当前位置： SCI文献检索 > DIABETES RESEARCH AND CLINICAL PRACTICE期刊下所有文献 > The effect of aldose reductase inhibition with ponalrestat on the width of the capillary basement membrane in diabetes mellitus.

The effect of aldose reductase inhibition with ponalrestat on the width of the capillary basement membrane in diabetes mellitus.

Abstract：

:There is evidence to suggest that hyperglycemia is required for the development of the microvascular complications of diabetes. However, the precise mechanism by which hyperglycemia might cause diabetic complications is not completely clear. One possibility is the increased activity of the polyol pathway. Capillary basement membrane thickness is a hallmark histological finding in diabetic microangiopathy. Previous studies in experimental models of diabetes have related the polyol pathway with the thickness of basement membrane in retinal capillaries. To study the effect of aldose reductase inhibition with ponalrestat on the width of the skeletal muscle capillary basement membrane in subjects with diabetes, we measured the capillary basement membrane width in 55 subjects with diabetes in a double masked, placebo controlled randomized trial over a period of 18 months. Twenty-nine patients received ponalrestat (two 300 mg tablets daily) and twenty-six received placebo tablets. The age, sex distribution, type and duration of diabetes were similar in both groups. The glycosylated hemoglobin remained at a constant level throughout the study in both groups. The baseline capillary basement membrane width of the ponalrestat group was 3134 +/- 146 A, it was 3074 +/- 226 A at month 12 and 2548 +/- 182 A at month 18 (P less than 0.001 vs baseline value). The placebo group also had a significant reduction in the width of the capillary basement membrane, from a baseline value of 3026 +/- 147 A to 2818 +/- 144 A at month 12 and 2618 +/- 156 A at month 18 (P less than 0.001 vs baseline value). There was no statistical difference in the capillary basement membrane width between the two groups at any time point.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Ramirez LC,Arauz C,Pruneda L,Hammon K,Rosenstock J,Raskin P

doi

10.1016/0168-8227(91)90094-t

subject

Has Abstract

pub_date

1991-02-01 00:00:00

pages

73-80

issue

eissn

0168-8227

issn

1872-8227

pii

0168-8227(91)90094-T

journal_volume

pub_type

临床试验,杂志文章,随机对照试验

在线工具

The effect of aldose reductase inhibition with ponalrestat on the width of the capillary basement membrane in diabetes mellitus.