LncRNA IUR downregulates ZEB1 by upregulating miR-200 to inhibit prostate carcinoma.

abstract：:To date, physical exercise is the only intervention consistently demonstrated to attenuate age-related declines in physical function. However, variability exists in seniors' responsiveness to training. One potential source of variability is the insertion (I allele) or deletion (D allele) of a 287 bp fragment in intron...

journal_title：Physiological genomics

authors： Buford TW,Hsu FC,Brinkley TE,Carter CS,Church TS,Dodson JA,Goodpaster BH,McDermott MM,Nicklas BJ,Yank V,Johnson JA,Pahor M,LIFE Research Group.

更新日期：2014-03-01 00:00:00

abstract：:The renin-angiotensin system (RAS), known for its roles in cardiovascular, metabolic, and developmental regulation, is present in both the circulation and in many individual tissues throughout the body. Substantial evidence supports the existence of a brain RAS, though quantification and localization of brain renin ha...

journal_title：Physiological genomics

authors： Xu D,Borges GR,Davis DR,Agassandian K,Sequeira Lopez ML,Gomez RA,Cassell MD,Grobe JL,Sigmund CD

更新日期：2011-03-29 00:00:00

abstract：:The mammalian liver works to keep the body in a state of homeostasis and plays an important role in systemic acute phase response to infections. In this study we investigated the bovine hepatic acute phase response at the gene transcription level in dairy cows with experimentally Escherichia coli-induced mastitis. At ...

journal_title：Physiological genomics

authors： Jørgensen HB,Buitenhuis B,Røntved CM,Jiang L,Ingvartsen KL,Sørensen P

更新日期：2012-06-01 00:00:00

abstract：:Large datasets from -omics studies need to be deeply investigated. The aim of this paper is to provide a new method (LEM method) for the search of transcriptome and metabolome connections. The heuristic algorithm here described extends the classical canonical correlation analysis (CCA) to a high number of variables (w...

journal_title：Physiological genomics

authors： Valour D,Hue I,Grimard B,Valour B

更新日期：2013-07-15 00:00:00

abstract：:The process of parturition involves the complex interplay of factors that change the excitability and contractile activity of the uterus. We have compared the relative gene expression profile of myometrium from rats before parturition (21 days pregnant) and during delivery, using high-density DNA microarray. Of 8,740 ...

journal_title：Physiological genomics

authors： Helguera G,Eghbali M,Sforza D,Minosyan TY,Toro L,Stefani E

更新日期：2009-01-08 00:00:00

abstract：:Our objective was to resequence insulin receptor substrate 2 (IRS2) to identify variants associated with obesity- and diabetes-related traits in Hispanic children. Exonic and intronic segments, 5' and 3' flanking regions of IRS2 (∼14.5 kb), were bidirectionally sequenced for single nucleotide polymorphism (SNP) discov...

journal_title：Physiological genomics

authors： Butte NF,Voruganti VS,Cole SA,Haack K,Comuzzie AG,Muzny DM,Wheeler DA,Chang K,Hawes A,Gibbs RA

更新日期：2011-09-22 00:00:00

abstract：:The gut microbiome plays a critical role in the onset and progression of obesity and the metabolic syndrome. However, it is not well documented whether the cecal vs. the fecal microbiome is more relevant when assessing their contributions to these diseases. Here, we amplified the V4 region of the 16S rRNA gene from ce...

journal_title：Physiological genomics

authors： Panasevich MR,Wankhade UD,Chintapalli SV,Shankar K,Rector RS

更新日期：2018-05-01 00:00:00

abstract：:Previous in vitro studies found that nuclear factor erythroid-derived 2-like 1 (NFE2L1) was involved in mediating ascorbic acid-induced osterix expression and osteoblast differentiation via binding to the antioxidant response element of the osterix promoter. To test the role of NFE2L1 in regulating bone formation in v...

journal_title：Physiological genomics

authors： Kim J,Xing W,Wergedal J,Chan JY,Mohan S

更新日期：2010-01-08 00:00:00

abstract：:Immobilization, bed rest, or denervation leads to muscle disuse and subsequent skeletal muscle atrophy. Muscle atrophy can also occur as a component of various chronic diseases such as cancer, AIDS, sepsis, diabetes, and chronic heart failure or as a direct result of genetic muscle disorders. In addition to this atrop...

journal_title：Physiological genomics

authors： Cho Y,Ross RS

更新日期：2018-09-01 00:00:00

abstract：:Understanding how vertebrates respond to hypoxia can have important clinical implications. Fish have evolved the ability to survive long exposure to low oxygen levels. However, little is known about the specific changes in gene expression that result from hypoxia. In this study we used a zebrafish cDNA microarray to e...

journal_title：Physiological genomics

authors： Ton C,Stamatiou D,Liew CC

更新日期：2003-04-16 00:00:00

abstract：:Peripheral blood cells are an accessible environment in which to visualize exercise-induced alterations in global gene expression patterns. We aimed to identify a peripheral blood mononuclear cell (PBMC) signature represented by alterations in gene expression, in response to a standardized endurance exercise training ...

journal_title：Physiological genomics

authors： Dias RG,Silva MS,Duarte NE,Bolani W,Alves CR,Junior JR,da Silva JL,de Oliveira PA,Alves GB,de Oliveira EM,Rocha CS,Marsiglia JD,Negrao CE,Krieger EM,Krieger JE,Pereira AC

更新日期：2015-02-01 00:00:00

abstract：:Caloric restriction (CR) is an effective method for prevention of age-associated diseases as well as overweight and obesity; however, there is controversy regarding the effects of dieting regimens on behavior. In this study, we investigated two different dieting regimens: repeated fasting and refeeding (RFR) and daily...

journal_title：Physiological genomics

authors： Yamamoto Y,Tanahashi T,Kawai T,Chikahisa S,Katsuura S,Nishida K,Teshima-Kondo S,Sei H,Rokutan K

更新日期：2009-11-06 00:00:00

abstract：:Bioaccumulative environmental estrogen, nonylphenol (NP; 4-nonylphenol), is widely used as a nonionic surfactant and can affect human health. Since genomes of Saccharomyces cerevisiae and higher eukaryotes share many structural and functional similarities, we investigated subcellular effects of NP on S. cerevisiae BY4...

journal_title：Physiological genomics

authors： Bereketoglu C,Arga KY,Eraslan S,Mertoglu B

更新日期：2017-10-01 00:00:00

abstract：:MicroRNAs (miRs) are small, noncoding RNAs that are emerging as crucial regulators of cardiac remodeling in left ventricular hypertrophy (LVH) and failure (LVF). However, there are no data on their role in right ventricular hypertrophy (RVH) and failure (RVF). This is a critical question given that the RV is uniquely ...

journal_title：Physiological genomics

authors： Reddy S,Zhao M,Hu DQ,Fajardo G,Hu S,Ghosh Z,Rajagopalan V,Wu JC,Bernstein D

更新日期：2012-05-01 00:00:00

abstract：:Its accessibility, unique evolutionary position, and recently assembled genome sequence have advanced the chicken to the forefront of comparative genomics and developmental biology research as a model organism. Several chicken expressed sequence tag (EST) projects have placed the chicken in 10th place for accrued ESTs...

journal_title：Physiological genomics

authors： Carre W,Wang X,Porter TE,Nys Y,Tang J,Bernberg E,Morgan R,Burnside J,Aggrey SE,Simon J,Cogburn LA

更新日期：2006-05-16 00:00:00

abstract：:High-frequency ultrasound biomicroscopy (UBM) has recently emerged as a high-resolution means of phenotyping genetically altered mice and has great potential to evaluate the cardiac morphology and hemodynamics of mouse mutants. However, there is no standard procedure of in vivo transthoracic cardiac imaging using UBM ...

journal_title：Physiological genomics

authors： Zhou YQ,Foster FS,Nieman BJ,Davidson L,Chen XJ,Henkelman RM

更新日期：2004-07-08 00:00:00

abstract：:Studies were performed to examine the extent to which mechanical stimuli mediate control of angiogenesis in bladder cells both in vitro and in vivo. Differential gene expression between control nonstretched and cyclically stretched bladder smooth muscle cells was assessed using oligonucleotide microarrays and pathway ...

journal_title：Physiological genomics

authors： Yang R,Amir J,Liu H,Chaqour B

更新日期：2008-12-12 00:00:00

abstract：:Current models in skeletal muscle biology do not fully account for the breadth, causes, and consequences of phenotypic variation among skeletal muscle groups. The muscle allotype concept arose to explain frank differences between limb, masticatory, and extraocular (EOM) muscles, but there is little understanding of th...

journal_title：Physiological genomics

authors： Cheng G,Merriam AP,Gong B,Leahy P,Khanna S,Porter JD

更新日期：2004-07-08 00:00:00

abstract：:Survival of near-freezing body temperatures and reduced blood flow during hibernation is likely the result of changes in the expression of specific genes. In this study, we described a comprehensive survey of mRNAs in the heart of the thirteen-lined ground squirrel (Spermophilus tridecemlineatus) before and during hib...

journal_title：Physiological genomics

authors： Brauch KM,Dhruv ND,Hanse EA,Andrews MT

更新日期：2005-10-17 00:00:00

abstract：:Gene induction and categorical reprogramming during in vitro human endometrial fibroblast decidualization. Physiol Genomics 7: 135-148, 2001. First published September 21, 2001; 10.1152/physiolgenomics.00061.2001.-Human decidual fibroblasts undergo a differentiative commitment to the acquisition of endocrine, metaboli...

journal_title：Physiological genomics

authors： Brar AK,Handwerger S,Kessler CA,Aronow BJ

更新日期：2001-12-21 00:00:00

abstract：:We previously mapped several gene loci influencing cancer risk of inbred BDIV and BDIX rats, resistant and susceptible, respectively, to N-ethyl-N-nitrosourea (ENU)-induced malignant peripheral nerve sheath tumors (MPNSTs). On the basis of a genomewide association analysis using a (BDIV × BDIX) F(2) generation the Mss...

journal_title：Physiological genomics

authors： Koelsch B,Winzen-Reichert B,Fischer C,Kutritz A,van den Berg L,Kindler-Röhrborn A

更新日期：2011-05-01 00:00:00

abstract：:Higher fat and lower carbohydrate and amino acid oxidation are observed in women compared with men during endurance exercise. We hypothesized that the observed sex difference is due to estrogen and that menstrual cycle phase or supplementation of men with 17beta-estradiol (E(2)) would coordinately influence the mRNA c...

journal_title：Physiological genomics

authors： Fu MH,Maher AC,Hamadeh MJ,Ye C,Tarnopolsky MA

更新日期：2009-12-30 00:00:00

abstract：:Mast cell numbers are significantly increased in bladder disorders including malignancy and interstitial cystitis, but their precise role has been difficult to determine. We characterized the role of mast cells on gene regulation associated with antigen-induced bladder inflammation in mice. For this purpose, we examin...

journal_title：Physiological genomics

authors： Saban R,Saban MR,Nguyen NB,Hammond TG,Wershil BK

更新日期：2001-10-10 00:00:00

abstract：:Stearoyl-CoA desaturases (SCDs) are key enzymes of fatty acid biosynthesis whose regulation underpins responses to dietary, thermal, and hormonal treatment. Although two isoforms are known to exist in the common carp and human and four in mouse, there is no coherent view on how this gene family evolved to generate fun...

journal_title：Physiological genomics

authors： Evans H,De Tomaso T,Quail M,Rogers J,Gracey AY,Cossins AR,Berenbrink M

更新日期：2008-09-17 00:00:00

abstract：:Gene expression was evaluated in mice divergently selected for 16 generations for heat loss, measured by direct calorimetry. The high (MH) heat loss line has approximately 50% greater heat loss, approximately 35% less body fat, approximately 20% greater feed intake, and twofold greater activity levels than the low (ML...

journal_title：Physiological genomics

authors： Allan MF,Nielsen MK,Pomp D

更新日期：2000-09-08 00:00:00

abstract：:The human miR-29 family of microRNAs has three mature members, miR-29a, miR-29b, and miR-29c. miR-29s are encoded by two gene clusters. Binding sites for several transcriptional factors have been identified in the promoter regions of miR-29 genes. The miR-29 family members share a common seed region sequence and are p...

journal_title：Physiological genomics

authors： Kriegel AJ,Liu Y,Fang Y,Ding X,Liang M

更新日期：2012-02-27 00:00:00

abstract：:Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that regulates the oxygen-dependent expression of a number of genes. This transcription factor may contribute to the abundant expression of many genes in renal medullary cells that function normally under hypoxic conditions. The present study was d...

journal_title：Physiological genomics

authors： Zou AP,Yang ZZ,Li PL,Cowley AW JR

更新日期：2001-08-28 00:00:00

abstract：:Leptin is known as a cytokine mostly produced by fat cells and implicated in regulation of energy metabolism and food intake but has also been shown to be involved in many physiological mechanisms such as tissue metabolism and cell differentiation and proliferation. In particular, leptin influences the development of ...

journal_title：Physiological genomics

authors： Koch E,Hue-Beauvais C,Galio L,Solomon G,Gertler A,Révillon F,Lhotellier V,Aujean E,Devinoy E,Charlier M

更新日期：2013-08-01 00:00:00

abstract：:Chromogranin A (CHGA) plays a catalytic role in formation of catecholamine storage vesicles and also serves as precursor to the peptide fragment catestatin, a catecholamine secretory inhibitor whose expression is diminished in the hypertensive individuals. We previously reported the hypertensive, hyperadrenergic pheno...

journal_title：Physiological genomics

authors： Vaingankar SM,Li Y,Corti A,Biswas N,Gayen J,O'Connor DT,Mahata SK

更新日期：2010-03-03 00:00:00

abstract：:Usher syndrome (USH) is a neurosensory disorder affecting both hearing and vision in humans. Linkage studies of families of USH patients, studies in animals, and characterization of purified proteins have provided insight into the molecular mechanisms of hearing. To date, 11 USH proteins have been identified, and evid...

journal_title：Physiological genomics

authors： Ahmed ZM,Frolenkov GI,Riazuddin S

更新日期：2013-11-01 00:00:00