Identification of genes whose expression is altered by obesity throughout the arterial tree.

abstract：:A cDNA microarray resource has been developed with the goal of providing integrated functional genomics resources for cattle. The National Bovine Functional Genomics Consortium's (NBFGC) expressed sequence tag (EST) collection was established in 2001 to develop resources for functional genomics research. The NBFGC EST...

journal_title：Physiological genomics

authors： Suchyta SP,Sipkovsky S,Kruska R,Jeffers A,McNulty A,Coussens MJ,Tempelman RJ,Halgren RG,Saama PM,Bauman DE,Boisclair YR,Burton JL,Collier RJ,DePeters EJ,Ferris TA,Lucy MC,McGuire MA,Medrano JF,Overton TR,Smith TP,

更新日期：2003-10-17 00:00:00

abstract：:Preeclampsia is a progressive hypertensive disorder of pregnancy affecting 2-8% of pregnancies globally. Preexisting chronic hypertension is a major risk factor associated with developing preeclampsia, and growing evidence suggests a role for the gut microbiome in the development of preeclampsia. However, neither alte...

journal_title：Physiological genomics

authors： Ishimwe JA,Akinleye AA,Johnson AC,Garrett MR,Sasser JM

更新日期：2021-01-25 00:00:00

abstract：:The purpose of this study was to identify novel transcriptional events occurring in the aortic wall before angiogenesis. We used a defined tissue culture system that takes advantage of the capacity of rat aortic rings to generate neovessels ex vivo in response to angiogenic factor stimulation. Total RNA isolated from ...

journal_title：Physiological genomics

authors： Aplin AC,Gelati M,Fogel E,Carnevale E,Nicosia RF

更新日期：2006-10-03 00:00:00

abstract：:Following vascular injury medial smooth muscle cells dedifferentiate and migrate through the internal elastic lamina where they form a neointima. The goal of the current study was to identify changes in gene expression that occur before the development of neointima and are associated with the early response to injury....

journal_title：Physiological genomics

authors： Herring BP,Hoggatt AM,Griffith SL,McClintick JN,Gallagher PJ

更新日期：2017-03-01 00:00:00

abstract：:We previously mapped several gene loci influencing cancer risk of inbred BDIV and BDIX rats, resistant and susceptible, respectively, to N-ethyl-N-nitrosourea (ENU)-induced malignant peripheral nerve sheath tumors (MPNSTs). On the basis of a genomewide association analysis using a (BDIV × BDIX) F(2) generation the Mss...

journal_title：Physiological genomics

authors： Koelsch B,Winzen-Reichert B,Fischer C,Kutritz A,van den Berg L,Kindler-Röhrborn A

更新日期：2011-05-01 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChR) are assembled from a pool of nine alpha-subunits and three beta-subunits into functional pentamers in peripheral autonomic neurons. The contribution of different subunits to native, physiologically important nAChR for synaptic transmission in autonomic ganglia is unclear. Here...

journal_title：Physiological genomics

authors： Deck J,Bibevski S,Gnecchi-Ruscone T,Bellina V,Montano N,Dunlap ME

更新日期：2005-06-16 00:00:00

abstract：:Growth hormone (GH) controls the physiology and pathophysiology of the liver, and its signals are conducted by two members of the family of signal transducers and activators of transcription, STAT5A and STAT5B. Mice in which the Stat5a/b locus has been inactivated specifically in hepatocytes display GH resistance, the...

journal_title：Physiological genomics

authors： Hosui A,Hennighausen L

更新日期：2008-07-15 00:00:00

abstract：:It has been found that Arabian and Thoroughbred horses differ in muscle fiber structure and thus in physiological changes occurring in muscles during exercise. The aim of the present study was to identify the global gene expression modifications that occur in skeletal muscle following a training regime to prepare for ...

journal_title：Physiological genomics

authors： Ropka-Molik K,Stefaniuk-Szmukier M,Z Ukowski K,Piórkowska K,Bugno-Poniewierska M

更新日期：2017-06-01 00:00:00

abstract：:Model organisms have been used over a century to understand basic, conserved biological processes. The study of these experimental systems began with genetics and development, moved into molecular and cellular biology, and most recently propelled into functional genomics and proteomics. The goal of this review is simp...

journal_title：Physiological genomics

authors： Barr MM

更新日期：2003-03-18 00:00:00

abstract：:Teleost fish represent unique models to study the role of neuroestrogens because of the extremely high activity of brain aromatase (AroB; the product of cyp19a1b). Aromatase respectively converts androstenedione and testosterone to estrone and 17beta-estradiol (E2). Specific inhibition of aromatase activity by fadrozo...

journal_title：Physiological genomics

authors： Zhang D,Popesku JT,Martyniuk CJ,Xiong H,Duarte-Guterman P,Yao L,Xia X,Trudeau VL

更新日期：2009-08-07 00:00:00

abstract：:Dahl salt-sensitive SS and consomic, salt-resistant SS-13(BN)/Mcw rats possess a highly similar genetic background but exhibit substantial differences in blood pressure salt sensitivity. We used cDNA microarrays to examine sequential changes of mRNA expression of approximately 2,000 currently known rat genes in the re...

journal_title：Physiological genomics

authors： Liang M,Yuan B,Rute E,Greene AS,Olivier M,Cowley AW Jr

更新日期：2003-02-06 00:00:00

abstract：:To facilitate the development of assays for the discovery of pharmaceuticals capable of mimicking the effects of caloric restriction (CR) on life- and healthspan (CR mimetics), we evaluated the effectiveness of glucoregulatory and putative cancer chemopreventatives in reproducing the hepatic gene expression profile pr...

journal_title：Physiological genomics

authors： Dhahbi JM,Mote PL,Fahy GM,Spindler SR

更新日期：2005-11-17 00:00:00

abstract：:The structural organization of the brain is important for normal brain function and is critical to understand in order to evaluate changes that occur during disease processes. Three-dimensional (3D) imaging of the mouse brain is necessary to appreciate the spatial context of structures within the brain. In addition, t...

journal_title：Physiological genomics

authors： Gleave JA,Wong MD,Dazai J,Altaf M,Henkelman RM,Lerch JP,Nieman BJ

更新日期：2012-08-01 00:00:00

abstract：:Ductus arteriosus (DA) closure is initiated by oxygen rise postnatally and progresses in two, functional-to-permanent, stages. Here, using GeneChip Arrays in rats (normoxic and hyperoxic fetus, normoxic newborn), we examined whether oxygen alone duplicates the birth process in affecting DA genes. In addition, by compa...

journal_title：Physiological genomics

authors： Costa M,Barogi S,Socci ND,Angeloni D,Maffei M,Baragatti B,Chiellini C,Grasso E,Coceani F

更新日期：2006-04-13 00:00:00

abstract：:To examine differences in cytokine profiles that may confer tolerance/susceptibility to bovine African trypanosomiasis, N'Dama (trypanotolerant, n = 8) and Boran (trypanosusceptible, n = 8) cattle were experimentally challenged with Trypanosoma congolense. Blood samples were collected over a 34-day period, and RNA was...

journal_title：Physiological genomics

authors： O'Gorman GM,Park SD,Hill EW,Meade KG,Mitchell LC,Agaba M,Gibson JP,Hanotte O,Naessens J,Kemp SJ,MacHugh DE

更新日期：2006-12-13 00:00:00

abstract：:Hypertension is a condition with major cardiovascular and renal complications, affecting nearly a billion patients worldwide. Few validated gene targets are available for pharmacological intervention, so there is a need to identify new biological pathways regulating blood pressure and containing novel targets for trea...

journal_title：Physiological genomics

authors： Puig O,Wang IM,Cheng P,Zhou P,Roy S,Cully D,Peters M,Benita Y,Thompson J,Cai TQ

更新日期：2010-09-01 00:00:00

abstract：:Hypertension poses a significant challenge to vasculature homeostasis and stands as the most common cardiovascular disease in the world. Its effects are especially profound on endothelial cells that form the inner lining of the vasculature and are directly exposed to the effects of excess pressure. Here, we characteri...

journal_title：Physiological genomics

authors： Nelson JW,Ferdaus MZ,McCormick JA,Minnier J,Kaul S,Ellison DH,Barnes AP

更新日期：2018-02-01 00:00:00

abstract：:We evaluated the association between insulin resistance and the angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) gene polymorphism in a group of older hypertensive subjects (63 +/- 1 yr, n = 35) before and after a 6-mo aerobic exercise program (AEX). Insulin sensitivity index (S(I)), assessed by the freq...

journal_title：Physiological genomics

authors： Dengel DR,Brown MD,Ferrell RE,Reynolds TH 4th,Supiano MA

更新日期：2002-10-29 00:00:00

abstract：:Mesodermal and epidermal precursor cells undergo phenotypic changes during differentiation to the smooth muscle cell (SMC) lineage that are relevant to pathophysiological processes in the adult. Molecular mechanisms that underlie lineage determination and terminal differentiation of this cell type have received much a...

journal_title：Physiological genomics

authors： Spin JM,Nallamshetty S,Tabibiazar R,Ashley EA,King JY,Chen M,Tsao PS,Quertermous T

更新日期：2004-11-17 00:00:00

abstract：:The genetically hypertensive fawn-hooded (FHH/Eur) rat is characterized by the early presence of systolic and glomerular hypertension, progressive proteinuria (UPV), and albuminuria (UAV), and focal glomerulosclerosis, resulting in premature death from renal failure. Previous studies showed that at least five genetic ...

journal_title：Physiological genomics

authors： Provoost AP,Shiozawa M,Van Dokkum RP,Jacob HJ

更新日期：2002-02-28 00:00:00

abstract：:Morbidity and mortality associated with acute lung injury (ALI) and acute respiratory distress syndrome remain substantial. Although many candidate genes have been tested, a clear understanding of the pathogenesis is lacking, as is our ability to predict individual outcome. Because ALI is a complex disease, single gen...

journal_title：Physiological genomics

authors： Prows DR,Winterberg AV,Gibbons WJ Jr,Burzynski BB,Liu C,Nick TG

更新日期：2009-07-09 00:00:00

abstract：:In several species caloric restriction (CR) extends life span. In this paper we integrate data from studies on CR and other sources to articulate the hypothalamic deregulation hypothesis by which estrogen receptor-alpha (ER-α) signaling in the hypothalamus and limbic system affects life span under the stress of CR in ...

journal_title：Physiological genomics

authors： Gouw AM,Efe G,Barakat R,Preecha A,Mehdizadeh M,Garan SA,Brooks GA

更新日期：2017-02-01 00:00:00

abstract：:The relative importance of regulatory versus structural evolution for the evolution of different biological systems is a subject of controversy. The primacy of regulatory evolution in the diversification of morphological traits has been promoted by many evolutionary developmental biologists. For physiological traits, ...

journal_title：Physiological genomics

authors： Rosati B,Dong M,Cheng L,Liou SR,Yan Q,Park JY,Shiang E,Sanguinetti M,Wang HS,McKinnon D

更新日期：2008-11-12 00:00:00

abstract：:Despite an abundance of evidence to the contrary from animal studies, large clinical trials on humans have shown that estrogen administered to postmenopausal women increases the risk of cardiovascular disease. However, timing may be everything, as estrogen is often administered immediately after ovariectomy (Ovx) in a...

journal_title：Physiological genomics

authors： Pechenino AS,Lin L,Mbai FN,Lee AR,He XM,Stallone JN,Knowlton AA

更新日期：2011-09-22 00:00:00

abstract：:Bone marrow mononuclear cells (BMMNCs) increase capillary density and reduce fibrosis in rodents after myocardial infarction, resulting in an overall improvement in left ventricular function. Little is known about the effectiveness of BMMNC therapy in hypertensive heart disease. In the current study, we show that deli...

journal_title：Physiological genomics

authors： Parker SJ,Didier DN,Karcher JR,Stodola TJ,Endres B,Greene AS

更新日期：2012-10-02 00:00:00

abstract：:Since the discovery of the microbiome in humans, it has been studied in many mammalian species. Different microbiological communities with variable richness and diversity have been found among these species in distinct areas of the reproductive tract. Human studies have shown that the composition of the microbiome is ...

journal_title：Physiological genomics

authors： Heil BA,Paccamonti DL,Sones JL

更新日期：2019-08-01 00:00:00

abstract：:Consumption of a protein-containing meal by a fasted animal promotes protein accretion in skeletal muscle, in part through leucine stimulation of protein synthesis and indirectly through repression of protein degradation mediated by its metabolite, α-ketoisocaproate. Mice lacking the mitochondrial branched-chain amino...

journal_title：Physiological genomics

authors： Lynch CJ,Kimball SR,Xu Y,Salzberg AC,Kawasawa YI

更新日期：2015-11-01 00:00:00

abstract：:Epistasis effects (gene interactions) have been increasingly recognized as important genetic factors underlying complex traits. The existence of a large number of single nucleotide polymorphisms (SNPs) provides opportunities and challenges to screen DNA variations affecting complex traits using a candidate gene analys...

journal_title：Physiological genomics

authors： Mao Y,London NR,Ma L,Dvorkin D,Da Y

更新日期：2006-12-13 00:00:00

abstract：:In this paper, two novel, powerful, and robust convolutional neural network (CNN) architectures are designed and proposed for two different classification tasks using publicly available data sets. The first architecture is able to decide whether a given chest X-ray image of a patient contains COVID-19 or not with 98.9...

journal_title：Physiological genomics

authors： Irmak E

更新日期：2020-12-01 00:00:00

abstract：:This study investigated the use of the hindlimb suspension (HS) and reloading model of mice for the mapping of ultrastructural and gene expressional alterations underlying load-dependent muscular adaptations. Mice were hindlimb suspended for 7 days or kept as controls (n = 12). Soleus muscles were harvested after HS (...

journal_title：Physiological genomics

authors： Däpp C,Schmutz S,Hoppeler H,Flück M

更新日期：2004-12-15 00:00:00