-induced bladder inflammation in mice. For this purpose, we examin...

journal_title：Physiological genomics

authors： Saban R,Saban MR,Nguyen NB,Hammond TG,Wershil BK

更新日期：2001-10-10 00:00:00

abstract：:The airway epithelium represents an important barrier between the host and the environment. It is a first site of contact with pathogens, particulates, and other stimuli, and has evolved the means to dynamically respond to these challenges. In an effort to define the transcript profile of airway epithelia, we created ...

journal_title：Physiological genomics

authors： Scheetz TE,Zabner J,Welsh MJ,Coco J,Eyestone Mde F,Bonaldo M,Kucaba T,Casavant TL,Soares MB,McCray PB Jr

更新日期：2004-03-12 00:00:00

abstract：:A single point mutation in a novel immune-associated nucleotide gene 5 (Ian5) coincides with severe T cell lymphopenia in BB rats. We used a transgenic rescue approach in lymphopenic BB-derived congenic F344.lyp/lyp rats to determine whether this mutation is responsible for lymphopenia and to establish the functional ...

journal_title：Physiological genomics

authors： Michalkiewicz M,Michalkiewicz T,Ettinger RA,Rutledge EA,Fuller JM,Moralejo DH,Van Yserloo B,MacMurray AJ,Kwitek AE,Jacob HJ,Lander ES,Lernmark A

更新日期：2004-10-04 00:00:00

abstract：:We previously constructed a congenic mouse, B6.S-D2Mit194-D2Mit311 (B6.S-2) with 27 Mb of SPRET/Ei donor DNA on distal chromosome 2 in a C57BL/6J background that captured an obesity quantitative trait locus (QTL). Mice homozygous for SPRET/Ei alleles at the donor region had decreased body weight and obesity-related ph...

journal_title：Physiological genomics

authors： Chiu S,Kim K,Haus KA,Espinal GM,Millon LV,Warden CH

更新日期：2007-09-19 00:00:00

abstract：:Although Escherichia coli LPS is known to elicit various proinflammatory responses in macrophages, its effect on the translational states of transcripts has not yet been explored on a genome-wide scale. To address this, we investigated the mRNA profiles in polysomal and free messenger ribonucleoprotein particle (mRNP)...

journal_title：Physiological genomics

authors： Kitamura H,Ito M,Yuasa T,Kikuguchi C,Hijikata A,Takayama M,Kimura Y,Yokoyama R,Kaji T,Ohara O

更新日期：2008-03-14 00:00:00

abstract：:Using CRISPR-Cas9 technology, we created a 5-HT7 receptor global knockout (KO) rat, on a Sprague-Dawley background, for use in cardiovascular physiology studies focused on blood pressure regulation. A stable line carrying indels in exons 1 and 2 of the rat Htr7 locus was established and validated. Surprisingly, 5-HT7 ...

journal_title：Physiological genomics

authors： Demireva EY,Xie H,Flood ED,Thompson JM,Seitz BM,Watts SW

更新日期：2019-07-01 00:00:00

abstract：:Valproic acid (VPA) and lithium are widely used in the treatment of bipolar disorder. However, the underlying mechanism of action of these drugs is not clearly understood. We used RNA-Seq analysis to examine the global profile of gene expression in a rat serotonergic cell line (RN46A) after exposure to these two mood ...

journal_title：Physiological genomics

authors： Balasubramanian D,Pearson JF,Kennedy MA

更新日期：2019-02-01 00:00:00

abstract：:In functional genomics, the high-throughput methods such as microarrays 1) allow analysis of the relationships between genes considering them as elements of a network and 2) lead to biological interpretations thanks to Gene Ontology. But up to now it has not been possible to find relationships between the functions an...

journal_title：Physiological genomics

authors： Gustin MP,Paultre CZ,Randon J,Bricca G,Cerutti C

更新日期：2008-06-12 00:00:00

abstract：:Phospholamban (PLN), the reversible inhibitor of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2a), is a key regulator of myocyte Ca(2+) cycling with a significant role in heart failure. We previously showed that the single amino acid difference between human and mouse PLN results in increased inhibition of Ca(...

journal_title：Physiological genomics

authors： Wang HS,Arvanitis DA,Dong M,Niklewski PJ,Zhao W,Lam CK,Kranias EG,Sanoudou D

更新日期：2011-04-12 00:00:00

abstract：:A microarray study of the effect of senescence in mice on gene expression in muscle has been published recently. The present analysis was done to evaluate the extent to which the age-related differences in gene expression in murine muscle are also evident in human muscle. RNA extracted from muscle of young (21-24 yr) ...

journal_title：Physiological genomics

authors： Welle S,Brooks A,Thornton CA

更新日期：2001-03-08 00:00:00

abstract：:Heart disease is the major cause of death in diabetes, a disorder characterized by chronic hyperglycemia and cardiovascular complications. Diabetic cardiomyopathy (DCM) is increasingly recognized as a major contributor to diastolic dysfunction and heart failure in diabetes, but its molecular basis has remained obscure...

journal_title：Physiological genomics

authors： Glyn-Jones S,Song S,Black MA,Phillips AR,Choong SY,Cooper GJ

更新日期：2007-02-12 00:00:00

abstract：:Recombinant human erythropoietin (rHuEPO) is frequently abused by athletes as a performance-enhancing drug, despite being prohibited by the World Anti-Doping Agency. Although the methods to detect blood doping, including rHuEPO injections, have improved in recent years, they remain imperfect. In a proof-of-principle s...

journal_title：Physiological genomics

authors： Durussel J,Haile DW,Mooses K,Daskalaki E,Beattie W,Mooses M,Mekonen W,Ongaro N,Anjila E,Patel RK,Padmanabhan N,McBride MW,McClure JD,Pitsiladis YP

更新日期：2016-03-01 00:00:00

abstract：:Survival of near-freezing body temperatures and reduced blood flow during hibernation is likely the result of changes in the expression of specific genes. In this study, we described a comprehensive survey of mRNAs in the heart of the thirteen-lined ground squirrel (Spermophilus tridecemlineatus) before and during hib...

journal_title：Physiological genomics

authors： Brauch KM,Dhruv ND,Hanse EA,Andrews MT

更新日期：2005-10-17 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disorder with immune-complex deposition that affects multiple organs. Previous studies have suggested the involvement of oxidative stress and apoptosis in SLE, but no clear link to etiology has been established. Here we show that mice deficient in a transcription fac...

journal_title：Physiological genomics

authors： Li J,Stein TD,Johnson JA

更新日期：2004-08-11 00:00:00

abstract：:Here we postulate that the heritability of complex disease traits previously ascribed solely to the inheritance of the nuclear and mitochondrial genomes is broadened to encompass a third component of the holobiome, the microbiome. To test this, we expanded on the selectively bred low capacity runner/high capacity runn...

journal_title：Physiological genomics

authors： Zhang Y,Kumarasamy S,Mell B,Cheng X,Morgan EE,Britton SL,Vijay-Kumar M,Koch LG,Joe B

更新日期：2020-01-01 00:00:00

abstract：:Vasopressin is a peptide hormone that regulates renal water excretion in part through its actions on the collecting duct. The regulation occurs in part via control of transcription of genes coding for the water channels aquaporin-2 (Aqp2) and aquaporin-3 (Aqp3). To identify transcription factors expressed in collectin...

journal_title：Physiological genomics

authors： Tchapyjnikov D,Li Y,Pisitkun T,Hoffert JD,Yu MJ,Knepper MA

更新日期：2010-02-04 00:00:00

abstract：:There exists a sense of urgency to begin to generate a cohesive assembly of biomedical knowledge as the pace of knowledge accumulation accelerates. The urgency is in part driven by the emergence of systems molecular medicine that emphasizes the combination of systems analysis and molecular dissection in the future of ...

journal_title：Physiological genomics

authors： Liang M

更新日期：2007-08-20 00:00:00

abstract：:Peroxisome proliferator-activated receptor type gamma (PPARgamma) is a subgroup of the PPAR transcription factor family. Recent studies indicate that loss of PPARgamma is associated with the development of pulmonary hypertension (PH). We hypothesized that the endothelial dysfunction associated with PPARgamma inhibitio...

journal_title：Physiological genomics

authors： Tian J,Smith A,Nechtman J,Podolsky R,Aggarwal S,Snead C,Kumar S,Elgaish M,Oishi P,Göerlach A,Fratz S,Hess J,Catravas JD,Verin AD,Fineman JR,She JX,Black SM

更新日期：2009-12-30 00:00:00

abstract：:The purpose of this study was to determine the influence of age, sex, and strength training (ST) on large-scale gene expression patterns in vastus lateralis muscle biopsies using high-density cDNA microarrays and quantitative PCR. Muscle samples from sedentary young (20-30 yr) and older (65-75 yr) men and women (5 per...

journal_title：Physiological genomics

authors： Roth SM,Ferrell RE,Peters DG,Metter EJ,Hurley BF,Rogers MA

更新日期：2002-09-03 00:00:00

abstract：:Mechanical ventilation is a life-saving intervention in patients with respiratory failure. However, human and animal studies have demonstrated that mechanical ventilation using large tidal volumes (>or=12 ml/kg) induces a potent inflammatory response and can cause acute lung injury. We hypothesized that mechanical ven...

journal_title：Physiological genomics

authors： Gharib SA,Liles WC,Klaff LS,Altemeier WA

更新日期：2009-05-13 00:00:00

abstract：:Sulfate plays an essential role during growth, development and cellular metabolism. In this study, we characterized the function and structure of the zebrafish (Danio rerio) Na+-sulfate cotransporter 1 (NaS1) cDNA and gene (slc13a1). Zebrafish NaS1 encodes a protein of 583 amino acids with 13 putative transmembrane do...

journal_title：Physiological genomics

authors： Markovich D,Romano A,Storelli C,Verri T

更新日期：2008-08-15 00:00:00

abstract：:Although some single polymorphism analyses of the angiotensinogen (AGT) gene have been found to be associated with hypertension, the results are still inconsistent. The objectives of this study are to evaluate the association of the genotype and haplotype distributions of three single-nucleotide polymorphisms (SNPs) (...

journal_title：Physiological genomics

authors： Wu SJ,Chiang FT,Chen WJ,Liu PH,Hsu KL,Hwang JJ,Lai LP,Lin JL,Tseng CD,Tseng YZ

更新日期：2004-04-13 00:00:00

abstract：:Uncoupling protein 1 (UCP1) is the first UCP described. It belongs to the family of mitochondrial carrier proteins and is expressed mainly in brown adipose tissue. Recently, the family of the UCPs has rapidly been growing due to the successive cloning of UCP2, UCP3, UCP4, and UCP5, also called brain mitochondrial carr...

journal_title：Physiological genomics

authors： Keller PA,Lehr L,Giacobino JP,Charnay Y,Assimacopoulos-Jeannet F,Giovannini N

更新日期：2005-08-11 00:00:00