Abstract：
:This study aims to investigate whether renal and cardiovascular phenotypes in Italian patients with type 2 diabetes (T2D) could be influenced by a number of disease risk SNPs recently found in genome-wide association studies (GWAS). In 1591 Italian subjects with T2D: (1) 47 SNPs associated to kidney function and/or chronic kidney disease (CKD) and 49 SNPs associated to cardiovascular disease (CVD) risk were genotyped; (2) urinary albumin/creatinine (A/C) ratio, glomerular filtration rate (eGFR) and lipid profile were assessed; (3) a standard electrocardiogram was performed; (4) two genotype risk scores (GRS) were computed (a renal GRS calculated selecting 39 SNPs associated with intermediate traits of kidney damage and a cardiovascular GRS determined selecting 42 SNPs associated to CVD risk phenotypes). After correction for multiple comparisons, the renal GRS was not associated to A/C ratio (p = 0.33), but it was significantly related to decreased eGFR (p = 0.005). No association between the cardiovascular GRS and electrocardiogram was detected. Thus, in Italian patients with T2D a renal GRS might predict the decline in glomerular function, suggesting that the clock of diabetes associated CKD starts ticking long before hyperglycemia. Our data support the feasibility of gene-based prediction of complications in people with T2D.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Zusi C,Trombetta M,Bonetti S,Dauriz M,Boselli ML,Trabetti E,Malerba G,Penno G,Zoppini G,Bonora E,Solini A,Bonadonna RCdoi
10.1016/j.diabres.2018.08.013subject
Has Abstractpub_date
2018-10-01 00:00:00pages
137-143eissn
0168-8227issn
1872-8227pii
S0168-8227(18)30429-7journal_volume
144pub_type
杂志文章abstract：AIM:Dozens of susceptibility loci have been identified by type 2 diabetes (T2D) genome wide association study (GWAS) in Europeans. In our previous studies, we systematically evaluated the association of 48 susceptibility loci with T2D risk in Chinese Hans. Because dyslipidemia and hyperglycemia are implicated in the pa...
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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journal_title：Diabetes research and clinical practice
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更新日期：1996-10-01 00:00:00
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journal_title：Diabetes research and clinical practice
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更新日期：2013-01-01 00:00:00
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journal_title：Diabetes research and clinical practice
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更新日期：1987-07-01 00:00:00
