ANP in regulation of arterial pressure and fluid-electrolyte balance: lessons from genetic mouse models.

abstract：:Physiological, morphological, and transcriptional alterations elicited by ethynyl estradiol in the uteri of Sprague-Dawley rats and C57BL/6 mice were assessed using comparable study designs, microarray platforms, and analysis methods to identify conserved estrogen signaling networks. Comparative analysis identified 15...

journal_title：Physiological genomics

authors： Kwekel JC,Burgoon LD,Burt JW,Harkema JR,Zacharewski TR

更新日期：2005-11-17 00:00:00

abstract：:Mast cell numbers are significantly increased in bladder disorders including malignancy and interstitial cystitis, but their precise role has been difficult to determine. We characterized the role of mast cells on gene regulation associated with antigen-induced bladder inflammation in mice. For this purpose, we examin...

journal_title：Physiological genomics

authors： Saban R,Saban MR,Nguyen NB,Hammond TG,Wershil BK

更新日期：2001-10-10 00:00:00

abstract：:Teleost fish represent unique models to study the role of neuroestrogens because of the extremely high activity of brain aromatase (AroB; the product of cyp19a1b). Aromatase respectively converts androstenedione and testosterone to estrone and 17beta-estradiol (E2). Specific inhibition of aromatase activity by fadrozo...

journal_title：Physiological genomics

authors： Zhang D,Popesku JT,Martyniuk CJ,Xiong H,Duarte-Guterman P,Yao L,Xia X,Trudeau VL

更新日期：2009-08-07 00:00:00

abstract：:Membrane-bound and membrane-associated proteins are difficult to analyze by mass spectrometry, since the association with lipids impedes the isolation and solubilization of the proteins in buffers suitable for mass spectrometry and the efficient generation of positively charged peptide ions by electrospray ionization....

journal_title：Physiological genomics

authors： Mirza SP,Halligan BD,Greene AS,Olivier M

更新日期：2007-06-19 00:00:00

abstract：:Bioaccumulative environmental estrogen, nonylphenol (NP; 4-nonylphenol), is widely used as a nonionic surfactant and can affect human health. Since genomes of Saccharomyces cerevisiae and higher eukaryotes share many structural and functional similarities, we investigated subcellular effects of NP on S. cerevisiae BY4...

journal_title：Physiological genomics

authors： Bereketoglu C,Arga KY,Eraslan S,Mertoglu B

更新日期：2017-10-01 00:00:00

abstract：:In functional genomics, the high-throughput methods such as microarrays 1) allow analysis of the relationships between genes considering them as elements of a network and 2) lead to biological interpretations thanks to Gene Ontology. But up to now it has not been possible to find relationships between the functions an...

journal_title：Physiological genomics

authors： Gustin MP,Paultre CZ,Randon J,Bricca G,Cerutti C

更新日期：2008-06-12 00:00:00

abstract：:Although Escherichia coli LPS is known to elicit various proinflammatory responses in macrophages, its effect on the translational states of transcripts has not yet been explored on a genome-wide scale. To address this, we investigated the mRNA profiles in polysomal and free messenger ribonucleoprotein particle (mRNP)...

journal_title：Physiological genomics

authors： Kitamura H,Ito M,Yuasa T,Kikuguchi C,Hijikata A,Takayama M,Kimura Y,Yokoyama R,Kaji T,Ohara O

更新日期：2008-03-14 00:00:00

abstract：:Growth hormone (GH) controls the physiology and pathophysiology of the liver, and its signals are conducted by two members of the family of signal transducers and activators of transcription, STAT5A and STAT5B. Mice in which the Stat5a/b locus has been inactivated specifically in hepatocytes display GH resistance, the...

journal_title：Physiological genomics

authors： Hosui A,Hennighausen L

更新日期：2008-07-15 00:00:00

abstract：:Vasopressin is a peptide hormone that regulates renal water excretion in part through its actions on the collecting duct. The regulation occurs in part via control of transcription of genes coding for the water channels aquaporin-2 (Aqp2) and aquaporin-3 (Aqp3). To identify transcription factors expressed in collectin...

journal_title：Physiological genomics

authors： Tchapyjnikov D,Li Y,Pisitkun T,Hoffert JD,Yu MJ,Knepper MA

更新日期：2010-02-04 00:00:00

abstract：:We previously reported that mice deficient in stearoyl-CoA desaturase-1 (Scd1) and maintained on a very low-fat (VLF) diet for 10 days developed severe loss of body weight, hypoglycemia, hypercholesterolemia, and many cholestasis-like phenotypes. To better understand the metabolic changes associated with these phenoty...

journal_title：Physiological genomics

authors： Flowers MT,Keller MP,Choi Y,Lan H,Kendziorski C,Ntambi JM,Attie AD

更新日期：2008-05-13 00:00:00

abstract：:Obesity is influenced by genetics and diet and has wide ranging comorbidities, including anxiety and depressive disorders. Outbred heterogeneous stock (HS) rats are used for fine-genetic mapping of complex traits and may be useful for understanding gene by diet interactions. In this study, HS rats were fed diets conta...

journal_title：Physiological genomics

authors： Deal AW,Seshie O,Lenzo A,Cooper N,Ozimek N,Solberg Woods LC

更新日期：2020-09-01 00:00:00

abstract：:Gene expression was evaluated in mice divergently selected for 16 generations for heat loss, measured by direct calorimetry. The high (MH) heat loss line has approximately 50% greater heat loss, approximately 35% less body fat, approximately 20% greater feed intake, and twofold greater activity levels than the low (ML...

journal_title：Physiological genomics

authors： Allan MF,Nielsen MK,Pomp D

更新日期：2000-09-08 00:00:00

abstract：:To further define genes that are differentially expressed during cysteine deprivation and to evaluate the roles of amino acid deprivation vs. oxidative stress in the response to cysteine deprivation, we assessed gene expression in human hepatoma cells cultured in complete or cysteine-deficient medium. Overall, C3A cel...

journal_title：Physiological genomics

authors： Lee JI,Dominy JE Jr,Sikalidis AK,Hirschberger LL,Wang W,Stipanuk MH

更新日期：2008-04-22 00:00:00

abstract：:Recombinant human erythropoietin (rHuEPO) is frequently abused by athletes as a performance-enhancing drug, despite being prohibited by the World Anti-Doping Agency. Although the methods to detect blood doping, including rHuEPO injections, have improved in recent years, they remain imperfect. In a proof-of-principle s...

journal_title：Physiological genomics

authors： Durussel J,Haile DW,Mooses K,Daskalaki E,Beattie W,Mooses M,Mekonen W,Ongaro N,Anjila E,Patel RK,Padmanabhan N,McBride MW,McClure JD,Pitsiladis YP

更新日期：2016-03-01 00:00:00

abstract：:This study analyzes the electrophysiological cause and behavioral consequence of dopaminergic cell loss in a knockin mouse strain bearing hypersensitive nicotinic alpha4-receptor subunits ("L9'S mice"). Adult brains of L9'S mice show moderate loss of substantia nigra dopaminergic neurons and of striatal dopaminergic i...

journal_title：Physiological genomics

authors： Orb S,Wieacker J,Labarca C,Fonck C,Lester HA,Schwarz J

更新日期：2004-08-11 00:00:00

abstract：:Protein restriction and hypercalcemia result in a urinary concentrating defect in rats and humans. Previous tubular perfusion studies show that there is an increased active urea transport activity in the initial inner medullary (IM) collecting duct in low-protein diet (LPD) and vitamin D (Vit D) animal models. To inve...

journal_title：Physiological genomics

authors： Chen G,Yang Y,Fröhlich O,Klein JD,Sands JM

更新日期：2010-05-01 00:00:00

abstract：:The structural organization of the brain is important for normal brain function and is critical to understand in order to evaluate changes that occur during disease processes. Three-dimensional (3D) imaging of the mouse brain is necessary to appreciate the spatial context of structures within the brain. In addition, t...

journal_title：Physiological genomics

authors： Gleave JA,Wong MD,Dazai J,Altaf M,Henkelman RM,Lerch JP,Nieman BJ

更新日期：2012-08-01 00:00:00

abstract：:A single point mutation in a novel immune-associated nucleotide gene 5 (Ian5) coincides with severe T cell lymphopenia in BB rats. We used a transgenic rescue approach in lymphopenic BB-derived congenic F344.lyp/lyp rats to determine whether this mutation is responsible for lymphopenia and to establish the functional ...

journal_title：Physiological genomics

authors： Michalkiewicz M,Michalkiewicz T,Ettinger RA,Rutledge EA,Fuller JM,Moralejo DH,Van Yserloo B,MacMurray AJ,Kwitek AE,Jacob HJ,Lander ES,Lernmark A

更新日期：2004-10-04 00:00:00

abstract：:Dynamic, epigenetic mechanisms can regulate macrophage phenotypes following exposure to different stimulating conditions and environments. However, temporal patterns of microRNAs (miRNAs or miRs) across multiple macrophage polarization phenotypes have not been defined. We determined miRNA expression in bone marrow-der...

journal_title：Physiological genomics

authors： Melton DW,Lei X,Gelfond JA,Shireman PK

更新日期：2016-05-01 00:00:00

abstract：:Preeclampsia is a progressive hypertensive disorder of pregnancy affecting 2-8% of pregnancies globally. Preexisting chronic hypertension is a major risk factor associated with developing preeclampsia, and growing evidence suggests a role for the gut microbiome in the development of preeclampsia. However, neither alte...

journal_title：Physiological genomics

authors： Ishimwe JA,Akinleye AA,Johnson AC,Garrett MR,Sasser JM

更新日期：2021-01-25 00:00:00

abstract：:The influence of inducible heat stress proteins on protecting contracting skeletal muscle against fatigue-induced injury was investigated. A line of transgenic mice overexpressing the inducible form of the 72-kDa heat shock protein (HSP72) in skeletal muscles was used. We examined the relationship between muscle contr...

journal_title：Physiological genomics

authors： Nosek TM,Brotto MA,Essig DA,Mestril R,Conover RC,Dillmann WH,Kolbeck RC

更新日期：2000-11-09 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disorder with immune-complex deposition that affects multiple organs. Previous studies have suggested the involvement of oxidative stress and apoptosis in SLE, but no clear link to etiology has been established. Here we show that mice deficient in a transcription fac...

journal_title：Physiological genomics

authors： Li J,Stein TD,Johnson JA

更新日期：2004-08-11 00:00:00

abstract：:This study investigated the use of the hindlimb suspension (HS) and reloading model of mice for the mapping of ultrastructural and gene expressional alterations underlying load-dependent muscular adaptations. Mice were hindlimb suspended for 7 days or kept as controls (n = 12). Soleus muscles were harvested after HS (...

journal_title：Physiological genomics

authors： Däpp C,Schmutz S,Hoppeler H,Flück M

更新日期：2004-12-15 00:00:00

abstract：:We evaluated the association between insulin resistance and the angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) gene polymorphism in a group of older hypertensive subjects (63 +/- 1 yr, n = 35) before and after a 6-mo aerobic exercise program (AEX). Insulin sensitivity index (S(I)), assessed by the freq...

journal_title：Physiological genomics

authors： Dengel DR,Brown MD,Ferrell RE,Reynolds TH 4th,Supiano MA

更新日期：2002-10-29 00:00:00

abstract：:The renin-angiotensin system (RAS), known for its roles in cardiovascular, metabolic, and developmental regulation, is present in both the circulation and in many individual tissues throughout the body. Substantial evidence supports the existence of a brain RAS, though quantification and localization of brain renin ha...

journal_title：Physiological genomics

authors： Xu D,Borges GR,Davis DR,Agassandian K,Sequeira Lopez ML,Gomez RA,Cassell MD,Grobe JL,Sigmund CD

更新日期：2011-03-29 00:00:00

abstract：:We previously mapped several gene loci influencing cancer risk of inbred BDIV and BDIX rats, resistant and susceptible, respectively, to N-ethyl-N-nitrosourea (ENU)-induced malignant peripheral nerve sheath tumors (MPNSTs). On the basis of a genomewide association analysis using a (BDIV × BDIX) F(2) generation the Mss...

journal_title：Physiological genomics

authors： Koelsch B,Winzen-Reichert B,Fischer C,Kutritz A,van den Berg L,Kindler-Röhrborn A

更新日期：2011-05-01 00:00:00

abstract：:Establishing standard operating procedures (SOPs) as tools for the analysis of behavioral phenotypes is fundamental to mouse functional genomics. It is essential that the tests designed provide reliable measures of the process under investigation but most importantly that these are reproducible across both time and la...

journal_title：Physiological genomics

authors： Mandillo S,Tucci V,Hölter SM,Meziane H,Banchaabouchi MA,Kallnik M,Lad HV,Nolan PM,Ouagazzal AM,Coghill EL,Gale K,Golini E,Jacquot S,Krezel W,Parker A,Riet F,Schneider I,Marazziti D,Auwerx J,Brown SD,Chambon P,Ro

更新日期：2008-08-15 00:00:00

abstract：:Our objective was to resequence insulin receptor substrate 2 (IRS2) to identify variants associated with obesity- and diabetes-related traits in Hispanic children. Exonic and intronic segments, 5' and 3' flanking regions of IRS2 (∼14.5 kb), were bidirectionally sequenced for single nucleotide polymorphism (SNP) discov...

journal_title：Physiological genomics

authors： Butte NF,Voruganti VS,Cole SA,Haack K,Comuzzie AG,Muzny DM,Wheeler DA,Chang K,Hawes A,Gibbs RA

更新日期：2011-09-22 00:00:00

abstract：:In Drosophila larvae, acquired synaptic thermotolerance after heat shock has previously been shown to correlate with the induction of heat shock proteins (Hsps) including HSP70. We tested the hypothesis that synaptic thermotolerance would be significantly diminished in a temperature-sensitive strain (Drosophila heat s...

journal_title：Physiological genomics

authors： Neal SJ,Karunanithi S,Best A,So AK,Tanguay RM,Atwood HL,Westwood JT

更新日期：2006-05-16 00:00:00

abstract：:Despite an abundance of evidence to the contrary from animal studies, large clinical trials on humans have shown that estrogen administered to postmenopausal women increases the risk of cardiovascular disease. However, timing may be everything, as estrogen is often administered immediately after ovariectomy (Ovx) in a...

journal_title：Physiological genomics

authors： Pechenino AS,Lin L,Mbai FN,Lee AR,He XM,Stallone JN,Knowlton AA

更新日期：2011-09-22 00:00:00