Angiopoietin-1 and vascular endothelial growth factor induce expression of inflammatory cytokines before angiogenesis.

abstract：:The zebrafish has become a popular model system for the study of vertebrate developmental biology because of its numerous strengths as a molecular genetic and embryological system. To determine the requirement for specific genes during embryogenesis, it is necessary to generate organisms carrying loss-of-function muta...

journal_title：Physiological genomics

authors： Lekven AC,Helde KA,Thorpe CJ,Rooke R,Moon RT

更新日期：2000-03-13 00:00:00

abstract：:Preeclampsia is a progressive hypertensive disorder of pregnancy affecting 2-8% of pregnancies globally. Preexisting chronic hypertension is a major risk factor associated with developing preeclampsia, and growing evidence suggests a role for the gut microbiome in the development of preeclampsia. However, neither alte...

journal_title：Physiological genomics

authors： Ishimwe JA,Akinleye AA,Johnson AC,Garrett MR,Sasser JM

更新日期：2021-01-25 00:00:00

abstract：:RNA viruses represent the predominant cause of many clinically relevant viral diseases in humans. Among several evolutionary advantages acquired by RNA viruses, the ability to usurp host cellular machinery and evade antiviral immune responses is imperative. During the past decade, RNA interference mechanisms, especial...

journal_title：Physiological genomics

authors： Swaminathan G,Martin-Garcia J,Navas-Martin S

更新日期：2013-11-15 00:00:00

abstract：:Exercise as well as hypoxia cause an increase in angiogenesis, changes in mitochondrial density and alterations in metabolism, but it is still under debate whether the hypoxia inducible factor (HIF) is active during both situations. In this study gene expression analysis of zebrafish larvae that were raised under norm...

journal_title：Physiological genomics

authors： Kopp R,Köblitz L,Egg M,Pelster B

更新日期：2011-05-13 00:00:00

abstract：:Previous in vitro studies found that nuclear factor erythroid-derived 2-like 1 (NFE2L1) was involved in mediating ascorbic acid-induced osterix expression and osteoblast differentiation via binding to the antioxidant response element of the osterix promoter. To test the role of NFE2L1 in regulating bone formation in v...

journal_title：Physiological genomics

authors： Kim J,Xing W,Wergedal J,Chan JY,Mohan S

更新日期：2010-01-08 00:00:00

abstract：:The influence of inducible heat stress proteins on protecting contracting skeletal muscle against fatigue-induced injury was investigated. A line of transgenic mice overexpressing the inducible form of the 72-kDa heat shock protein (HSP72) in skeletal muscles was used. We examined the relationship between muscle contr...

journal_title：Physiological genomics

authors： Nosek TM,Brotto MA,Essig DA,Mestril R,Conover RC,Dillmann WH,Kolbeck RC

更新日期：2000-11-09 00:00:00

abstract：:Recombinant human erythropoietin (rHuEPO) is frequently abused by athletes as a performance-enhancing drug, despite being prohibited by the World Anti-Doping Agency. Although the methods to detect blood doping, including rHuEPO injections, have improved in recent years, they remain imperfect. In a proof-of-principle s...

journal_title：Physiological genomics

authors： Durussel J,Haile DW,Mooses K,Daskalaki E,Beattie W,Mooses M,Mekonen W,Ongaro N,Anjila E,Patel RK,Padmanabhan N,McBride MW,McClure JD,Pitsiladis YP

更新日期：2016-03-01 00:00:00

abstract：:Protein restriction and hypercalcemia result in a urinary concentrating defect in rats and humans. Previous tubular perfusion studies show that there is an increased active urea transport activity in the initial inner medullary (IM) collecting duct in low-protein diet (LPD) and vitamin D (Vit D) animal models. To inve...

journal_title：Physiological genomics

authors： Chen G,Yang Y,Fröhlich O,Klein JD,Sands JM

更新日期：2010-05-01 00:00:00

abstract：:The Wfs1 gene codes for a protein with unknown function, but deficiency in this protein results in a range of neuropsychiatric and neuroendocrine syndromes. In the present study we aimed to find the functional networks influenced by Wfs1 in the hypothalamus. We performed gene expression profiling (Mouse Gene 1.0 ST Ar...

journal_title：Physiological genomics

authors： Kõks S,Soomets U,Plaas M,Terasmaa A,Noormets K,Tillmann V,Vasar E,Fernandes C,Schalkwyk LC

更新日期：2011-12-16 00:00:00

abstract：:The mammary gland undergoes extensive remodeling between the beginning of pregnancy and lactation; this involves cellular processes including cell proliferation, differentiation, and apoptosis, all of which are under the control of numerous regulators. To unravel the role played by miRNA, we describe here 47 new ovine...

journal_title：Physiological genomics

authors： Galio L,Droineau S,Yeboah P,Boudiaf H,Bouet S,Truchet S,Devinoy E

更新日期：2013-02-15 00:00:00

abstract：:Autosomal recessive mandibuloacral dysplasia [mandibuloacral dysplasia type A (MADA); Online Mendelian Inheritance in Man (OMIM) no. 248370] is caused by a mutation in LMNA encoding lamin A/C. Here we show that this mutation causes accumulation of the lamin A precursor protein, a marked alteration of the nuclear archi...

journal_title：Physiological genomics

authors： Filesi I,Gullotta F,Lattanzi G,D'Apice MR,Capanni C,Nardone AM,Columbaro M,Scarano G,Mattioli E,Sabatelli P,Maraldi NM,Biocca S,Novelli G

更新日期：2005-10-17 00:00:00

abstract：:Adeno-associated virus (AAV) vectors might offer solutions for restenosis and angiogenesis by transducing nondividing cells and providing long-term gene expression. We investigated the feasibility of vascular cell transduction by AAV vectors in an in vivo rabbit carotid artery model. Time course of gene expression, in...

journal_title：Physiological genomics

authors： Richter M,Iwata A,Nyhuis J,Nitta Y,Miller AD,Halbert CL,Allen MD

更新日期：2000-04-27 00:00:00

abstract：:In several species caloric restriction (CR) extends life span. In this paper we integrate data from studies on CR and other sources to articulate the hypothalamic deregulation hypothesis by which estrogen receptor-alpha (ER-α) signaling in the hypothalamus and limbic system affects life span under the stress of CR in ...

journal_title：Physiological genomics

authors： Gouw AM,Efe G,Barakat R,Preecha A,Mehdizadeh M,Garan SA,Brooks GA

更新日期：2017-02-01 00:00:00

abstract：:This study investigated the use of the hindlimb suspension (HS) and reloading model of mice for the mapping of ultrastructural and gene expressional alterations underlying load-dependent muscular adaptations. Mice were hindlimb suspended for 7 days or kept as controls (n = 12). Soleus muscles were harvested after HS (...

journal_title：Physiological genomics

authors： Däpp C,Schmutz S,Hoppeler H,Flück M

更新日期：2004-12-15 00:00:00

abstract：:Although increased vascular stiffness is more prominent in aging males than females, and males are more prone to vascular disease with aging, no study has investigated the genes potentially responsible for sex differences in vascular aging. We tested the hypothesis that the transcriptional adaptation to aging differs ...

journal_title：Physiological genomics

authors： Qiu H,Tian B,Resuello RG,Natividad FF,Peppas A,Shen YT,Vatner DE,Vatner SF,Depre C

更新日期：2007-04-24 00:00:00

abstract：:Hypoxia is a widely occurring condition experienced by diverse organisms under numerous physiological and disease conditions. To probe the molecular mechanisms underlying hypoxia responses and tolerance, we performed a genome-wide screen to identify mutants with enhanced hypoxia tolerance in the model eukaryote, the y...

journal_title：Physiological genomics

authors： Shah AN,Cadinu D,Henke RM,Xin X,Dastidar RG,Zhang L

更新日期：2011-07-27 00:00:00

abstract：:Uncoupling protein 1 (UCP1) is the first UCP described. It belongs to the family of mitochondrial carrier proteins and is expressed mainly in brown adipose tissue. Recently, the family of the UCPs has rapidly been growing due to the successive cloning of UCP2, UCP3, UCP4, and UCP5, also called brain mitochondrial carr...

journal_title：Physiological genomics

authors： Keller PA,Lehr L,Giacobino JP,Charnay Y,Assimacopoulos-Jeannet F,Giovannini N

更新日期：2005-08-11 00:00:00

abstract：:Since the discovery of the microbiome in humans, it has been studied in many mammalian species. Different microbiological communities with variable richness and diversity have been found among these species in distinct areas of the reproductive tract. Human studies have shown that the composition of the microbiome is ...

journal_title：Physiological genomics

authors： Heil BA,Paccamonti DL,Sones JL

更新日期：2019-08-01 00:00:00

abstract：:Several critical cell functions are influenced not only by internal cellular machinery but also by external mechanical and biochemical cues from the surrounding microenvironment. Slight changes to the microenvironment can result in dramatic changes to the cell's phenotype; for example, a change in the nutrients or pH ...

journal_title：Physiological genomics

authors： Bloom AB,Zaman MH

更新日期：2014-05-01 00:00:00

abstract：:The bacterium Piscirickettsia salmonis is the etiological agent of salmonid rickettsial septicemia (SRS), a severe disease that causes major economic losses to the Atlantic salmon aquaculture industry every year. Little is known about the infective strategy of P. salmonis, which is able to infect, survive within, and ...

journal_title：Physiological genomics

authors： Tacchi L,Bron JE,Taggart JB,Secombes CJ,Bickerdike R,Adler MA,Takle H,Martin SA

更新日期：2011-11-07 00:00:00

abstract：:Establishing standard operating procedures (SOPs) as tools for the analysis of behavioral phenotypes is fundamental to mouse functional genomics. It is essential that the tests designed provide reliable measures of the process under investigation but most importantly that these are reproducible across both time and la...

journal_title：Physiological genomics

authors： Mandillo S,Tucci V,Hölter SM,Meziane H,Banchaabouchi MA,Kallnik M,Lad HV,Nolan PM,Ouagazzal AM,Coghill EL,Gale K,Golini E,Jacquot S,Krezel W,Parker A,Riet F,Schneider I,Marazziti D,Auwerx J,Brown SD,Chambon P,Ro

更新日期：2008-08-15 00:00:00

abstract：:Cystic fibrosis (CF) lung disease severity is influenced by unknown genetic factors apart from the disease causative gene, cystic fibrosis transmembrane conductance regulator (CFTR). Previous studies have shown the C57BL/6J congenic Cftr(-/-) (B6 CF) mouse to develop a fibrotic lung disease compared with both CF mice ...

journal_title：Physiological genomics

authors： Haston CK,Cory S,Lafontaine L,Dorion G,Hallett MT

更新日期：2006-04-13 00:00:00

abstract：:Phospholamban (PLN), the reversible inhibitor of the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA2a), is a key regulator of myocyte Ca(2+) cycling with a significant role in heart failure. We previously showed that the single amino acid difference between human and mouse PLN results in increased inhibition of Ca(...

journal_title：Physiological genomics

authors： Wang HS,Arvanitis DA,Dong M,Niklewski PJ,Zhao W,Lam CK,Kranias EG,Sanoudou D

更新日期：2011-04-12 00:00:00

abstract：:Herbivores are predicted to evolve appropriate mechanisms to process the plant secondary compounds (PSCs) in their diet, and these mechanisms are likely specific to particular suites of PSCs. Changes in diet composition over evolutionary time should select for appropriate alterations in metabolism of the more recent d...

journal_title：Physiological genomics

authors： Magnanou E,Malenke JR,Dearing MD

更新日期：2013-09-03 00:00:00

abstract：:Epistasis effects (gene interactions) have been increasingly recognized as important genetic factors underlying complex traits. The existence of a large number of single nucleotide polymorphisms (SNPs) provides opportunities and challenges to screen DNA variations affecting complex traits using a candidate gene analys...

journal_title：Physiological genomics

authors： Mao Y,London NR,Ma L,Dvorkin D,Da Y

更新日期：2006-12-13 00:00:00

abstract：:The cardiovascular restricted transcription factor CHF1/Hey2 has been previously shown to regulate the smooth muscle response to growth factors. To determine how CHF1/Hey2 affects the smooth muscle response to growth factors, we performed a genomic screen for transcripts that are differentially expressed in wild-type ...

journal_title：Physiological genomics

authors： Shirvani SM,Mookanamparambil L,Ramoni MF,Chin MT

更新日期：2007-06-19 00:00:00

abstract：:Epigenetic differences between male and female bovine blastocysts provide a plausible link between physiological and gene transcription differences observed between male and female embryos. The aim of this study was to examine sex-related epigenetic differences in bovine blastocysts produced in vitro. Oocytes were mat...

journal_title：Physiological genomics

authors： Bermejo-Alvarez P,Rizos D,Rath D,Lonergan P,Gutierrez-Adan A

更新日期：2008-01-17 00:00:00

abstract：:Mammalian heart development is built on highly conserved molecular mechanisms with polygenetic perturbations resulting in a spectrum of congenital heart diseases (CHD). However, knowledge of cardiogenic ontogeny that regulates proper cardiogenesis remains largely based on candidate-gene approaches. Mapping the dynamic...

journal_title：Physiological genomics

authors： Li X,Martinez-Fernandez A,Hartjes KA,Kocher JP,Olson TM,Terzic A,Nelson TJ

更新日期：2014-07-01 00:00:00

abstract：:Disordered angiogenesis is implicated in pulmonary vascular remodeling secondary to congenital heart diseases (CHD). However, the underlying genes are not well delineated. We showed previously that an ovine model of CHD with increased pulmonary blood flow (PBF, Shunt) has an "angiogenesis burst" between 1 and 4 wk of ...

journal_title：Physiological genomics

authors： Tian J,Fratz S,Hou Y,Lu Q,Görlach A,Hess J,Schreiber C,Datar SA,Oishi P,Nechtman J,Podolsky R,She JX,Fineman JR,Black SM

更新日期：2011-01-01 00:00:00

abstract：:Previously we demonstrated that aging in coronary arteries is associated with proinflammatory phenotypic changes and decreased NO bioavailability, which, we hypothesized, promotes vascular disease by enhancing endothelial apoptosis. To test this hypothesis we characterized proapoptotic alterations in the phenotype of ...

journal_title：Physiological genomics

authors： Csiszar A,Ungvari Z,Koller A,Edwards JG,Kaley G

更新日期：2004-03-12 00:00:00