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High levels of very long-chain saturated fatty acid in erythrocytes correlates with atherogenic lipoprotein profiles in subjects with metabolic syndrome.

Abstract：

AIM:Very long chain saturated fatty acid (VLCFA) levels in erythrocytes are associated with metabolic syndrome (MS). However, the relationship between levels of the VLCFA ligonoceric acid (C24:0) in erythrocytes and the atherogenic lipoprotein profiles and inflammatory state in MS remain unclear. METHODS:Based on the International Diabetes Federation (IDF) definition of MS, 195 apparently healthy males were assigned to either an MS group (n=38) or a non-MS group (n=157). Fatty acid composition of erythrocytes was determined by gas liquid chromatography. RESULTS:Erythrocytes from the MS group had a significantly higher level of C24:0 than cells from the non-MS group (4.06±0.48% versus 3.88±0.34%; p=0.03). C24:0 levels were significantly correlated with several components of MS. The C24:0 levels showed a significant negative correlation with LDL and HDL particle size. Multivariate linear regression analysis showed that C24:0 levels were independently correlated with LDL particle size after adjusting for age and each MS criterion. C24:0 levels were also positively correlated with log-transformed high-sensitivity CRP levels (p=0.04). CONCLUSION:C24:0 levels in erythrocytes are associated with specific atherogenic lipoprotein profiles and inflammation status in subjects with MS.

journal_name

Diabetes Res Clin Pract

journal_title

Diabetes research and clinical practice

authors

Matsumori R,Miyazaki T,Shimada K,Kume A,Kitamura Y,Oshida K,Yanagisawa N,Kiyanagi T,Hiki M,Fukao K,Hirose K,Ohsaka H,Mokuno H,Daida H

doi

10.1016/j.diabres.2012.10.025

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

12-8

issue

1

eissn

0168-8227

issn

1872-8227

pii

S0168-8227(12)00392-0

journal_volume

99

pub_type

杂志文章

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