Roles of estrogen receptor-alpha in mediating life span: the hypothalamic deregulation hypothesis.

abstract：:Retinoid-related orphan receptor (ROR)α4 is the major RORα isoform expressed in adipose tissues and liver. In this study we demonstrate that RORα-deficient staggerer mice (RORα(sg/sg)) fed with a high-fat diet (HFD) exhibited reduced adiposity and hepatic triglyceride levels compared with wild-type (WT) littermates an...

journal_title：Physiological genomics

authors： Kang HS,Okamoto K,Takeda Y,Beak JY,Gerrish K,Bortner CD,DeGraff LM,Wada T,Xie W,Jetten AM

更新日期：2011-07-14 00:00:00

abstract：:Cardiac microvascular endothelial cells (CMVECs) are the most numerous cells in the myocardium and orchestrate cardiogenesis during development, regulate adult cardiac function, and modulate pathophysiology of heart failure. It has been shown that the transcriptome of CMVECs differs from other endothelial cell types, ...

journal_title：Physiological genomics

authors： Vermeulen Z,Mateiu L,Dugaucquier L,De Keulenaer GW,Segers VFM

更新日期：2019-06-01 00:00:00

abstract：:Previous studies have indicated that hemorrhage may predispose the lung to respiratory distress syndrome. Gene expression profiling with oligonucleotide microarrays was used to evaluate the genetic responses of the lung to hemorrhage. Conscious rats, chronically instrumented with a catheter and telemetry device to rec...

journal_title：Physiological genomics

authors： Bowman PD,Sondeen JL,Zhao B,Coppes VG,Nelson JJ,Dubick MA,Vaughan GM

更新日期：2005-11-17 00:00:00

abstract：:The nucleus tractus solitarii (NTS) controls the cardiovascular system during exercise, and alteration of its function may underlie exercise-induced cardiovascular adaptation. To understand the molecular basis of the NTS's plasticity in regulating blood pressure (BP) and its potential contribution to the antihypertens...

journal_title：Physiological genomics

authors： Waki H,Gouraud SS,Bhuiyan ME,Takagishi M,Yamazaki T,Kohsaka A,Maeda M

更新日期：2013-01-07 00:00:00

abstract：:In this paper, two novel, powerful, and robust convolutional neural network (CNN) architectures are designed and proposed for two different classification tasks using publicly available data sets. The first architecture is able to decide whether a given chest X-ray image of a patient contains COVID-19 or not with 98.9...

journal_title：Physiological genomics

authors： Irmak E

更新日期：2020-12-01 00:00:00

abstract：:Membrane-bound and membrane-associated proteins are difficult to analyze by mass spectrometry, since the association with lipids impedes the isolation and solubilization of the proteins in buffers suitable for mass spectrometry and the efficient generation of positively charged peptide ions by electrospray ionization....

journal_title：Physiological genomics

authors： Mirza SP,Halligan BD,Greene AS,Olivier M

更新日期：2007-06-19 00:00:00

abstract：:Although the genetics of rare, monogenic, forms of human hypertension are fairly well defined, the genetics of the common polygenic form of human essential hypertension is only emerging. With the ability to control environmental variables, animal models have provided valuable tools with which to study blood pressure (...

journal_title：Physiological genomics

authors： Woo DD,Kurtz I

更新日期：2003-11-11 00:00:00

abstract：:Adenosine deaminase acting on RNA (ADAR) in Drosophila and mammals has recently become the target of numerous investigations. It is now clear that this protein has a number of functions in the nervous system. Indeed, the mutation of ADAR in Drosophila (dADAR) results in many pathological and physiological changes, suc...

journal_title：Physiological genomics

authors： Xia S,Yang J,Su Y,Qian J,Ma E,Haddad GG

更新日期：2005-01-20 00:00:00

abstract：:Hypertension is a condition with major cardiovascular and renal complications, affecting nearly a billion patients worldwide. Few validated gene targets are available for pharmacological intervention, so there is a need to identify new biological pathways regulating blood pressure and containing novel targets for trea...

journal_title：Physiological genomics

authors： Puig O,Wang IM,Cheng P,Zhou P,Roy S,Cully D,Peters M,Benita Y,Thompson J,Cai TQ

更新日期：2010-09-01 00:00:00

abstract：:Hypertension (HTN) is a prevalent condition with complex etiology and pathophysiology. Evidence exists of significant communication between the nervous system and the immune system (IS), and there appears to be a direct role for inflammatory bone marrow (BM) cells in the pathophysiology of hypertension. However, the m...

journal_title：Physiological genomics

authors： Ahmari N,Schmidt JT,Krane GA,Malphurs W,Cunningham BE,Owen JL,Martyniuk CJ,Zubcevic J

更新日期：2016-07-01 00:00:00

abstract：:Usher syndrome (USH) is a neurosensory disorder affecting both hearing and vision in humans. Linkage studies of families of USH patients, studies in animals, and characterization of purified proteins have provided insight into the molecular mechanisms of hearing. To date, 11 USH proteins have been identified, and evid...

journal_title：Physiological genomics

authors： Ahmed ZM,Frolenkov GI,Riazuddin S

更新日期：2013-11-01 00:00:00

abstract：:Growth hormone is one of few pharmacologic agents known to augment milk production in humans. We hypothesized that recombinant human GH (rhGH) increases the expression of cell proliferation and milk protein synthesis genes. Sequential milk and blood samples collected over four days were obtained from five normal lacta...

journal_title：Physiological genomics

authors： Maningat PD,Sen P,Rijnkels M,Hadsell DL,Bray MS,Haymond MW

更新日期：2011-04-27 00:00:00

abstract：:Nicotinic acetylcholine receptors (nAChR) are assembled from a pool of nine alpha-subunits and three beta-subunits into functional pentamers in peripheral autonomic neurons. The contribution of different subunits to native, physiologically important nAChR for synaptic transmission in autonomic ganglia is unclear. Here...

journal_title：Physiological genomics

authors： Deck J,Bibevski S,Gnecchi-Ruscone T,Bellina V,Montano N,Dunlap ME

更新日期：2005-06-16 00:00:00

abstract：:The mammary gland undergoes extensive remodeling between the beginning of pregnancy and lactation; this involves cellular processes including cell proliferation, differentiation, and apoptosis, all of which are under the control of numerous regulators. To unravel the role played by miRNA, we describe here 47 new ovine...

journal_title：Physiological genomics

authors： Galio L,Droineau S,Yeboah P,Boudiaf H,Bouet S,Truchet S,Devinoy E

更新日期：2013-02-15 00:00:00

abstract：:The purpose of this study was to identify novel transcriptional events occurring in the aortic wall before angiogenesis. We used a defined tissue culture system that takes advantage of the capacity of rat aortic rings to generate neovessels ex vivo in response to angiogenic factor stimulation. Total RNA isolated from ...

journal_title：Physiological genomics

authors： Aplin AC,Gelati M,Fogel E,Carnevale E,Nicosia RF

更新日期：2006-10-03 00:00:00

abstract：:We previously constructed a congenic mouse, B6.S-D2Mit194-D2Mit311 (B6.S-2) with 27 Mb of SPRET/Ei donor DNA on distal chromosome 2 in a C57BL/6J background that captured an obesity quantitative trait locus (QTL). Mice homozygous for SPRET/Ei alleles at the donor region had decreased body weight and obesity-related ph...

journal_title：Physiological genomics

authors： Chiu S,Kim K,Haus KA,Espinal GM,Millon LV,Warden CH

更新日期：2007-09-19 00:00:00

abstract：:We previously generated a conditional floxed mouse line to study androgen action, in which exon 3 of the androgen receptor (AR) gene is flanked by loxP sites, with the neomycin resistance gene present in intron 3. Deletion of exon 3 in global AR knockout mice causes androgen insensitivity syndrome, characterized by ge...

journal_title：Physiological genomics

authors： MacLean HE,Chiu WS,Ma C,McManus JF,Davey RA,Cameron R,Notini AJ,Zajac JD

更新日期：2008-03-14 00:00:00

abstract：:To date, physical exercise is the only intervention consistently demonstrated to attenuate age-related declines in physical function. However, variability exists in seniors' responsiveness to training. One potential source of variability is the insertion (I allele) or deletion (D allele) of a 287 bp fragment in intron...

journal_title：Physiological genomics

authors： Buford TW,Hsu FC,Brinkley TE,Carter CS,Church TS,Dodson JA,Goodpaster BH,McDermott MM,Nicklas BJ,Yank V,Johnson JA,Pahor M,LIFE Research Group.

更新日期：2014-03-01 00:00:00

abstract：:Hypoxia is an important ecological, evolutionary, and biomedical stressor. While physiological acclimatization of mammals to hypoxia is well studied, the variation in gene expression that underlies acclimatization is not well studied. We acclimatized inbred mice for 32 days to hypoxic conditions that simulated altitud...

journal_title：Physiological genomics

authors： Baze MM,Schlauch K,Hayes JP

更新日期：2010-05-01 00:00:00

abstract：:Physiological, morphological, and transcriptional alterations elicited by ethynyl estradiol in the uteri of Sprague-Dawley rats and C57BL/6 mice were assessed using comparable study designs, microarray platforms, and analysis methods to identify conserved estrogen signaling networks. Comparative analysis identified 15...

journal_title：Physiological genomics

authors： Kwekel JC,Burgoon LD,Burt JW,Harkema JR,Zacharewski TR

更新日期：2005-11-17 00:00:00

abstract：:The full extent to which 1,25-dihydroxyvitamin D(3) affects gene expression in human intestinal epithelial cells is unknown. We used oligonucleotide arrays to catalog vitamin D-induced changes in gene expression in Caco-2 cells, a human colon carcinoma cell line. Five paired sets of Caco-2 cell cultures were subjected...

journal_title：Physiological genomics

authors： Wood RJ,Tchack L,Angelo G,Pratt RE,Sonna LA

更新日期：2004-04-13 00:00:00

abstract：:Sulfate plays an essential role during growth, development and cellular metabolism. In this study, we characterized the function and structure of the zebrafish (Danio rerio) Na+-sulfate cotransporter 1 (NaS1) cDNA and gene (slc13a1). Zebrafish NaS1 encodes a protein of 583 amino acids with 13 putative transmembrane do...

journal_title：Physiological genomics

authors： Markovich D,Romano A,Storelli C,Verri T

更新日期：2008-08-15 00:00:00

abstract：:There exists a sense of urgency to begin to generate a cohesive assembly of biomedical knowledge as the pace of knowledge accumulation accelerates. The urgency is in part driven by the emergence of systems molecular medicine that emphasizes the combination of systems analysis and molecular dissection in the future of ...

journal_title：Physiological genomics

authors： Liang M

更新日期：2007-08-20 00:00:00

abstract：:Preeclampsia (PE) is a devastating adverse outcome of pregnancy. Characterized by maternal hypertension, PE, when left untreated, can result in death of both mother and baby. The cause of PE remains unknown, and there is no way to predict which women will develop PE during pregnancy. The only known treatment is delive...

journal_title：Physiological genomics

authors： Olson KN,Redman LM,Sones JL

更新日期：2019-03-01 00:00:00

abstract：:Chromogranin A (CHGA) plays a catalytic role in formation of catecholamine storage vesicles and also serves as precursor to the peptide fragment catestatin, a catecholamine secretory inhibitor whose expression is diminished in the hypertensive individuals. We previously reported the hypertensive, hyperadrenergic pheno...

journal_title：Physiological genomics

authors： Vaingankar SM,Li Y,Corti A,Biswas N,Gayen J,O'Connor DT,Mahata SK

更新日期：2010-03-03 00:00:00

abstract：:Although some single polymorphism analyses of the angiotensinogen (AGT) gene have been found to be associated with hypertension, the results are still inconsistent. The objectives of this study are to evaluate the association of the genotype and haplotype distributions of three single-nucleotide polymorphisms (SNPs) (...

journal_title：Physiological genomics

authors： Wu SJ,Chiang FT,Chen WJ,Liu PH,Hsu KL,Hwang JJ,Lai LP,Lin JL,Tseng CD,Tseng YZ

更新日期：2004-04-13 00:00:00

abstract：:A novel coronavirus disease, COVID-19, has created a global pandemic in 2020, posing an enormous challenge to healthcare systems and affected communities. COVID-19 is caused by Severe Acute Respiratory Syndrome (SARS)-CoronaVirus-2 (CoV-2) that manifests as bronchitis, pneumonia, or a severe respiratory illness. SARS-...

journal_title：Physiological genomics

authors： Ashraf UM,Abokor AA,Edwards JM,Waigi EW,Royfman RS,Hasan SA,Smedlund KB,Hardy AMG,Chakravarti R,Koch LG

更新日期：2020-12-04 00:00:00

abstract：:Protein restriction and hypercalcemia result in a urinary concentrating defect in rats and humans. Previous tubular perfusion studies show that there is an increased active urea transport activity in the initial inner medullary (IM) collecting duct in low-protein diet (LPD) and vitamin D (Vit D) animal models. To inve...

journal_title：Physiological genomics

authors： Chen G,Yang Y,Fröhlich O,Klein JD,Sands JM

更新日期：2010-05-01 00:00:00

abstract：:Previously we demonstrated that aging in coronary arteries is associated with proinflammatory phenotypic changes and decreased NO bioavailability, which, we hypothesized, promotes vascular disease by enhancing endothelial apoptosis. To test this hypothesis we characterized proapoptotic alterations in the phenotype of ...

journal_title：Physiological genomics

authors： Csiszar A,Ungvari Z,Koller A,Edwards JG,Kaley G

更新日期：2004-03-12 00:00:00

abstract：:Dynamic, epigenetic mechanisms can regulate macrophage phenotypes following exposure to different stimulating conditions and environments. However, temporal patterns of microRNAs (miRNAs or miRs) across multiple macrophage polarization phenotypes have not been defined. We determined miRNA expression in bone marrow-der...

journal_title：Physiological genomics

authors： Melton DW,Lei X,Gelfond JA,Shireman PK

更新日期：2016-05-01 00:00:00