Distinct profiles of expressed sequence tags during intestinal regeneration in the sea cucumber Holothuria glaberrima.

abstract：:Using CRISPR-Cas9 technology, we created a 5-HT7 receptor global knockout (KO) rat, on a Sprague-Dawley background, for use in cardiovascular physiology studies focused on blood pressure regulation. A stable line carrying indels in exons 1 and 2 of the rat Htr7 locus was established and validated. Surprisingly, 5-HT7 ...

journal_title：Physiological genomics

authors： Demireva EY,Xie H,Flood ED,Thompson JM,Seitz BM,Watts SW

更新日期：2019-07-01 00:00:00

abstract：:Retinoid-related orphan receptor (ROR)α4 is the major RORα isoform expressed in adipose tissues and liver. In this study we demonstrate that RORα-deficient staggerer mice (RORα(sg/sg)) fed with a high-fat diet (HFD) exhibited reduced adiposity and hepatic triglyceride levels compared with wild-type (WT) littermates an...

journal_title：Physiological genomics

authors： Kang HS,Okamoto K,Takeda Y,Beak JY,Gerrish K,Bortner CD,DeGraff LM,Wada T,Xie W,Jetten AM

更新日期：2011-07-14 00:00:00

abstract：:ATP-sensitive K+ (KATP) channels play a crucial role in coupling cellular metabolism to membrane potential. In addition to the orthologs corresponding to Kir6.1 and Kir6.2 of mammals, we have identified a novel member, designated Kir6.3 (zKir6.3), of the inward rectifier K+ channel subfamily Kir6.x in zebrafish. zKir6...

journal_title：Physiological genomics

authors： Zhang C,Miki T,Shibasaki T,Yokokura M,Saraya A,Seino S

更新日期：2006-02-14 00:00:00

abstract：:The liver of dairy cows is involved in signaling the current hepatic metabolic state to the brain via metabolites and nerval afferents to control and adjust feed intake. Feed deprivation may result in mobilization of body reserves favoring hepatic steatosis. While the overall metabolic changes are well characterized, ...

journal_title：Physiological genomics

authors： Kuhla B,Albrecht D,Kuhla S,Metges CC

更新日期：2009-04-10 00:00:00

abstract：:Cystic fibrosis (CF) lung disease severity is influenced by unknown genetic factors apart from the disease causative gene, cystic fibrosis transmembrane conductance regulator (CFTR). Previous studies have shown the C57BL/6J congenic Cftr(-/-) (B6 CF) mouse to develop a fibrotic lung disease compared with both CF mice ...

journal_title：Physiological genomics

authors： Haston CK,Cory S,Lafontaine L,Dorion G,Hallett MT

更新日期：2006-04-13 00:00:00

abstract：:Herbivores are predicted to evolve appropriate mechanisms to process the plant secondary compounds (PSCs) in their diet, and these mechanisms are likely specific to particular suites of PSCs. Changes in diet composition over evolutionary time should select for appropriate alterations in metabolism of the more recent d...

journal_title：Physiological genomics

authors： Magnanou E,Malenke JR,Dearing MD

更新日期：2013-09-03 00:00:00

abstract：:Besides neuronal plasticity, the neurotrophin brain-derived neurotrophic factor (BDNF) is also important in vascular function. The BDNF has been associated with angiogenesis through its specific receptor tropomyosin-related kinase B (TrkB). Additionally, Val66Met polymorphism decreases activity-induced BDNF. Since BDN...

journal_title：Physiological genomics

authors： Lemos JR Jr,Alves CR,de Souza SB,Marsiglia JD,Silva MS,Pereira AC,Teixeira AL,Vieira EL,Krieger JE,Negrão CE,Alves GB,de Oliveira EM,Bolani W,Dias RG,Trombetta IC

更新日期：2016-02-01 00:00:00

abstract：:Little is known regarding the graft response to transplantation injury. This study investigates the posttransplantation response of genes that are constitutively expressed in the heart. Constitutive heart and lymph node tissue-restricted gene expression was first analyzed with DNA microarrays. To demonstrate changes f...

journal_title：Physiological genomics

authors： Christopher K,Mueller TF,DeFina R,Liang Y,Zhang J,Gentleman R,Perkins DL

更新日期：2003-09-29 00:00:00

abstract：:Gene expression was evaluated in mice divergently selected for 16 generations for heat loss, measured by direct calorimetry. The high (MH) heat loss line has approximately 50% greater heat loss, approximately 35% less body fat, approximately 20% greater feed intake, and twofold greater activity levels than the low (ML...

journal_title：Physiological genomics

authors： Allan MF,Nielsen MK,Pomp D

更新日期：2000-09-08 00:00:00

abstract：:Metazoan akirin genes regulate innate immunity, myogenesis, and carcinogenesis. Invertebrates typically have one family member, while most tetrapod and teleost vertebrates have one to three. We demonstrate an expanded repertoire of eight family members in genomes of four salmonid fishes, owing to paralog preservation ...

journal_title：Physiological genomics

authors： Macqueen DJ,Kristjánsson BK,Johnston IA

更新日期：2010-06-01 00:00:00

abstract：:The Ala allele of PPARG Pro12Ala ( rs1801282 ) is associated with greater improvements to the glucose metabolism in exercise studies, but whether this extends to peripheral insulin sensitivity is unknown. Our objective was to investigate the effect of PPARG Pro12Ala on exercise-induced changes in peripheral insulin se...

journal_title：Physiological genomics

authors： Blond MB,Schnurr TM,Rosenkilde M,Quist JS,Gram AS,Reichkendler MH,Auerbach PL,Nordby P,Skovgaard LT,Ribel-Madsen R,Justesen JM,Kilpeläinen TO,Ploug T,Stallknecht BM,Hansen T

更新日期：2019-06-01 00:00:00

abstract：:Essential hypertension is highly prevalent in the elderly population, exceeding 70% in people older than 60 yr of age, and remains a leading risk factor for heart disease, stroke, and chronic renal disease. Elucidation of genetic determinants is critical but remains a challenge due to its complex, multifactorial patho...

journal_title：Physiological genomics

authors： Glorioso N,Herrera VL,Didishvili T,Argiolas G,Troffa C,Bulla P,Bulla E,Ruiz-Opazo N

更新日期：2011-11-07 00:00:00

abstract：:To better understand the genetic basis of essential hypertension, we conducted a quantitative trait locus (QTL) analysis of a population of 207 (BALB/cJ x CBA/CaJ) F(2) male mice to identify genomic regions that regulate blood pressure, heart rate, and heart weight. We identified two loci, Bpq6 (blood pressure quantit...

journal_title：Physiological genomics

authors： Sugiyama F,Churchill GA,Li R,Libby LJ,Carver T,Yagami K,John SW,Paigen B

更新日期：2002-07-12 00:00:00

abstract：:Creatine monohydrate (CrM) supplementation has been shown to increase fat-free mass and muscle power output possibly via cell swelling. Little is known about the cellular response to CrM. We investigated the effect of short-term CrM supplementation on global and targeted mRNA expression and protein content in human sk...

journal_title：Physiological genomics

authors： Safdar A,Yardley NJ,Snow R,Melov S,Tarnopolsky MA

更新日期：2008-01-17 00:00:00

abstract：:Several critical cell functions are influenced not only by internal cellular machinery but also by external mechanical and biochemical cues from the surrounding microenvironment. Slight changes to the microenvironment can result in dramatic changes to the cell's phenotype; for example, a change in the nutrients or pH ...

journal_title：Physiological genomics

authors： Bloom AB,Zaman MH

更新日期：2014-05-01 00:00:00

abstract：:The cardiovascular restricted transcription factor CHF1/Hey2 has been previously shown to regulate the smooth muscle response to growth factors. To determine how CHF1/Hey2 affects the smooth muscle response to growth factors, we performed a genomic screen for transcripts that are differentially expressed in wild-type ...

journal_title：Physiological genomics

authors： Shirvani SM,Mookanamparambil L,Ramoni MF,Chin MT

更新日期：2007-06-19 00:00:00

abstract：:Psoriasis is a chronic and common human skin disorder currently with no cure. Psoriatic skin displays inflammatory, raised, and scaly lesions with widely aberrant gene expression. Recent studies have revealed critical roles that microRNAs play as a class of posttranscriptional gene regulator in skin development and sk...

journal_title：Physiological genomics

authors： Xia J,Zhang W

更新日期：2014-02-15 00:00:00

abstract：:Protein restriction and hypercalcemia result in a urinary concentrating defect in rats and humans. Previous tubular perfusion studies show that there is an increased active urea transport activity in the initial inner medullary (IM) collecting duct in low-protein diet (LPD) and vitamin D (Vit D) animal models. To inve...

journal_title：Physiological genomics

authors： Chen G,Yang Y,Fröhlich O,Klein JD,Sands JM

更新日期：2010-05-01 00:00:00

abstract：:In several species caloric restriction (CR) extends life span. In this paper we integrate data from studies on CR and other sources to articulate the hypothalamic deregulation hypothesis by which estrogen receptor-alpha (ER-α) signaling in the hypothalamus and limbic system affects life span under the stress of CR in ...

journal_title：Physiological genomics

authors： Gouw AM,Efe G,Barakat R,Preecha A,Mehdizadeh M,Garan SA,Brooks GA

更新日期：2017-02-01 00:00:00

abstract：:The objectives of this study were to examine systemic insulin response to a glucose tolerance test (GTT) and transcript abundance of genes of the insulin signaling pathway in skeletal muscle, during both dietary restriction and re-alimentation-induced compensatory growth. Holstein Friesian bulls were blocked to one of...

journal_title：Physiological genomics

authors： Keogh K,Kenny DA,Kelly AK,Waters SM

更新日期：2015-08-01 00:00:00

abstract：:To facilitate the development of assays for the discovery of pharmaceuticals capable of mimicking the effects of caloric restriction (CR) on life- and healthspan (CR mimetics), we evaluated the effectiveness of glucoregulatory and putative cancer chemopreventatives in reproducing the hepatic gene expression profile pr...

journal_title：Physiological genomics

authors： Dhahbi JM,Mote PL,Fahy GM,Spindler SR

更新日期：2005-11-17 00:00:00

abstract：:Epistasis effects (gene interactions) have been increasingly recognized as important genetic factors underlying complex traits. The existence of a large number of single nucleotide polymorphisms (SNPs) provides opportunities and challenges to screen DNA variations affecting complex traits using a candidate gene analys...

journal_title：Physiological genomics

authors： Mao Y,London NR,Ma L,Dvorkin D,Da Y

更新日期：2006-12-13 00:00:00

abstract：:A high-fat (HF) diet is associated with progression of liver diseases. To illustrate genome-wide landscape of DNA methylation in liver of rats fed either a control or HF diet, two enrichment-based methods, namely methyl-DNA immunoprecipitation assay with high-throughput sequencing (MeDIP-seq) and methylation-sensitive...

journal_title：Physiological genomics

authors： Zhang Y,Wang H,Zhou D,Moody L,Lezmi S,Chen H,Pan YX

更新日期：2015-10-01 00:00:00

abstract：:Mouse lines divergently selected for heat loss were evaluated for correlated responses in the hypothalamic transcriptome. High (MH) heat loss mice have approximately 50% greater heat loss, approximately 35% less body fat, approximately 20% greater feed intake, approximately 100% greater locomotor activity levels, and ...

journal_title：Physiological genomics

authors： Wesolowski SR,Allan MF,Nielsen MK,Pomp D

更新日期：2003-04-16 00:00:00

abstract：:Dietary fructose intake has dramatically increased over recent decades and is implicated in the high rates of obesity, hypertension, and type 2 diabetes (metabolic syndrome) in Western societies. The molecular determinants of this epidemiologic correlation are incompletely defined, but high-flux fructose catabolism in...

journal_title：Physiological genomics

authors： Diggle CP,Shires M,McRae C,Crellin D,Fisher J,Carr IM,Markham AF,Hayward BE,Asipu A,Bonthron DT

更新日期：2010-11-29 00:00:00

abstract：:Myocardial infarction (MI) induced by acute coronary arterial occlusion is usually secondary to atherosclerotic plaque rupture. Dysregulated response of vascular smooth muscle cells (VSMCs) in atherosclerotic plaques may promote plaque rupture. Cadherins (CDHs) form adherens junctions and are known stabilizers of athe...

journal_title：Physiological genomics

authors： Derda AA,Woo CC,Wongsurawat T,Richards M,Lee CN,Kofidis T,Kuznetsov VA,Sorokin VA

更新日期：2018-08-01 00:00:00

abstract：:To examine differences in cytokine profiles that may confer tolerance/susceptibility to bovine African trypanosomiasis, N'Dama (trypanotolerant, n = 8) and Boran (trypanosusceptible, n = 8) cattle were experimentally challenged with Trypanosoma congolense. Blood samples were collected over a 34-day period, and RNA was...

journal_title：Physiological genomics

authors： O'Gorman GM,Park SD,Hill EW,Meade KG,Mitchell LC,Agaba M,Gibson JP,Hanotte O,Naessens J,Kemp SJ,MacHugh DE

更新日期：2006-12-13 00:00:00

abstract：:Heterotrimeric G proteins (Galphabetagamma) play an essential role in coupling membrane receptors to effector proteins such as ion channels and enzymes. Among the five mammalian Gbeta-subunits cloned, the human G protein beta4 has not been described. The purpose of the present study was to functionally characterize th...

journal_title：Physiological genomics

authors： Ruiz-Velasco V,Ikeda SR,Puhl HL

更新日期：2002-02-11 00:00:00

abstract：:We previously reported that markers on rat chromosome 1 are genetically linked to blood pressure in an F(2) population derived from Dahl salt hypertension-sensitive (S) and Lewis (LEW) rats. Because there was evidence for more than one blood pressure quantitative trait locus (QTL) on chromosome 1, an initial congenic ...

journal_title：Physiological genomics

authors： Saad Y,Garrett MR,Lee SJ,Dene H,Rapp JP

更新日期：1999-11-11 00:00:00

abstract：:In functional genomics, the high-throughput methods such as microarrays 1) allow analysis of the relationships between genes considering them as elements of a network and 2) lead to biological interpretations thanks to Gene Ontology. But up to now it has not been possible to find relationships between the functions an...

journal_title：Physiological genomics

authors： Gustin MP,Paultre CZ,Randon J,Bricca G,Cerutti C

更新日期：2008-06-12 00:00:00