Abstract:
AIMS:We determined levels of the inflammatory marker YKL-40 in a population of patients with type 2 diabetes (T2D) and investigated the association with mortality. METHODS:In a prospective observational follow-up study, 290 patients with T2D, normoalbuminuria (n=177), microalbuminuria (n=71) and macroalbuminuria (n=42) were followed for a median (range) of 17.2 (0.2-23.0) years. Serum YKL-40 concentration was determined at baseline. RESULTS:Baseline median (IQR) YKL-40 level was 46ng/ml (36-67) in patients with normoalbuminuria, 61ng/ml (43-114) in microalbuminuric patients, and 81.5ng/ml (60-157) in patients with macroalbuminuria, p<0.001. During follow-up 189 patients (65.2%) died, 119 (41.0%) from cardiovascular causes. All-cause mortality was increased in patients with YKL-40 levels in the second and third tertile (hazard ratios (95% CI) compared with the first tertile, (1.50 (1.03-2.19), p=0.034, and 2.88 (2.01-4.12), p<0.001). This association persisted after adjustment for cardiovascular risk factors but was attenuated after additional adjustment for urinary albumin excretion rate and glomerular filtration rate. Cardiovascular mortality was increased with YKL-40 levels in the third tertile compared with the first tertile, (2.70 (1.78-4.08)), p<0.001. This association was diminished after adjustment for covariates. CONCLUSIONS:In patients with T2D and increasing albuminuria high YKL-40 levels predict all-cause mortality.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Persson F,Rathcke CN,Gall MA,Parving HH,Vestergaard H,Rossing Pdoi
10.1016/j.diabres.2011.12.008subject
Has Abstractpub_date
2012-04-01 00:00:00pages
84-9issue
1eissn
0168-8227issn
1872-8227pii
S0168-8227(11)00676-0journal_volume
96pub_type
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,meta分析
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2004.12.008
更新日期:2005-08-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/0168-8227(90)90117-c
更新日期:1990-03-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2003.12.004
更新日期:2004-08-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2008.11.023
更新日期:2009-02-01 00:00:00
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journal_title:Diabetes research and clinical practice
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journal_title:Diabetes research and clinical practice
pub_type: 临床试验,杂志文章
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更新日期:2014-10-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,随机对照试验
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更新日期:2011-10-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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更新日期:2000-08-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2008.07.009
更新日期:2008-10-01 00:00:00
abstract:AIMS:To compare the estimates and projections of type 2 diabetes mellitus (T2DM) prevalence in Saudi Arabia from a validated Markov model against other modelling estimates, such as those produced by the International Diabetes Federation (IDF) Diabetes Atlas and the Global Burden of Disease (GBD) project. METHODS:A dis...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2020.108471
更新日期:2020-12-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/s0168-8227(87)80053-0
更新日期:1987-09-01 00:00:00
abstract:OBJECTIVE:The effects of intensive blood pressure (BP) lowering for hypertensive patients with coronary artery disease (CAD) and diabetes mellitus on their clinical outcomes have not been fully evaluated. The aim was to explore the optimal systolic BP target in such patients in a substudy of a prospective, randomized t...
journal_title:Diabetes research and clinical practice
pub_type: 杂志文章
doi:10.1016/j.diabres.2019.01.031
更新日期:2019-03-01 00:00:00
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journal_title:Diabetes research and clinical practice
pub_type: 杂志文章,评审
doi:10.1016/j.diabres.2008.01.009
更新日期:2008-06-01 00:00:00